Patents Examined by M. C. Eakin
  • Patent number: 4482744
    Abstract: A process is provided wherein methanol is converted over spent shale to products such as mercaptans, disulfides and ethylene.
    Type: Grant
    Filed: November 12, 1982
    Date of Patent: November 13, 1984
    Assignee: Mobil Oil Corporation
    Inventor: Costandi A. Audeh
  • Patent number: 4479963
    Abstract: 1-Carboxy-(alkanoyl or aralkanoyl)-indoline-2-carboxylic acids, e.g., those of the formula ##STR1## R=H, alkyl, alkoxy, halogeno or CF.sub.3 ; R'=H or R-phenyl;m=0 or 1;p,q=0 to 2;and derivatives thereof, are antihypertensive and cardioactive agents.
    Type: Grant
    Filed: April 26, 1982
    Date of Patent: October 30, 1984
    Assignee: Ciba-Geigy Corporation
    Inventor: Norbert Gruenfeld
  • Patent number: 4478847
    Abstract: The invention provides a pharmaceutical composition comprising an aldose reductase inhibitory 1'-substituted-spiro[pyrrolidine-3,3'-indoline]-2,2',5-trione of the formula: ##STR1## wherein Ra is (2-7C)alkyl or (3-7C)alkenyl, naphthylmethyl or cinnamyl optionally bearing one or two halogeno nuclear substituents, or Ra is benzyl optionally bearing one or two substituents and benzene ring A optionally bears one or two substituents, trifluoromethyl and nitro; or a salt thereof with a base affording a pharmaceutically acceptable cation; or a non-toxic, biodegradable precursor thereof; together with a pharmaceutically acceptable diluent or carrier. The invention also provides novel compounds of formula I and processes for their manufacture.The compositions are of application in the treatment or prophylaxis of the side effects of diabetes or galactosemia.
    Type: Grant
    Filed: May 11, 1982
    Date of Patent: October 23, 1984
    Assignee: Imperial Chemical Industries PLC
    Inventors: David R. Brittain, Robin Wood
  • Patent number: 4476309
    Abstract: A method for making aromatic ether imides is provided by effecting the displacement of reactive radicals on a phthalimide nucleus with a mono- or bis-alkali metal phenoxide in the presence of a nonpolar solvent and a phase transfer catalyst, such as a triorganoborate. The aromatic ether imide made by the present invention are useful intermediates for making aromatic ether anhydrides and aromatic bis(ether anhydrides).
    Type: Grant
    Filed: March 21, 1983
    Date of Patent: October 9, 1984
    Assignee: General Electric Company
    Inventors: John W. Verbicky, Jr., Elbridge A. O'Neil, Jr.
  • Patent number: 4471125
    Abstract: A method is provided for making aromatic ether imides in the substantial absence of a solvent. A mixture of at least one halo-substituted phthalimide and at least one anhydrous alkali metal phenoxide salt is heated at a temperature at least sufficient to convert the halo-substituted phthalimide to the molten state and below the temperature at which the alkali metal phenoxide is thermally unstable.
    Type: Grant
    Filed: September 29, 1982
    Date of Patent: September 11, 1984
    Assignee: General Electric Company
    Inventors: John W. Verbicky, Jr., Brent A. Dellacoletta
  • Patent number: 4469874
    Abstract: Alkyl thiosalicylate prevulcanization inhibitors having a pleasant odor are described.Claimed compounds include those of the formula: ##STR1## in which X is an amide inhibitor moiety attached through the nitrogen atom derived from the group consisting of 2-benzimidazolinone, 2-imidazolidinone, 2-benzothiazolone, 2-thiazolone, phthalimide, succinimide, glutarimide, hexahydrophthalimide, maleimide, hydantoin, urea, napthalimide, oxamide, oxanilide, phenylcarbamic acid ester, formamide, formanilide, acetamide, benzamide, acetanilide, benzanilide, propionamide, butyramide, pivalamide, valeramide and hexanamide, R is alkyl of 1-8 carbon atoms, R' is alkyl of 1-8 carbon atoms, alkoxy of 1-8 carbon atoms, --CO.sub.2 --R, or halo, and n is 0, 1 or 2.
    Type: Grant
    Filed: February 12, 1981
    Date of Patent: September 4, 1984
    Assignee: Monsanto Company
    Inventor: Otto W. Maender
  • Patent number: 4467097
    Abstract: A method is provided for making aromatic bis(etherimide)s by effecting reaction between an aromatic bisphenoxide salt and a nitro-substituted N-alkyl phthalimide in the presence of a non-polar organic solvent and an effective amount of a phase transfer catalyst. There is utilized as the phase transfer catalyst, a mixture of a dipolar aprotic solvent and a polyvalent metal salt such as zinc chloride.
    Type: Grant
    Filed: September 29, 1982
    Date of Patent: August 21, 1984
    Assignee: General Electric Company
    Inventors: John W. Verbicky, Jr., James A. Cella, Elbridge A. O'Neil, Jr.
  • Patent number: 4465842
    Abstract: The N-benzylimides having the structural formula: ##STR1## wherein Ar comprises a benzene radical and R.sub.1 is an aliphatic or aromatic hydrocarbon, are prepared in good yield by reacting a compound having the structural formula:ArH (II)with a compound having the structural formula: ##STR2## in the presence of hydrofluoric acid.
    Type: Grant
    Filed: May 14, 1982
    Date of Patent: August 14, 1984
    Assignee: Rhone-Poulenc Specialites Chimiques
    Inventors: Michel Desbois, Michel Reppelin
  • Patent number: 4465860
    Abstract: Non-ionic products of the formula:R--X-- [C.sub.2 H.sub.3 (OCH.sub.2 CH.sub.2).sub.n (OH)-- CH.sub.2 --Y--R'in which R and R' denote alkyl or alkenyl radicals having from 6 to 20 carbon atoms, the sum of the numbers of carbon atoms in R and R' being 24 to 32; X denotes an oxygen atom, a sulphur atom or a sulphoxide group; Y denotes a sulphur atom, a sulphoxide group or a methylene group (if Y denotes methylene, the sum of the numbers of carbon atoms in R and R' is 22 to 30); and n denotes an integer or decimal number from 1 to 40 are disclosed. These non-ionic compounds are suitable for use in pharmaceutical or cosmetic applications, in particular for the care of the skin or hair.
    Type: Grant
    Filed: December 21, 1982
    Date of Patent: August 14, 1984
    Assignee: Societe Anonyme dite: L'Oreal
    Inventors: Guy Vanlerberghe, Henri Sebag
  • Patent number: 4460791
    Abstract: The instant invention relates to the recovery of oil from subterranean oil reservoirs involving the injection of an aqueous based liquid containing a fluorochemical surfactant possessing an oleophobic-hydrophobic fluoroaliphatic group, a hydrophilic group and an oleophilic group, optionally in conjugation with a conventional enhanced oil recovery surfactant.
    Type: Grant
    Filed: May 20, 1982
    Date of Patent: July 17, 1984
    Assignee: Ciba-Geigy Corporation
    Inventor: Thomas W. Cooke
  • Patent number: 4459239
    Abstract: Chloroformates of alkyl esters of C-alkyl or C-haloalkyl tartronic acids of the general formula: ##STR1## in which: R represents an alkyl or haloalkyl group having from 1 to 5 carbon atoms, andR.sup.1 represents an alkyl group having from 1 to 5 carbon atoms,may be prepared by reaction of phosgene in an inert solvent with the corresponding ester of the C-alkyl-tartronic acid of the desired compound at a temperature of from 0.degree. to 20.degree. C. in the presence of at least a stoichiometric amount of a tertiary amine.
    Type: Grant
    Filed: January 11, 1982
    Date of Patent: July 10, 1984
    Assignee: Montedison S.p.A.
    Inventors: Vincenzo Di Toro, Franco Gozzo, Pier M. Boschi
  • Patent number: 4455430
    Abstract: Chemical process for preparing tricholomic acid and its analogs which are useful for the preparation of AT-125.
    Type: Grant
    Filed: January 28, 1981
    Date of Patent: June 19, 1984
    Assignee: The Upjohn Company
    Inventors: Robert C. Kelly, Wendell Wierenga
  • Patent number: 4454292
    Abstract: Disclosed herein are 2,3-dihydro-1H-indole-2-carboxylic acids substitued on the nitrogen with 3-mercapto-2-alkyl-1-oxoalkyl, 3-phosphoryl-2-alkyl-1-oxopropyl, or 2-amino-2-alkyl-1-oxoalkyl derivatives which act as inhibitors of angiotensin converting enzyme and as antihypertensive agents. The compounds of the invention (excluding disclosed intermediates) have the general formula: ##STR1## wherein: n is 1 or 0;R.sub.1 is hydrogen, lower alkyl, aryl or aralkyl;R.sub.2 is hydrogen or lower alkyl;R.sub.3 is hydrogen, lower alkyl or aroyl;R.sub.5 is hydroxy, amino, or lower alkoxy;X is hydrogen, hydroxy, lower alkyl, lower alkoxy, or halogen; Y is hydrogen, lower alkyl, or aryl;Y is hydrogen, lower alkyl, or aryl;R.sub.4 is ##STR2## wherein: L is O, NR.sub.7 or S (where R.sub.7 is hydrogen or lower alkyl);M is R.sub.8, OR.sub.8, SR.sub.8, or NR.sub.9 R.sub.10 (where R.sub.8 is hydrogen, lower alkyl, aryl, or aralkyl; and R.sub.9 and R.sub.10 are, independently, hydrogen, lower alkyl, or aryl);A is O, NR.sub.
    Type: Grant
    Filed: June 22, 1982
    Date of Patent: June 12, 1984
    Assignee: American Home Products Corporation
    Inventors: Dong H. Kim, Ronald J. McCaully
  • Patent number: 4454291
    Abstract: Disclosed herein are 2,3-dihydro-1H-indole-2-carboxylic acids substituted on the nitrogen with 3-mercapto-2-alkyl-1-oxoalkyl, 3-phosphoryl-2-alkyl-1-oxopropyl, or 2-amino-2-alkyl-1-oxoalkyl derivatives which act as inhibitors of angiotensin converting enzyme and as antihypertensive agents. The compounds of the invention (excluding disclosed intermediates) have the general formula: ##STR1## wherein: n is 1 or 0;R.sub.1 is hydrogen, lower alkyl, aryl or aralkyl;R.sub.2 is hydrogen or lower alkyl;R.sub.3 is hydrogen, lower alkyl or aroyl;R.sub.5 is hydroxy, amino, or lower alkoxy;X is hydrogen, hydroxy, lower alkyl, lower alkoxy, or halogen;Y is hydrogen, lower alkyl, or aryl;Y is hydrogen, lower alkyl, or aryl;R.sub.4 is ##STR2## wherein: L is O, NR.sub.7 or S (where R.sub.7 is hydrogen or lower alkyl);M is R.sub.8, OR.sub.8, SR.sub.8, or NR.sub.9 R.sub.10 (where R.sub.8 is hydrogen, lower alkyl, aryl, or aralkyl; and R.sub.9 and R.sub.10 are, independently, hydrogen, lower alkyl, or aryl);A is O, NR.sub.
    Type: Grant
    Filed: June 22, 1982
    Date of Patent: June 12, 1984
    Assignee: American Home Products Corporation
    Inventors: Dong H. Kim, Ronald J. McCaully
  • Patent number: 4449006
    Abstract: A process is provided for the manufacture of methyl mercaptan with substantial reduction of by-product methane by intimate mixture of carbon oxide, sulfur or hydrogen sulfide and hydrogen at elevated temperature and pressure with a single-phase, solid catalyst system comprising a porous alumina-containing support upon which is deposited a mixture of manganese sulfide and alkali metal sulfide.
    Type: Grant
    Filed: September 29, 1982
    Date of Patent: May 15, 1984
    Assignee: Pennwalt Corporation
    Inventor: Paul G. Haines
  • Patent number: 4449005
    Abstract: Aliphatic and cycloaliphatic halogen compounds containing a halogen atom and a hydrogen atom attached to adjacent carbon atoms are dehydrohalogenated to the corresponding unsaturated compounds by contact with a quaternary ammonium fluoride or quaternary phosphonium fluoride.
    Type: Grant
    Filed: August 6, 1982
    Date of Patent: May 15, 1984
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: William R. Hydro, George T. Davis, deceased
  • Patent number: 4448727
    Abstract: Thermally stable, color-stabilized halobisphenolethylene polycarbonates comprising halobisphenolethylene polycarbonates containing an effective amount of a stabilizing organophosphite are described. The stabilized halobisphenolethylene polycarbonates can be molded or formed into films, sheets, fibers, laminates or other molded articles including reinforced articles by conventional molding techniques.
    Type: Grant
    Filed: September 2, 1981
    Date of Patent: May 15, 1984
    Assignee: General Electric Company
    Inventors: Arnold Factor, Keith N. Sannes
  • Patent number: 4439228
    Abstract: Oxime derivatives of the formula (I) ##STR1## wherein n is 0, 1 or 2 and m is 0 or 1, and Ar is a phenyl radical ##STR2## a naphthyl radical substituted by R.sub.2 and R.sub.3, a 5- to 10-membered heterocyclic radical which contains not more than 3 identical or different heteroatoms N, O and/or S and which is substituted by R.sub.2, R.sub.3 and R.sub.4 and can be substituted by oxo or thiono, or if m is O, Ar is a radical R--CO, wherein R is a radical --OR.sub.5, in which R.sub.5 is an aliphatic group containing not more than 8 carbon atoms or is an araliphatic group containing not more than 15 carbon atoms or is a cycloaliphatic or aromatic group, each containing not more than 10 carbon atoms, while the possible substituents of the aromatic radicals or of the cycloaliphatic radical are halogen, --CN, --NO.sub.2, lower alkyl, lower alkoxy, haloalkyl; or R is a radical --NH--CO--NH--R.sub.7 or a radical --N(R.sub.6)(R.sub.7), wherein R.sub.6 is hydrogen or lower alkyl and R.sub.
    Type: Grant
    Filed: July 14, 1982
    Date of Patent: March 27, 1984
    Assignee: Ciba-Geigy Corporation
    Inventors: Werner Fory, Henry Martin, Georg Pissiotas
  • Patent number: 4439229
    Abstract: Compounds of the formula: ##STR1## wherein A is O or S, halo is chloro, bromo or fluoro; X' is --CH.sub.2 --, O or S; X is hydrogen or halo; R.sup.1 and R.sup.2 are the same or different radicals selected from hydrogen or lower alkyl; and Z can be a variety of substituents and agronomically acceptable salts, esters and amides as well as other heterocyclic benzenes are disclosed as selective herbicides.
    Type: Grant
    Filed: May 6, 1982
    Date of Patent: March 27, 1984
    Assignee: Rohm and Haas Company
    Inventor: Colin Swithenbank
  • Patent number: 4439230
    Abstract: Oxime derivatives of the following formula are described: ##STR1## wherein R.sub.1 is hydrogen or halogen, and R.sub.8 is phthalimido, 4, 5, 6, 7-tetrahydrophthalimido or 3a, 4, 7, 7a-tetrahydrophthalimido attached at the nitrogen atom to the remainder of the molecule. These compounds are used for protecting plant crops from the action of aggressive agricultural chemicals.
    Type: Grant
    Filed: July 14, 1982
    Date of Patent: March 27, 1984
    Assignee: Ciba-Geigy Corporation
    Inventors: Werner Fory, Henry Martin, Georg Pissiotas