Patents Examined by Mary C. Lee
  • Process for the preparation of a block oligocarbonate
    Patent number: 5294729
    Abstract: A process for preparing a block oligocarbonate is disclosed. The oligocarbonate conforms to ##STR1## where R denotes hydrogen or ##STR2## and where A denotes an aromatic carbonate structure conforming to ##STR3## where Ar is an aromatic radical, n is 2-6 and where B is the residue of an aliphatic polyol is disclosed. In the process a high molecular weight aromatic polycarbonate is reacted, in the melt and in the presence of a catalyst, with an aliphatic polyol. The block oligocarbonate is useful as a reactant in a process for the preparation of copolymers.
    Type: Grant
    Filed: July 27, 1993
    Date of Patent: March 15, 1994
    Assignee: Miles Inc.
    Inventors: Douglas A. Wicks, Dittmar K. Nerger, Rick L. Archey, Gary W. Munko
  • Myoinositol derivatives and preparation process thereof
    Patent number: 5292913
    Abstract: Disclosed herein are phosphoric acid esters of myoinositol, which are represented by the following general formula (I): ##STR1## and their salts, as well as a preparation process thereof. The myoinositol derivatives can each be obtained by causing a phosphorylating agent to act on a myoinositol derivative substituted with catalytic reduction removable substituent groups at the positions other than those desired to be substituted by phosphoric acid residual groups and then catalytically reducing the thus-phosphorylated myoinositol.
    Type: Grant
    Filed: September 24, 1992
    Date of Patent: March 8, 1994
    Assignee: Mitsui Toatsu Chemicals, Incorporated
    Inventors: Shoichiro Ozaki, Yutaka Watanabe, Akira Awaya, Yusaku Ishizuka
  • Method of synthesizing sulfurized oligonucleotide analogs
    Patent number: 5292875
    Abstract: A method for synthesizing sulfurized oligonucleotide analogs, such as phosphorothioate and phosphorodithioate analogs, is provided that employs a thiophosphorus compound, such as a thiophosphoric, dithiophosphoric, thiophosphinic, or dithiophosphinic acid disulfide or polysulfide, as a sulfurizing agent. The method of the invention may be used to sulfurize any phosphorous(III)containing intermediate. Preferably, the method is practiced on a commercial DNA synthesizer using phosophoramidite and/or phosphorthioamidite intermediates.
    Type: Grant
    Filed: August 27, 1993
    Date of Patent: March 8, 1994
    Assignee: Lynx Therapeutics, Inc.
    Inventors: Wojciech J. Stec, Bogdan Uznanski, B. John Bergot, Bernard L. Hirschbein, Karen L. Fearson
  • N,N'-bis(sulfonamido)-2-amino-4-iminonaphthalen-1-ones and N,N'-bis(amido)-2-amino-4-iminonaphthalen-1-ones
    Patent number: 5292737
    Abstract: N,N'-Bis(sulfonamido)-2-amino-4-iminonaphthalen-1-ones and N,N'-Bis(amido)-2-amino-4-iminonaphthalen-1-ones are disclosed. Methods of inhibiting protein kinase C activity which comprises contacting protein kinase C with an effective amount of an N,N'-Bis(sulfonamido)-2-amino-4-iminonaphthalen-1-one or an N,N'-Bis(amido)-2-amino-4-iminonaphthalen-1-one are disclosed. Methods of treating an animal that is suspected of suffering from inflammatory, cardiovascular and/or neoplastic diseases which comprises administering an effective amount of an N,N'-Bis(sulfonamido)-2-amino-4-iminonaphthalen-1-one or an N,N'-Bis(amido)-2-amino-4-iminonaphthalen-1-one are disclosed.
    Type: Grant
    Filed: October 23, 1992
    Date of Patent: March 8, 1994
    Assignee: Sphinx Pharmaceuticals Corporation
    Inventor: Jean M. Defauw
  • 1,3,4-oxadiazoles containing the pentafluorothio (SF.sub.5) group
    Patent number: 5292951
    Abstract: 1,3,4-Oxadiazoles of the formula ##STR1## are prepared by cyclization (dehydration) of the corresponding diacylhydines of the formula R.sub.1 C(O)NHNHC(O)R.sub.2 with phosphorous pentachloride or phosphorous oxychloride wherein R.sub.1 is --CF.sub.2 CF.sub.2 CF.sub.2 SF.sub.5, --CF.sub.2 CF.sub.2 SF.sub.5, or --CH.sub.2 SF.sub.5 and R.sub.2 is --CH.sub.2 CH.sub.2 C(NO.sub.2).sub.3, --CH.sub.2 CH.sub.2 C(NO.sub.2).sub.2 F, --CF.sub.2 CF.sub.2 CF.sub.3, --CF.sub.2 CF.sub.3, --CF.sub.3, or --CH.sub.2 SF.sub.5.
    Type: Grant
    Filed: September 10, 1993
    Date of Patent: March 8, 1994
    Assignee: The United States of America as represented by the Secretary of the Navy
    Inventor: Michael E. Sitzmann
  • Method of producing carbonic acid diester
    Patent number: 5292916
    Abstract: A carbonic acid diester is stably and safely produced at a high selectivity and at a high yield by catalytically reacting carbon monoxide with a nitrous acid ester in a gas phase in the presence of a solid catalyst comprising a catalytic solid material carried on a solid carrier and comprising:(a) a platinum group metal and/or a compound thereof,(b) a compound of Fe, Cu, Bi, Co, Ni and/or Sn, and(c) a vanadium compound, molybdenum compound, tungsten compound, sulfuric acid and/or phosphoric acid.
    Type: Grant
    Filed: May 22, 1992
    Date of Patent: March 8, 1994
    Assignee: Ube Industries, Ltd.
    Inventors: Tokuo Matsuzaki, Tuneo Shimamura, Satoru Fujitsu, Yoshinobu Toriyahara
  • Monoazo dispersed dyes, mixtures containing them, and the preparation and the use thereof
    Patent number: 5292872
    Abstract: A Monoazo dye of the general formula I ##STR1## in which X is methyl, chlorine or bromineR.sup.1 is ethyl, n-propyl, i-propyl, n-butyl or i-butylR.sup.2 is methyl, ethyl, n-propyl, i-propyl, n-butyl or i-butyl andn is 2 or 3,mixtures containing dyes of the general formula I and the preparation of these dyes and their mixtures and their use for the dyeing of hydrophobic synthetic materials, in particular for automotive cover fabrics.
    Type: Grant
    Filed: November 24, 1992
    Date of Patent: March 8, 1994
    Assignee: Hoechst Mitsubishi Kasei Co.
    Inventor: Ulrich Buhler
  • Process for purifying dimethyl carbonate
    Patent number: 5292917
    Abstract: Disclosed a process for purifying dimethyl carbonate which comprises distillating a mixture of dimethyl carbonate and methanol in the presence of dimethyl oxalate to separate and remove methanol.
    Type: Grant
    Filed: May 5, 1993
    Date of Patent: March 8, 1994
    Assignee: Ube Industries, Ltd.
    Inventors: Keigo Nishihira, Shinichi Yoshida, Shuji Tanaka
  • Compound, use and preparation
    Patent number: 5290810
    Abstract: A compound of the formula ##STR1## in which R.sup.1 and R.sup.2 taken together represent a polymethylene chain having 3 or 4 carbon atoms, or a polymethylene chain having 3 or 4 carbon atoms substituted by at least one lower alkyl radical having 1 to 4 carbon atoms, R.sup.3 is hydrogen, hydrocarbyl or substituted hydrocarbyl and X represents cyano, a group --SO.sub.3 M or a group --S--R.sup.4 where M is hydrogen or an alkali metal such as sodium and R.sup.4 is hydrocarbyl or substituted hydrocarbyl. Typically R.sup.1 and R.sup.2 complete a cyclopentene ring, R.sup.3 is alkyl such as methyl and X is a group --SO.sub.3 Na. The compounds have microbiological activity.
    Type: Grant
    Filed: September 24, 1991
    Date of Patent: March 1, 1994
    Assignee: Imperial Chemical Industries PLC
    Inventor: Peter W. Austin
  • Benzimidazoles for the treatment of atherosclerosis
    Patent number: 5290801
    Abstract: This invention relates to imidazoles, namely, fused-ring heterocycles as inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT), pharmaceutical compositions containing them, processes for their preparation, and their use as antihypercholesterolemic and/or antiatherosclerotic agents for the treatment of atherosclerosis.
    Type: Grant
    Filed: May 29, 1992
    Date of Patent: March 1, 1994
    Assignee: The Du Pont Merck Pharmaceutical Company
    Inventors: C. Anne Higley, Thomas P. Muduskuie, Jr., Ruth R. Wexler, Richard G. Wilde
  • Intermediates and colorants having primary hydroxyl enriched poly (oxyalkylene) moieties and their preparation
    Patent number: 5290921
    Abstract: The present invention provides primary hydroxyl enhanced colorants having markedly improved reactivities in e.g., polyurethane foams for imparting permanent coloring thereto, the colorants having the formulaC--(Z).sub.1-4are provided wherein C is an azo, methine, or azamethine chromogen and Z is a poly(oxyalkylene) moiety comprised of (1) at least two (A) units independently selected from those of the formulae--CH.sub.2 CH(O--T)CH.sub.2 O-- or --CH.sub.2 CH(O--T)CH.sub.2 O--Tand (2) from none to about 200 (B) units of the formula (--RO--) wherein R is straight or branched chain hydrocarbon of 2-4 carbons, T is a moiety of the formula--CH.sub.2 CH(R.sub.1)--O--(RO).sub.0-40 --CH.sub.2 CH.sub.2 OHwherein R.sub.1 is selected from unsubstituted or substituted alkyl, aryl, alkenyloxyalkyl, alkoxyalkyl or aryloxyalkyl, and wherein the A units comprise at least 0.5 percent of the total A+B units.
    Type: Grant
    Filed: January 8, 1990
    Date of Patent: March 1, 1994
    Assignee: Milliken Research Corporation
    Inventors: David J. Moody, Edward W. Kluger, John W. Rekers
  • Process for preparing bisimide products
    Patent number: 5290945
    Abstract: This invention relates to a process for preparing a white bisimide product which principally contains N,N'-alkylene-bis(tetrabromophthalimide) or N,N'-bis(tetrabromophthalimide). The process features: providing, in a reaction vessel, a solution containing tetrabromophthalic anhydride and a solvent which contains at least about 15 weight percent of a mono-, di- or tri- carboxylic acid having a dissociation constant not higher than 1.0.times.10.sup.-3 at 25.degree. C.; forming a reaction mass by adding to the solution a diamine or a diamine salt formed by the partial or total diamine neutralization of a mono-, di- or tri- carboxylic acid having a dissociation constant not higher than 1.0.times.10.sup.-3 at 25.degree. C.
    Type: Grant
    Filed: August 11, 1992
    Date of Patent: March 1, 1994
    Assignee: Ethyl Corporation
    Inventors: Ranjit K. Roy, Ali M. Dadgar, Donald O. Hutchinson, Keith G. Anderson
  • Monoazo reactive dye which contains a dicyanoaminotriazinyl group and a group of the vinylsulfone series
    Patent number: 5290923
    Abstract: Monoazo compounds which possess fiber-reactive groups and have useful dye properties and are capable of dyeing hydroxyl- and/or carboxamido-containing materials, in particular fiber materials, such as cellulose fibers and natural and synthetic polyamide, such as wool, in strong, fast shades. They conform to the formula ##STR1## wherein D, K and Me are as defined in the specification.
    Type: Grant
    Filed: January 21, 1993
    Date of Patent: March 1, 1994
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Hartmut Springer, Rolf Gleissner
  • Disazo compounds containing a cyanoamidotriazinyl radical as a bridging member (middle component) and fiber-reactive groups of the vinylsulfone series, suitable as dyestuffs
    Patent number: 5290922
    Abstract: Disazo compounds which possess fiber-reactive groups and have useful dye properties and are capable of dyeing hydroxyl- and/or carboxamido-containing materials, in particular fiber materials, such as cellulose fibers and natural and synthetic polyamide, such as wool, in strong, fast shades. They conform to the formula ##STR1## wherein the substituents are as defined in the specification.
    Type: Grant
    Filed: December 30, 1992
    Date of Patent: March 1, 1994
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Hartmut Springer, Rolf Gleibner
  • Pentaerythryl phosphonates and their use in self-extinguishing thermoplastic polymeric compositions
    Patent number: 5288869
    Abstract: A new group of pentaerythryl diphosphonates and poly(pentaerythryl diphosphonates) are described. Flame-retardant compositions are also described, which include a thermoplastic polymer and a certain amount of self-extinguishing agent consisting of one of the above-mentioned pentaerythryl diphosphonates or poly(pentaerythryl diphosphonates).
    Type: Grant
    Filed: August 6, 1992
    Date of Patent: February 22, 1994
    Assignee: Enichem Synthesis S.p.A.
    Inventors: William Giroldini, Gianluigi Landoni, Antonio Rinaldi, Carlo Neri
  • Diazo dyes containing a hydroxy alkoxybenzene middle component and a pyrazole coupling component
    Patent number: 5288858
    Abstract: The invention relates to azo dyes of the formula ##STR1## in which R, R.sub.1 and R.sub.2, independently of one another, are hydrogen, substituted or unsubstituted C.sub.1 -C.sub.8 alkyl or phenyl, R.sub.3 is hydrogen or substituted or unsubstituted C.sub.1 -C.sub.8 alkyl, C.sub.5 -C.sub.7 cycloalkyl or phenyl and the benzene rings I and II may be further substituted.The azo dyes are suitable for the dyeing or printing of natural or synthetic polyamide fibre materials, in particular in combination with other dyes and in particular from short liquors. The azo dyes are distinguished by generally good properties, in particular good affinity.
    Type: Grant
    Filed: July 14, 1992
    Date of Patent: February 22, 1994
    Assignee: Ciba-Geigy Corporation
    Inventor: Jurgen Schaetzer
  • Nitrogen-containing bicyclic compounds and pharmaceutical compositions thereof
    Patent number: 5286732
    Abstract: The invention relates to the compounds of formula (I): ##STR1## in which: A represents, with the nitrogen and carbon atoms to which it is bound, a heterocycle,B represents, with the nitrogen atom to which it is bound, a heterocycle,R.sub.1 represents alkoxy, benzyloxy, phenoxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkenyl or substituted or unsubstituted cycloalkyl,their enantiomers, diastereoisomers and epimers as well as their addition salts with a pharmaceutically acceptable acid, medicinal products containing the same.
    Type: Grant
    Filed: September 25, 1992
    Date of Patent: February 15, 1994
    Assignee: Adir et Compagnie
    Inventors: Michel Vincent, Georges Remond, Bernard Portevin, Yolande Herve, Jean Lepagnol, Guillaume de Nanteuil
  • Pyrrole thiocarboxamide insecticidal and acaricidal agents
    Patent number: 5286742
    Abstract: There are provided pyrrole thiocarboxamide compounds which are useful for the control of insects and acarina. Further provided are compositions and methods comprising those compounds for the protection of plants from attack by insects and acarina.
    Type: Grant
    Filed: November 3, 1992
    Date of Patent: February 15, 1994
    Assignee: American Cyanamid Company
    Inventors: Kevin E. Henegar, Roger W. Addor
  • Carbamoyl derivatives
    Patent number: 5286740
    Abstract: The present invention concerns novel carbamoyl derivatives of formula I, set out herein, which antagonize the pharmacological actions of one or more of the arachidonic acid metabolites known as leukotrienes, making them useful whenever such antagonism is desired, such as in the treatment of those diseases in which leukotrienes are implicated, for example, in the treatment of allergic or inflammatory diseases, or of endotoxic or traumatic shock conditions. The invention also provides pharmaceutical compositions containing the novel derivatives for use in such treatments, methods for their use and processes and intermediates for the manufacture of the novel derivatives.
    Type: Grant
    Filed: August 10, 1992
    Date of Patent: February 15, 1994
    Assignee: Imperial Chemical Industries PLC
    Inventor: Robert T. Jacobs
  • 1,4-dihydropyridine derivatives
    Patent number: 5286869
    Abstract: 1,4-Dihydropyridine derivatives of formula: ##STR1## wherein Ar.sup.1 represents an aromatic hydrocarbon group or an aromatic heteromonocyclic or heterobicyclic group containing therein 1 to 3 atoms selected from the group consisting of oxygen, sulfur and nitrogen; R.sup.1 represents a hydrocarbon group which may have one or more substituents; A represents (i) a straight chain or branched chain unsaturated hydrocarbon group, (ii) a cyclic unsaturated hydrocarbon group, or (iii) a group selected from the group consisting of --R--O--N.dbd.CH--, --R--N.dbd.N--, --R--CH.dbd.N-- and --R--N.dbd.CH--, in which R is an alkylene group having 1 to 6 carbon atoms; B represents an alkylene or alkenylene group having 1 to 3 carbon atoms, which may have a substituent; Ar.sup.2 represents an aromatic hydrocarbon group or a heterocyclic group; Ar.sup.
    Type: Grant
    Filed: March 12, 1990
    Date of Patent: February 15, 1994
    Assignee: Fujirebio Kabushiki Kaisha
    Inventors: Hiroshi Ikawa, Akiyoshi Kadoiri, Yasuo Sekine