Abstract: A process for producing a 3-iminohaloisoindoline-1-one which comprises treating a halophthalodinitrile with ammonia and/or an organic amine together with hydrogen peroxide in a mixed reaction medium comprising water and an organic solvent.

Abstract: -Dimethyl 7-[.omega.-N-(phthalimido)alkyl]aminonaphthalene -1,2-dicarboxylates of the formula: ##STR1## wherein R is hydrogen or straight chain alkyl containing 1-4 carbon atoms and n=2-6. The compounds are intermediates in the synthesis of chemiluminescent naphthalene-1,2-dicarboxylic acid hydrazide-labeled conjugates which are useful as reagents in specific binding assays for determining ligands or their specific binding partners in liquid media.

Abstract: There is provided a vaccine material capable of providing a substantial level of protection against infection by enterotoxogenic organisms of Escherichia coli. The protecting means comprises pili of the infecting organism. The protection is given either by administering the pili directly to the subject to be protected or to a pregnant female where protection of the newborn is desired. In the case of piglets, where there is substantially no transplacental transfer of immunity from mother to offspring, the pili are administered to mothers, who are then caused to feed the offspring to be protected, whereby the immunization is transferred via the colostrum of the mother.

Abstract: New compounds which are herbicide antagonists that are useful for protection of plants from various herbicides are members of the group having the general structural formulas: ##STR1## in which R is hydrogen or C.sub.1 to C.sub.4 alkyl, alkenyl or alkynyl, branched or straight chain, R.sup.1 is C.sub.1 to C.sub.3 alkyl, alkenyl or alkynyl, branched or straight chain, with the total number of carbon atoms in R and R.sup.1 being less than six, preferably less than four, on compounds with both R and R.sup.1 substituents. The novel plant protection agents may be applied both to seeds and to the soil.

Abstract: Tetrahydro-2H-benzo[c]pyrroles, useful as dopamine agonists, particularly as inhibitors of prolactin secretion and in treatment of Parkinson's syndrome.

Abstract: The disclosure is of a method for encapsulating biologically active materials in synthetic, oligolamellar lipid vesicles (liposomes). The method comprises providing a mixture of lipid in organic solvent and an aqueous mixture of the material for encapsulation, emulsifying the provided mixture, removing the organic solvent and suspending the resultant gel in water. The method of the invention is advantageous over prior art methods of encapsulating biologically active materials in that it provides a means for a relatively high capture efficiency of the material for encapsulation. The disclosure is also of intermediate compositions in the encapsulation method, the product vesicles, compositions including the product vesicles as an active ingredient and their use.

Abstract: Benzylpyrrolylmethyl esters of 3-(1,2-dibromo-2,2-dichloroethyl)-2,2-dimethylcyclopropanecarboxylic acid, synthesis thereof and the use of said esters for the control of pests.

Abstract: The substituted 5H-dibenz[b,f]azepine of the formula ##STR1## a process for its manufacture, pharmaceutical compositions which contain the novel compound, and a method of treating epilepsy which comprises the use thereof.

Abstract: The invention relates to an avian vaccine and to the preparation thereof.The vaccine according to the invention is a Newcastle disease virus vaccine. Its active ingredient is the P/77/8 NDV strain.The vaccine of the invention is useful in the prevention of Newcastle disease by administration to chickens in the form of an aerosol.

Abstract: A carbonylation process which comprises contacting a .beta.-fluoroalkanol, carbon monoxide, a base, and the Group IIB element mercury present in an oxidation state greater than zero. The resulting .beta.-fluoroaliphatic carbonates can be employed in combination with alkanols and/or phenols to prepare aliphatic and aromatic mono- and polycarbonates. The resulting carbonates are useful in a wide variety of applications, especially polycarbonates which can be molded or formed into films, sheets, fibers, laminates, or reinforced plastics by conventional techniques.

Abstract: Pyroglutamic acid derivatives and analogs having the formula ##STR1## and salts thereof, wherein R is hydrogen, alkyl or diphenylmethyl;R.sub.1 is hydrogen, alkyl or trifluoromethyl;R.sub.2 is hydrogen, ##STR2## or ##STR3## R.sub.3 is hydrogen, alkyl, phenyl, or phenylalkyl; X is oxygen or sulfur; andn is 0 or 1;have useful hypotensive activity.

Abstract: Novel cyclopropane carboxylic acid esters of the formula ##STR1## wherein X.sub.1 is selected from the group consisting of hydrogen, fluorine, chlorine and bromine, X.sub.2 is selected from the group consisting of fluorine, chlorine and bromine, X.sub.3 is selected from the group consisting of chlorine, bromine and iodine and R is selected from the group consisting of ##STR2## and benzyl optionally substituted with at least one member of the group consisting of alkyl of 1 to 4 carbon atoms, alkenyl of 2 to 6 carbon atoms, alkenyloxy of 2 to 6 carbon atoms, alkadienyl of 4 to 8 carbon atoms, methylenedioxy, benzyl and halogens, R.sub.1 is selected from the group consisting of hydrogen and methyl, R.sub.2 is selected from the group consisting of monocyclic aryl and --CH.sub.2 --C.tbd.CH,R.sub.3 is an aliphatic of 2 to 6 carbon atoms having at least one double bond, R.sub.4 is selected from the group consisting of hydrogen, --CN and --C.tbd.CH, R.sub.

Abstract: An antibody-specific solid phase immunoadsorbent is prepared by adsorptively binding a lipid-containing viral antigen, such as hepatitis B surface antigen, to the surface of a porous glass carrier having an average pore diameter within the range of about 40-200 nm and an adsorptive surface which within the pH range of 2-8 is capable of selectively and stably binding lipid-containing materials, employing an adsorption buffer having a pH within such range. The high adsorptive selectivity of the carrier surface for the antigen under such conditions, enables preparation of the immunoadsorbent directly from whole human plasma containing the antigen, without the necessity for prior antigen purification.

Abstract: An antibody is prepared from a stable new form of nerve growth factor having a molecular weight of about 116,000. The pure nerve growth factor is obtained from an extract of mouse submandibular gland or mouse saliva which is subjected to ion-exchange chromatography to recover a component of the gland or saliva rich in the nerve growth factor and containing proteinaceous material which does not degrade the nerve growth factor. The component rich in nerve growth factor is subjected to at least one additional chromatography step, usually two to four, to obtain pure nerve growth factor. The pure nerve growth factor then is injected into the blood system of an animal to form the antibody which is recovered from the animal's blood serum.

Abstract: N-Sulphenylated carbamoyl compounds of the formula ##STR1## in which Z represents two adjacent C atoms of a bifunctional lower aliphatic radical, of a cycloaliphatic radical or of an optionally substituted aromatic radical,m denotes the number 0 or 1 andn denotes the number 0, 1, 2 or 3,which possess fungicidal properties.

Abstract: A compound of the formula: ##STR1## wherein R is methyl or 2-methylthioethyl, is prepared by either (A) condensing a compound of the formula: ##STR2## wherein R is the same as above, or a reactive derivative thereof with 3,4-diethoxycarboxyphenethylamine, or (B) condensing the compound (II) or a reactive derivative thereof with dopamine, followed by reacting the resultant product with an ethoxycarbonyl halide. The compound (I) shows potent renal blood flow-increasing activity and is useful for the treatment of renal hypertension, congestive heart failure and other diseases due to renal blood flow disturbances.

Abstract: 8-Chloro-5,6,7,8-tetrahydro-2-quinolone and 8-bromo-5,6,7,8-tetrahydro-2-quinolone, the hydrochloride or hydrobromide thereof and their manufacture by reacting 3,4,5,6,7,8-hexahydro-2-quinolone with chlorine or bromine in an inert solvent at 10.degree. to 50.degree. C. with heating of the reaction mixture to 60.degree. to 80.degree. C. after the halogen addition.

Abstract: In preparing organic sulfides by reacting olefins (e.g., butylenes) with a sulfur halide to form a sulfohalogenated intermediate which is subsequently sulfurized and dehalogenated by reaction with an aqueous solution of an alkali metal sulfide compound to form a noncorrosive organic sulfide product of high sulfur content, the copper strip corrosion activity is improved by resulfurizing the sulfurized olefin by contacting it with additional aqueous metal sulfide in the presence of a lower molecular weight alcohol, such as isopropanol.

Abstract: A material capable of forming hydrogen bonds or covalent bonds with loading materials incorporated in loaded cells is introduced into the cells with the loading materials to inhibit the destruction of the cell membranes by the loading material after the permeability of the membranes is brought back down to its normal value. In order to provide for the hydrogen bond formation with common loading materials, such as methotrexate, proteins such as albumin and sugars such as sucrose are effective. The time period during which these materials inhibit a destructive effect on the membranes of loaded cells is well defined.

Abstract: Plant growth-regulating compounds of the formula ##STR1## wherein X and Y are separately oxygen, sulfur, N-B where B is hydrogen, lower alkyl, or acyl; R and R' are separately lower alkyl, acyl, amido, or form a cycle with ##STR2## corresponding to the formula ##STR3## in which R.sub.1, R.sub.2, R.sub.3, and R.sub.4 are separately hydrogen, lower alkyl, halogen-substituted lower alkyl, NO.sub.