Abstract: The present invention relates to drive mechanisms suitable for use in drug delivery devices, in particular pen-type injectors, wherein a number of pre-set doses of medicinal product can be administered. In particular, the present invention relates to such drug delivery devices where a user may activate the drug delivery device.

Abstract: An infusion pump comprises an elastomeric hemispheric deformable rolling diaphragm, an external rigid housing with internal area no greater than that of the rolling diaphragm exterior, and a rigid cap structure which sealingly fastens the rim of the rolling diaphragm to the rim of the external housing. Thickness of the flexing wall of the diaphragm is tapered from rim to a region on the central axis to provide approximately constant pressure as the pump empties its contents. The rigid housing has an port in its center opposite its rim to allow insertion of fluid to roll the diaphragm inward, and to allow outflow of the stored pressurized fluid as desired. The housing and/or cap structure may have an external belt mounting fixture to facilitate donning the infusion pump for ambulatory users. The simplified design enables low manufacturing cost and hence single-use disposability.

Abstract: A syringe for use with a medical injector system includes a barrel and a semi-rigid hub, the hub having an outer surface adapted to slidingly move within the barrel, and an inner surface having a continous circumferential wall. The hub further includes an annular engaging portion recessed within at least part of the continous circumferential wall forming a groove, at least one radially extendable and retractable retention member disposed at partially within a proximal cylindrical portion of the hub, and the elastometric seal engaged with a seal engaging portion on the hub and slidingly engaged with the barrel of the syringe. The semi-rigid hub and the elastomeric seal are reciprocally slidable within the barrel, and the at least one radially entendable and retractable retention member is configured to releasably engage the groove upon retraction of the plunger to permit the semi-rigid hub to be selectively withdrawn within the barrel.

Abstract: An introducer catheter for obtaining access to a blood vessel includes a hollow needle with a beveled tip extending from a needle hub as well as a flexible sheath slidingly positioned over the needle. The needle hub includes an actuator configured to rotate the needle tip by about ½ of a turn upon reaching the target vessel. Rotation of the needle tip allows a more confident motion of advancing the sheath further into the vessel to secure the sheath therein. The introducer catheter of the invention is designed to increase success rate of vessel access using minimal number of needle punctures and to decrease the rate of vascular complications, especially in vulnerable patients such as children.

Abstract: The present invention is directed to methods for reducing systemic absorption of therapeutic compounds or agents while enhancing efficiency of delivery and targeting of intranasal administration of such compounds or agents to the central nervous system. More specifically, use of ultrasound technology in conjunction with intranasal delivery of a therapeutic compound, or pharmaceutical composition, wherein the intranasal delivery is preferably to the upper one third of a patient's nasal cavity, thereby reducing therapeutic compound or agent absorption into the blood. At the same time, the present invention results in reducing the delivery of therapeutic compounds and/or agents to the peripheral tissues, increases therapeutic delivery of the compounds and/or agents to the central nervous system generally, and increases targeting of the therapeutics and/or agents to specific target regions within the central nervous system.

Abstract: A medical device is disclosed. The medical device may include an elongate member having a lumen extending at least partially between a proximal end and a distal end of the elongate member. The medical device may also include a plurality of legs coupled to a distal portion of the elongate member, and a distal end piece connected to each of the plurality of legs and located distally to the distal end of the elongate member. The medical device may also include an actuating member coupled to the distal end piece and extending between the plurality of legs and through the lumen. The reciprocal movement of the actuating member may be configured to reversibly move the plurality of legs from a first position to a second position. The medical device may also include a stopping member coupled to the actuating member and configured to limit a movement of the actuating member.

Abstract: A medical device is disclosed which includes a delivery member having at least two lumens extending within. Each lumen may include a rotational element within. Each rotational element may be configured to convert linear motion into rotational motion. The medical device may also include a snare element including a distal snare loop and two proximally extending legs. Each leg of the snare element may be within one of the two lumens. Further, the rotational element in a first lumen may be configured to impart a clock-wise rotation to a first leg of the two proximally extending legs, while the rotational element in a second lumen of the at least two lumens may be configured to impart a counter clock-wise rotation to a second leg of the two proximally extending legs.

Abstract: The present invention provides test or training a cartridge for a drug delivery device as well as a method for resetting of such cartridge, wherein the cartridge comprises: a body of substantially cylindrical shape, a piston slidably disposed in the body in an axial direction, a closure means disposed at an axial end portion of the body, wherein the body, the piston and the closure means confine an interior volume coupled to the exterior via at least one fluid escape channel.

Abstract: A novel design of a polymer retention hub created having an innovative feature used to permanently attach a thin wall nozzle core without use of adhesives or ancillary parts to form a conjunct nozzle. Additional polymer in the correct amount is molded into a polymer retention hub in close proximity to a location where a mechanical lock must be formed to join the two components together. The inventive design of the polymer retention hub is configured to produce an enclosed cavity with the strength required for separation of a nozzle core from a standard taper.

Abstract: An ostomy appliance consisting of an adhesive wafer (1) that permits exposing the skin (2) and Stoma (3) to the air and covering back repeatedly without removing the said adhesive wafer (1) from the said skin (2), comprising an annular adhesive wafer fabric membrane skirt (4) with a void (5), adhesive free interior, equipped with an annular male coupling (6) at the upper inner periphery of the said annular adhesive wafer fabric membrane skirt (4) to which a corresponding annular female coupling (7) fixed on the annular periphery of an annular impermeable barrier membrane (8) that has a central stoma size orifice (9) is coupled together, to which in turn an exact duplicate annular female coupling (10) as the said corresponding annular female coupling (7), equipped with a pouch (11) or other body waste or mucous collecting appliance, attaches together by way of piggyback or superimposition on top of the said corresponding annular female coupling (7).

Abstract: An infusion set includes a base with a rigid piercing cannula or a soft catheter and rigid introducer needle. The infusion set also includes a line set with a fluid connector. The base and line set are configured such that the fluid connector can be used as a protector for the piercing cannula or the soft catheter, either before the device is attached to a user, or after the device is detached from the user, or both.

Abstract: A holder with a safety shield for a drug delivery device; the shield obstructing access to a needle of the drug delivery device following use thereof. The safety shield may be actively deployed, in which case the health care worker must perform an action beyond complete depression of the pusher into the body of the drug delivery device to deploy the shield. Alternatively, the safety shield may be deployed passively or automatically, in which case deployment of the shield occurs upon complete depression of the pusher into the body, with no additional action required of the health care worker. The safety shield is spring-loaded and released to its extended position by a mechanical coupling of a series of position members, including levers, formed on the holder and the drug delivery device.

Abstract: This invention is an air block for industrial, medical, and non-medical uses. For example, the air block is connected to the proximal end of a vascular access catheter. The air block is either removably connected to the proximal end of the catheter or it is integral to the proximal end of the catheter. The air block permits introduction of other catheters or instrumentation through its central lumen and on into a lumen of the catheter while minimizing fluid loss or gain into the catheter. The air block further prevents air from entering the catheter and provides for removal of the air or other gas from the central lumen before it can enter the catheter where it could cause harm to the patient. The air block can be attached to various standard proximal catheter terminations including Luer fittings and hemostasis valve outer barrels.

Abstract: A medical device and a system for medical treatment comprising the medical device are disclosed. The medical device comprises a fluidic conduit and/or is configured to be operatively coupled to a fluidic conduit. The medical device comprises a flow regulator for regulating the flow of a fluid in the fluidic conduit and at least two movable elements, which are passively displaceable as a function of a fluidic pressure change in the fluidic conduit or actively displaceable for regulating the flow of fluid in the fluidic conduit. The medical device further comprises at least one transponder circuit comprising at least one transponder element chosen from a capacitor, an inductor, a resistor, or combinations thereof, being arranged with respect to the movable elements such that the transponder circuit has a capacitance or inductance or resistance or resonant frequency or Q factor, which changes as a function of the displacement of the movable elements.

Abstract: A barrier system is provided for use in reducing infections associated with a percutaneous medical device, such as a catheter, that is disposed within a percutaneous incision. Such a barrier system can include: a barrier device having a skin-contacting surface and a catheter-receiving surface; and an adhesive composition configured for adhering to skin, the barrier device, and/or the catheter so as to form a barrier at or adjacent to an incision in the skin where the catheter is percutaneously inserted through the skin. The barrier device can include a conduit configured to receive the catheter. Alternatively, the barrier device can include a groove in a base surface that is configured to receive the catheter. A system that includes a medical device, the barrier device, and adhesive can also be provided.

Abstract: New nanotechnology and other small-scale devices for performing intravenous medical procedures are provided. In some aspect of the invention, a group of encapsulated injectable machines is delivered intravenously into a bloodstream via a syringe. A treatment area within a patient's body is specified and targeted for action by an external control system, which also monitors blood flow and other environmental. Externally applied magnetic and/or electrostatic signaling and direction devices controlled by the control system then trigger the release of encapsulation layers surrounding the injectable machines upon reaching the treatment area. The externally applied magnetic signaling and direction devices then drive the machines into treatment targets within the treatment area, exploiting an overall charge and polarity of the machines distinct from their condition during encapsulation.

Abstract: An injection device tip includes a body configured to be removably connected to an injection device and a needle having a portion projecting from a proximal end of the body. The body at least one of has flexible portions which can be deflected inwardly to cause release of an engagement between the body and a proximal end of the injection device, has two oppositely arranged flexible portions arranged outside an imaginary circle defined by an outside surface of two opposite portions arranged between the two oppositely arranged flexible portions, is generally oval in shape, is generally rectangular in shape, is generally square in shape, and is non-circular in shape. This Abstract is not intended to define the invention disclosed in the specification, nor intended to limit the scope of the invention in any way.

Abstract: A single-use needle cover configured to obscure, protect, or hide at least a portion of a needle from view before, during, and/or after an injection and/or aspiration procedure is disclosed. In some embodiments, the cover includes a housing at least partially containing the needle and configured to couple to a syringe, wherein the housing includes an axis and a guide member. In some embodiments, a sleeve has a plurality of tracks configured to slidingly receive the guide member, wherein the sleeve is configured to retract, extend, and rotate with respect to the housing. In some embodiments, after the sleeve has been retracted and extended one time, a first locking member inhibits further retraction of the sleeve and a second locking member inhibits rotation of the sleeve.

Abstract: The present invention presents a positioning assembly to guide an invasive device toward a tissue object of a living body under ultrasonographic visualization. The positioning assembly is a part of an apparatus that controllably introduces an invasive device into a tissue object. The positioning assembly of the present invention is configured to improve on ultrasonographic guidance and to reduce chances of contamination of the apparatus.

Abstract: A tool or computer-readable medium for interfacing with an infusion pump includes i) computer-readable code for generating a drug library, generating a run profile, or a combination thereof, and ii) computer-readable code for configuring the infusion pump.