Abstract: A pen-type drug injection device is disclosed which comprises a housing having a longitudinal axis, a threaded piston rod, a guide member for guiding the piston rod in a drug dispense operation, and a cartridge holder for receiving a cartridge, wherein the cartridge holder is detachable from the housing and wherein the guide member comprises an iris type aperture defined by a plurality of threaded pivotable segments. The drug delivery device is configured such that the aperture increases in diameter when the cartridge holder is being detached from the housing, such that the piston rod is free of the threaded engagement with the guide member and can be reset or pushed back to its initial position, and decreases in diameter when the cartridge holder is attached, such that the threads on segments reengage the piston rod.

Abstract: Retention devices and methods are provided for drug delivery. The device may include a housing configured for intraluminal deployment into a human or animal subject and at least one reservoir contained within the housing. The at least one reservoir may have an actuation end and a release end and contain at least one drug formulation. A plug may be contained within the at least one reservoir and be moveable from the actuation end toward the release end. The device may also include an actuation system operably connected to the actuation end of the at least one reservoir and configured to drive the at least one drug formulation from the reservoir. The device may also include at least one retention member affixed to the housing and movable between a non-stressed position, a deployment position, and a retention position for retaining the device in an intraluminal location in the subject.

Abstract: A multi-dose disposable fluid delivery system includes at least one fluid container, a multi-use fluid path set, and a plurality of single-use fluid path sets. The at least one fluid container has a connection port configured for fluidly connecting with a first end of the multi-use fluid path set. The second end of the multi-fluid path set is configured for fluidly connecting to a fluid injection apparatus. The plurality of single-use fluid path sets is connected in sequence to define a fluid path extending from a first single-use fluid path set to a last single- use fluid path set. Each of the plurality single-use fluid path sets has a first end and a second end. The first end of the first single-use fluid path set is configured for connecting to a delivery line. The second end of the last single-use fluid path set is configured for connecting to the injection apparatus.

Abstract: According to embodiments of the present invention, a subcutaneous implant delivery apparatus is provided. The apparatus includes a receiving portion configured to receive a subcutaneous implantable device; and a stabilizing portion configured to cooperate with the receiving portion to hold the subcutaneous implantable device in a fixed position. The receiving portion and the stabilizing portion are movable relative to each other between a released configuration, wherein the receiving portion and the stabilizing portion are configured to move apart from each other to allow the receiving portion to be inserted under a skin layer, and a closed configuration, wherein the receiving portion and the stabilizing portion are configured to move toward each other to allow the subcutaneous implantable device to be held adjacent to the skin layer. According to further embodiments of the present invention, a method of delivering a subcutaneous implantable device for accessing a vascular site is also provided.

Abstract: An injection device for injecting medicament in a patient includes a syringe coupled to a housing and radially retained by a retaining rib. A needle guard is slideably coupled to the housing and spring biased in a distal direction by a return spring. A ram is slideably coupled to the housing and spring biased in the distal direction by a main spring. An initial position is defined by a retaining arm being disposed in the longitudinal path of the ram preventing firing. A released position is defined by the retaining arm being clear from the longitudinal path of the ram allowing the ram to extend distally. A locked position is defined by the retaining arm being disposed in the longitudinal path of the ram and a lock arm of the ram being disposed in the longitudinal path of the needle guard preventing the needle guard from being retracted.

Abstract: The invention relates to a safety device for avoiding stabbing injuries, for a syringe having a syringe body and a piercing means arranged on the distal end of said syringe body. The safety device comprises a sleeve element that extends in an axial direction (X) and encloses at least partly the piercing means and the syringe body, and a collar element that is arranged on a distal end region of the syringe body and locks the safety device in the axial direction (X), said collar element having at least one guide projection which is guided in at least one guide track of the sleeve element during a movement of the syringe body relative to the sleeve element substantially in the axial direction.

Abstract: The invention relates to a safety device for a syringe for avoiding stab wounds, said syringe having a syringe body and a piercing means arranged on the distal end of the syringe body. The safety device comprises a sleeve element that extends along an axial direction (X) and at least partially encloses the piercing means and the syringe body, and an inner element which is at least arranged at least in sections inside the sleeve element and surrounds the piercing means. Said safety device is characterised in that the inner element comprises a rim section and a piercing means protection section surrounding the piercing means. Said rim section can be arranged on a distal end of the syringe body, the safety device is secured to the syringe body, and the piercing means protection section can be removed from the rim section before using the syringe.

Abstract: A deflectable medical device (1) includes a shape memory alloy wire (15) integrated into a flexible elongated body (11). The shape memory alloy wire (15) is arranged to shorten upon receiving energy from an energy supply (2,4), thereby deflecting the medical device (1). A rod (18) positioned in a lumen (14) of the flexible elongated body (11) and compressed between a fixture (16) in the proximal end (12) of the elongated body (11) and the distal end (13) of the elongated body (11) is responsible for the shape memory alloy wire (15) recovering its initial length upon discontinuation of energy supply.

Abstract: A sterile filtered luer slip iv set for serum bottle high volume infusion for veterinary use, having a luer fitting assembly that has an air inlet connective tube connected to an air valve assembly, which has a filter. The luer fitting assembly fits into a mouth of a bottle and connects to a connector assembly for veterinary use infusions. The luer fitting assembly has a tubing connector sidewall, and a base sidewall having an air inlet face, which has an air inlet. The luer fitting assembly further has a flange and an insert sidewall. The air inlet connective tube extends from the interior base wall to the insert edge and aligns with the air inlet to allow air to enter via the air inlet through the air inlet connective tube and the filter, reaching an interior of the bottle.

Abstract: Systems and methods for systems and methods for focal cooling of the brain and spinal cord are disclosed. Some embodiments may be directed to a neuroprotection system that includes a cerebrospinal fluid processing platform. Embodiments may provide rapid and selective spinal cord hypothermia and drainage. Embodiments may be tailored to selective spinal cord cooling, pressure monitoring and automated drainage. Embodiments may enable local hypothermic neuroprotection, limit the stress of systemic cooling, minimize secondary neuronal damage and achieve maximal neuroprotection while at the same time improving workflow as a result of automated drainage. Embodiments may include a multi-lumen catheter, a drainage collection reservoir bag, a pump to circulate coolant, sensor hardware and controllers to modulate the flow of a heat transfer fluid for cooling to modulate therapeutic hypothermia and re-warming. Certain embodiments may include extracorporeal cooling of cerebrospinal fluid (CSF).

Abstract: The present disclosure includes an expandable medical device and outer sheath combination. The outer sheath is capable of being split to form multiple sheath sections that may be peeled back to expose a portion or all of the expandable medical device. The medical device, as well as the outer sheath, may include one or more therapeutic agents for delivery to a treatment area within a patient.

Abstract: The present disclosure relates to a connector for connecting flow channels, flow regulators and/or reservoirs for directing flow. In some embodiments, the connector is a medical connector for connecting fluid flow controlling elements used in medical applications, particularly in infusion systems, such as tubes, syringes, needles, catheters and fluid reservoirs. The connector reduces the risk of contamination during handling and enhances safety when administering therapeutic solutions into a patient.

Abstract: An intrathecal delivery system for a pharmaceutical includes a reservoir containing a volume of the pharmaceutical agent, and a pump configured to deliver a portion of the pharmaceutical agent contained in the reservoir. A controller is configured to receive biological cycle information pertaining to a biological cycle (e.g., cardiac cycle), and configured, based on the received biological cycle information, to control the pump to deliver the pharmaceutical agent into a patient's intrathecal space as a high-speed bolus at a time corresponding to a time determined based on Processing the biological cycle information. The high-speed bolus may be delivered at a rate of 10-100 ?L per second. The timing of such delivery corresponds to a time within the biological cycle when cerebrospinal fluid flow is optimal for intrathecal delivery of the pharmaceutical agent. Conditions for which treatment is enhanced by the intrathecal delivery system include refractory hypertension, spasticity and chronic pain management.

Abstract: A feeding pouch assembly includes a pouch defining a fluid chamber with an outlet port extending from the pouch. The outlet port is in fluid communication with the fluid chamber. A valve is positioned at the outlet port and is biased to a natural sealing position wherein flow from the fluid chamber to the outlet port is prevented. The valve moves to a non-sealing position, wherein fluid is free to flow from the fluid chamber to the outlet, upon connection of the outlet port to a feeding tube. The valve automatically moves to the sealing position upon disconnection of the feeding tube from the outlet port.

Abstract: A syringe assembly includes a barrel, and a seal cap mounted to the barrel. The seal cap includes a closed distal end portion, an open proximal end portion, a hollow portion including a barrel end storage portion configured to store a barrel end portion, and a puncture needle storage portion extending from the barrel end storage portion, an insertion allowing portion configured to receive a puncture needle tip of a puncture needle guided to the distal end of the puncture needle storage portion, and a projection portion formed on an inner surface of the barrel end storage portion. The projection portion has a top portion, a distal inclined portion, and a proximal inclined portion extending from the top portion toward the open proximal end portion. A non-stick surface for inhibiting sticking to a barrel end portion of the barrel is formed on an inner surface of the projection portion.

Abstract: A medical connector for providing a sterile connection between a multi-use portion and a single-use portion of a fluid delivery system is provided. The medical connector includes a fluid inlet port configured for removable engagement with a connection port of a multi-use disposable set (MUDS) to establish a fluid connection therewith and a waste outlet port configured for removable engagement with a waste inlet port of the MUDS to establish a fluid connection therewith. A patient fluid line is connected, at a first end, to the fluid inlet port and connected, at a second end, to the waste outlet port. Fluid flow through the patient fluid line is unidirectional from the first end to the second end. The patient fluid line is configured for being disconnected from the waste outlet port for delivering fluid to a patient. A multi-fluid delivery system having the medical connector and MUDS is also provided.

Abstract: In some examples, a medical dispensing device includes a housing and a trigger. A first engager of the device is configured to move axially as the trigger pivots. As the first engager moves, it engages a rod. A maximum proximal position of the rod is defined by a stop. A spring presses the first engager into the trigger such that either the trigger or the first engager rests against a stop limiting rotation of the trigger. A second engager moves axially as the trigger pivots. At the actuated position the second engager, defined by a stop, the second engager limits proximal movement of the rod. An assembly transfers movement of the trigger to the second engager after the trigger has pivoted a threshold amount. A member of the assembly distally moves the second engager. Until it is at the actuated position, the second engager enables the rod to proximally move.

Abstract: A syringe member comprising a safety device to prevent pricking injuries; the syringe member comprises a pricking element, and the safety device includes at least one guided pin and a recess which forms a guide slot for guiding the guided pin in a longitudinal direction of the syringe member during movement of the syringe member relative to the safety device; said guide slot includes a first slot region and a second slot region which are separated by a notional separation line extending in a longitudinal direction of the syringe member; the guided pin can be placed in the first slot region in a starting position and can be moved from the first slot region into the second slot region into a final position by having the guided pin cross the separation line when a distal end of the pricking element is located at the level of an exit opening of the safety device.

Abstract: A retractable needle assembly (1) is disclosed comprising a body portion (10); a needle (50) having a forward end (52) and being movable between an operable orientation in which the forward end projects forwardly from the body portion, and a safe orientation in which said forward end (52) is retracted into the body portion (50). The needle assembly further comprises a deflector (70) mounted in the body portion (50), which is moveable between a first position and a second position, wherein the movement of the deflector (70) between its first and second position urges the needle into its safe orientation, the deflector being biased towards the second position; a latching mechanism which holds the deflector in the first position; and an actuator (90), operable to release the latching mechanism.

Abstract: An apparatus for irrigating the vas deferens in connection with a vasectomy reversal is described. The apparatus comprises a fluid delivery device having a first portion that connects to the vas deferens, the fluid delivery device connecting such that a catheter tip inserts into the vas deferens and is held in stable position relative thereto and such that fluid enters the vas deferens through the catheter tip.