Patents Examined by Lydia Edwards
  • Patent number: 9994806
    Abstract: A transport device for a container has a base, a vertical member extending up from the base and a complementary handling unit extending from an end of the vertical member spaced from the base. The complementary handling unit is configured for releasably engaging a container, such as a bioreactor container, so that the container can be transported to a holding device.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: June 12, 2018
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Bernward Husemann, Wolfgang Kahlert, Sebastien Chaussin, Reiner Seitz
  • Patent number: 9994807
    Abstract: A temperature sensor means comprising a thermally conducting layer arranged to face the surface to be measured, a thermally insulating layer attached to the thermally conducting layer on the opposite side to the surface to be measured, a temperature sensor provided between the thermally conducting layer and the thermally insulating layer and being completely surrounded on all its sides by either the thermally conducting or the thermally insulating layers.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: June 12, 2018
    Inventors: Patrik Akerstrom, Hakan Wahlnas
  • Patent number: 9993782
    Abstract: A bioreactor has a stirrer shaft that is driveable by a drive and on which a stirrer element is positioned. The position of the stirrer element is determined by a stirrer installation aid. The stirrer installation aid has a free end with an abutment surface on which the free end of the stirrer element abuts. The stirrer installation aid is designed as a sleeve that comprises a slot extending between the axial ends of the sleeve. The slot is delimited by opposite flanks of a wall, and the sleeve is placed on the stirrer shaft. The stirrer installation aid can be pulled off laterally from the stirrer shaft. A method for installing the stirrer element on the stirrer shaft arranged in the bioreactor also is provided.
    Type: Grant
    Filed: August 29, 2013
    Date of Patent: June 12, 2018
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Thomas Dreher, Oliver Scheibe, Gerhard Greller, Ute Husemann, Oscar-Werner Reif
  • Patent number: 9994808
    Abstract: The present invention is directed to compositions, tools, methods and devices to culture microorganisms and, in particular, to compositions, tools, methods and devices for the detection of microorganisms in biological samples.
    Type: Grant
    Filed: August 11, 2016
    Date of Patent: June 12, 2018
    Assignee: Vax-Immune, LLC
    Inventors: Bhairavi Parikh, James Stone
  • Patent number: 9983197
    Abstract: Low-cost and portable microfluidic systems are needed for cell migration research and Point of Care (POC) testing. This study introduces a low-cost and portable USB Microscope Microfluidic Chemotaxis Analysis System (UMCAS) for rapid analysis of cell chemotaxis studies. A standalone microfluidic gradient generator is also developed for rapid generation of chemical gradient in microfluidic device without need of any peripheral perfusion apparatus. A smart phone based application program was developed for the real-time remote monitoring of the migration data. This system is validated by observing the neutrophil migration in three different conditions: 1) medium control, 2) uniform IL-8 control, and 3) IL-8 gradient. The results show that neutrophils exhibit random migration in both medium and uniform IL-8 control experiments, while they show strong directional migration to the IL-8 gradient. These results successfully validated the developed UMCAS system.
    Type: Grant
    Filed: September 10, 2013
    Date of Patent: May 29, 2018
    Inventors: Francis Lin, Jiandong Wu
  • Patent number: 9970922
    Abstract: With the object of preventing deterioration of or damage to a photodetector caused by excessive light by more reliably preventing the excessive light from entering the photodetector, a microscope of the present invention is provided with a high-sensitivity detector, such as an HPD, a GaAsP, an EM-CCD or the like, that detects observation light coming from a specimen, a box-shaped casing that has an opening that allows contained items to be placed therein and removed therefrom and that covers the high-sensitivity detector, a door that can close off the opening of the casing, a switch that restricts light detection by the high-sensitivity detector by turning on and off a drive voltage to be applied to the high-sensitivity detector, and an opening restricting mechanism that allows the opening of the casing in the closed state imposed by the door to be opened only when the light detection by the high-sensitivity detector is restricted by the switch.
    Type: Grant
    Filed: October 27, 2015
    Date of Patent: May 15, 2018
    Inventors: Atsuhiro Tsuchiya, Hiroyuki Okahira, Koichiro Izumi
  • Patent number: 9963665
    Abstract: The present invention relates to a biogas plant and to a process for the production of biogas from ligneous renewable resources, in particular straw. Means are provided for pre-treating the ligneous renewable resource in order to bring about chemical, thermal and/or mechanical digestion of said resource before it is introduced into a fermenter in which anaerobic bacterial fermentation takes place.
    Type: Grant
    Filed: July 27, 2007
    Date of Patent: May 8, 2018
    Inventor: Michael Feldmann
  • Patent number: 9963668
    Abstract: The invention relates to a device for culturing cells in a bioreactor, the waste-air line of which leading out of the reactor interior comprises a waste-air filter having a sterile-filtration microfilter membrane, wherein at least one prefilter having a hydrophobic filter material is placed upstream of the waste-air filter toward the reactor interior.
    Type: Grant
    Filed: July 16, 2013
    Date of Patent: May 8, 2018
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Oscar-Werner Reif, Gerhard Greller, Paschalis Nikoloudis, Ralf Lausch, Ute Husemann, Thomas Loewe, Thomas Friese, Thomas Dreher
  • Patent number: 9926525
    Abstract: The present invention relates to systems and methods for optimising the usage of laboratory and cell culturing space for cell culture and biomanufacturing. The invention provides a system and method that can be used to provide a plurality of workstations and/or storage bays for bioreactors in cell culturing and/or biomanufacturing facilities.
    Type: Grant
    Filed: February 10, 2014
    Date of Patent: March 27, 2018
    Assignee: GE Healthcare UK Limited
    Inventors: Christopher George Norey, Michelle Louise Janas, Anthony Patterson, Adrian Crawley
  • Patent number: 9918464
    Abstract: The straw comprises a tube (11) having a swelling plug (15) provided with a fibrous support agent and a swelling agent combined with the support agent and configured, at least close to a second end (18) of the swelling plug, after a liquid-based substance has come up against its second end, to be in a state of swelling constrained by said tube such that if a first part (26) of the swelling plug of length comprised between 2 mm and 3 mm starting from its second end has come out of the tube via a second end (14) of the tube, whereas a second part of the swelling plug remains in the tube, the first part of the swelling plug becomes decompacted and expands with the second end of the swelling plug which assumes a diameter (d) at least equal to one and a half times the inner diameter of the tube.
    Type: Grant
    Filed: February 20, 2015
    Date of Patent: March 20, 2018
    Inventors: Eric Schmitt, Jean-Charles Gorges
  • Patent number: 9920290
    Abstract: The present disclosure relates to a continuous fermentation apparatus and a multi-step continuous fermentation process using the same.
    Type: Grant
    Filed: October 26, 2012
    Date of Patent: March 20, 2018
    Assignees: Biol Systems Co., Ltd., Daewoo Shipbuilding & Marine Engineering Co., Ltd.
    Inventors: Myung Kyo Shin, Jin Hyuk Shin, In Sik Kim, Dongjoong Im
  • Patent number: 9908119
    Abstract: A thermal cycling apparatus having a sample interfacing wall extending from a mounting wall. The sample interfacing wall can accept and apply thermal cycles to samples. An air source can direct an air stream to cool the sample. Another source can direct heated air away from the sample.
    Type: Grant
    Filed: May 15, 2013
    Date of Patent: March 6, 2018
    Assignee: Cepheid
    Inventor: Doug Dority
  • Patent number: 9910030
    Abstract: Small and extremely small molecules and ions or atoms may be detected with the novel device with exceptional sensitivity. The detection is implemented in a simple manner by the known acoustic resonator FBAR or by means of other technologies that measure the physical properties of the filled layer. The permeability of substances (e.g. active ingredients) through membranes such as cell membranes, lipid bilayers, and cell walls can be examined by combining a sensor with the reservoir and the membrane.
    Type: Grant
    Filed: January 9, 2012
    Date of Patent: March 6, 2018
    Inventors: Martin Nirschl, Kaori Sugihara, Janos Vörös, Tomaso Zambelli
  • Patent number: 9901887
    Abstract: An automated template bead preparation system is provided and includes a membrane-based emulsion generation subsystems, a thermal plate and subsystem, and a continuous centrifugation emulsion breaking and templated bead collection subsystem. The emulsion generation subsystem provides uniformity in the preparation of an inverse emulsion and may be used to create large or small volume inverse emulsions rapidly and reproducibly. An emulsion-generating device is provided that can supply a continuous stream of an inverse emulsion to a thermal subsystem, in automated fashion. The thermal subsystem can treat an inverse emulsion passed therethrough. The continuous centrifugation subsystem can continuously break a thermally cycled inverse emulsion and collect template beads formed in the aqueous microreactor droplets of the inverse emulsion.
    Type: Grant
    Filed: September 30, 2016
    Date of Patent: February 27, 2018
    Assignee: Life Technologies Corporation
    Inventors: Jonathan Schultz, John Nobile, Brian Reed, Prasanna Thwar, Todd Roswech, John Andrew Sheridan
  • Patent number: 9903857
    Abstract: A testing apparatus for performing an assay, the testing apparatus comprising: a receptacle (2) containing a reagent, the reagent being reactive to an applied test sample by developing a color or pattern variation; a portable device (1), e.g. a mobile phone or a laptop, comprising a processor and an image capture device (3), wherein the processor is configured to process data captured by the image capture device and output a test result for the applied test sample.
    Type: Grant
    Filed: March 30, 2012
    Date of Patent: February 27, 2018
    Assignee: Norarum DX Limited
    Inventors: Neil Polwart, Graham Tyrie, Anthony Peter Ashbrook
  • Patent number: 9890343
    Abstract: The invention relates to a process and a biofilter system (10) for removing H2S from a H2S contaminated energy production gas stream containing methane. The aqueous biofilter system comprises a biofilter (6) having biofilter support material constituting a biofilter bed supporting a humidified biofilm having microorganisms that are capable of oxidizing H2S. The process comprises the steps of contacting the H2S contaminated energy production gas stream with the microorganisms of the humidified biofilm, and oxidation of at least part of the H2S in the H2S contaminated energy production gas stream by the microorganisms, resulting in a H2S depleted energy production gas stream, wherein the process further comprises the step of adding an aqueous nitrate solution to the H2S contaminated energy production gas stream prior to being contacted with the microorganisms, enabling the microorganisms to oxidize the H2S under anoxic conditions.
    Type: Grant
    Filed: September 18, 2014
    Date of Patent: February 13, 2018
    Inventors: Marina Ettl, Wolfram Franke, Werner Van Borm
  • Patent number: 9890352
    Abstract: An injectable tissue engineered cartilage in vitro construction apparatus, comprising an incubator (1), a centrifugal device arranged in the incubator (1), and a control system for controlling a temperature in the incubator (1) and an action of the centrifugal device. The centrifugal device comprises a centrifuge, a container base (2) mounted onto the centrifuge, a dosing system for adding preparation reagent, and a stirring system for stirring the reagent. With a controller (17) and a pH sensor (16), a measured pH value will be transmitted by the pH sensor (16) to the controller (17) in real time. The controller (17) controls an action of a driving mechanism via a control module II (21), to drive a piston rod to add NaOH solution into a container tank (6). When the pH value of the solution falls in a predetermined range, the driving mechanism is stopped, to precisely control the pH value of the solution.
    Type: Grant
    Filed: July 21, 2014
    Date of Patent: February 13, 2018
    Inventors: Fuyou Wang, Junli Liu, Liu Yang, Ying Zhang, Guangxing Chen, Lin Guo, Xiaojun Duan
  • Patent number: 9862918
    Abstract: A well plate is formed with a well for holding a subject to be sucked by a suction nozzle on an inner bottom part and storing liquid and, a clearance forming member for forming a clearance to allow the liquid to flow in a state where a tip part of the suction nozzle is inserted into and held in contact with the well is provided in the well. According to the present invention, the clearance enabling the liquid to flow is formed even in the state where the tip part of the suction nozzle is inserted into and held in contact with the well in sucking the subject held in the well by the suction nozzle. The suction nozzle can suck the liquid around through the clearance and the subject held in the well is efficiently sucked through the suction port along the flow of the sucked liquid.
    Type: Grant
    Filed: January 19, 2012
    Date of Patent: January 9, 2018
    Inventor: Saburo Ito
  • Patent number: 9855558
    Abstract: An apparatus and method for thermal cycling including a pasting edge heater. The pasting edge heater can provide substantial temperature uniformity throughout the retaining elements during thermal cycling by a thermoelectric module.
    Type: Grant
    Filed: April 30, 2013
    Date of Patent: January 2, 2018
    Inventors: Hon Siu Shin, Hock Lai Khoo
  • Patent number: 9845453
    Abstract: A cell culture apparatus is provided which can continuously and accurately measure turbidity of a cell culture solution and culture a cell, without inserting a turbidity sensor from outside into a sterile bag. The cell culture apparatus includes: a flexible and transparent sterile bag that is installed at a prescribed position in the cell culture apparatus and in which a cell contained in a cell culture solution is cultured; and a turbidity sensor that includes a light emitter which emits light to the cell culture solution in the sterile bag via a portion of the sterile bag, a light receiver which receives the light transmitted through the cell culture solution via another portion of the sterile bag, and that is configured to place the light emitter, the portion of the sterile bag, another portion of the sterile bag, and the light receiver, optically on a same straight line.
    Type: Grant
    Filed: August 1, 2014
    Date of Patent: December 19, 2017
    Assignee: HITACHI, LTD.
    Inventors: Masaru Nanba, Ryouichi Haga, Sei Murakami, Haruo Suzuki