Patents Examined by Lydia Edwards
  • Patent number: 10138451
    Abstract: The present invention relates to a novel culturing apparatus (assembly) which can be termed a cell culture dish. More particularly, the present invention is a “combined cell culture dish” or “dish-in-dish” apparatus comprising at least one smaller cell culture dish fixedly positioned within a larger cell culture dish, and the number of such fixated cell culture dishes can include a multiple number of fixated cell culture dishes within one another, either concentric or eccentric, in any number of geometric shapes, and without limitation to the number of petri dishes included. An alternate embodiment of this invention can include a plurality of cell culture dishes juxtaposed side-by-side having common interior well walls, and the well walls may or may not be different in height depending on the application.
    Type: Grant
    Filed: January 29, 2014
    Date of Patent: November 27, 2018
    Inventors: Christopher B. Reid, Keith Norris, Taehoon Cho, Victor Chaban
  • Patent number: 10130922
    Abstract: A receptacle has a wall defining a receptacle interior and a shaft housing for guiding a shaft through the wall into the receptacle interior. The shaft housing defines an annular cap with spaced apart inner and outer walls connected by an inner end face facing the receptacle interior. A shaft guide part has an end facing the receptacle interior and an outer surface that defines a gap relative to the inner wall of the shaft housing. The shaft guide part has an annular wall spaced apart from and parallel to its outer surface. The annular wall extends over the free end of the inner wall of the shaft housing and is sealed to the inner and outer walls of the shaft housing by at least one seal each. The shaft guide part is mounted in the shaft housing by a radial ball bearing and by an axial ball bearing.
    Type: Grant
    Filed: May 28, 2014
    Date of Patent: November 20, 2018
    Assignee: SARTORIUS STEDIM BIOTECH GMBH
    Inventors: Reiner Seitz, Rainer Salzmann, Thomas Regen, Matthias Hielscher, Bernward Husemann, Stefan Zeuch, Ute Husemann, Gerhard Greller
  • Patent number: 10124291
    Abstract: A modular biofiltration support system for a bed of organic filter medium, formed of a multiplicity of rectangular bed platform modules or floor tiles, provides for bridging across an air/gas supply trench which can be up to 36 inches or even 48 inches wide. The bridging sections, formed of a mix of recycled plastic materials in a high-pressure molding operation, interconnect with edges of the floor tile assemblies on each side of the trench, and also engage with one another at sides. Each module is a high strength beam.
    Type: Grant
    Filed: February 23, 2016
    Date of Patent: November 13, 2018
    Assignee: Hallsten Corporation
    Inventors: Jeffrey A. Hallsten, Ronald Kuehne, Gary Powell
  • Patent number: 10119109
    Abstract: An improved tissue engineering bioreactor and testing platform has been designed that integrates multiple testing and stimulation capabilities. The system allows for growth of multiple tissue strips in parallel with mechanical and electrical stimulation, media perfusion, and the automated monitoring of contractile force and extracellular electrical activity. The system is designed to be low-cost and scalable, to provide for high-content, biofidelic, non-destructive testing of engineered muscle tissue performance that is conventionally measured using muscle-bath systems.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: November 6, 2018
    Assignee: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
    Inventors: Kevin D. Costa, Peter Backeris
  • Patent number: 10093963
    Abstract: A system and method for processing and detecting nucleic acids from a set of biological samples, comprising: a molecular diagnostic module configured to receive nucleic acids bound to magnetic beads, isolate nucleic acids, and analyze nucleic acids, comprising a cartridge receiving module, a heating/cooling subsystem and a magnet configured to facilitate isolation of nucleic acids, a valve actuation subsystem including an actuation substrate, and a set of pins interacting with the actuation substrate, and a spring plate configured to bias at least one pin in a configurations, the valve actuation subsystem configured to control fluid flow through a microfluidic cartridge for processing nucleic acids, and an optical subsystem for analysis of nucleic acids; and a fluid handling system configured to deliver samples and reagents to components of the system to facilitate molecular diagnostic protocols.
    Type: Grant
    Filed: March 22, 2017
    Date of Patent: October 9, 2018
    Assignee: NeuMoDx Molecular, Inc.
    Inventors: Michael T. Kusner, Jeffrey Williams
  • Patent number: 10087409
    Abstract: Provided is a cell culturing vessel for holding and culturing cells. It has a first vessel that stores a culture medium and cells or only a culture medium, a second vessel that is placed above the first vessel and stores a culture medium and cells or only a culture medium, a main vessel that holds the first vessel and houses the second vessel, and a lid member that engages with the main vessel. The main vessel has a pressing member that fixes and holds the first vessel in the main vessel and the second vessel is eccentrically held in the first vessel by the pressing member.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: October 2, 2018
    Assignee: Hitachi, Ltd.
    Inventors: Masaharu Kiyama, Guangbin Zhou, Ryota Nakajima, Takayuki Nozaki, Naoko Senda, Shizu Matsuoka
  • Patent number: 10086374
    Abstract: Disclosed is a multi-stage thermal convection apparatus and uses thereof. In one embodiment, the invention features a three-stage thermal convection apparatus that includes a temperature shaping element for assisting a thermal convection mediated Polymerase Chain Reaction (PCR). The invention has a wide variety of applications including amplifying nucleic acid without cumbersome and expensive hardware associated with many prior devices. In a typical embodiment, the apparatus can fit in the palm of a user's hand for use as a portable, simple to operate, and low cost PCR amplification device.
    Type: Grant
    Filed: January 4, 2017
    Date of Patent: October 2, 2018
    Assignee: Ahram Biosystems, Inc.
    Inventor: Hyun Jin Hwang
  • Patent number: 10086375
    Abstract: Disclosed is a multi-stage thermal convection apparatus such as a two-stage thermal convection apparatus and uses thereof. In one embodiment, the two-stage thermal convection apparatus includes a temperature shaping element that assists a thermal convection mediated Polymerase Chain Reaction (PCR). The invention has a wide variety of applications including amplifying nucleic acid without cumbersome and expensive hardware associated with many prior devices. In a typical embodiment, the apparatus can fit in the palm of a user's hand for use as a portable, simple to operate, and low cost PCR amplification device.
    Type: Grant
    Filed: January 4, 2017
    Date of Patent: October 2, 2018
    Assignee: Ahram Biosystems, Inc.
    Inventor: Hyun Jin Hwang
  • Patent number: 10081788
    Abstract: A product concentration device that utilizes a reservoir connected to a hollow-fiber filter element where the reservoir can serve as a container for filtrate emanating from another filtering device, such that product in the reservoir can be stored, concentrated and/or further processed as desired. Enclosed reactor systems, each of at least three chambers, fluid flow between the chambers controlled by selectively permeable barriers, flow controlled by an alternating flow diaphragm pump.
    Type: Grant
    Filed: September 19, 2016
    Date of Patent: September 25, 2018
    Assignee: Repligen Corporation
    Inventor: Jerry Shevitz
  • Patent number: 10071403
    Abstract: A system and method for decomposing municipal solid waste (MSW) under anaerobic conditions. The system includes a bioreactor landfill with the MSW, a leachate recirculation unit in connection with the bioreactor landfill, a multilevel thermocouple unit, placed inside the bioreactor landfill for monitoring temperature in the bioreactor landfill. Further, the system includes a sensor for monitoring moisture level within the bioreactor landfill. Furthermore, the system includes the leachate recirculation unit configured to initiate recirculation of a leachate, collected from the bioreactor landfill, when temperature in the bioreactor reaches a determined temperature and a determined moisture level.
    Type: Grant
    Filed: January 20, 2016
    Date of Patent: September 11, 2018
    Assignee: Indian Institute of Technology Bombay
    Inventors: Devendra Narain Singh, Bhagawan Shamrao Patil
  • Patent number: 10066198
    Abstract: A device for in-vitro modelling in-vivo tissues of organs that includes a first body portion with at least one access chamber, a second body portion with at least one culturing chamber, and a culturing membrane dividing the at least one access chamber from the culturing chamber. The device further includes a third body portion with at least one actuation chamber having at least one limitation cavity, and an actuation membrane dividing the at least one culturing chamber from the at least one actuation chamber. With the device, a robust actuation system can be provided that does not depend on the mechanical properties of the actuation membrane material, nor on the pressure, and that allows to mimic three-dimensional deformations of the tissue, in particular of lung alveoli.
    Type: Grant
    Filed: September 5, 2014
    Date of Patent: September 4, 2018
    Assignee: Universität Bern
    Inventors: Olivier Thierry Guenat, Marcel Felder, Andreas Stucki, Janick Daniel Stucki, Thomas Geiser
  • Patent number: 10058869
    Abstract: A micro-fluidic device includes a plurality of heating elements on a substrate for heating the substrate. They define a plurality of temperature regions having distinct temperatures on the substrate. A flow feature layer is formed above the substrate to define a channel extending across the substrate through each temperature region. As fluid is repeatedly pumped within the channel, it flows from one temperature region to a next temperature region to undergo thermal cycling. Fluid wells reside in the flow feature layer under a cover and connect to the channel whereby fluid can dwell for diagnostic applications.
    Type: Grant
    Filed: March 21, 2016
    Date of Patent: August 28, 2018
    Assignee: Microfluidic MEMS Solution, LLC
    Inventors: Steven Wayne Bergstedt, Stephen Jacob DeMoor, Yimin Guan
  • Patent number: 10047331
    Abstract: A tray (100; 400; 500; 600) for accommodating a cell culture (101), such as an embryo, for use during culturing thereof and for optical monitoring of the cell culture, e.g. during in vitro fertilization comprises a carrier structure (104;404;504;604) defining at least one accommodating zone (102; 402; 502; 602) for accommodating the cell culture. At least one focal lens (110; 410; 510; 610), notably a numerical aperture increasing lens is integrally formed with the carrier structure to facilitate monitoring of the cell culture through the carrier structure. A diameter of the focal lens may exceed a diameter of the at least one accommodating zone. The focal lens may be integrally molded with the carrier structure from a thermoplastic material.
    Type: Grant
    Filed: March 13, 2014
    Date of Patent: August 14, 2018
    Assignee: UNISENSE FERTILITECH A/S
    Inventors: Jonas Lerche Hansen, Niels B. Ramsing, Søren Porsgaard, Holger Søe Plougsgaard, Mai Faurschou Isaksen
  • Patent number: 10041062
    Abstract: A system and method for processing and detecting nucleic acids from a set of biological samples, comprising: a capture plate and a capture plate module configured to facilitate binding of nucleic acids within the set of biological samples to magnetic beads; a molecular diagnostic module configured to receive nucleic acids bound to magnetic beads, isolate nucleic acids, and analyze nucleic acids, comprising a cartridge receiving module, a heating/cooling subsystem and a magnet configured to facilitate isolation of nucleic acids, a valve actuation subsystem configured to control fluid flow through a microfluidic cartridge for processing nucleic acids, and an optical subsystem for analysis of nucleic acids; a fluid handling system configured to deliver samples and reagents to components of the system to facilitate molecular diagnostic protocols; and an assay strip configured to combine nucleic acid samples with molecular diagnostic reagents for analysis of nucleic acids.
    Type: Grant
    Filed: April 21, 2016
    Date of Patent: August 7, 2018
    Assignee: NeuMoDx Molecular, Inc.
    Inventors: Jeffrey Williams, Sundaresh Brahmasandra, Michael T. Kusner
  • Patent number: 10023833
    Abstract: A temperature sensor means comprising a thermally conducting layer arranged to face the surface to be measured, a thermally insulating layer attached to the thermally conducting layer on the opposite side to the surface to be measured, a temperature sensor provided between the thermally conducting layer and the thermally insulating layer and being completely surrounded on all its sides by either the thermally conducting or the thermally insulating layers.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: July 17, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Patrik Akerstrom, Hakan Wahlnas
  • Patent number: 10010888
    Abstract: A system and method for processing and detecting nucleic acids from a set of biological samples, comprising: a capture plate and a capture plate module configured to facilitate binding of nucleic acids within the set of biological samples to magnetic beads; a molecular diagnostic module configured to receive nucleic acids bound to magnetic beads, isolate nucleic acids, and analyze nucleic acids, comprising a cartridge receiving module, a heating/cooling subsystem and a magnet configured to facilitate isolation of nucleic acids, a valve actuation subsystem configured to control fluid flow through a microfluidic cartridge for processing nucleic acids, and an optical subsystem for analysis of nucleic acids; a fluid handling system configured to deliver samples and reagents to components of the system to facilitate molecular diagnostic protocols; and an assay strip configured to combine nucleic acid samples with molecular diagnostic reagents for analysis of nucleic acids.
    Type: Grant
    Filed: January 24, 2017
    Date of Patent: July 3, 2018
    Assignee: NeuMoDx Molecular, Inc.
    Inventors: Jeffrey Williams, Sundaresh Brahmasandra, Michael T. Kusner
  • Patent number: 10006861
    Abstract: An improved device and system for facilitating polymerase chain reaction including a light source, detector, waveguide, and filters that occupy minimal space and facilitate detection of stationary samples, reduced sample read time, and simultaneous reading of multiple light wavelengths.
    Type: Grant
    Filed: June 30, 2014
    Date of Patent: June 26, 2018
    Assignee: Streck, Inc.
    Inventors: Matthew R. Kreifels, Scott E. Whitney, Gregg Wilder, John Flanagan, James Dowling, Philip Hills, Michael Tilleman, Jeremie Jackson
  • Patent number: 9994807
    Abstract: A temperature sensor means comprising a thermally conducting layer arranged to face the surface to be measured, a thermally insulating layer attached to the thermally conducting layer on the opposite side to the surface to be measured, a temperature sensor provided between the thermally conducting layer and the thermally insulating layer and being completely surrounded on all its sides by either the thermally conducting or the thermally insulating layers.
    Type: Grant
    Filed: June 16, 2014
    Date of Patent: June 12, 2018
    Assignee: GE HEALTHCARE BIO-SCIENCES AB
    Inventors: Patrik Akerstrom, Hakan Wahlnas
  • Patent number: 9994808
    Abstract: The present invention is directed to compositions, tools, methods and devices to culture microorganisms and, in particular, to compositions, tools, methods and devices for the detection of microorganisms in biological samples.
    Type: Grant
    Filed: August 11, 2016
    Date of Patent: June 12, 2018
    Assignee: Vax-Immune, LLC
    Inventors: Bhairavi Parikh, James Stone
  • Patent number: 9993782
    Abstract: A bioreactor has a stirrer shaft that is driveable by a drive and on which a stirrer element is positioned. The position of the stirrer element is determined by a stirrer installation aid. The stirrer installation aid has a free end with an abutment surface on which the free end of the stirrer element abuts. The stirrer installation aid is designed as a sleeve that comprises a slot extending between the axial ends of the sleeve. The slot is delimited by opposite flanks of a wall, and the sleeve is placed on the stirrer shaft. The stirrer installation aid can be pulled off laterally from the stirrer shaft. A method for installing the stirrer element on the stirrer shaft arranged in the bioreactor also is provided.
    Type: Grant
    Filed: August 29, 2013
    Date of Patent: June 12, 2018
    Assignee: Sartorius Stedim Biotech GmbH
    Inventors: Thomas Dreher, Oliver Scheibe, Gerhard Greller, Ute Husemann, Oscar-Werner Reif