Patents Examined by Lydia Edwards
  • Patent number: 9926525
    Abstract: The present invention relates to systems and methods for optimising the usage of laboratory and cell culturing space for cell culture and biomanufacturing. The invention provides a system and method that can be used to provide a plurality of workstations and/or storage bays for bioreactors in cell culturing and/or biomanufacturing facilities.
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: March 27, 2018
    Assignee: GE Healthcare UK Limited
    Inventors: Christopher George Norey, Michelle Louise Janas, Anthony Patterson, Adrian Crawley
  • Patent number: 9918464
    Abstract: The straw comprises a tube (11) having a swelling plug (15) provided with a fibrous support agent and a swelling agent combined with the support agent and configured, at least close to a second end (18) of the swelling plug, after a liquid-based substance has come up against its second end, to be in a state of swelling constrained by said tube such that if a first part (26) of the swelling plug of length comprised between 2 mm and 3 mm starting from its second end has come out of the tube via a second end (14) of the tube, whereas a second part of the swelling plug remains in the tube, the first part of the swelling plug becomes decompacted and expands with the second end of the swelling plug which assumes a diameter (d) at least equal to one and a half times the inner diameter of the tube.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: March 20, 2018
    Inventors: Eric Schmitt, Jean-Charles Gorges
  • Patent number: 9920290
    Abstract: The present disclosure relates to a continuous fermentation apparatus and a multi-step continuous fermentation process using the same.
    Type: Grant
    Filed: October 26, 2012
    Date of Patent: March 20, 2018
    Assignees: Biol Systems Co., Ltd., Daewoo Shipbuilding & Marine Engineering Co., Ltd.
    Inventors: Myung Kyo Shin, Jin Hyuk Shin, In Sik Kim, Dongjoong Im
  • Patent number: 9908119
    Abstract: A thermal cycling apparatus having a sample interfacing wall extending from a mounting wall. The sample interfacing wall can accept and apply thermal cycles to samples. An air source can direct an air stream to cool the sample. Another source can direct heated air away from the sample.
    Type: Grant
    Filed: May 15, 2013
    Date of Patent: March 6, 2018
    Assignee: Cepheid
    Inventor: Doug Dority
  • Patent number: 9910030
    Abstract: Small and extremely small molecules and ions or atoms may be detected with the novel device with exceptional sensitivity. The detection is implemented in a simple manner by the known acoustic resonator FBAR or by means of other technologies that measure the physical properties of the filled layer. The permeability of substances (e.g. active ingredients) through membranes such as cell membranes, lipid bilayers, and cell walls can be examined by combining a sensor with the reservoir and the membrane.
    Type: Grant
    Filed: January 9, 2012
    Date of Patent: March 6, 2018
    Inventors: Martin Nirschl, Kaori Sugihara, Janos Vörös, Tomaso Zambelli
  • Patent number: 9901887
    Abstract: An automated template bead preparation system is provided and includes a membrane-based emulsion generation subsystems, a thermal plate and subsystem, and a continuous centrifugation emulsion breaking and templated bead collection subsystem. The emulsion generation subsystem provides uniformity in the preparation of an inverse emulsion and may be used to create large or small volume inverse emulsions rapidly and reproducibly. An emulsion-generating device is provided that can supply a continuous stream of an inverse emulsion to a thermal subsystem, in automated fashion. The thermal subsystem can treat an inverse emulsion passed therethrough. The continuous centrifugation subsystem can continuously break a thermally cycled inverse emulsion and collect template beads formed in the aqueous microreactor droplets of the inverse emulsion.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: February 27, 2018
    Assignee: Life Technologies Corporation
    Inventors: Jonathan Schultz, John Nobile, Brian Reed, Prasanna Thwar, Todd Roswech, John Andrew Sheridan
  • Patent number: 9903857
    Abstract: A testing apparatus for performing an assay, the testing apparatus comprising: a receptacle (2) containing a reagent, the reagent being reactive to an applied test sample by developing a color or pattern variation; a portable device (1), e.g. a mobile phone or a laptop, comprising a processor and an image capture device (3), wherein the processor is configured to process data captured by the image capture device and output a test result for the applied test sample.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: February 27, 2018
    Assignee: Norarum DX Limited
    Inventors: Neil Polwart, Graham Tyrie, Anthony Peter Ashbrook
  • Patent number: 9890343
    Abstract: The invention relates to a process and a biofilter system (10) for removing H2S from a H2S contaminated energy production gas stream containing methane. The aqueous biofilter system comprises a biofilter (6) having biofilter support material constituting a biofilter bed supporting a humidified biofilm having microorganisms that are capable of oxidizing H2S. The process comprises the steps of contacting the H2S contaminated energy production gas stream with the microorganisms of the humidified biofilm, and oxidation of at least part of the H2S in the H2S contaminated energy production gas stream by the microorganisms, resulting in a H2S depleted energy production gas stream, wherein the process further comprises the step of adding an aqueous nitrate solution to the H2S contaminated energy production gas stream prior to being contacted with the microorganisms, enabling the microorganisms to oxidize the H2S under anoxic conditions.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: February 13, 2018
    Inventors: Marina Ettl, Wolfram Franke, Werner Van Borm
  • Patent number: 9890352
    Abstract: An injectable tissue engineered cartilage in vitro construction apparatus, comprising an incubator (1), a centrifugal device arranged in the incubator (1), and a control system for controlling a temperature in the incubator (1) and an action of the centrifugal device. The centrifugal device comprises a centrifuge, a container base (2) mounted onto the centrifuge, a dosing system for adding preparation reagent, and a stirring system for stirring the reagent. With a controller (17) and a pH sensor (16), a measured pH value will be transmitted by the pH sensor (16) to the controller (17) in real time. The controller (17) controls an action of a driving mechanism via a control module II (21), to drive a piston rod to add NaOH solution into a container tank (6). When the pH value of the solution falls in a predetermined range, the driving mechanism is stopped, to precisely control the pH value of the solution.
    Type: Grant
    Filed: July 21, 2014
    Date of Patent: February 13, 2018
    Inventors: Fuyou Wang, Junli Liu, Liu Yang, Ying Zhang, Guangxing Chen, Lin Guo, Xiaojun Duan
  • Patent number: 9862918
    Abstract: A well plate is formed with a well for holding a subject to be sucked by a suction nozzle on an inner bottom part and storing liquid and, a clearance forming member for forming a clearance to allow the liquid to flow in a state where a tip part of the suction nozzle is inserted into and held in contact with the well is provided in the well. According to the present invention, the clearance enabling the liquid to flow is formed even in the state where the tip part of the suction nozzle is inserted into and held in contact with the well in sucking the subject held in the well by the suction nozzle. The suction nozzle can suck the liquid around through the clearance and the subject held in the well is efficiently sucked through the suction port along the flow of the sucked liquid.
    Type: Grant
    Filed: January 19, 2012
    Date of Patent: January 9, 2018
    Inventor: Saburo Ito
  • Patent number: 9855558
    Abstract: An apparatus and method for thermal cycling including a pasting edge heater. The pasting edge heater can provide substantial temperature uniformity throughout the retaining elements during thermal cycling by a thermoelectric module.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: January 2, 2018
    Inventors: Hon Siu Shin, Hock Lai Khoo
  • Patent number: 9845453
    Abstract: A cell culture apparatus is provided which can continuously and accurately measure turbidity of a cell culture solution and culture a cell, without inserting a turbidity sensor from outside into a sterile bag. The cell culture apparatus includes: a flexible and transparent sterile bag that is installed at a prescribed position in the cell culture apparatus and in which a cell contained in a cell culture solution is cultured; and a turbidity sensor that includes a light emitter which emits light to the cell culture solution in the sterile bag via a portion of the sterile bag, a light receiver which receives the light transmitted through the cell culture solution via another portion of the sterile bag, and that is configured to place the light emitter, the portion of the sterile bag, another portion of the sterile bag, and the light receiver, optically on a same straight line.
    Type: Grant
    Filed: August 1, 2014
    Date of Patent: December 19, 2017
    Assignee: HITACHI, LTD.
    Inventors: Masaru Nanba, Ryouichi Haga, Sei Murakami, Haruo Suzuki
  • Patent number: 9840688
    Abstract: A bioreactor system includes a sample chamber capable of receiving a specimen and a cover which can be placed on the chamber to enclose the specimen within the chamber. A first member is movable between (i) a closed position in which the member restricts the cover from being moved away from the chamber in a first direction, and (ii) an open position in which the member does not restrict the cover from being moved away from the chamber. When the first member is in the closed position there is a substantially liquid proof seal between the cover and the chamber.
    Type: Grant
    Filed: May 14, 2014
    Date of Patent: December 12, 2017
    Inventors: Aaron M. Owens, Stefanie Vawn Biechler, David Louis Dingmann, Charles W. Groepper, Tomas M. Hays, Chrysanthi Williams
  • Patent number: 9828579
    Abstract: A cell culture apparatus comprises at least one storage space, at least one barrier, a working space, a sterilization space, and a control space. The at least one storage space comprises a container shelf, an upright track, a rotatable holder, and a light tube. The working space comprises a filling station and an inspecting station. The filling station comprises a first delivering device, an open-close device, and a filling mechanism. The inspecting station comprises a first inspecting mechanism and a second delivering device. Also provided is a method of using the cell culture apparatus including steps of filling, inspecting, or collecting cell cultures, therefore, the cell culture apparatus performs multiple cell culture processes automatically.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: November 28, 2017
    Assignee: DrSignal BioTechnology co., Ltd
    Inventors: Hsin-Wu Mi, Ming-Cheng Lee
  • Patent number: 9803168
    Abstract: An incubator 1 includes a cultivating chamber 4 for cultivating culture in a plurality of containers 3 and a supply device 5 provided outside the cultivating chamber 4 and supplying steam into the cultivating chamber 4 for humidification. The supply device 5 includes a supply chamber 5A in which a tray 42 for reserving water is accommodated and an ultrasonic atomizing device 43 for atomizing water. The water in the tray 42 is easily made into steam by the ultrasonic atomizing device 43, passes through an HEPA filter 45 provided in an opening portion 5B and is supplied into the circulation passage 37 of the cultivating chamber 4.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: October 31, 2017
    Inventors: Tetsuya Nishimura, Masaomi Shioya, Katsuki Hashimoto
  • Patent number: 9789459
    Abstract: A nucleic acid amplification reaction vessel includes a first inner wall, and a second inner wall that is arranged opposite to the first inner wall, in which a distance between the first inner wall and the second inner wall is a length in which a nucleic acid amplification reaction solution comes into contact with both the first inner wall and the second inner wall when the nucleic acid amplification reaction solution is poured.
    Type: Grant
    Filed: February 18, 2015
    Date of Patent: October 17, 2017
    Assignee: Seiko Epson Corporation
    Inventor: Toshiro Murayama
  • Patent number: 9791433
    Abstract: The present invention is directed to a multi-organ-chip device comprising a base layer; an organ layer arranged on the base layer; an antra layer arranged on the organ layer; and an actuator layer; wherein the base layer is configured to provide a solid support for the further layers; the organ layer is configured to comprise a multiplicity of individual organ equivalents, each organ equivalent comprising one or more organ growth sections, each of the organ growth sections being configured to comprise an organoid cavity for housing at least one organoid of an organ and to comprise a micro-inlet and a micro-outlet for fluid communication between the organoid cavity of the organ growth section and a self-contained circulation system, wherein the organ layer comprises at least one organ equivalent configured to represent the organs lung, small intestine, spleen, pancreas, liver, kidney and bone marrow, respectively, and a self-contained circulation system configured to be in direct fluid communication with the o
    Type: Grant
    Filed: August 15, 2013
    Date of Patent: October 17, 2017
    Assignee: TISSUSE GMBH
    Inventor: Uwe Marx
  • Patent number: 9783773
    Abstract: A cell culture apparatus includes: an isolator in which a sterile space accommodating a cell incubator filled with a culture solution containing cells to be cultured is disposed; a sampling unit configured to sample the culture solution in the cell incubator; a delivery flow path through which an inside of the sterile space and an outside of the sterile space communicate with each other, the delivery flow path configured to limit a flow in the delivery flow path to a direction that is directed from the inside of the sterile space toward the outside of the sterile space; and a culture solution delivering section configured to deliver the sampled culture solution to the outside of the sterile space via the delivery flow path.
    Type: Grant
    Filed: March 28, 2012
    Date of Patent: October 10, 2017
    Inventors: Mitsuhiro Oura, Teruo Okano, Tatsuya Shimizu, Hirotsugu Kubo, Sunao Takeda
  • Patent number: 9784653
    Abstract: A first apparatus for processing a liquid sample is disclosed. The apparatus includes a sample-receiving, a filtrate-receiving component, and an analyte-capture element. The apparatus forms a liquid flow path through which the sample passes, thereby causing the analyte-capture element to capture an analyte, if present. A method is disclosed whereby a liquid sample is passed through the first apparatus and the analyte-capture element is easily separated from the apparatus for further processing and detection of the analyte. A structurally-related second apparatus for processing a plurality of liquid samples, and a corresponding method of use, also is disclosed.
    Type: Grant
    Filed: February 8, 2016
    Date of Patent: October 10, 2017
    Inventors: Wensheng Xia, Jon A. Kirschhoffer, Andrew W. Rabins
  • Patent number: 9783768
    Abstract: The automated cell culture arrangement according to the invention comprises at least one closed cell culture module with at least one bioreactor. The closed cell culture module is a closed system, which means that within the closed cell culture module a closed sterile environment can be maintained. The automated cell culture arrangement according to the invention, further comprises at least one pump for pumping liquids within the closed cell culture module and at least one additional tool module, which is configured or configurable to act upon or to monitor the contents of a bioreactor and is movable relative to the at least one closed cell culture module or it is movable relative to one or several components of the at least one closed cell culture module.
    Type: Grant
    Filed: April 20, 2011
    Date of Patent: October 10, 2017
    Assignee: Octane Biotech, Inc.
    Inventors: Yves Larcher, Rupert Hagg