Abstract: Systems, devices, and methods are described for assessing the risk of developmental, cognitive, social, or mental abilities or disabilities in very young patients (e.g., in the first 2-6 months of life). Generally, the decline in visual fixation of a subject over time with respect to certain dynamic stimuli provides a marker of possible abilities or disabilities (such as ASD). The visual fixation of the subject is identified, monitored, and tracked over time through repeated eye tracking sessions, and data relating to the visual fixation is then analyzed to determine a possible increased risk certain conditions in the subject. A change in visual fixation as compared to similar visual fixation data of typically-developing subjects or to a subject's own, prior visual fixation data provides an indication of a developmental, cognitive, or mental ability or disability.

Abstract: Provided is an electronic device to monitor a user's biological measurements, where a sensor is configured to acquire a raw signal from a user, and the electronic device determines a snoring signal from the raw signal by appropriately processing the raw signal.

Abstract: An actively-powered medical system for monitoring a body temperature of a patient includes a temperature data logger patch with wireless data communication includes a sealed, flexible battery comprising a printed electrochemical cell with an anode and a cathode, and a flexible circuit including a microprocessor, a temperature sensor configured to sense a temperature of a target subject, a wireless communication transceiver and an antenna. In one example, the patch is configured to conform to a curved surface of the target subject. In another example, the patch is used in an actively-powered medical system for monitoring a body temperature of a patient, and includes an adhesive configured to be removably applied to skin of the patient. An external computing device is capable of communication with the wireless communication transceiver of the patch via an electromagnetic field.

Abstract: The invention provides methods and kits for detecting, screening, quantifying or localizing the etiology for reduced or impaired cranial nerve function or conduction; localizing a central nervous system lesion; detecting, diagnosing or screening for increased intracranial pressure, pressure or disruption of central nervous system physiology as seen with concussion; or detecting, diagnosing, monitoring progression of or screening for a disease or condition featuring increased intracranial pressure or concussion by tracking eye movement of the subject.

Abstract: A catheter includes a proximal segment and a distal segment. The catheter is configured to permit relative movement between the distal segment and the proximal segment in response to an application of force on the distal segment. The catheter further includes an inductive sensing element configured to measure displacement between the proximal segment and the distal segment.

Abstract: An adhesive patch arrangement for a sensor includes a flexible patch, a sensor-affixing feature located in a sensor mounting region of the component-facing side of the flexible patch, the sensor-affixing feature securing the sensor to the flexible patch, and a device-affixing feature located in a device mounting region of the component-facing side of the flexible patch. The device-affixing feature secures a device to the flexible patch. The sensor mounting and device mounting regions are distinct and separate regions. The arrangement also includes a removable reinforcement liner adhered to, and covering, the device-affixing feature, and shaped to define a cutout area that partially surrounds the sensor-affixing feature. The arrangement also includes a removable backing liner adhered to, and covering, the adhesive skin-facing side of the flexible adhesive patch.

Abstract: Method of operating a non-invasive blood pressure, NIBP, monitor to measure the blood pressure of a subject, the NIBP monitor comprising a cuff, a pressure sensor for measuring the pressure in the cuff and for outputting a pressure signal representing the pressure in the cuff and a physiological parameter sensor, the method comprising obtaining a first measurement of pulse rate or heart rate for the subject during inflation of the cuff, the first measurement being obtained from the pressure signal; obtaining a second measurement of the pulse rate or heart rate for the subject during inflation of the cuff, the second measurement being obtained from the physiological parameter sensor; comparing the first measurement and the second measurement; and estimating the reliability of a blood pressure measurement obtained by the NIBP monitor during inflation of the cuff based on the result of the step of comparing.

Abstract: Compact devices are provided to measure hematocrit of a blood sample. These devices include first and second chambers that receive respective portions of a blood sample via respective filters. The material of the filters prevents passage of red blood cells while permitting passage of blood plasma. One of the filters has one or more holes to permit the passage of whole blood. Thus, when an example device is presented with a sample of blood, one of the chambers contains whole blood and the other contains blood from which the red blood cells have been filtered. Electrodes in each of the chambers can then be used to detect the impedances of the whole blood and the filtered blood, and the detected impedances can be used to determine a hematocrit of the sample of blood.

Abstract: The present disclosure provides methods for identifying non-penetrating brain injury in a subject, as well as methods for classifying a subject that received a hit to the body that transmitted an impulsive force to the brain as either having a non-penetrating brain injury or not, by analyzing one or more components of frequency-following response (FFR) following administration of an acoustic stimulus to the subject. In addition, the present disclosure provides methods for assessing a subject's recovery from a non-penetrating brain injury. Also disclosed herein are processes and systems for automatically generating acoustic stimuli and processing brain response data to identify non-penetrating brain injuries in subjects.

Abstract: The present invention relates to systems and methods for management of brain and body functions and sensory perception. For example, the present invention provides systems and methods of sensory substitution and sensory enhancement (augmentation) as well as motor control enhancement. The present invention also provides systems and methods of treating diseases and conditions, as well as providing enhanced physical and mental health and performance through sensory substitution, sensory enhancement, and related effects.

Abstract: An apparatus for detecting abnormal masses such as breast cancer includes a measurement sensor configured to obtain a voltage at a first area of a first breast of a subject; a reference sensor configured to obtain a voltage at a second area of a second breast of the subject, a position of the first area corresponding to a position of the second area; and a detector, wherein the detector includes a differential amplifier configured to amplify a voltage input from the at least one of the measurement sensor and the reference sensor; an active low pass filter configured to pass a signal frequency of a low frequency band among signals transmitted from the differential amplifier; a driver amplifier configured to amplify a signal passed through the active low pass filter; and an analog-to-digital (AD) converter configured to convert the signal amplified by the driver amplifier into a digital signal.

Abstract: Disclosed are methods to induce dislodgement of target prostatic cells from the prostate organ, collecting said cells, and subsequently examining the cell population. Such methods comprise the administration of an agent that facilitates the dislodgement of the target cells from within the prostate, which then migrate into the urethra. Exemplary agents include 5 alpha-reductase inhibitors. The cells induced to pass into the urethra are then collected non-invasively, such as through urine or semen samples. Such collection is further strategically calculated relative the administration of the agent so as to maximize the sample collection of the target cells of interest.

Abstract: The present invention is generally directed to apparatuses and methods for evaluating the amount of “play” in a joint. In one embodiment, an apparatus is provided that quantifies the rotation of the tibia in response to a known torque. The apparatus is configured to minimize the influence of other joints on the rotation analysis. Other embodiments provide data related to movement of the tibia in other degrees of freedom.

Abstract: A method for assessment and/or monitoring a person's cardiovascular state comprises: using a sound and vibration transducer to acquire a vascular sound signal in order to detect a vascular sound from a cervical, thoracic, abdominal, pelvic, or lower limb region of the person; filtering the vascular sound signal to isolate the vascular sound, said filtering using a filter which attenuates frequencies below a lower cut-off frequency in a range of 100-300 Hz; and analyzing the filtered sound signal in order to determine whether an indication of a dicrotic notch in the vascular sound exceeds a set threshold.

Abstract: A method includes accepting from a medical imaging system a plurality of map points, each map point including a respective coordinate on a surface of a body organ measured by bringing a medical probe into proximity with the surface. An operator input, which specifies a spatial density at which the map points are to be displayed, is accepted. A subset of the map points is selected responsively to the operator input. The surface is visualized at the specified spatial density by displaying the selected subset of the map points.

Abstract: A method for mapping the trajectory of a part of the anatomy of a human or animal body. The method comprises receiving first sensor signals from a sensor attached to part of the anatomy of the human or animal body. The first sensor signals comprise three dimensional position information indicating the location of the sensor; determining from the first sensor signals at least two angles of rotation of the part of the anatomy to which the sensor is attached with respect to a centre of rotation of another part of the body, wherein the angles of rotation are selected from pitch, yaw and roll. Transforming the signals to provide two dimensional coordinate data defined in a two dimensional coordinate space wherein a first dimension in the two dimensional coordinate space represents a first angle of rotation of the part of the anatomy and a second dimension in the two dimensional coordinate space represents a second angle of rotation of the part of the anatomy; and stores the two dimensional coordinate data.

Abstract: Detection of a fall of a user wearing the device. A processor is configured to time sample and to input multiple values over time of: the acceleration vector, the angular velocity and the point-to-point distance. The processor is configured to determine over time the direction of gravity from the acceleration vector. The processor is configured to integrate over time the angular velocity to produce an orientation angle of the protection device relative to the direction of gravity. The processor, responsive to the point-to-point distance and the orientational angle, is configured to determine heights over time of the distance sensor from the ground. The processor is configured to indicate initiation of a potential fall event by a change in downward acceleration measured by the accelerometer or a rapid decrease in the determined heights of the distance sensor from the ground.

Abstract: A hybrid MEMS microfluidic gyroscope is disclosed. The hybrid MEMS microfluidic gyroscope may include a micro-machined base enclosure having a top fluid enclosure, a fluid sensing enclosure and a bottom fluid enclosure. The hybrid MEMS microfluidic gyroscope may include a plurality of cantilevers disposed within the bottom semi-circular portion of the micro-machined base enclosure or a single membrane disposed within the bottom semi-circular portion of the micro-machined base enclosure.

Abstract: A device and method for spectrum analysis in which differences among skin spectra are quantitatively analyzed, and a blood glucose measurement device are provided. The device for spectrum analysis includes an obtainer configured to acquire a plurality of skin spectra; and a processor configured to generate a plot of difference degree of spectra which represents differences among the acquired plurality of skin spectra, and determine whether the plurality of skin spectra are appropriate for blood glucose measurement based on the plot of difference degree of spectra.

Abstract: A method, including pressing a distal end of a medical probe against a wall of a body cavity, and receiving from the probe first measurements of a force exerted by the distal end on the wall. The method also includes receiving from the probe second measurements indicating a displacement of the wall in response to the force. The method further includes estimating a thickness of the wall based on the first and the second measurements.