Patents Examined by Lydia Edwards
  • Patent number: 9862918
    Abstract: A well plate is formed with a well for holding a subject to be sucked by a suction nozzle on an inner bottom part and storing liquid and, a clearance forming member for forming a clearance to allow the liquid to flow in a state where a tip part of the suction nozzle is inserted into and held in contact with the well is provided in the well. According to the present invention, the clearance enabling the liquid to flow is formed even in the state where the tip part of the suction nozzle is inserted into and held in contact with the well in sucking the subject held in the well by the suction nozzle. The suction nozzle can suck the liquid around through the clearance and the subject held in the well is efficiently sucked through the suction port along the flow of the sucked liquid.
    Type: Grant
    Filed: January 19, 2012
    Date of Patent: January 9, 2018
    Inventor: Saburo Ito
  • Patent number: 9855558
    Abstract: An apparatus and method for thermal cycling including a pasting edge heater. The pasting edge heater can provide substantial temperature uniformity throughout the retaining elements during thermal cycling by a thermoelectric module.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: January 2, 2018
    Inventors: Hon Siu Shin, Hock Lai Khoo
  • Patent number: 9845453
    Abstract: A cell culture apparatus is provided which can continuously and accurately measure turbidity of a cell culture solution and culture a cell, without inserting a turbidity sensor from outside into a sterile bag. The cell culture apparatus includes: a flexible and transparent sterile bag that is installed at a prescribed position in the cell culture apparatus and in which a cell contained in a cell culture solution is cultured; and a turbidity sensor that includes a light emitter which emits light to the cell culture solution in the sterile bag via a portion of the sterile bag, a light receiver which receives the light transmitted through the cell culture solution via another portion of the sterile bag, and that is configured to place the light emitter, the portion of the sterile bag, another portion of the sterile bag, and the light receiver, optically on a same straight line.
    Type: Grant
    Filed: August 1, 2014
    Date of Patent: December 19, 2017
    Assignee: HITACHI, LTD.
    Inventors: Masaru Nanba, Ryouichi Haga, Sei Murakami, Haruo Suzuki
  • Patent number: 9840688
    Abstract: A bioreactor system includes a sample chamber capable of receiving a specimen and a cover which can be placed on the chamber to enclose the specimen within the chamber. A first member is movable between (i) a closed position in which the member restricts the cover from being moved away from the chamber in a first direction, and (ii) an open position in which the member does not restrict the cover from being moved away from the chamber. When the first member is in the closed position there is a substantially liquid proof seal between the cover and the chamber.
    Type: Grant
    Filed: May 14, 2014
    Date of Patent: December 12, 2017
    Inventors: Aaron M. Owens, Stefanie Vawn Biechler, David Louis Dingmann, Charles W. Groepper, Tomas M. Hays, Chrysanthi Williams
  • Patent number: 9828579
    Abstract: A cell culture apparatus comprises at least one storage space, at least one barrier, a working space, a sterilization space, and a control space. The at least one storage space comprises a container shelf, an upright track, a rotatable holder, and a light tube. The working space comprises a filling station and an inspecting station. The filling station comprises a first delivering device, an open-close device, and a filling mechanism. The inspecting station comprises a first inspecting mechanism and a second delivering device. Also provided is a method of using the cell culture apparatus including steps of filling, inspecting, or collecting cell cultures, therefore, the cell culture apparatus performs multiple cell culture processes automatically.
    Type: Grant
    Filed: April 14, 2015
    Date of Patent: November 28, 2017
    Assignee: DrSignal BioTechnology co., Ltd
    Inventors: Hsin-Wu Mi, Ming-Cheng Lee
  • Patent number: 9803168
    Abstract: An incubator 1 includes a cultivating chamber 4 for cultivating culture in a plurality of containers 3 and a supply device 5 provided outside the cultivating chamber 4 and supplying steam into the cultivating chamber 4 for humidification. The supply device 5 includes a supply chamber 5A in which a tray 42 for reserving water is accommodated and an ultrasonic atomizing device 43 for atomizing water. The water in the tray 42 is easily made into steam by the ultrasonic atomizing device 43, passes through an HEPA filter 45 provided in an opening portion 5B and is supplied into the circulation passage 37 of the cultivating chamber 4.
    Type: Grant
    Filed: January 25, 2016
    Date of Patent: October 31, 2017
    Inventors: Tetsuya Nishimura, Masaomi Shioya, Katsuki Hashimoto
  • Patent number: 9791433
    Abstract: The present invention is directed to a multi-organ-chip device comprising a base layer; an organ layer arranged on the base layer; an antra layer arranged on the organ layer; and an actuator layer; wherein the base layer is configured to provide a solid support for the further layers; the organ layer is configured to comprise a multiplicity of individual organ equivalents, each organ equivalent comprising one or more organ growth sections, each of the organ growth sections being configured to comprise an organoid cavity for housing at least one organoid of an organ and to comprise a micro-inlet and a micro-outlet for fluid communication between the organoid cavity of the organ growth section and a self-contained circulation system, wherein the organ layer comprises at least one organ equivalent configured to represent the organs lung, small intestine, spleen, pancreas, liver, kidney and bone marrow, respectively, and a self-contained circulation system configured to be in direct fluid communication with the o
    Type: Grant
    Filed: August 15, 2013
    Date of Patent: October 17, 2017
    Assignee: TISSUSE GMBH
    Inventor: Uwe Marx
  • Patent number: 9789459
    Abstract: A nucleic acid amplification reaction vessel includes a first inner wall, and a second inner wall that is arranged opposite to the first inner wall, in which a distance between the first inner wall and the second inner wall is a length in which a nucleic acid amplification reaction solution comes into contact with both the first inner wall and the second inner wall when the nucleic acid amplification reaction solution is poured.
    Type: Grant
    Filed: February 18, 2015
    Date of Patent: October 17, 2017
    Assignee: Seiko Epson Corporation
    Inventor: Toshiro Murayama
  • Patent number: 9784653
    Abstract: A first apparatus for processing a liquid sample is disclosed. The apparatus includes a sample-receiving, a filtrate-receiving component, and an analyte-capture element. The apparatus forms a liquid flow path through which the sample passes, thereby causing the analyte-capture element to capture an analyte, if present. A method is disclosed whereby a liquid sample is passed through the first apparatus and the analyte-capture element is easily separated from the apparatus for further processing and detection of the analyte. A structurally-related second apparatus for processing a plurality of liquid samples, and a corresponding method of use, also is disclosed.
    Type: Grant
    Filed: February 8, 2016
    Date of Patent: October 10, 2017
    Inventors: Wensheng Xia, Jon A. Kirschhoffer, Andrew W. Rabins
  • Patent number: 9783768
    Abstract: The automated cell culture arrangement according to the invention comprises at least one closed cell culture module with at least one bioreactor. The closed cell culture module is a closed system, which means that within the closed cell culture module a closed sterile environment can be maintained. The automated cell culture arrangement according to the invention, further comprises at least one pump for pumping liquids within the closed cell culture module and at least one additional tool module, which is configured or configurable to act upon or to monitor the contents of a bioreactor and is movable relative to the at least one closed cell culture module or it is movable relative to one or several components of the at least one closed cell culture module.
    Type: Grant
    Filed: April 20, 2011
    Date of Patent: October 10, 2017
    Assignee: Octane Biotech, Inc.
    Inventors: Yves Larcher, Rupert Hagg
  • Patent number: 9783773
    Abstract: A cell culture apparatus includes: an isolator in which a sterile space accommodating a cell incubator filled with a culture solution containing cells to be cultured is disposed; a sampling unit configured to sample the culture solution in the cell incubator; a delivery flow path through which an inside of the sterile space and an outside of the sterile space communicate with each other, the delivery flow path configured to limit a flow in the delivery flow path to a direction that is directed from the inside of the sterile space toward the outside of the sterile space; and a culture solution delivering section configured to deliver the sampled culture solution to the outside of the sterile space via the delivery flow path.
    Type: Grant
    Filed: March 28, 2012
    Date of Patent: October 10, 2017
    Inventors: Mitsuhiro Oura, Teruo Okano, Tatsuya Shimizu, Hirotsugu Kubo, Sunao Takeda
  • Patent number: 9738863
    Abstract: The present invention relates to a bioreactor including at least one reactor vessel in form of a plastic bag, a tray (4) for holding said at least one bag, a rocking device for limited rocking motions of the tray (4) around a rocking axis (2). According to the invention the bioreactor comprises a device (6,7,8,9) for enabling swinging of the tray (4) around a second axis (7) parallel to and distanced from the rocking axis (2).
    Type: Grant
    Filed: February 21, 2012
    Date of Patent: August 22, 2017
    Assignee: GE Healthcare Bio-Sciences AB
    Inventors: Andreas Andersson, Johan L. Carlsson, Christian Elnegard, Henrik K. Eriksson, Thomas Falkman, Patric Fricking, Linnea Pauler, Claes Petterson
  • Patent number: 9739699
    Abstract: A device for performing a cell study. The device comprises a plate having a plurality of wells, each configured for containing aqueous solution and having a well bottom with a plurality of picowells and a plurality of biosensors each configured for measuring at least one cell characteristic while being in contact with the aqueous solution in a respective the well. The position of each the biosensor in a respective the well is limited by at least one pin.
    Type: Grant
    Filed: August 31, 2015
    Date of Patent: August 22, 2017
    Assignee: Seng Enterprises Ltd.
    Inventors: Mordechai Deutsch, Assaf Deutsch
  • Patent number: 9731296
    Abstract: A biochemical reactor includes a temperature control device containing a substrate, a first conductive layer, a second conductive layer, a receiving hole, and a heating element. The substrate has a through hole for accommodating the vessel; the receiving hole is adjacent to the through hole for receiving the heating element; the first conductive layer has a connecting region formed on the wall of the through hole; and two terminals of the heating element are respectively connected electrically to the first and the second conductive layers. As such, the heat generated from the heating element can be transferred to the through hole via the first conductive layer to heat the vessel.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: August 15, 2017
    Inventors: Chen Su, Hsiao-Fen Chang, Pei-Yu Li, Yun-Lung Tsai, Ching-Ko Lin, Wen-Hao Cheng
  • Patent number: 9732314
    Abstract: An apparatus for culturing cells of the present disclosure includes: a cabinet that has a main surface and a side surface, the main surface having a window; a main surface aspiration port disposed at the main surface of the cabinet; and a side surface aspiration port disposed at the side surface of the cabinet. In the cross section of the cabinet taken along the horizontal direction, a first vessel supplying part for supplying a first vessel is disposed at a midportion of the cabinet, and a second vessel supplying part for supplying a second vessel is disposed at an inner peripheral portion of the cabinet. The first vessel supplying part has a first lid capable of entirely covering the first vessel supplying part. The first vessel has no lid. The second vessel supplying part has no lid. The second vessel has a second lid.
    Type: Grant
    Filed: March 19, 2016
    Date of Patent: August 15, 2017
    Assignee: Panasonic Corporation
    Inventors: Norihiro Shibata, Toshiaki Yamauchi, Takeshi Ando
  • Patent number: 9723830
    Abstract: A filter for filtering perfusate is integrated with an exterior portion of an organ container. The filter may be used in an apparatus for perfusing an organ. The perfusion apparatus may include an organ container configured to contain an organ, the filter integrated with an exterior portion of the organ container, and another filter. At least the filter integrated with an exterior portion of the organ container may be provided in a sterilized disposable kit.
    Type: Grant
    Filed: June 15, 2015
    Date of Patent: August 8, 2017
    Inventors: Christopher P. Steinman, Jeffrey S. Louis
  • Patent number: 9718029
    Abstract: The invention resides in an apparatus for treatment of a substance. The apparatus has a substance tube for enabling a substance to be treated to pass in to the substance tube via the substance-inlet and out of the substance tube through the substance-outlet. The apparatus also has a cleaning chamber, wherein the substance tube is configured in fluid communication with the cleaning chamber to enable a substance to diffuse the permeable membrane between the substance tube and the cleaning chamber such that a substance can be substantially cleaned by a cleaner, the substance comprising blood or plasma and the cleaner comprising a cell culture. The substance tube is removably connectable with the cleaning chamber for inter-changeability or serviceability. The apparatus can further comprise a support compartment configured to connect to, or enclosing, the cleaning chamber, which functions to carry a fluid to substantially maintain the functionality of the cleaner.
    Type: Grant
    Filed: April 15, 2013
    Date of Patent: August 1, 2017
    Inventors: Ali Abdullah Hilal-Alnaqbi, Abdel-Hamid Ismail Mourad
  • Patent number: 9702823
    Abstract: An instrument for processing and/or measuring a biological process contains an excitation source, a sample holder, an optical sensor, an excitation optical system, and an emission optical system. The sample holder is configured to receive a plurality of biological samples. The optical sensor is configured to receive an emission from the biological samples. The excitation optical system is disposed along an excitation optical path and is configured to direct the electromagnetic radiation from the excitation source to the biological samples. The emission optical system is disposed along an emission optical path and is configured to direct electromagnetic emissions from the biological samples to the optical sensor. The instrument further contains a plurality of filter assemblies configured to be interchangeably located along at least one of the optical paths.
    Type: Grant
    Filed: September 28, 2012
    Date of Patent: July 11, 2017
    Inventors: Kevin Maher, Mingsong Chen, Jacob Freudenthal, Kuan Moon Boo, Soo Yong Lau, David Fortescue, Ming Shen, Woon Liang Terence Soh
  • Patent number: 9695391
    Abstract: One aspect relates to a container for inserting into a holding device, comprising: a wall that is flexible at least in some areas, which wall is squashed, at least in some areas, in a transport condition in a direction opposite to a stretching direction; a handling unit connected to the wall, which is designed to come into engagement with a complementary handling unit of a transport device; a securing unit which in a transport condition hinders stretching of the wall of the bioreactor container along the stretching direction, wherein the container can, when the securing unit is released, be extended at least in some areas along the stretching direction, as well as a transport device, a use and a method.
    Type: Grant
    Filed: February 4, 2014
    Date of Patent: July 4, 2017
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Bernward Husemann, Wolfgang Kahlert, Sebastien Chaussin, Reiner Seitz
  • Patent number: 9670451
    Abstract: Embodiments described herein generally relate to methods and systems for using an air removal chamber as a control for a process in a cell expansion system. The air removal chamber may be mounted on a fluid conveyance assembly for use with the system. Fluid is pumped into a fluid containment chamber of the air removal chamber, in which the level of fluid in the fluid containment chamber may be monitored through the use of one or more sensors. The sensors are capable of detecting air, a lack of fluid, fluid, and/or a gas/fluid interface, e.g., an air/fluid interface, at measuring positions within the air removal chamber. Protocols for use with the system may include one or more stop conditions. In an embodiment, the stopping of a process is automated based on the detection of air, a lack of fluid, and/or a gas/fluid interface in the air removal chamber.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: June 6, 2017
    Assignee: Terumo BCT, Inc.
    Inventors: Thomas G. Dilorenzo, Edward Allan Stanton, IV, Glen Delbert Antwiler, Michael E. Kinzie, Brian J. Nankervis, Monique Givens, Casey V. Medina, Jon A. Dodd