Patents Examined by Lydia Edwards
  • Patent number: 10258032
    Abstract: A bag includes an organ transporter compartment to contain an organ transporter disposed in the transporter compartment. The bag may include openings to access portions of the organ transporter, such as a battery or power cable, when the organ transporter is disposed in the bag. The bag may also include a frame and handles. The handles may include structure adapted to mate with handles on the organ transporter. The bag may also include a single cover that provides access to multiple compartments with their own internal covers. Also, the bag may include windows to view documents stored in the bag and/or to view and/or display control panels on the organ transporter.
    Type: Grant
    Filed: January 11, 2012
    Date of Patent: April 16, 2019
    Inventors: David C. Kravitz, Peter DeMuylder, Brian Otts, Stephan Merkle, Jeremiah P. O'Leary, Christopher E. Svensrud
  • Patent number: 10240118
    Abstract: A system for monitoring growth media within a controlled environment is provided and includes a well plate having a plate top and a plate side and defines at least one well cavity. The plate top includes a top opening and the plate side includes a side opening and the side opening is communicated with one of the at least one well cavity. The system includes a sensor assembly unit that includes a unit structure defining a reference material chamber containing a reference material, a sensor chamber having a chamber opening, and a base chamber. Additionally, the system includes a reference electrode communicated with the reference material and the base chamber. A media sensor is provided and is communicated with the chamber opening and a media sensor electrode communicated with the media sensor. The reference electrode and media sensor electrode are communicated with a processing device.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: March 26, 2019
    Inventor: Mark Langley
  • Patent number: 10221384
    Abstract: A bioreactor system comprising a base station comprising a control system, a tray arranged to be provided on the base station and arranged to house a bioreactor bag, wherein said base station comprises at least one temperature sensor means and in that said tray comprises at least one opening for receiving said temperature sensor means such that it will contact a surface of a bioreactor provided in the tray.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: March 5, 2019
    Inventors: Patrik Akerstrom, Patric Fricking, Lars Johan Carlsson, Hakan Wahlnas
  • Patent number: 10214718
    Abstract: Embodiments provide a distributed bioreactor system in which a plurality of modular bioreactors are operated in parallel to produce and maintain a biological cell culture. A central or nurse perfusion bioreactor produces and maintains a cell culture and transfers portions of the cell culture to a plurality of modular peripheral perfusion bioreactors, each of which produces and maintains the cell culture in turn. In order to prevent contamination and facilitate segregation of particular peripheral bioreactors, the distributed system is configured such that one-way fluid communication is established from the central/nurse bioreactor to each of the peripheral bioreactors while maintaining fluid isolation among the peripheral bioreactors. Each modular peripheral bioreactor unit has a plug-and-play configuration and may be plugged into or otherwise coupled to the central/nurse bioreactor to scale up the overall size of the cell culture without requiring sterilization or redesign or reconfiguration of the system.
    Type: Grant
    Filed: July 1, 2014
    Date of Patent: February 26, 2019
    Assignees: University of Massachusetts, APIcells Inc.
    Inventors: Olivier Berteau, Seongkyu Yoon, David Sergeant, Thierry Poskin
  • Patent number: 10207016
    Abstract: A sample preparation container, preferably for use in sterility testing, comprising a housing (1) having a housing wall (2) defining an inside space (3), a support on which a membrane filter is placed or is to be placed so as to get in contact with a sampling fluid to be introduced into the inside space (3), and at least one inlet opening (4) to the inside space (3) and at least one outlet opening from the inside space (3). A sampling port (5) is provided for allowing access from the outside to the inside space (3), wherein said sampling port (5) is closed by a septum (6) and the septum (6) is separated from the inside space (3) by a barrier wall (7) which is preferably piercable or breakable on application of an external force, preferably applied through a sampling instrument like a needle (8).
    Type: Grant
    Filed: September 16, 2015
    Date of Patent: February 19, 2019
    Assignee: Merck Patent GmbH
    Inventors: Gerard Muller, Mathieu Arrault
  • Patent number: 10203284
    Abstract: The present disclosure provides methods and hardware for real-time amplification and detection of nucleic acid molecules.
    Type: Grant
    Filed: August 26, 2014
    Date of Patent: February 12, 2019
    Assignee: DIAGENETIX, INC.
    Inventor: Daniel M. Jenkins
  • Patent number: 10202570
    Abstract: A blade tip-provided micropipette holding apparatus has a tubular micropipette holder so constructed that a blade tip-provided micropipette to be inserted into a living cell can be mounted on a front-end portion thereof and a holder-holding device for holding the micropipette holder. The holder-holding device has a base member and a tubular rotating member which is rotatably held by the base member and into which the tubular micropipette holder can be penetrated. The tubular rotating member has holder position adjusting mechanisms each composed of a plurality of side holes formed on a side surface of the tubular rotating member at different positions of the side surface thereof in a circumferential direction thereof and holder position adjusting members each capable of entering into the tubular rotating member from the side holes and contacting an outer surface of the micropipette holder penetrating through the tubular rotating member.
    Type: Grant
    Filed: November 11, 2016
    Date of Patent: February 12, 2019
    Inventors: Masao Jinno, Futoshi Inoue
  • Patent number: 10195310
    Abstract: The invention relates to a device and a method for compressing a hydrogel layer (H), wherein a separate piston (600) that is designed to be connected to a second component (400) of the device in a releasable manner in an operating mode of the device, particularly by means of a latching connection, presses along a compression direction (C) against said hydrogel layer (H) residing on a membrane bottom (501) of a graft frame (500) so as to compress the hydrogel layer (H) between the piston (600) and the membrane bottom (501).
    Type: Grant
    Filed: June 27, 2014
    Date of Patent: February 5, 2019
    Inventor: Ernst Reichmann
  • Patent number: 10138451
    Abstract: The present invention relates to a novel culturing apparatus (assembly) which can be termed a cell culture dish. More particularly, the present invention is a “combined cell culture dish” or “dish-in-dish” apparatus comprising at least one smaller cell culture dish fixedly positioned within a larger cell culture dish, and the number of such fixated cell culture dishes can include a multiple number of fixated cell culture dishes within one another, either concentric or eccentric, in any number of geometric shapes, and without limitation to the number of petri dishes included. An alternate embodiment of this invention can include a plurality of cell culture dishes juxtaposed side-by-side having common interior well walls, and the well walls may or may not be different in height depending on the application.
    Type: Grant
    Filed: January 29, 2014
    Date of Patent: November 27, 2018
    Inventors: Christopher B. Reid, Keith Norris, Taehoon Cho, Victor Chaban
  • Patent number: 10130922
    Abstract: A receptacle has a wall defining a receptacle interior and a shaft housing for guiding a shaft through the wall into the receptacle interior. The shaft housing defines an annular cap with spaced apart inner and outer walls connected by an inner end face facing the receptacle interior. A shaft guide part has an end facing the receptacle interior and an outer surface that defines a gap relative to the inner wall of the shaft housing. The shaft guide part has an annular wall spaced apart from and parallel to its outer surface. The annular wall extends over the free end of the inner wall of the shaft housing and is sealed to the inner and outer walls of the shaft housing by at least one seal each. The shaft guide part is mounted in the shaft housing by a radial ball bearing and by an axial ball bearing.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: November 20, 2018
    Inventors: Reiner Seitz, Rainer Salzmann, Thomas Regen, Matthias Hielscher, Bernward Husemann, Stefan Zeuch, Ute Husemann, Gerhard Greller
  • Patent number: 10124291
    Abstract: A modular biofiltration support system for a bed of organic filter medium, formed of a multiplicity of rectangular bed platform modules or floor tiles, provides for bridging across an air/gas supply trench which can be up to 36 inches or even 48 inches wide. The bridging sections, formed of a mix of recycled plastic materials in a high-pressure molding operation, interconnect with edges of the floor tile assemblies on each side of the trench, and also engage with one another at sides. Each module is a high strength beam.
    Type: Grant
    Filed: February 23, 2016
    Date of Patent: November 13, 2018
    Assignee: Hallsten Corporation
    Inventors: Jeffrey A. Hallsten, Ronald Kuehne, Gary Powell
  • Patent number: 10119109
    Abstract: An improved tissue engineering bioreactor and testing platform has been designed that integrates multiple testing and stimulation capabilities. The system allows for growth of multiple tissue strips in parallel with mechanical and electrical stimulation, media perfusion, and the automated monitoring of contractile force and extracellular electrical activity. The system is designed to be low-cost and scalable, to provide for high-content, biofidelic, non-destructive testing of engineered muscle tissue performance that is conventionally measured using muscle-bath systems.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: November 6, 2018
    Inventors: Kevin D. Costa, Peter Backeris
  • Patent number: 10093963
    Abstract: A system and method for processing and detecting nucleic acids from a set of biological samples, comprising: a molecular diagnostic module configured to receive nucleic acids bound to magnetic beads, isolate nucleic acids, and analyze nucleic acids, comprising a cartridge receiving module, a heating/cooling subsystem and a magnet configured to facilitate isolation of nucleic acids, a valve actuation subsystem including an actuation substrate, and a set of pins interacting with the actuation substrate, and a spring plate configured to bias at least one pin in a configurations, the valve actuation subsystem configured to control fluid flow through a microfluidic cartridge for processing nucleic acids, and an optical subsystem for analysis of nucleic acids; and a fluid handling system configured to deliver samples and reagents to components of the system to facilitate molecular diagnostic protocols.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: October 9, 2018
    Assignee: NeuMoDx Molecular, Inc.
    Inventors: Michael T. Kusner, Jeffrey Williams
  • Patent number: 10087409
    Abstract: Provided is a cell culturing vessel for holding and culturing cells. It has a first vessel that stores a culture medium and cells or only a culture medium, a second vessel that is placed above the first vessel and stores a culture medium and cells or only a culture medium, a main vessel that holds the first vessel and houses the second vessel, and a lid member that engages with the main vessel. The main vessel has a pressing member that fixes and holds the first vessel in the main vessel and the second vessel is eccentrically held in the first vessel by the pressing member.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: October 2, 2018
    Assignee: Hitachi, Ltd.
    Inventors: Masaharu Kiyama, Guangbin Zhou, Ryota Nakajima, Takayuki Nozaki, Naoko Senda, Shizu Matsuoka
  • Patent number: 10086374
    Abstract: Disclosed is a multi-stage thermal convection apparatus and uses thereof. In one embodiment, the invention features a three-stage thermal convection apparatus that includes a temperature shaping element for assisting a thermal convection mediated Polymerase Chain Reaction (PCR). The invention has a wide variety of applications including amplifying nucleic acid without cumbersome and expensive hardware associated with many prior devices. In a typical embodiment, the apparatus can fit in the palm of a user's hand for use as a portable, simple to operate, and low cost PCR amplification device.
    Type: Grant
    Filed: January 4, 2017
    Date of Patent: October 2, 2018
    Assignee: Ahram Biosystems, Inc.
    Inventor: Hyun Jin Hwang
  • Patent number: 10086375
    Abstract: Disclosed is a multi-stage thermal convection apparatus such as a two-stage thermal convection apparatus and uses thereof. In one embodiment, the two-stage thermal convection apparatus includes a temperature shaping element that assists a thermal convection mediated Polymerase Chain Reaction (PCR). The invention has a wide variety of applications including amplifying nucleic acid without cumbersome and expensive hardware associated with many prior devices. In a typical embodiment, the apparatus can fit in the palm of a user's hand for use as a portable, simple to operate, and low cost PCR amplification device.
    Type: Grant
    Filed: January 4, 2017
    Date of Patent: October 2, 2018
    Assignee: Ahram Biosystems, Inc.
    Inventor: Hyun Jin Hwang
  • Patent number: 10081788
    Abstract: A product concentration device that utilizes a reservoir connected to a hollow-fiber filter element where the reservoir can serve as a container for filtrate emanating from another filtering device, such that product in the reservoir can be stored, concentrated and/or further processed as desired. Enclosed reactor systems, each of at least three chambers, fluid flow between the chambers controlled by selectively permeable barriers, flow controlled by an alternating flow diaphragm pump.
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: September 25, 2018
    Assignee: Repligen Corporation
    Inventor: Jerry Shevitz
  • Patent number: 10071403
    Abstract: A system and method for decomposing municipal solid waste (MSW) under anaerobic conditions. The system includes a bioreactor landfill with the MSW, a leachate recirculation unit in connection with the bioreactor landfill, a multilevel thermocouple unit, placed inside the bioreactor landfill for monitoring temperature in the bioreactor landfill. Further, the system includes a sensor for monitoring moisture level within the bioreactor landfill. Furthermore, the system includes the leachate recirculation unit configured to initiate recirculation of a leachate, collected from the bioreactor landfill, when temperature in the bioreactor reaches a determined temperature and a determined moisture level.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: September 11, 2018
    Assignee: Indian Institute of Technology Bombay
    Inventors: Devendra Narain Singh, Bhagawan Shamrao Patil
  • Patent number: 10066198
    Abstract: A device for in-vitro modelling in-vivo tissues of organs that includes a first body portion with at least one access chamber, a second body portion with at least one culturing chamber, and a culturing membrane dividing the at least one access chamber from the culturing chamber. The device further includes a third body portion with at least one actuation chamber having at least one limitation cavity, and an actuation membrane dividing the at least one culturing chamber from the at least one actuation chamber. With the device, a robust actuation system can be provided that does not depend on the mechanical properties of the actuation membrane material, nor on the pressure, and that allows to mimic three-dimensional deformations of the tissue, in particular of lung alveoli.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: September 4, 2018
    Assignee: Universität Bern
    Inventors: Olivier Thierry Guenat, Marcel Felder, Andreas Stucki, Janick Daniel Stucki, Thomas Geiser
  • Patent number: 10058869
    Abstract: A micro-fluidic device includes a plurality of heating elements on a substrate for heating the substrate. They define a plurality of temperature regions having distinct temperatures on the substrate. A flow feature layer is formed above the substrate to define a channel extending across the substrate through each temperature region. As fluid is repeatedly pumped within the channel, it flows from one temperature region to a next temperature region to undergo thermal cycling. Fluid wells reside in the flow feature layer under a cover and connect to the channel whereby fluid can dwell for diagnostic applications.
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: August 28, 2018
    Assignee: Microfluidic MEMS Solution, LLC
    Inventors: Steven Wayne Bergstedt, Stephen Jacob DeMoor, Yimin Guan