Abstract: A sustained release composition for releasing a biologically active compound into an aqueous liquid environment comprises the biologically active compound dispersed in a bioerodible matrix, the matrix comprising a mixture of(a.) 5% to 99.5% by weight of a solid water-dispersible polyether diol having a molecular weight from about 1000 to about 20,000, and(b.) 95 to 0.5% by weight of an erosion rate modifier component comprising a combination of stearyl alcohol and stearic acid.Dosage forms comprising the erodible matrix are prepared by molding, particularly by injection molding.
Abstract: This invention relates to aryloxycycloalkanolaminoalkylene aryl ketones to the processes for their preparation and to their use as antihypertensive agents.
Type:
Grant
Filed:
April 17, 1984
Date of Patent:
May 17, 1988
Assignee:
Merrell Dow Pharmaceuticals Inc.
Inventors:
Michael E. LeTourneau, James R. McCarthy, Donald L. Trepanier
Abstract: This invention is a polyurethane and/or polyurea elastomer prepared in the reaction of:(a) an organic polyisocyanate;(b) a chain extender and(c) a polyether having a molecular weight from about 500 to about 10,000, which polyether is a block copolymer of ethylene oxide and butylene oxide comprising an internal poly(EO) block bonded on each side to a poly(BO) block, wherein oxybutylene moieties comprise from about 10 to about 90 percent of the total weight of the polyether.
Type:
Grant
Filed:
July 25, 1985
Date of Patent:
May 17, 1988
Assignee:
The Dow Chemical Company
Inventors:
Kimbley A. Bushman, Michael K. Laughner
Abstract: High molecular weight polyphenylene ethers are prepared from monohydric phenols by a conventional polycondensation, by a method in which the resulting polymers are reacted with an epoxide of the general formula (I) ##STR1## where R.sup.1 and R.sup.2 can be identical or different and are each alkyl, cycloalkyl, aryl, aryloxy, alkoxy or carboxyalkyl, each of which may contain a further epoxide group, or C.sub.3 -C.sub.20 -alkyl-substituted amino, or R.sup.1 is hydrogen and R.sup.2 is one of the above groups, or R.sup.1 and R.sup.2 form part of a cycloalkyl ring.
Type:
Grant
Filed:
August 5, 1986
Date of Patent:
May 10, 1988
Assignee:
BASF Aktiengesellschaft
Inventors:
Konrad Mitulla, Juergen Hambrecht, Helmut Tesch, Burghard Schmitt, Hansjoachim Maeder
Abstract: Urethane oligomer modified epoxy resin compositions are prepared by copolymerization of (A) an epoxy resin and (B) a urethane oligomer containing at least one oxyalkylene group and both polymerizable ethylenic unsaturation and isoeyanate (isothiocyanate) groups in the presence of a suitable amount of a suitable catalyst for oxazolidinone (thiazolidinone) formation.These modified epoxy resin compositions can be cured with conventional epoxy curing agents and they can be used to prepare vinyl ester resins.
Abstract: High temperature fluorinated polyimides having repeating polymer units of the formula ##STR1## wherein X is aromatic or aliphatic. The polyimides can be made by oxidizing 1-phenyl-1,1-bis (3,4-xylyl)-2,2,2-trifluorethane to form 4,4'(2,2,2-trifluoro-1-phenylethylidene)biphthalic tetra carboxylic acid and dehydrating that to form 4,4'(2,2,2-trifluoro-1-phenyl-ethylidene-biphthalic tetra carboxylic acid dianhydride. The dianhydride is polymerized with a diamine to form a polyamic acid which is further imidized to the polyimide. Alternatively, the dianhydride can be esterified to form a 4,4'(2,2,2-trifluoro-1-phenylethylidene)-biphthalic tetracarboxylic acid dialkylester which is then polymerized with a diamine to form a polyamic acid which can then be imidized to a polyimide.
Abstract: An improved process for preparing polyimides is disclosed which involves end capping intermediate polyamic acids with dicarboxylic acid monoanhydrides and thermally converting to high molecular weight polyimides.
Abstract: The invention describes a process for the preparation of N,o-substituted mono- and/or polyurethanes of formulaR.sup.1 [--NHCOOR.sup.2 ].sub.n,in whichR.sup.1 is an aliphatic, cycloaliphatic, aromatic, araliphatic, or heterocyclic radical, which may be substituted,R.sup.2 is an aliphatic, cycloaliphatic, or araliphatic radical which may be substituted with alkoxy or polyoxyalkylene groups, andn is a whole number from 1 to 5,through the reaction of N-substituted allophanates and/or polyallophanates with alcohols R.sup.2 OH in the presence or absence of catalysts at temperatures of at least 160.degree. C., preferably from 165.degree. to 250.degree. C.
Abstract: There is disclosed an improved prosthesis coated, respectively, with a cationic surfactant, an antibiotic compound and treated with an cationic exchange compound, to remove un-antibiotic bound cationic surfactant.
Type:
Grant
Filed:
July 23, 1984
Date of Patent:
April 26, 1988
Assignee:
University of Medicine & Dentistry of New Jersey
Inventors:
Ralph S. Greco, Richard Harvey, Stanley Z. Trooskin
Abstract: The solvent resistance of polysulfone, polyether sulfone, and polyesters is enhanced by using difunctional end-cap monomers of the present invention to provide improved crosslinking. The imidophenol monomers include two unsaturated functionalities capable of crosslinking upon thermal or chemical activation. Oligomer, oligomer blends, pregregs, and composites using the novel end caps are also described.
Abstract: New alkoxylated aminopolyethers of the formula ##STR1## in which Q denotes a polyalkylene oxide radical which has a valency corresponding to n, which has a structure derived from an aminopolyether by removal of the terminal amino groups and which has an average molecular weight of 82 to 30,000,A.sub.1 and A.sub.2 denote identical or different mono- or polyalkylene oxide radicals of the type (RO).sub.y,whereineach radical R represents an alkylene radical with 2 to 40 C atoms andy represents an integer from 1 to 200,B.sub.1 and B.sub.2 denote identical or different mono- or polyalkylene oxide radicals of the type (R'O).sub.z,whereinat least 50% of the R' radicals represent a --CH.sub.2 --CH.sub.2 -- group,the other R' radicals which may be present each represent an alkylene radical with 3 to 40 C atoms andz represents an integer from 1 to 300,Z denotes hydrogen, ##STR2## wherein M.sup..sym. represents one equivalent of a metal ion or represents NH.sub.4.sup..sym.
Type:
Grant
Filed:
December 10, 1985
Date of Patent:
April 19, 1988
Assignee:
Bayer Aktiengesellschaft
Inventors:
Jan Mazanek, Hanns P. Muller, Roland Nast, Wolfgang Oberkirch, Franz-Moritz Richter, Walter Schafer
Abstract: Aromatic polyimide compositions, useful in particular for manufacturing adhesive materials, varnishes and films withstanding high temperatures, having a high solubility in organic solvents, particularly polar solvents and which are manufactured by reacting, in such a solvent, a tetraester or diacid-diester of benzhydrol 3,3', 4, 4' tetracarboxylic acid with an aromatic diamine for a sufficient time to obtain a polycondensation reaction product having an inherent viscosity at 30.degree. C., at a concentration of 5 g/liter in N-methyl pyrrolidone, ranging from 0.1 to 2 dl/g.
Type:
Grant
Filed:
October 19, 1982
Date of Patent:
April 5, 1988
Assignee:
Institut Francais du Petrole
Inventors:
Guy Rabilloud, Michel Senneron, Choua Cohen, Paul Mariaggi, Bernard Sillion
Abstract: A semiconductor device containing an .alpha.-rays shielding resin layer on at least active portion of a semiconductor element, said .alpha.-rays shielding resin being a special polyimide resin, is excellent in thermal resistance at the time of sealing the semiconductor element, adhesion of the .alpha.-rays shielding layer to the semiconductor element, and .alpha.-rays shielding ability.
Abstract: Described herein are novel poly(aryl ether ketones) which display unique and outstanding high temperature properties, a unique blending behavior and excellent fabricability characteristics.
Abstract: Improved imaging device for applying temporary indicia to substrate of the type having a base covered with a relatively light color, opaque, open cell microvoid-containing layer that is rendered translucent when the microvoids are filled with a liquid having a refractive index similar to that of the layer. The improvement in the imaging device involves insuring that the imaging liquid contains no substance having an evaporation rate less than about one-half of the liquid, thereby permitting the imaging device to be repeatedly applied to the same area of the substrate without leaving ghost images.
Type:
Grant
Filed:
September 26, 1986
Date of Patent:
March 8, 1988
Assignee:
Minnesota Mining and Manufacturing Company
Abstract: Described herein is a solution comprising a select group of poly(aryl ether sulfones) dissolved in a cyclohexanone solvent. The solution is suitable for use in coatings or for casting into film.
Abstract: A synthetic resin which contains quaternary ammonium groups, and its preparation.The water-dilutable synthetic resin which contains quaternary ammonium groups and furthermore contains one or more basic secondary and/or tertiary amino groups per quaternary ammonium group is an adduct of(A) a quaternary ammonium salt which is obtained by reacting(a) an organic compound containing two or more basic amino groups per molecule, one of which is a primary group and is protected as a ketimine by prior reaction with a ketone, and the remaining groups are tertiary groups, with(b) an organic or inorganic acid and(c) a monoepoxide compound, and, if necessary, then eliminating the ketone hydrolytically,(B) a resin which contains on average from 1.5 to 3.0 epoxide groups per molecule, and, if required,(C) one or more monofunctional organic compounds whose functional group is capable of undergoing an addition reaction with an epoxide.
Type:
Grant
Filed:
August 15, 1985
Date of Patent:
March 8, 1988
Assignee:
BASF Aktiengesellschaft
Inventors:
Werner Loch, Rolf Osterloh, Eberhard Schupp, Klaas Ahlers
Abstract: Carboxy-terminated prepolymers are prepared by the reaction of a diamine, preferably an aromatic diamine, or a mixture thereof with a triamine, with a carboxy anhydride such as trimellitic anhydride and a dianhydride such as bisphenol A dianhydride. The prepolymers, or functional derivatives thereof, are then reacted with a diisocyanate or diamine, or a mixture thereof with a triisocyanate or triamine, preferably an aromatic diisocyanate, to produce copolyamideimides. The products prepared using triamines or triisocyanates are crosslinked. Other products containing alkyl or alicyclic groups attached to aromatic radicals can be oxidatively crosslinked, e.g., by heating in air.
Abstract: The present invention is directed to a coating composition produced by reacting an organic isocyanate with an active hydrogen containing organic material at an isocyanate group to active hydrogen ratio of from 1:1 to 2:1, said composition:(i) capable of swelling at least 300% by volume at a film thickness of 3 mils or less within 5 minutes after immersion in a hydrocarbon solvent,(ii) having a heteroatom content of from 1 to 12% by weight based on the total weight of the composition, and(iii) having a mean chain length between cross-linking sites of at least 4000.