Patents Examined by Melissa S Mercier
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Patent number: 11969440Abstract: The present invention relates to a metal (hydr)oxide composite comprising a poorly soluble drug, a method for manufacturing same, and a pharmaceutical composition comprising same.Type: GrantFiled: August 18, 2022Date of Patent: April 30, 2024Assignees: Webiotree Co., Ltd., CNPharm Co., Ltd.Inventors: Ho Jun Kim, Geun Woo Jin, Ki Yeok Kim
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Patent number: 11969508Abstract: A plastic material for extended release of a bio-active agent, the plastic material comprising a structural polymer, at least one bio-active ingredient embedded within the structural polymer as solid islands, a liquid binding material embedded within the structural polymer as granules, and a carrier liquid absorbed within the liquid-absorbent material. The carrier liquid may be sufficiently non-compatible with the structural polymer so that at least a portion of the carrier liquid is released from the liquid-absorbent material through the structural polymer to an outer surface of the plastic material over a period of time, such as a week or more, a month or more, or about three months. The bio-active agent comprised in the at least one bio-active ingredient may be sufficiently soluble in the carrier liquid at room or body temperature so that the carrier liquid released to the outer surface comprises the bio-active agent in solution.Type: GrantFiled: May 2, 2023Date of Patent: April 30, 2024Inventor: Amnon Vardi
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Patent number: 11969526Abstract: A tissue adhesion prevention hydrogel is provided and engineered with essential features for maintaining separation between tissues and organs in any part of the body, thus preventing adhesion formation, are their shear-thinning, viscoelasticity, and rapid self-healing. A method of using the tissue adhesion prevention hydrogel for tissue adhesion prevention is also provided. A method of interposing the tissue adhesion prevention in between tissue layers for tissue adhesion prevention is further provided.Type: GrantFiled: April 2, 2018Date of Patent: April 30, 2024Assignee: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITYInventors: Eric Andrew Appel, Y. Joseph Woo, Lyndsay Stapleton
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Patent number: 11964059Abstract: A method of delivering a health care active having the steps of administering to a mammal in need of a health benefit or a treatment for a health condition a personal health care article and consuming the article. The article contains one or more filaments that contain a backbone material, a health care active and optionally aesthetic agents, extensional aids, plasticizers, and crosslinking agents.Type: GrantFiled: January 5, 2021Date of Patent: April 23, 2024Assignee: The Procter & Gamble CompanyInventors: Trevor John Darcy, Steven Ray Gilbert, Gregory Charles Gordon, Rajeev Chhabra, William Maxwell Allen
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Patent number: 11951206Abstract: The present disclosure provides a cell housing device and a method of manufacturing such a device that has an array of channels to increase the ratio of surface area to volume.Type: GrantFiled: September 29, 2018Date of Patent: April 9, 2024Assignee: Vertex Pharmaceuticals IncorporatedInventors: Christopher Thanos, Danya M. Lavin, Briannan E. Bintz, Divya Bhatnagar, John Mills, Megan Billings
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Patent number: 11944704Abstract: The present invention provides a formulation of Coenzyme Q10 that can be re-dispersed from a stable dry powder to formulation to yield a nanodispersion that can be readily aerosolized for inhalation.Type: GrantFiled: May 3, 2021Date of Patent: April 2, 2024Assignee: UNM Rainforest InnovationsInventors: Jason Thomas McConville, Thiago Cardoso Carvalho, Kristina Schonhoff
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Patent number: 11938228Abstract: A device for delivery of a first therapeutic agent and a second therapeutic agent to a site in epithelial tissue includes a first layer having a first, freeze-dried polymeric matrix having first and second opposed surfaces, formed by a composition including chitosan, a hydration promoter, a particle adhesion inhibitor, and a particle aggregation inhibitor, and a plurality of first particles embedded within the first matrix so as to be directly surrounded by, and in contact with, the first matrix, the first particles containing the first therapeutic agent and having a coating around the first therapeutic agent, the coating including chitosan. The device further includes a second layer, adjacent to the first layer, having a second, freeze-dried polymeric matrix containing the second therapeutic agent, the first layer and/or the second layer is configured to be attached to the site in the epithelial tissue.Type: GrantFiled: January 7, 2019Date of Patent: March 26, 2024Assignee: PRIVO TECHNOLOGIES, INC.Inventors: Manijeh Nazari Goldberg, Brandon LaPorte, Aaron Manzi, Amritpreet Birdi
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Patent number: 11931485Abstract: A biocompatible and bioresorbable implantable device that is intended to be deployed in the middle meningeal artery through intra-arterial catheters and release an anesthetic agent for a prolonged period into the branches of the middle meningeal artery to treat severe headaches including migraine and trigeminal neuralgias. The implantable device may be a mesh with multiple helical loops, fenestrated collapsible hollow shell or spheroid, or folded sheath.Type: GrantFiled: March 9, 2021Date of Patent: March 19, 2024Inventor: Adnan I. Qureshi
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Patent number: 11931369Abstract: Disclosed herein are compositions and methods for delivering compositions to a subject in need of treatment for epilepsy. The disclosed compositions are orally delivered. Further disclosed are kits comprising the disclosed compositions as part of a method of delivering cannabidiol and CBD-containing compositions to subjects in need of treatment for epilepsy.Type: GrantFiled: July 24, 2023Date of Patent: March 19, 2024Assignee: POVIVA CORPInventors: John Docherty, Christopher Andrew Bunka
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Patent number: 11911507Abstract: The present invention provides liposomes comprising a lipid bilayer and a polymer-conjugated lipid, wherein said polymer-conjugated lipid is incorporated into said lipid bilayer. The present invention also provides methods of producing the liposomes as well as a method of delivering a nucleic acid to a subject comprising the step of administering said nucleic acid encapsulated in a mixed liposome, a method for performing diagnostic imaging in a subject, comprising the step of administering a diagnostic agent encapsulated in a mixed liposome, and methods for treating, inhibiting, or suppressing a pathological condition in a subject comprising administering to said subject a mixed liposome.Type: GrantFiled: July 15, 2021Date of Patent: February 27, 2024Assignee: Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.Inventor: Saul Yedgar
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Patent number: 11911512Abstract: In certain embodiments, the present invention is directed to a solid controlled release dosage form comprising: a core comprising a first portion of an opioid analgesic dispersed in a first matrix material; and a shell encasing the core and comprising a second portion of the opioid analgesic dispersed in a second matrix material; wherein the amount of opioid analgesic released from the dosage form is proportional within 20% to elapsed time from 8 to 24 hours, as measured by an in-vitro dissolution in a USP Apparatus 1 (basket) at 100 rpm in 900 ml simulated gastric fluid without enzymes (SGF) at 37 C.Type: GrantFiled: January 13, 2023Date of Patent: February 27, 2024Assignee: Purdue Pharma L.P.Inventor: Haiyong Hugh Huang
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Patent number: 11911494Abstract: Disclosed is a method of treating a fine line or wrinkle in a person's skin, the method comprising topically applying to the fine line or wrinkle a composition comprising an effective amount of Commiphora mukul resin or an extract thereof that includes oleo gum resin, glycerin, water, and hyaluronic acid or a salt form thereof, wherein topical application of the composition to the fine line or wrinkle reduces the appearance of the fine line or wrinkle.Type: GrantFiled: October 13, 2022Date of Patent: February 27, 2024Assignee: MARY KAY INC.Inventors: Tiffany Florence, Michelle Hines, David Gan, Wanli Zhao
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Patent number: 11903992Abstract: The present disclosure provides a composition comprising Lidocaine or salt or hydrate or solvate thereof, L-Carnosine or salt or hydrate or solvate thereof and dexpanthenol or salt or hydrate or solvate thereof. The composition may further comprise one or more other active agents. In an embodiment, the composition is formulated as an oral formulation. The compositions of the present disclosure may find utility in treatment of oral mucositis, ulcers, ulcer mediated pain and the like conditions. Aspects of the present disclosure also relates to method of treating oral, pharyngeal, oropharyngeal and esophageal diseases or conditions using the advantageous compositions of the present disclosure.Type: GrantFiled: February 10, 2022Date of Patent: February 20, 2024Assignee: Cellix Bio Private LimitedInventor: Mahesh Kandula
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Patent number: 11896638Abstract: A topical skin cream is provided. The topical skin cream includes Acalypha indica oil, Rosa damascena Mill oil, at least one emulsion stabilizer, at least one exfoliant, at least one preservative and water. In an embodiment, the topical skin cream may include Acalypha indica oil, Rosa damascena Mill oil, hydroxypropylmethyl cellulose, polyethylene glycol, sucrose, an alpha-hydroxy acid, water, and at least one preservative. The topical skin cream can be used to treat various related problems, including but not limited to treatment of acne, fungal infections, skin allergies, and other skin conditions.Type: GrantFiled: September 1, 2023Date of Patent: February 13, 2024Assignee: KING FAISAL UNIVERSITYInventor: Nazargi Mahabob
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Patent number: 11896738Abstract: An electrically conductive hyaluronic acid-based hydrogel is disclosed that is a crosslinked porous scaffold having a graphene-based material encapsulated or in contact within the porous scaffold. The graphene-based material includes one or more of graphene oxide foam, reduced graphene oxide foam, nanoplatelets, nanoparticles, or fibers. The porous scaffold may be formed over an implanted bioelectronic device such as a microelectrode array having a plurality of electrodes. The porous scaffold may also be used to control the differentiation of cells including Neural Stem/Progenitor Cells (NS/PCs).Type: GrantFiled: March 10, 2021Date of Patent: February 13, 2024Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIAInventor: Rebecca Bierman
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Patent number: 11896742Abstract: Various aspects of the present invention provide compositions and implantable devices including a water-insoluble therapeutic agent solubilized in a matrix of a gallate-containing compound. Other aspects provide methods of manufacturing and using such compositions and devices.Type: GrantFiled: June 28, 2021Date of Patent: February 13, 2024Assignee: COOK MEDICAL TECHNOLOGIES LLCInventors: John Jackson, Lindsay Stuart Machan, Kevin Letchford
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Patent number: 11891482Abstract: The present disclosure relates to the field of polymer chemistry and more particularly to multiblock copolymers comprising a poly(sarcosine) block and a D,L-mixed poly(amino acid) block and uses thereof.Type: GrantFiled: February 15, 2022Date of Patent: February 6, 2024Assignee: TYNDALL FORMULATION SERVICES, LLCInventors: Kevin N. Sill, Bradford T. Sullivan
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Patent number: 11883536Abstract: A method of preparing polylactic acid (PLA) microsphere and polylactic-co-glycolic acid (PLGA) microsphere is provided, including the following steps. A first solution is provided, including polylactic acid or polylactic-co-glycolic acid and an organic solvent. A second solution is provided, including polyvinyl alcohol, sodium carboxymethyl cellulose and an aqueous solution. The first solution is added to the second solution and, at the same time, the second solution is agitated until polylactic acid is solidified to form a plurality of polylactic acid microspheres, or until polylactic-co-glycolic acid is solidified to form a plurality of polylactic-co-glycolic acid microspheres. The polylactic acid microspheres or polylactic-co-glycolic acid microspheres are collected.Type: GrantFiled: March 31, 2021Date of Patent: January 30, 2024Assignees: TAIPEI MEDICAL UNIVERSITY, PANION & BF BIOTECH INC.Inventors: Ming-Thau Sheu, Yu-Ying Hsu, Yu-De Su, Yu-Hsuan Liu, Pu-Sheng Wei
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Patent number: 11883557Abstract: A process forms an implantable product including poly(glycerol sebacate) urethane (PGSU) loaded with an active pharmaceutical ingredient (API). The process includes homogeneously mixing a flowable poly(glycerol sebacate) (PGS) resin with the API and a catalyst to form a resin blend. The process also includes homogeneously combining the resin blend with an isocyanate to form a reaction mixture and injecting the reaction mixture to form the PGSU loaded with the API. An implantable product includes a PGSU loaded with an API. In some embodiments, the implantable product includes at least 40% w/w of the API, and the implantable product releases the API by surface degradation of the PGSU at a predetermined release rate for at least three months under physiological conditions. In some embodiments, the PGSU is formed from a PGS reacted with an isocyanate at an isocyanate-to-hydroxyl stoichiometric (crosslinking) ratio in the range of 1:0.25 to 1:1.25.Type: GrantFiled: May 9, 2022Date of Patent: January 30, 2024Assignee: THE SECANT GROUP, LLCInventors: Stephanie Reed, Carissa Smoot, Dennis Shull, Todd Crumbling, John D'Ottavio, Peter D. Gabriele, Jeremy J. Harris, Charles Brendan Nicholson, Jared Ely
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Patent number: 11878079Abstract: The instant disclosure provides a capsule composition comprising pullulan, a setting system and a surfactant system that is a sucroglyceride or a sugar fatty acid ester, and methods for making such capsules.Type: GrantFiled: December 22, 2022Date of Patent: January 23, 2024Assignee: Capsugel Belgium NVInventors: Takahisa Takubo, Claire Geneviève Odile Tardy