Abstract: Octahydro-1H-benzo[4,5]furo[3,2-e]isoquinoline compounds and processes for their manufacture are provided. The compounds correspond to the formula ##STR1## These compounds exhibit both analgesic and narcotic antagonistic properties, as well as low abuse liability.

Abstract: Sulfonylurea compounds have the formula ##STR1## in which R is selected from the group consisting of 1-4 carbon alkyl, phenyl, and methyl substituted phenyl;R.sub.1 is selected from the group consisting of hydrogen and 1-4 carbon alkyl; andR.sub.2 is selected from the group consisting of mono- and polyhalosubstituted phenyl, 3-6 carbon alkynyl, and 2-6 carbon alkoxyalkyl.

Abstract: A class of novel 2-oxazolyl ureas and carbamates having anti-allergic activity are described together with methods of making such compounds and pharmaceutical compositions containing the active compounds of the invention.

Abstract: Compounds having the formula ##STR1## in which R is selected from the group consisting of chloro and fluoro;R.sub.1 -R.sub.4 are each independently selected from the group consisting of hydrogen and 1-4 carbon alkyl; andX is oxygen or sulfur protect crops from thiocarbamate herbicidal injury.

Abstract: A method is provided for making alkali metal bisphenoxide salts by refluxing a heterogenous mixture of a non-polar organic solvent and an aqueous solution of an alkali metal bisphenoxide. These bisphenoxide salts can be used thereafter to make aromatic bis(ether phthalimides) by reaction with nuclear ring substituted N-organo phthalimides.

Abstract: A process is disclosed for preparing a mixture of hydroxyl containing di- and trisulfides, from either 2-mercaptoethanol or 3-mercaptopropanol, directly in two steps, without the formation of deleterious byproducts. Precise control of process conditions (a) in a first step in which the disulfide is formed, includes oxidation of mercapto-lower alkanol with a stoichiometric amount of H.sub.2 O.sub.2 while maintaining the pH and temperature of a relatively dilute aqueous reaction mixture within a specific narrow range; and, (b) in a second step in which a predetermined portion of the disulfide is converted substantially exclusively to the trisulfide, requires controlled heating of the reaction mixture to a temperature not to exceed 100.degree. C. The process may be carried out in a single reaction vessel, and directly yields a preselected distribution of disulfide and trisulfide in the mixture.

Abstract: 1-Halo-2-alkylthioethyl and 1-halo-2-arylthioethyl sulfones, having algicidal and fungicidal activity, are prepared by the addition of arylsulfenyl or alkylsulfenyl halides to alkyl or aryl vinyl sulfones. The thioethyl sulfone products are treated with a base to produce 2-alkylthiovinyl or 2-arylthiovinyl sulfones, which also have algicidal and fungicidal activity. The vinyl sulfones are halogenated to produce 1,2-dihalothioethyl sulfones, which have superior fungicidal activity, especially for tomato and celery late blight.

Abstract: The reaction of formamide at high temperature with a 4-halo-5-hydroxy-2(5H)-furanone provides high yields of 5-chloro or 5-bromopyrimidines.

Abstract: A process for the production of aromatic carbonic acid esters by transesterifying a mixture of dimethylcarbonamate/methanol and a methanol-immiscible azeotrope former for methanol with phenols in the presence of transesterification catalysts.

Abstract: Novel enzyme conjugates useful in immunoassay methods are prepared with the use of a novel coupling reagent of N-succinimidyl (4-iodoacetyl) aminobenzoate by reacting the coupling reagent, firstly, with an amino-containing macromolecule, and, thereafter, with a sulfhydryl-containing enzyme, the enzyme conjugate prepared in a high yield and of high specificity.

Abstract: The compounds according to the invention have the formulae Ia or Ib ##STR1## in which Y is a divalent organic radical and Z is --NH.sub.2, --NH-alkyl having 1-4 C atoms, --OH, --COOH, --COCl, --O--CO--CH.dbd.CH.sub.2, ##STR2## --COO--CH.dbd.CH.sub.2 or --O--CH.dbd.CH.sub.2. These novel 3- or 4-azidophthalic acid derivatives may be used for the preparation of photo-crosslinkable polymers. Compared to corresponding photosensitive polymers of the prior art, these novel polymers have the advantages that they are even more photosensitive and that they also absorb in the long wavelength UV region (at wavelengths greater than 320 nm).

Abstract: 1-(3-Mercapto-2-methylpropanoyl)prolyl amino acid derivatives of the formula ##STR1## wherein R represents a hydrogen atom, a lower alkyl group, a phenyl-lower alkyl group or a substituted phenyl-lower alkyl group, R.sub.1 represents a hydrogen atom, R.sub.4 CO--, R.sub.5 S--, or ##STR2## R.sub.2 represents a hydrogen atom or a lower alkyl group, R.sub.3 represents a hydrogen atom, a phenyl group, a lower alkyl group, or a substituted lower alkyl group, or R.sub.2 and R.sub.3 form a heterocyclic ring together with the nitrogen and carbon atoms to which they are respectively bonded; salts of these compounds; compositions comprising these compounds or salts; and processes for preparing these compounds or salts. These compounds and salts have excellent antihypertensive activity.

Abstract: 2,2'-bis[4-(1,1,3,3-tetramethylbutyl)phenol]sulfide is prepared by suspending 4-(1,1,3,3-tetramethylbutyl)phenol in an organic solvent, reacting it with sulfur dichloride or sulfur monochloride at a temperature of from -10.degree. to 40.degree. C., and isolating the precipitate so formed.

Abstract: A liquid extraction method is provided for recovering aromatic bisimides from an organic solvent aromatic bisimide reaction mixture having a variety of reaction by-products. An organic solvent solution of the bisimide reaction mixture is extracted with water and/or an aqueous alkali metal hydroxide to effect removal of such reaction by-products, and provide an organic solvent phase of the aromatic bisimide which can be obtained in substantially pure form upon removal of the organic solvent.

Abstract: The present invention relates to a new organic heterocyclic isocyanate which is the reaction product of an organic diisocyanate and an amino or hydroxy nitrile. The invention also relates to a process of producing such isocyanates by reacting an excess of the diisocyanate with the nitrile under conditions under which the nitrile will not decompose and then maintaining the reaction mixture at an elevated temperature until the isocyanate nitrile adduct cyclizes. The reaction may be carried out in the presence of a catalyst for isocyanate addition reactions. Additionally, the invention relates to a process for the production of polyurethane by the reaction of the heterocyclic isocyanates with compounds carrying at least two isocyanate reactive hydrogen atoms per molecule.

Abstract: Derivatives of 1,3-dihydro-3-(2-hydroxyethyl) -2H-isoindol-1-one are disclosed. The derivatives are useful for treating ulcers in a mammal and for preventing or decreasing the secretion or availability of excessive amounts of gastric or hydrochloric acid in a mammal suffering from hyperchlorhydria and/or associated conditions.

Abstract: Octahydro-1H-benzo[4,5]furo[3,2-e]isoquinoline compounds and processes for their manufacture are provided. The compounds correspond to the formula ##STR1## These compounds exhibit both analgesic and narcotic antagonistic properties, as well as low abuse liability.

Abstract: Novel unsubstituted and 4-substituted, 2,6-dinitrophenyl seleninic acids, selenium halides and diselenides are described. The above-described selenium compounds are particularly useful to catalyze the oxidation of olefins to the corresponding epoxide in the presence of hydrogen peroxide.

Abstract: Novel tricyclic imidyl derivatives, for example those of the formula ##STR1## [n=1 or 2, Y=a bridge member and X=a functional group] are described. The novel tricyclic imidyl derivatives are suitable for the preparation of photocrosslinkable polymers by incorporation into existing polymer chains or by building up the polymer chain from tricyclic imidyl derivatives, according to the definition, with suitable functional groups X by polymerization or polycondensation. The photocrosslinkable polymers obtained by this means can be used, for example, to produce printing plates for the offset printing process and especially as photoresists.

Abstract: A process for the preparation of an indolenine of the general formula I ##STR1## where R, R.sup.1 and R.sup.2 are aliphatic radicals and R.sup.1 and R.sup.2 may also be linked and the ring A may be additionally substituted, wherein a compound of the formula II ##STR2## is heated in the presence of a Lewis acid and of a halide. The products are valuable starting compounds for the preparation of dyes.