Patents Examined by Lydia Edwards
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Patent number: 11788040Abstract: The present invention relates to a device (10; 30; 50) for analysing liquid samples comprising amplified nucleic acids, said device comprising: a sample pad (16); a first (18) and a second (19) sample analysis strip configured to analyse different aspects of the nucleic acid sample wherein said segments comprise nucleic acid sequences which are complementary to the predetermined sequences of target nucleic acids whose presence or absence is analysed; and a housing (11) enclosing said sample pad and at least two elongated sample analysis strips wherein the analysis result is detectable from the outside of the housing from the combination of aligned segments of said first and second analysis strips. The invention furthermore relates to a method for determining the presence or absence of a target nucleic acid, providing confirmatory results, in combination with a predetermined sequence in a sample from a subject using the device according to the invention.Type: GrantFiled: February 15, 2017Date of Patent: October 17, 2023Assignee: EMPE DIAGNOSTICS ABInventors: Pavankumar Asalapuram, Mats Nilsson Bernitz
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Patent number: 11788047Abstract: The present invention provides a parallel bioreactor system, comprising: an oscillator for generating oscillating motion; a plurality of culture vessels mounted on the oscillator, wherein each culture vessel is provided with an inner cavity, the inner cavity comprises a cylindrical portion at the upper part and an inverted truncated conical bottom at the lower part, a cross section of the cylindrical portion is consistent with the cross section of the top of the inverted truncated conical bottom, and the bottom of the cylindrical portion is joined with the top of the inverted truncated conical bottom; disposable culture bags arranged in the inner cavities of the culture vessels and used for accommodating culture solution, wherein each disposable culture bag is provided with a multifunctional cover plate, and the multifunctional cover plate is connected to the top of the culture bag to seal the culture bag, and is provided with a plurality of connection holes leading to interior of the disposable culture bag;Type: GrantFiled: July 20, 2021Date of Patent: October 17, 2023Assignee: Zhejiang Jinyishengshi Bioengineering Co., LtdInventors: Shun Luo, Fulin Hu, Shiping Yuan, Jinpei Song
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Patent number: 11773364Abstract: An automated cell culturing device, which expands, detaches and prepares cells, ready to be implanted in vivo is disclosed. The device is composed by a multi-layered cell culture chamber, a cell preparation chamber, and critical parameters control units which automatically drive the cell culture medium circulation, change and refill. The device according to the invention is characterized in that all the components contacting cells and culture medium constitute a totally disposable “cartridge” in order to avoid cross-contamination and improve safety. The device is particularly useful for expanding and preparing mesenchymal stem cells for osteoarthritis (OA) therapy, and for other cell based therapies in mammals.Type: GrantFiled: April 8, 2015Date of Patent: October 3, 2023Assignee: VivaBioCell S.p.A.Inventors: Giacomo Cattaruzzi, Massimo Moretti, Antonio Sfiligoj, Francesco Curcio
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Patent number: 11773362Abstract: Bioreactors and components of bioreactors are described as may be beneficially utilized in development and conditioning of cellular materials for study or implant. The bioreactors are modular, and components of the bioreactors can be easily assembled with alternatives provided to develop specific, predetermined conditioning environments for cellular materials (e.g., implantable tissue). By selection of one of multiple alternative compliance chambers, a bioreactor can be utilized to condition tissue in a low-pressure circuit (e.g., a pulmonary heart circuit), and by utilization of an alternative compliance chamber, the bioreactor can instead condition tissue in a high-pressure circuit (e.g., an aortic heart circuit).Type: GrantFiled: April 29, 2021Date of Patent: October 3, 2023Assignee: Clemson University Research FoundationInventors: Leslie Sierad, Christopher Delaney, Richard Pascal, III, Dan Simionescu, Agneta Simionescu
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Patent number: 11717829Abstract: A system and method for processing and detecting nucleic acids from a set of biological samples, comprising: a capture plate and a capture plate module configured to facilitate binding of nucleic acids within the set of biological samples to magnetic beads; a molecular diagnostic module configured to receive nucleic acids bound to magnetic beads, isolate nucleic acids, and analyze nucleic acids, comprising a cartridge receiving module, a heating/cooling subsystem and a magnet configured to facilitate isolation of nucleic acids, a valve actuation subsystem configured to control fluid flow through a microfluidic cartridge for processing nucleic acids, and an optical subsystem for analysis of nucleic acids; a fluid handling system configured to deliver samples and reagents to components of the system to facilitate molecular diagnostic protocols; and an assay strip configured to combine nucleic acid samples with molecular diagnostic reagents for analysis of nucleic acids.Type: GrantFiled: May 7, 2020Date of Patent: August 8, 2023Assignee: NeuMoDx Molecular, Inc.Inventors: Jeffrey Williams, Sundaresh Brahmasandra, Michelle Mastronardi
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Patent number: 11718819Abstract: A bioreactor includes a culture medium vessel housing culture medium. The culture medium vessel further includes a first side surface including a first transparent optical window; and a second side surface parallel to the first surface and including one or more sensor adapters to fix optical sensors. A cell retention vessel is disposed underneath and connected to the culture medium vessel, the cell retention vessel housing biological cells and having: a top surface that intersects a base of the culture medium vessel, and a second transparent optical window indented into the top surface at a first corner of the top surface. A semipermeable membrane is disposed at a bottom of the cell retention vessel, and a frame comprising a grid is disposed underneath the semipermeable membrane.Type: GrantFiled: October 13, 2021Date of Patent: August 8, 2023Assignee: Shanghai Longevity Co., Ltd.Inventors: Tian Xia, Ke Ma
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Patent number: 11708597Abstract: A system and method for processing and detecting nucleic acids from a set of biological samples, comprising: a molecular diagnostic module configured to receive nucleic acids bound to magnetic beads, isolate nucleic acids, and analyze nucleic acids, comprising a cartridge receiving module, a heating/cooling subsystem and a magnet configured to facilitate isolation of nucleic acids, a valve actuation subsystem including an actuation substrate, and a set of pins interacting with the actuation substrate, and a spring plate configured to bias at least one pin in a configurations, the valve actuation subsystem configured to control fluid flow through a microfluidic cartridge for processing nucleic acids, and an optical subsystem for analysis of nucleic acids; and a fluid handling system configured to deliver samples and reagents to components of the system to facilitate molecular diagnostic protocols.Type: GrantFiled: September 5, 2018Date of Patent: July 25, 2023Assignee: NeuMoDx Molecular, Inc.Inventors: Michael T. Kusner, Jeffrey Williams
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Patent number: 11708552Abstract: A multi-chamber single-use bioreactor for cell culture expansion has bag assembly and a rigid support structure defining a bag receiving space. The bag assembly disposed in the bag receiving space of the rigid support structure and supported by the rigid support structure. The bag assembly has at least a first flexible bag and a second flexible bag. The first bag defines a first reaction chamber, and the second bag defines a second reaction chamber. The first reaction chamber has a first volume, a first inlet, and a first outlet, and the second reaction chamber has a second volume different from the first volume, a second inlet, and a second outlet. The second inlet of the second bag is fluidically connected to the first outlet of the first bag so liquid in first reaction chamber can be transferred to the second reaction chamber.Type: GrantFiled: April 11, 2018Date of Patent: July 25, 2023Assignee: The Board of Regents for Oklahoma State UniversityInventors: Momen Mohsen Ahmed Amer, Joshua D. Ramsey
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Patent number: 11709160Abstract: A skin sample culture apparatus which has a base frame, with a skin sample receiving surface upon which at least part of the skin sample may be placed and which extends across an area defined by the shape of the frame. A securing member which is releasably connectable to the base frame and a grip which holds the skin sample under tension. The apparatus may include a tensioner to hold the sample under tension and means for introducing a fluid to the upper or lower surface of the sample.Type: GrantFiled: May 22, 2017Date of Patent: July 25, 2023Assignee: The University of DundeeInventors: Robyn Patricia Hickerson, Michael John Conneely
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Patent number: 11697790Abstract: A probe holder (1), for positioning at least one probe (50) such that the probe (50) at least partially engages in a system (100) for biotechnological uses, comprises a holder base (10) for positioning the probe holder (1) on the system (100) for biotechnological uses and at least one probe positioning means (20), which is designed to position the at least one probe (50) such that the probe (50) extends in a probe extension direction (S; S1, S2, S3, S4). The probe positioning means (20) is positioned on the holder base (10) such that the position of the probe (50) is variably adjustable in a probe extension direction (S; S1, S2, S3, S4).Type: GrantFiled: March 14, 2017Date of Patent: July 11, 2023Assignee: Sartorius Stedim Blotech GmbHInventors: Simon Topp-Manske, Christian Zahnow, Ute Husemann, Bernward Husemann
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Patent number: 11698371Abstract: A testing apparatus for performing an assay, the testing apparatus comprising: a receptacle (2) containing a reagent, the reagent being reactive to an applied test sample by developing a colour or pattern variation; a portable device (1), e.g. a mobile phone or a laptop, comprising a processor and an image capture device (3), wherein the processor is configured to process data captured by the image capture device and output a test result for the applied test sample.Type: GrantFiled: December 20, 2017Date of Patent: July 11, 2023Assignee: Novarum DX LimitedInventors: Neil Polwart, Graham Tyrie, Anthony Peter Ashbrook
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Patent number: 11691152Abstract: Systems, methods, and apparatuses are provided for self-contained nucleic acid preparation, amplification, and analysis.Type: GrantFiled: May 23, 2018Date of Patent: July 4, 2023Assignees: BioFire Defense, LLC, BioFire Diagnostics, LLCInventors: Kirk M. Ririe, Aaron D Wernerehl, Christopher P. Pasko, Ali Laayoun, Carole Vachon, Agnès Dupont-Filliard, Laurent Mesta, Andrew C. Hatch, Erik W. Huynh, David E. Jones
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Patent number: 11667879Abstract: A dynamic incubator system and method for mammalian cells. The dynamic incubator system includes an incubator and a programming device communicatively coupled to the incubator. The programming device includes a memory, one or more processors, a display, and an input mechanism. The programming device is adapted to enable at least one preset temperature and gas concentration sequence to be one or more of designed for the interior of the incubator, saved to the memory of the programming device and/or selected for implementation within the interior of the incubator. The at least one temperature and gas concentration sequence includes programmed changes to the temperature and a CO2 gas concentration. A purging mechanism is coupled to the incubator and releases a portion of a gas concentration to enable rapid changes in the temperature and gas concentration in the incubator.Type: GrantFiled: March 10, 2020Date of Patent: June 6, 2023Assignee: FOREVER LABS, INC.Inventor: Mark Katakowski
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Patent number: 11655467Abstract: A system and method for processing and detecting nucleic acids from a set of biological samples, comprising: a capture plate and a capture plate module configured to facilitate binding of nucleic acids within the set of biological samples to magnetic beads; a molecular diagnostic module configured to receive nucleic acids bound to magnetic beads, isolate nucleic acids, and analyze nucleic acids, comprising a cartridge receiving module, a heating/cooling subsystem and a magnet configured to facilitate isolation of nucleic acids, a valve actuation subsystem configured to control fluid flow through a microfluidic cartridge for processing nucleic acids, and an optical subsystem for analysis of nucleic acids; a fluid handling system configured to deliver samples and reagents to components of the system to facilitate molecular diagnostic protocols; and an assay strip configured to combine nucleic acid samples with molecular diagnostic reagents for analysis of nucleic acids.Type: GrantFiled: August 29, 2016Date of Patent: May 23, 2023Assignee: NeuMoDx Molecular, Inc.Inventors: Jeffrey Williams, Sundaresh Brahmasandra, Michael T. Kusner
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Patent number: 11648561Abstract: A system and method for processing and detecting nucleic acids from a set of biological samples, comprising: a capture plate and a capture plate module configured to facilitate binding of nucleic acids within the set of biological samples to magnetic beads; a molecular diagnostic module configured to receive nucleic acids bound to magnetic beads, isolate nucleic acids, and analyze nucleic acids, comprising a cartridge receiving module, a heating/cooling subsystem and a magnet configured to facilitate isolation of nucleic acids, a valve actuation subsystem configured to control fluid flow through a microfluidic cartridge for processing nucleic acids, and an optical subsystem for analysis of nucleic acids; a fluid handling system configured to deliver samples and reagents to components of the system to facilitate molecular diagnostic protocols; and an assay strip configured to combine nucleic acid samples with molecular diagnostic reagents for analysis of nucleic acids.Type: GrantFiled: February 19, 2020Date of Patent: May 16, 2023Assignee: NeuMoDx Molecular, Inc.Inventors: Jeffrey Williams, Sundaresh Brahmasandra, Michelle Mastronardi
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Patent number: 11643630Abstract: An illuminated container for the growth of biological entities is provided. The container is illuminated by a flexible light diffusing fiber. The light diffusing fiber includes a core formed from a silica-based glass and a cladding in direct contact with the core. The light diffusing fiber also includes an outer polymer coating layer surrounding the cladding, the outer polymer coating layer being the cured product of a liquid polymer blend including a scattering material and a luminophore.Type: GrantFiled: November 18, 2016Date of Patent: May 9, 2023Assignee: CORNING INCORPORATEDInventors: Edward John Fewkes, Stephan Lvovich Logunov
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Patent number: 11643633Abstract: The present invention relates to a device (100) for monitoring the development of a biological material, said device in the orientation intended for use comprising: a housing (2) having an extension in a longitudinal direction (X) and an extension in a transversal direction (Y), said housing comprises: two or more culture dish compartments (4), each adapted to accommodate a culture dish (6) comprising a biological material (8) to be monitored, each said compartment being separated from each of said other compartments, said two or more compartments being arranged along the longitudinal direction; each said culture dish compartment (4) comprising a lid (10) adapted to be able to be shifted between an open configuration in which access to the interior (12) of said culture dish compartment is provided, and a closed configuration sealing off the interior of said culture dish compartment from its surroundings; wherein each said culture dish compartment comprises an inlet (14) for supplying gas to and an outlet (16Type: GrantFiled: July 5, 2013Date of Patent: May 9, 2023Assignee: ESCO MEDICAL TECHNOLOGIES, UABInventor: Thomas William Pedersen
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Patent number: 11613726Abstract: The present invention relates to a bioreactor including at least one reactor vessel in form of a plastic bag, a tray (4) for holding said at least one bag, a rocking device for limited rocking motions of the tray (4) around a rocking axis (2). According to the invention the bioreactor comprises a device (6,7,8,9) for enabling swinging of the tray (4) around a second axis (7) parallel to and distanced from the rocking axis (2).Type: GrantFiled: July 18, 2017Date of Patent: March 28, 2023Assignee: CYTIVA SWEDEN ABInventors: Andreas Andersson, Lars Johan Carlsson, Christian Elnegard, Henrik K. Eriksson, Thomas Falkman, Patric Fricking, Linnea Pauler, Claes Peterson
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Patent number: 11613725Abstract: Improved cell culture devices and related methods that overcome the limitations of prior devices and methods, by creating devices that can integrate a variety of novel attributes. These various attributes include the use of gas permeable material and medium volumes that exceed conventional devices as well as compartments that can facilitate the long term study of high density cultures with reduced disruption of the culture environment, the ability to study the migration of items of interest including substances such as chemokine, track the movement of cells, and monitor cell to cell interactions.Type: GrantFiled: May 9, 2016Date of Patent: March 28, 2023Assignee: Wilson Wolf ManufacturingInventors: John R. Wilson, Daniel P. Welch
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Patent number: 11584907Abstract: A cell culture apparatus is provided, including a storage tank including one or a plurality of cell culture units, in which the cell culture unit includes a culture chamber having an inner surface-side space in which a culture solution is stored, a permeable membrane having a first surface to which cells are adherable and a second surface opposite to the first surface, the first surface facing the inner surface-side space, a culture solution storage chamber that stores the culture solution, a culture solution introduction flow path that introduces the culture solution in the culture solution storage chamber to the inner surface-side space, and a culture solution discharge flow path that sends, to the culture solution storage chamber, the culture solution which permeates through the membrane from the inner surface-side space and flows into an outer surface-side space that the second surface of the membrane faces.Type: GrantFiled: September 7, 2018Date of Patent: February 21, 2023Inventors: Shinji Sugiura, Taku Satoh, Reiko Nagasaki, Toshiyuki Kanamori