Abstract: Infusion systems, infusion devices, and related operating methods are provided. An exemplary method of operating an infusion device capable of delivering fluid to a user involves obtaining a sequence of measurements indicative of a condition of the user that is influenced by the fluid and modifying one or more unusable measurements in the sequence using one or more other usable measurements in the sequence to obtain a modified sequence of measurements. The method continues by determining a predicted value for the condition of the user at a time in the future based at least in part on the modified sequence of measurements and operating the infusion device in a manner that is influenced by the predicted value.

Abstract: A desiccation device for operation on a target tissue includes a handle, a shaft extending distally from the handle, and a head. The shaft defines a lumen therethrough, and the head has a loop configuration supported on a distal end of the shaft. The head is hollow and defines a lumen therethrough. The lumen of the head is in fluid communication with the lumen of the shaft. At least a portion of the head is electrically connected to a source of electrosurgical energy. A fluid is circulatable through the lumens of the shaft and the head.

Abstract: A method and device for local delivery of a water-insoluble therapeutic agent to the tissue of a normal or diseased body lumen is disclosed. An expandable structure of a medical disposable device, such as a balloon of a balloon catheter, is coated with a non-durable coating which includes an amphiphilic polymer or copolymer, in embodiments polyethylene glycol, having a substantially water-insoluble therapeutic agent dispersed therein. In some embodiments, the coating may also include iodine. The medical disposable device is inserted into a body lumen, and expanded to contact the non-durable coating against the body lumen and deliver the substantially water-insoluble therapeutic agent to the body lumen tissue.

Abstract: A medical connector includes a body having a distal end, a proximal end, and a sidewall extending between the distal end and the proximal end, a helical thread extending radially outward from a surface of the sidewall and comprising a crest portion, flank portions, and a root portion with the flank portions connecting the crest portion to the root portion, and at least one deformable protrusion extending radially outward from the root portion of the helical thread.

Abstract: This invention relates to a method of identifying an accurate dosage of medicine in a dosage chamber of a syringe including the steps of providing an accurate dosage of a detailed single dosage medicine for insertion into a dosage chamber of a syringe; identifying the accurate dosage of medicine in the dosage chamber by retaining a notifier of the accurate dosage; securing the notifier with the syringe wherein the accurate dosage of medicine in a dosage chamber of a syringe is shown by the details on the notifier when secured with the syringe and allowing usage of the syringe to dispense the accurate dosage.

Abstract: Systems and methods for determining the position of a fluid within a fluid source and infusion line coupled to an infusion flow control device are described herein. An exemplary system and method includes sampling fluid pressure upstream of an infusion pump, and calculating fluid pressure slope profiles. By sampling fluid pressure upstream of an infusion pump at discrete intervals and monitoring fluid pressure slope profiles, conditions of fluid flow, including unintentional fluid flow through an infusion line or a defective check valve in an infusion line, are detected, and fluid flow through an infusion pump is controlled.

Abstract: Systems and methods for intelligently delivering fluid to a targeted tissue are described. The systems and methods may include directing a pump to distribute fluid to a targeted tissue and receiving one or more signals from an intracorporeal sensing system, where the one or more signals correspond to one or more sensed feedback parameters at the targeted tissue. The systems and methods may also include determining whether the one or more sensed feedback parameters are within an acceptable range. If the one or more sensed feedback parameters are not within the acceptable range, the systems and methods may include determining an adjusted velocity for the plunger necessary to adjust the pressure of the fluid in the pump so that the one or more sensed feedback parameters move within the acceptable range and directing the pump to distribute the fluid at the adjusted velocity.

Abstract: A method for forming a catheter tube assembly includes providing a reinforcement structure and disposing a catheter tube over the reinforcement structure. The reinforcement structure includes a first outer wall reinforcement portion, a second outer wall reinforcement portion, and a septum reinforcement portion connecting the first outer wall reinforcement portion to the second outer wall reinforcement portion. The catheter tube includes an outer wall and a septum. The catheter tube is disposed over the reinforcement structure such that the catheter tube septum envelopes the septum reinforcement portion of the reinforcement structure.

Abstract: A medical device control handle or catheter includes deflection assembly and at least one of the following: a disk actuator, a lever actuator and a ring actuator for actuating additional puller wires in manipulation of multiple features of the medical device or catheter independently of each other. The disk actuator has a common rotational axis with but is rotationally independent of the deflection assembly. The lever actuator has a separate rotational axis. The ring is mounted outside of the control handle and rotatable relative to the control handle to actuate another puller wire for manipulating another feature of the catheter. Each of the disk, lever and ring actuators are of a design that allows existing control handles and catheters to be readily modified to include these actuators.

Abstract: Described is a medicament delivery device (1), comprising a piston rod (11), and a container carrier (7) for retaining a medicament container, such as a syringe (8), within the body (2). At least one longitudinal rib (2.2) associated with the piston rod (11) is arranged to engage the carrier (7). At least one of the carrier (7) and the at least one rib (2.2) comprises a resilient material adapted to be deformed by the engagement between the carrier (7) and the at least one rib (2.2).

Abstract: A steerable tube (100), comprising a hollow elongate tubular member (1) having a proximal end (2), distal end (3), a wall surface disposed between said proximal (2) and distal end (4), a bend-resistive zone (6) flanked by a proximal bendable zone (4) that forms a controller and a distal bendable zone (5) that forms an effector that moves responsive to movements of the controller, whereby the wall of the tubular member (1) in the bend-resistive zone (6) comprises a structure that is a plurality of longitudinal slits (7), forming a plurality of longitudinal strips (8, 8?), the wall of the tubular member (1) in the proximal bendable zone (4) and the distal bendable zone (5) comprises a structure that is a plurality of longitudinal wires (9, 9?, 10, 10?), at least one strip (8) is in connection with a wire (9) in the proximal bendable zone (4) and a wire (10) in the distal bendable zone (5), such that translation by said wire (9) in the controller is transmitted via the strip (8) to said wire (10) in the effector

Abstract: The present invention relates to a shield (10) for the distal extremity of an administration device (3) comprising a hub (2) on which said shield (10) is to be removably engaged, said shield (10) having a wall (13) the internal face (14) of which defining an interior cavity (15) for receiving the extremity of the administration device (3), at least a portion (14a) of said internal face (14) being intended to be in contact with said hub (2) when said shield (10) is engaged on the extremity of said administration device (3), whereby said portion (14a) has, distributed over a major portion of said portion (14a), a surface feature (16, 17) that defines the amount of contact between said portion (14a) and said hub (2).

Abstract: A device (2) for continuous infusions has a housing (4) in which an infusion appliance seat (6) is provided for receiving an infusion appliance (18) with at least one container (22) that can be pressed empty by means of a ram (20), which infusion appliance seat (6) extends along a main axis of extent (AA) from a ram-side end (26) to an outlet-side end (28). The continuous infusion device (2) moreover has an actuator (30) for automatically emptying the infusion appliance (18), a drive (32) for moving a ram abutment/actuation element (24) of the actuator (30), and a control arrangement (72) by means of which a speed of advance of the actuator (30) is adjustable. Provision is made here that the main axis of extent (AA) of the infusion appliance seat (6) has a predetermined relief angle (W) in relation to a support plane (E) of the housing (4), and here the outlet-side end (28) is arranged above the ram-side end (26) of the infusion appliance seat (6).

Abstract: An insertion tool for inserting a catheter into a body of a patient is disclosed. The insertion tool unifies needle insertion, guidewire advancement, and catheter insertion in a single device. In one embodiment, the insertion tool comprises a housing in which at least a portion of the catheter is initially disposed, a hollow needle distally extending from the housing with at least a portion of the catheter pre-disposed over the needle, and a guidewire pre-disposed within the needle. A guidewire advancement assembly is also included for selectively advancing the guidewire distally past a distal end of the needle in preparation for distal advancement of the catheter. In one embodiment a catheter advancement assembly is also included for selectively advancing the catheter into the patient. Each advancement assembly can include a slide or other actuator that enables a user to selectively advance the desired component.

Abstract: Limiting joint temperature. At least some of the example embodiments are systems including an electrosurgical probe and a high frequency power supply. The electrosurgical probe may include: a shaft with a distal end, a proximal end, and lumen defined within the shaft; an active electrode disposed near the distal end; a return electrode disposed on the shaft; and a temperature sensor disposed on the shaft spaced away from the active electrode and the return electrode, the temperature sensor is electrically insulated from the electrically conductive fluid. The high frequency power supply may be coupled to the active electrode, and configured to provide an electrical energy output between the active electrode and the return electrode.

Abstract: A disposable injector comprising a housing, a spring-loaded piston-actuating plunger arranged in the housing and able to be released by a trigger unit. A cylinder-piston unit comprising a cylinder and a piston that is positioned at a distance from the piston-actuating plunger. A closed layer made on an elastically-deformable material surrounds the piston-actuating plunger in at least some sections and projects beyond same in the trigger direction, resulting in a disposable injector that will not alarm a patient during use thereof.

Abstract: An apparatus for injectate delivery includes a cartridge, a linear actuator, a rotary motor mechanically coupled the actuator, and a controller coupled to the motor. The controller controls a linear motion of the actuator by controlling an electrical input supplied to the motor in a first interval during which the motor is stationary with the linear actuator engaged with the cartridge to displace an injectate in the cartridge, a second interval following the first interval during which the controller accelerates the motor from stationary to a first speed selected to create a jet of the injectate from the cartridge with a velocity sufficient to pierce human tissue to a subcutaneous depth, a third interval during which the controller maintains the motor at or above the first speed, and a fourth interval during which the controller decelerates the motor to a second speed to deliver the injectate at the subcutaneous depth.

Abstract: The invention provides methods and systems for introducing a catheter into a blood vessel. A catheter set comprising a pre-loaded stylet in a catheter is connectable to a guidewire. The guidewire may be introduced into the patient through a hollow needle. The stylet can then be connected to the guidewire, and the catheter advanced over the stylet and the guidewire into the access site and into position in the blood vessel of the patient. The invention reduces the time and placement steps required to position a catheter in a vessel and lowers the associated procedural costs. The invention reduces the frequency and severity of complications generally associated with introducing a catheter, thereby improving patient outcomes and lowering healthcare costs.

Abstract: The present invention provides a next-generation pre-filled syringe having a reduced number of components and requiring reduced costs and including a safety mechanism for preventing needlestick injuries. In the syringe of the present invention, elastic engagement members 11 of the cover 6 engage the injection needle 5 so as to prevent the injection needle 5 from being withdrawn from the elastic engagement members 11 of the cover in a retracted state toward the base end, and the elastic engagement members and injection needle are disengaged from each other as the elastic engagement members 11 are diametrically expanded/deformed. Further, the plunger 4 includes an integrated deformation-prevention part 41 covering the outer peripheries of the plurality of elastic engagement members 11 so as to prevent the elastic engagement members 11 and the injection needle 5 from being disengaged from each other as the elastic engagement members 11 are diametrically expanded/deformed.

Abstract: An apparatus and method for anesthetizing various portions of a patient's nasal sinuses. For example, a kit can be provided that includes a first agent configured to modulate a rate of absorption of a subsequently-applied topical agent by one or more nasal structures. The kit also includes a first applicator configured to apply the first agent to a first portion of the one or more nasal structures. The kit also includes a second agent configured to anesthetize the first portion of the one or more nasal structures subsequent to application of the first agent and a second applicator configured to apply the second agent to the second portion of the one or more nasal structures.