Abstract: Systems and methods for treating congestive heart failure with high frequency stimulation are disclosed. A representative method for treating a patient includes applying an electrical signal having a frequency of from about 1 kHz to about 100 kHz to the patient via a treatment system that includes a signal delivery element in electrical communication with the patient's vagus nerve at a portion of the vagus nerve located at or proximate to the anterior interventricular junction of the patient's heart. The method can further include automatically detecting at least one physiological parameter of the patient, automatically determining at least one of an ejection fraction of the patient's heart and a correlate of the ejection fraction based on the detected parameter, and automatically adjusting the applied signal based on the determined ejection fraction.

Abstract: This application describes a variety of approaches for generating high voltage sinusoidal signals whose output voltage can be adjusted rapidly, without introducing high-frequency artifacts on the output. When these approaches are used, stronger electric fields can be applied to the tumor for a higher percentage of time, which can increase the efficacy of TTFields therapy. In some embodiments, this is accomplished by preventing adjustments to a DC power source during times when the output of that DC power source is powering the output signal. In some embodiments, this is accomplished by synchronizing the operation of an AC voltage generator and an electronic switch that is connected to the output of the AC voltage generator.

Abstract: Devices and methods can be used to treat dermatologic disorders, hyperhidrosis, and wrinkles using DC electroporation. In some cases, such electroporation is essentially non-thermal modulation that can be used to ablate keratinocyte neoplasms, such as seborrheic keratosis, and other non-keratinocyte derived neoplasms of the skin and adnexal structures and related structures in other anatomic sites. In some implementations, the devices and methods described herein can be used for therapy delivery for the treatment of early or pre-malignant skin cancers. In some implementations, the devices and methods described herein can be used for treatment of hyperhidrosis and cosmetic issues.

Abstract: A catheter device for use in the photodynamic treatment of a body cavity or hollow organ of the body, such as the bladder, the device being used in the photodynamic treatment of abnormalities, disorders or diseases of the internal surfaces of said body cavity or hollow organ.

Abstract: The invention relates to a high voltage source to be coupled to an electrode arrangement for a dielectric barrier discharge plasma treatment. It has a high voltage transformer device including a primary and secondary inductor coupled via a magnetic circuit. A feed circuit including a power capacitor, the power capacitor coupled with the primary inductor and a first controllable conductor in series. A controller is arranged to intermittent switching of the first controllable conductor in on- and off-states; and a second controllable conductor is coupled in parallel to the primary windings; the controller arranged to switch the second controllable conductor to a conducting on-state when the first controllable conductor is in an on-state to short the resonating current in the primary inductor.

Abstract: Implantable leadless cardiac pacing systems and methods for providing substernal pacing using the leadless cardiac pacing systems are described. In one embodiment, an implantable leadless cardiac pacing system includes a housing, a first electrode on the housing, a second electrode on the housing, and a pulse generator within the housing and electrically coupled to the first electrode and the second electrode. The housing is implanted substantially within an anterior mediastinum of a patient and the pulse generator is configured to deliver pacing pulses to a heart of the patient via a therapy vector formed between the first and second electrodes.

Abstract: An intraseptal multi-electrode cardiac pacemaker has a plurality of first individual electrodes implanted at an interventricular septum at varying depths and/or lateral distances from the distal end of a flexible conduit and configured to provide a cardiac pacing therapy by stimulating left bundle branch conduction fibers. A plurality of second individual electrodes may also be implanted in the septum at suitable depths to stimulate conduction fibers of the right bundle branch. After implantation, first and second individual electrodes are interrogated to select a subset of electrodes suitable to deliver the pacing therapy according to a predetermined criterion such as capturing the left ventricle or capturing the right ventricle via normal conduction system of the heart at the lowest voltage level via corresponding bundle branches. A combination of the pacemaker with a cardioverter/defibrillator is provided by positioning a defibrillator coil near the distal end of the flexible conduit of the pacemaker.

Abstract: The present invention relates to an apparatus and a method for neuromuscular stimulation which is useful for stimulation of weak muscles in general, in sports clinical mode for muscle growth and endurance and in clinical mode for muscular rehabilitation. EMG signals are received from the subject adjacent a muscle whose contraction is to be stimulated. A succession of stimulation (STIM) pulses are supplied to the muscle to be stimulated. The EMG-receiving module is operated during quiescent periods between successive pulses, and the amplitude of stimulation pulses supplied to the subject in the succession is modulated proportionately depending on the a detected voluntary component of the received EMG signals. Modulation is in real time during supply of stimulation pulses whereby the subject is given a sensation of natural muscle control and/or the possibility for greater precision of neuromuscular control.

Abstract: A non-invasive method and device for promoting a localized change in a flow of blood through a blood vessel in a limb segment of a body by a series of electrically stimulated contractions of muscle tissue in the limb segment, the method including the steps of: (a) providing a device including: (i) first, second and third electrodes, each adapted to operatively contact the limb segment; (ii) a signal generator, operatively connected to the electrodes, adapted to produce a series of electrical impulses to the limb segment via the electrodes, and (iii) a control unit adapted to control the signal generator to produce the series of electrical impulses; (b) positioning the electrodes on the limb segment, wherein the first electrode is positioned on a lower end of the lower leg, the second electrode is positioned on the lower leg, and the third electrode is positioned on an upper end of the lower leg, whereby the first and third electrodes are disposed on opposite ends of the lower leg, and the second electrode and

Abstract: The present disclosure provides a neuromodulation method for treating the syndromes of a low urinary tract dysfunction. The neuromodulation method comprises attaching a first active electrode to a first patient's leg in the back of the knee area in proximity of a peroneal nerve of the first leg. Attaching a second active electrode to a second patient's leg in the back of the knee area in proximity of a peroneal nerve of the second leg. Attaching a grounding electrode to the patient's body. Generating electrical pulses by a pulse generator connected to the first, the second active electrode and a grounding electrode. Stimulating by the first and the second active electrodes the peroneal nerve of the first and the second leg and controlling via control unit a flow of the generated pulses to each of the first and second active electrode.

Abstract: A method for operating an external component of a cochlear implant hearing system. The external component includes a speech processor module operable in a stand-alone mode of operation and a body-worn mode of operation, and a protective case. The method includes operating the speech processor module in the stand-alone mode, determining when the speech processor module is mounted in the case, and operating the speech processor module in the body-worn mode in response to determining that the speech processor module is mounted in the case.

Abstract: The present disclosure provides improved leadless pacemakers. In one embodiment, the leadless pacemaker includes an implantable pulse generator releasably coupled to a collapsible anchoring device. The collapsible anchoring device includes at least one pacing electrode configured to contact tissue at a target site.

Abstract: An ambulatory medical device is provided. The ambulatory medical device includes at least one sensor configured to acquire physiological data of a patient, at least one network interface and at least one processor coupled to the at least one sensor and the at least one network interface. The at least one processor is configured to detect, via the at least one network interface, a medical device, to establish a secure communication session with the medical device via the at least one network interface, to detect a data capacity of the secure communication session, to identify a category of patient data associated with the data capacity, and to transmit patient data of the category to the medical device via the secure communication session.

Abstract: The invention provides a device for stimulating peripheral nerves, comprising a memory, at least one electrode attached to the patient's body for generating pulses, and a control unit connected with an electrode for setting at least one electrode pulse parameter. The device further includes a detector of response to neuromodulation connected with a control unit for transmitting information on a frequency of movement of at least a part of the body to the control unit, and a controller connected with the control unit for acquiring a user input. The control unit of the device further sets flow of current of electrode pulses automatically, depending on information on a frequency value of movement of a part of the body. The invention further provides a method for treating the syndromes of an overactive bladder using a neuromodulation device. And method of collecting information of such devices.

Abstract: Systems, methods, and computer software for detecting atrial fibrillation are described. Photoplethysmographic (PPG) signal data may be received as communicated by a PPG sensor of a wearable device worn by a user. Heartbeats from a portion of the PPG signal data may be determined and a heart rhythm type may be determined based on at least the heartbeats. A determination of whether the heart rhythm type includes Atrial Fibrillation (AF) may be made, and, when AF is detected, an AF detection alert may be displayed at the wearable device.

Abstract: Semiconductor electroacupuncture needles are disclosed, as well methods of making and using the semiconductor electroacupuncture needles. A controller for controlling the characteristics of the voltage applied to the needles and/or the current flowing through the needles is described. In some embodiments, a portion of the electro acupuncture needle is insulated to control the position below the skin at which the current enters the patient. In some embodiments, an LED on the needle lights when current above a threshold value is passing through the needle and into the patient.

Abstract: A disclosed apparatus or method can include or use a non-transluminally implantable blood pump housing, which can be sized and shaped to be implanted at an aortic valve of a human subject, the pump housing can include: a pump housing cross-sectional profile size that is larger than is passable via a blood vessel of the human subject; and a power connection, configured for being electrically connected to an intravascular lead that is sized and shaped to extend from the pump housing through a subclavian artery of the human subject.

Abstract: An implantable medical device performs a method that includes detecting a cardiac event interval that is greater than a P-wave oversensing threshold interval. In response to detecting the cardiac event interval greater than the P-wave oversensing threshold interval, the device determines the amplitude of the sensed cardiac signal and withholds restarting a pacing interval in response to the amplitude satisfying P-wave oversensing criteria. A pacing pulse may be generated in response to the pacing interval expiring without sensing an intrinsic cardiac electrical event that is not detected as a P-wave oversensing event.

Abstract: Presented herein are techniques for electrically stimulating a recipient's vestibular nerve in order to mask vestibular noise signals (vestibular noise) generated by the peripheral vestibular system (e.g., prevent erroneous balance information generated by the peripheral vestibular system from being sent to the brain of the recipient). A vestibular nerve stimulator in accordance with embodiments presented herein includes a plurality of electrodes implanted in an inner ear of a recipient at a location that is adjacent to the otolith organs of the inner ear. The vestibular nerve stimulator is configured to generate one or more continuous pulse trains and to deliver the one or more continuous pulse trains to the inferior branch of the recipient's vestibular nerve.

Abstract: A device for providing cardiac pacing of triangle of Koch and bundle of His zones by multiple electrodes inserted using in a single conduit is disclosed. The single conduit includes a plurality of individual electrodes capable of expanding from the distal end and forming a scattered pattern once deployed in the heart. Individual or group testing against a predetermined acceptance criterion is used to select a subset of individual electrodes for use in cardiac pacing.