Patents Examined by M. C. Eakin
  • Patent number: 4407825
    Abstract: Compounds of formulaR.sub.1 O--(CH.sub.2).sub.m --S--S--(CH.sub.2).sub.p --S].sub.x S--(CH.sub.2).sub.n --OR.sub.2wherein R.sub.1 and R.sub.2 are, independently, hydrogen, C.sub.1-5 alkyl or a physiologically-hydrolyzable and -acceptable acid residue; m and n are, independently, 2 or 3; p is an integer of fron 2 to 6; and x is 1, 2 or 3; whereby when x is 2 or 3, each p may be the same or different, having immunostimulant activity.
    Type: Grant
    Filed: January 29, 1982
    Date of Patent: October 4, 1983
    Assignee: Sandoz Ltd.
    Inventors: Peter Hiestand, Michael Strasser
  • Patent number: 4405355
    Abstract: Compounds of the formula ##STR1## wherein R is aliphatic hydrocarbyl, alicyclic hydrocarbyl or aryl suitably substituted, if desired, or a heterocyclic group, R.sup.1 is hydrogen or alkyl, R.sup.2 is alkyl or alkoxy, R.sup.3 is ##STR2## wherein a is 0 or 1, R.sup.4 is hydrogen or CW'.sub.3, the W' being hydrogen or halogen, Z is halogen and X is halogen, hydroxy, alkoxy, acetoxy, carbethoxyalkoxy, phenoxy, alkylthio, carbethoxyalkylthio, phenylthio, phosphono, dithiophosphonoxy, phosphoramido, isocyanato, isothiocyanato, alkyl- and dialkylthiocarbamoylthio, alkyl- and dialkylcarbamoyloxy, alkylsulfonyl, etc., have herbicidal activity.
    Type: Grant
    Filed: January 26, 1981
    Date of Patent: September 20, 1983
    Assignee: Chevron Research Company
    Inventor: Malcolm S. Singer
  • Patent number: 4400541
    Abstract: Bis-(diphenylsulfoniophenyl)-sulfide-bis-chloride and related aryl sulfonium halides are produced in high yields and in high purity by reacting diphenyl disulfide (Ph--S--S--Ph) in benzene in the presence of aluminum chloride with gaseous chlorine according to the disclosed process.
    Type: Grant
    Filed: February 1, 1982
    Date of Patent: August 23, 1983
    Assignee: The Southland Corporation
    Inventor: Shankar S. Iyer
  • Patent number: 4400520
    Abstract: A process for the preparation of an isoindoline derivative of the following general formula (II): ##STR1## wherein R.sup.2 is a hydrogen atom or lower alkyl group and X is a carboxyl group, carboalkoxy group, amide group or cyano group, which comprisescycling a benzylidene derivative of the following general formula (I) ##STR2## wherein R.sup.1 is a hydrogen atom or lower alkyl group, and R.sup.2 and X are as defined above, in the presence of a reducing agent such as sodium boron hydride. In one embodiment, the benzylidene derivative may be substituted by a reaction mixture containing the same, the reaction mixture being prepared by reacting o-phthalaldehydic acid or its ester with an aniline derivative.
    Type: Grant
    Filed: September 4, 1981
    Date of Patent: August 23, 1983
    Assignee: Hisamitsu Pharmaceutical Co., Inc.
    Inventors: Kanji Noda, Akira Nakagawa, Toshiharu Motomura, Hiroyuki Ide
  • Patent number: 4396778
    Abstract: A continuous process is provided for the vapor-phase preparation of C.sub.1 -C.sub.18 alkyl mercaptans where a di C.sub.1 -C.sub.18 alkyl sulfide is reacted with a molar excess of hydrogen sulfide at elevated temperature in the presence of a specified synthetic zeolite containing at least 10 percent by weight of an alkali metal, expressed as Na.sub.2 O.
    Type: Grant
    Filed: December 17, 1981
    Date of Patent: August 2, 1983
    Assignee: Pennwalt Corporation
    Inventor: Robert B. Hager
  • Patent number: 4395370
    Abstract: Described are branched chain alkenyl methyl carbonates and branched chain alkenyl formates defined according to the structure: ##STR1## wherein R.sub.3 represents hydrogen or methoxy and wherein in each of the molecules described by the structure, one of the dashed lines is a carbon-carbon double bond and each of the other of the dashed lines is a carbon-carbon single bond; and uses of the compounds wherein R.sub.3 is methoxy in augmenting or enhancing the aroma of perfume compositions, colognes and perfumed articles such as solid or liquid anionic, cationic, nonionic or zwitterionic detergents, fabric softener compositions, fabric softener articles, hair sprays, shampoos, bath oils and plastic fragrances.
    Type: Grant
    Filed: December 10, 1981
    Date of Patent: July 26, 1983
    Assignee: International Flavors & Fragrances Inc.
    Inventors: Richard M. Boden, Theodore J. Tyszkiewicz, Michael Licciardello
  • Patent number: 4393241
    Abstract: Provided is a novel process for the synthesis of aryl sulfides substituted with an alkoxy or phenoxy substituent. The process comprises reacting an alkoxy or phenoxy substituted aromatic compound with a sulfur dihalide, preferably sulfur dichloride, in the presence of an alkali metal tetrafluoroborate catalyst, with the amount of said aromatic reactant compound preferably being sufficient to solvate the sulfur dichloride and catalyst sufficiently to allow the reaction to occur.
    Type: Grant
    Filed: February 1, 1982
    Date of Patent: July 12, 1983
    Assignee: Celanese Corporation
    Inventors: Harry T. Hanson, John B. Sapp, Jr.
  • Patent number: 4391980
    Abstract: The invention relates to a process for inverting the configuration in optically active compounds of the formula ##STR1## in which Ar.sub.1 represents a monocyclic or polycyclic, carbocyclic or heterocyclic radical that has at least one ring of aromatic character and is bonded to the oxygen atom by way of a ring carbon atom, preferably of the ring of aromatic character, andR.sub.1 represents an optionally substituted aliphatic, cycloaliphatic or araliphatic hydrocarbon radical,or the salts thereof, characterized in that an optically active compound of the formula ##STR2## having a R(+) or S(-) configuration, in which R.sub.2 represents a monocyclic or polycyclic, carbocyclic or heterocyclic radical, or an optionally substituted aliphatic, cycloaliphatic or araliphatic hydrocarbon radical,is converted, by treating with a strong oxygen-containing inorganic or organic acid or halides thereof, into an optically active compound of the formula ##STR3## in which x.sup..crclbar.
    Type: Grant
    Filed: May 11, 1981
    Date of Patent: July 5, 1983
    Assignee: Ciba-Geigy Corporation
    Inventor: Janos Zergenyi
  • Patent number: 4391627
    Abstract: Novel N-(heterocyclicaminocarbonyl)carbonyl-substituted benzothiophene- and benzofuransulfonamides are useful as herbicides. The invention also includes novel sulfonamides and sulfonyl isocyanates useful in preparing such compounds.
    Type: Grant
    Filed: June 22, 1981
    Date of Patent: July 5, 1983
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: George Levitt
  • Patent number: 4390703
    Abstract: Some derivatives of interphenylene-9-thia-11-oxo-12-azaprostanoic acid which are active renal vasodilator agents are resolved via diastereomeric camphanyl or camphorcarbonyl esters. Upon hydrolysis, the separated diastereoisomers yield optically pure enantiomers.
    Type: Grant
    Filed: June 22, 1981
    Date of Patent: June 28, 1983
    Assignee: Merck & Co., Inc.
    Inventors: Mark G. Bock, Robert M. Di Pardo
  • Patent number: 4389406
    Abstract: Compounds of formula (I) in the 1-form ##STR1## wherein R.sup.1 and R.sup.2 are the same or different and each is selected from hydrogen, optionally substituted (C.sub.1-7) alkyl, optionally substituted aryl and aromatic heterocyclyl and the dotted line is an optional direct bond, and acid addition salts thereof, are useful in treating worm infections in mammals. Compounds (I) are produced by forming the amide of m-aminotetramisole or by closing the dihydroimidazoline ring.
    Type: Grant
    Filed: May 15, 1981
    Date of Patent: June 21, 1983
    Assignee: Beecham Group Limited
    Inventors: Roderick J. Dorgan, Richard A. Webster
  • Patent number: 4388247
    Abstract: When the reaction of aldehydes with alkali metal trihaloacetates is carried out in the presence of a highly polar aprotic solvent (DMF, DMSO), novel organic alkali metal carbonates, which are precursors of pyrethroid insecticides, are formed in high yields and at a high rate. Novel sulfonates and dihalophosphites, derived from these carbonates have also been claimed.
    Type: Grant
    Filed: August 25, 1980
    Date of Patent: June 14, 1983
    Assignee: Shell Oil Company
    Inventors: Petrus A. Kramer, Pieter A. Verbrugge
  • Patent number: 4386221
    Abstract: The present invention provides a process for the preparation of aryl alkyl sulfones and aryl vinyl sulfones. The process comprises reacting an aryl compound with an alkyl sulfonyl fluoride or with a vinyl sulfonyl fluoride in the presence of a catalyst selected from AlCl.sub.3 and AlBr.sub.3. The aryl compound is preferably selected from chlorobenzene, the isomeric xylenes, the isomeric trimethyl benzenes, and mixtures thereof. The alkyl group of the alkyl sulfonyl fluoride preferably contains 1-18 carbon atoms, and the vinyl group of the vinyl sulfonyl fluoride is unsubstituted or substituted with one or more alkyl groups containing 1-5 carbon atoms. The reaction is conducted at a temperature between about C. and C. in the presence or absence of an inert solvent.
    Type: Grant
    Filed: October 28, 1981
    Date of Patent: May 31, 1983
    Assignee: Eastman Kodak Company
    Inventors: John A. Hyatt, Alan W. White
  • Patent number: 4384143
    Abstract: Purified bis(3,5-dialkyl-4-hydroxyphenyl) sulfone useful for production of improved carbonate polymer is described. This sulfone is precipitated by deammoniation of an aqueous solution and then removed from the supernatant solution. This produces a product having minimal phenol sulfonic impurities. It may be employed to form carbonate polymer having improved physical properties.
    Type: Grant
    Filed: May 1, 1981
    Date of Patent: May 17, 1983
    Assignee: General Electric Company
    Inventors: Daniel W. Fox, Edward N. Peters
  • Patent number: 4382147
    Abstract: 4,4'-Dihydroxydiphenyl sulfone is isolated from a mixture of dihydroxydiphenyl sulfone isomers by heat dissolving the mixture in phenol and then cooling the resulting solution thereby allowing 4,4'-dihydroxydiphenyl sulfone to precipitate as an adduct with phenol.
    Type: Grant
    Filed: September 9, 1981
    Date of Patent: May 3, 1983
    Assignee: Tokai Denka Kogyo Kabushiki Kaisha
    Inventors: Hirotsugu Kitamura, Yasumasa Shimizu, Osami Ohura
  • Patent number: 4380671
    Abstract: Disclosed is a process for the preparation of 2,2'-bis(4-substituted phenol)sulfides which comprises reacting a 4-substituted phenol with sulfur dichloride in a hydrocarbon solvent at a temperature of from to C. in the presence of a Lewis acid catalyst. For example, 2,2'-bis(4-cumylphenol)-sulfide, i.e. 2,2'-bis(4-.alpha.,.alpha.-dimethyl benzyl-phenol)monosulfide, which is a novel compound can be prepared by reacting 4-cumylphenol with sulfur dichloride in benzene at a temperature of from C. in the presence of zinc chloride.
    Type: Grant
    Filed: July 30, 1981
    Date of Patent: April 19, 1983
    Assignee: Mitsui Toatsu Chemicals, Incorporated
    Inventors: Akihiro Yamaguchi, Tadashi Kobayashi, Keizaburo Yamaguchi, Hisamichi Murakami
  • Patent number: 4380466
    Abstract: A novel hexahydroisoindole derivative of the formula, ##STR1## which can be produced by dehydration of the corresponding 3a-hydroxy-octahydroisioindole derivative or by reaction of the corresponding 3-chloro-hexahydroisoindole with a thiol sulfonate.The derivative is useful as an intermediate for producing a compound having a substituted or unsubstituted thiol group at 3-position and can be utilized as a herbicide possessing low toxicity to crops and animal.
    Type: Grant
    Filed: May 20, 1981
    Date of Patent: April 19, 1983
    Assignee: Takeda Chemical Industries, Ltd.
    Inventor: Yasuo Ishida
  • Patent number: 4380642
    Abstract: A process for the simultaneous preparation of pyrazole and triazoles by reacting a triazoline compound with a basic compound and then oxidizing the product with hydrogen peroxide.The triazoles and pyrazole obtainable by the process of the invention are valuable starting materials for the preparation of dyes, pesticides and drugs.
    Type: Grant
    Filed: July 17, 1981
    Date of Patent: April 19, 1983
    Assignee: BASF Aktiengesellschaft
    Inventors: Norbert Rieber, Rolf Platz, Werner Fuchs
  • Patent number: 4377699
    Abstract: An improved process for the preparation of 5-chloro-indole comprising reacting indoline in a chlorine-inert organic solvent with an acylating agent of an organic carboxylic acid to obtain the corresponding 1-acyl-indoline, reacting the latter in the presence of water and a basic agent with chlorine to form 5-chloro-1-acyl-indoline, subjecting the latter to saponification to obtain 5-chloro-indoline and reacting the latter in a water-immiscible organic solvent by heating with an aromatic nitrocompound in the presence of a finely powdered ruthenium catalyst to form 5-chloro-indole in excellent yields.
    Type: Grant
    Filed: September 9, 1981
    Date of Patent: March 22, 1983
    Assignee: Rutgerswerke Aktiengesellschaft
    Inventors: Manfred Maurer, Winfried Orth, Werner Fickert
  • Patent number: 4377054
    Abstract: 2-Chloro-4,5-disubstituted-thiazoles have been found to be effective in reducing herbicidal injury to sorghum plants due to the application thereto of acetanilide and thiocarbamate herbicides.
    Type: Grant
    Filed: August 28, 1980
    Date of Patent: March 22, 1983
    Assignee: Monsanto Company
    Inventors: Robert K. Howe, Len F. Lee