Abstract: Compositions comprising starch-acrylic polymers combined with elemental iodine are disclosed. The SAP-I compositions release non-toxic amounts of iodophor iodine in a sustained, controlled manner. Methods of formation and use of the compositions along with methods of creation and use of devices incorporating the compositions in a variety of healthcare and non-healthcare settings are set forth in detail herein.

Abstract: An object of the present invention is to provide a novel use of fermented papaya preparation. A composition of the present invention is a composition for elongating telomeres comprising fermented papaya preparation as an active ingredient.

Abstract: The present application relates to a novel and efficient process with high yield for preparing methyl {4,6-diamino-2-[5-fluoro-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate of the formula (I) in the crystalline form of modification I, wherein the x-ray diffractogram of the compound of the formula (I) in modification exhibits peak maxima of the 2 theta angle at 5.9, 6.9, 22.7, in very high purity which is significantly more cost-effective than the process known from the art and can be performed in customary pilot- and production plant-equipment (stirred tank/devices for isolation).

Abstract: The present technology provides regenerative treatment methods and apparatus to promote regeneration of target biological tissue. Regenerative treatments include the subcutaneous and cutaneous application of carbon dioxide. Regenerative treatment methods include an initial treatment phase and a maintenance treatment phase. Regenerative treatment apparatus include effervescent mineral compositions for cutaneous application of carbon dioxide.

Abstract: A method of reducing the virulence of microbes in or on the human body and a method of sanitizing or disinfecting a surface, area, object, or porous or non porous material is provided. The methods comprise applying or injecting a solution having an effective amount of a conjugated diene for substantially reducing the virulence of the microbes or sanitizing or disinfecting a surface, area, object, or porous or non porous material.

Abstract: The present invention relates to methods and compositions for the treatment and prophylaxis of pulmonary arterial hypertension (PAH) in a human subject in need of such treatment, the methods comprising the pulmonary administration to the subject, preferably via inhalation of a composition comprising rapamycin or a prodrug or derivative thereof.

Abstract: The present invention relates to novel heteroaryl-triazole compounds of the general formula (I), in which the structural elements X, R1, R2, R3 and R4 have the meaning given in the description, to formulations and compositions comprising such compounds and for their use in the control of animal pests including arthropods and insects in plant protection and to their use for control of ectoparasites on animals.

Abstract: A microemulsion composition containing: (A) a polyether-modified organopolysiloxane shown in the following general formula (1) having an HLB of 8.0 or more calculated by Griffin's method; (B) a polyether-modified organopolysiloxane shown in the following general formula (7) having an HLB of 5.0 or less calculated by Griffin's method; (C) a glycerol derivative shown in the following general formula (8); (D) a polyhydric alcohol other than the (C); (E) a silicone oil having a kinematic viscosity of 20 mm2/s or less at 25° C.; and (F) water, where a ratio (A)/(B) of a mass of the (A) to a mass of the (B) satisfies 1.0 to 15.0 and the microemulsion composition has a transparent to translucent appearance at 25° C. This provides a microemulsion composition having a transparent to translucent appearance.

Abstract: Disclosed in the present invention are a preparation method for and a use method of a collagen microfiber hemostatic material. Collagen microfibers are obtained by performing high-speed shearing on a solid collagen material; after the collagen microfibers are dispersed in an aqueous phase, a procoagulant active ingredient modifies the surfaces of the collagen microfibers by means of linking molecules; and a collagen microfiber hemostatic material is obtained by performing high-speed shearing again after freeze drying. The collagen microfiber material can be prepared simply and efficiently by means of high-speed shearing; the biological activity of the collagen material is maintained as much as possible; and the microfibers have a length range of 10-1000 ?m and high dispersibility, thus facilitating spray processing.

Abstract: A wound healing composition is provided that includes a tissue adhesive or epithelial tissue healing agent and metal-modified cerium oxide nanoparticles (mCNPs). The nCNPs have a predominant 3+ surface charge and are in a range of about 3-35 nanometers (nm) in size and mixed in an amount that is in a range of about 0.01 to 0.1 weight percentage of a mixture having the tissue adhesive or epithelial tissue healing agent and the mCNPs. The metal (m) is a stable metallic metal with antimicrobial properties and non-ionizing. The mCNPs includes AgCNP2. A method is provided that uses the healing composition to treat a wound or epithelial tissue. The composition can be used to treat the skin or eye and/or subcutaneous tissue.

Abstract: The present invention relates generally to methods of use and compositions useful for treating skin. The composition includes a combination of one or more of Butyrospermum parkii (shea butter), PEG-50 shea butter, glycerin, Helianthus annuus (sunflower) seed oil, Prunus armeniaca (apricot) kernel oil, acrylates copolymer, sodium lauryl sulfate, lauramidopropyl betaine, sodium methyl cocoyl taurate, glycerin, and polyquaternium-7.

Abstract: A therapeutic article of manufacture that includes a body having fibers treated with a mixture including metal-modified cerium oxide nanoparticles (mCNPs) and one or more of a polymeric binder, a dispersant and a stabilizer. The mCNPs have a predominant 3+ surface charge and in a range of about 3-35 nanometers (nm) in size. The mCNPs are mixed in an amount that is in a range of about 0.01 to 0.1 weight percentage of the mixture having the mCNPs and the one or more of a polymeric binder, a dispersant and a stabilizer. The metal (m) is an antimicrobial promoting metal that is non-ionizing. A method is also provided that promotes wound healing and/or antimicrobial infection control with a barrier of the therapeutic article of manufacture.

Abstract: There is provided a method for enhanced extraction of cannabis oil from a cannabis plant material, and a free-flowing powder consisting of particles of cannabis plant material for use in such method for enhanced extraction. The cannabis plant material is characterized by a cannabis strain and a cannabis plant part. The method comprising a step of comminuting said cannabis plant material to a powder of a preselected particle size distribution (PSD) characterized by 10?Dv(90)?100 ?m as determined by laser diffraction particle size analysis prior to extraction process. The PSD is preselected in accordance with said cannabis strain and said plant part.

Abstract: The invention relates to beads and a composition comprising an aqueous phase comprising a plurality of beads, the beads comprising or consisting in a hydrogel matrix comprising at least one carboxyalkyl chitosan having glucosamine units, N-acetyl-glucosamine units and glucosamine units substituted with a carboxyalkyl group, the carboxyalkyl chitosan being crosslinked by covalent bonds between the carboxyalkyl chitosan chains and/or co-crosslinked by covalent bonds with one or more other polymers. The invention also relates to processes for their preparation and applications thereof.

Abstract: The invention relates to an artificial vitreous humor composition comprising a phosphate buffer, wherein the phosphate buffer has a pH value in the range from 7.0 to 7.7, particularly from 7.1 to 7.6, more particularly from 7.2 to 7.5. The invention further relates to a method of production of an artificial vitreous humor composition, a method for analyzing the behavior of a substance, a method for analyzing the change of the artificial vitreous humor composition upon contact with a substance and a kit of parts.

Abstract: Disclosed herein are immediate release oral dosage forms that contain abuse-deterrent and abuse-resistant features. In particular, the disclosed dosage forms can provide deterrence of abuse by ingestion of multiple individual doses. The disclosed dosage forms can likewise provide protection from overdose in the event of accidental or intentional ingestion of multiple individual doses. The dosage forms may also exhibit abuse resistant properties when physically manipulated, and also when physically manipulated and then administered in a manner not consistent with oral dosing. The dosage forms may also exhibit abuse resistant properties when administered in a manner intended to result in administration of the esketamine in a higher than therapeutic dose.

Abstract: Provided herein are compositions and methods for delivering pharmaceutical agents. In particular, provided herein are hydrogel formulations of suramin for use in wound healing, wound prevention, and other applications.

Abstract: Provided is a method for producing a biomimetic nutrient mixture via biomimicry, comprising: Step (1) providing a mineral nutrient element precursor solution, and Step (2) reacting the mineral nutrient element precursor solution with a natural bio-reactor to obtain the biomimetic nutrient mixture, wherein the biomimetic nutrient mixture comprises a mineral nutrient element and a nutrient solution. The method can produce high biologically active mineral nutrient by an auto-synthesizing natural antioxidant through photosynthesis in the natural bio-reactor containing chlorophyll, which can provide mineral nutrient element without additional extraction procedure or extra component for manufacturing a nutritional supplement.

Abstract: The present disclosure provides novel associated form (AF) of ketoprofen/dexketoprofen and lidocaine, and topical compositions thereof for use in topical products to treat patients with localized pain and inflammation. The novel ketoprofen/dexketoprofen and lidocaine AF acts as an extended-release drug delivery system due to extended release of the two drugs from the AF.

Abstract: The present disclosure provides compositions and methods for enhancing immunity (or immune response). The compositions and methods are particularly useful for potentiating immune response of a lymphoid cell. The compositions and methods are also applicable for treating cancer and other diseases.