Abstract: Various aspects of the present disclosure provide compositions including a water-insoluble therapeutic agent and a gallate-containing compound. Other aspects provide methods of using such compositions.
Abstract: The present invention relates to a method for preparing a lyophilized cyclophosphamide composition, wherein 99% or more of the finally prepared lyophilized cyclophosphamide composition is reconstituted within 15 seconds when water for pharmaceutical use is injected thereinto at a ratio of 50 mL per 1 g of anhydrous cyclophosphamide, comprising a step of dissolving D-mannitol or lactose, as a lyoprotectant, and cyclophosphamide in a water solvent in a selected reaction vessel; and a lyophilized cyclophosphamide composition for injection prepared thereof.
Type:
Grant
Filed:
April 11, 2019
Date of Patent:
July 25, 2023
Assignee:
KOREA UNITED PHARM. INC.
Inventors:
Won Ho Kang, Won Tae Jung, Jung Hoon Kang, Youn Woong Choi
Abstract: Disclosed is a pharmaceutical composition containing dabigatran etexilate and a preparation method thereof. The pharmaceutical composition comprises a pharmaceutically active ingredient, dabigatran etexilate and/or dabigatran etexilate mesylate, and a amphiphilic polymer of polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol graft copolymer. The mass ratio of the two is 1:0.23 to 1:3. The pharmaceutical composition not only increases the bioavailability of the pharmaceutically active ingredient, but also reduces absorption variability, and provides a more stable concentration of dabigatran in plasma, thereby reducing adverse side effects.
Type:
Grant
Filed:
November 27, 2018
Date of Patent:
July 25, 2023
Assignee:
SHANGHAI WD PHARMACEUTICAL CO., LTD
Inventors:
Liang Chang Dong, Shizhong Zhang, Yan Jiao, Danyong Zhang, Wenfang Zhao, Jingmin Shi
Abstract: Provided herein are micellic assemblies comprising a plurality of copolymers. In certain instauces, micellic assemblies provided herein are pH sensitive particles.
Type:
Grant
Filed:
September 23, 2019
Date of Patent:
July 25, 2023
Assignees:
UNIVERSITY OF WASHINGTON, GENEVANT SCIENCES GMBH
Inventors:
Patrick S. Stayton, Allan S. Hoffman, Anthony Convertine, Craig L. Duvall, Danielle Benoit, Robert Overell, Paul H. Johnson, Anna S. Gall, Mary G. Prieve, Amber E. E. Paschal, Charbel Diab, Priyadarsi De
Abstract: Aspects of the invention described herein include a hydrogel prodrug and methods of making a hydrogel prodrug for drug delivery. Also contemplated are methods of treating, inhibiting, ameliorating or inhibiting a disease or disorder. Without being limiting, the methods for treatment can be directed to a cancer, HIV, a virus, pain, a bacterial infection, a neurological disorder, hemorrhaging, multiple sclerosis, diabetes, high blood pressure, Alzheimer's, or inhibiting a fungal growth in a subject in need.
Abstract: The present invention discloses an extended release multi-particulate sprinkle composition comprising a plurality of discrete units, each discrete unit comprising quetiapine or a pharmaceutically acceptable salt thereof and one or more pharmaceutically acceptable excipients.
Type:
Grant
Filed:
December 14, 2021
Date of Patent:
July 4, 2023
Assignee:
Sun Pharmaceutical Industries Limited
Inventors:
Amit Kumar, Ravindra Agarwal, Pulak Kumar Metia, Kalaiselvan Ramaraju, Sumit Madan, Romi Barat Singh
Abstract: Intraocular pressure sensors, systems, and methods of use. Implantable intraocular pressure sensing devices that are hermetically sealed and adapted to wirelessly communicate with an external device. The implantable devices can include a hermetically sealed housing, the hermetically sealed housing including therein: an antenna in electrical communication with a rechargeable power source, the rechargeable power source in electrical communication with an ASIC, and the ASIC in electrical communication with a pressure sensor.
Abstract: The present invention relates to a multilayer composite material for the treatment of wounds and lesions and to a dressing comprising said multilayer material.
Type:
Grant
Filed:
February 26, 2019
Date of Patent:
June 27, 2023
Assignee:
FIDIA FARMACEUTICI S.P.A.
Inventors:
Giovanni Gennari, Monica Campisi, Anna Maria Zanellato
Abstract: The present disclosure relates to ready-to-use liquid aqueous bortezomib compositions bortezomib and pharmaceutical excipients. Other aspects include methods of preparing such ready-to-use liquid aqueous bortezomib compositions, and methods of using such ready-to-use liquid bortezomib compositions in therapeutic applications.
Type:
Grant
Filed:
September 23, 2022
Date of Patent:
June 20, 2023
Assignee:
MAIA PHARMACEUTICALS, INC.
Inventors:
Srikanth Sundaram, Daniel Charles Stewart
Abstract: A plastic material for extended release of a bio-active agent, the plastic material comprising a structural polymer, at least one bio-active ingredient embedded within the structural polymer as solid islands, a liquid binding material embedded within the structural polymer as granules, and a carrier liquid absorbed within the liquid-absorbent material. The carrier liquid may be sufficiently non-compatible with the structural polymer so that at least a portion of the carrier liquid is released from the liquid-absorbent material through the structural polymer to an outer surface of the plastic material over a period of time, such as a week or more, a month or more, or about three months. The bio-active agent comprised in the at least one bio-active ingredient may be sufficiently soluble in the carrier liquid at room or body temperature so that the carrier liquid released to the outer surface comprises the bio-active agent in solution.
Abstract: The invention provides an oral solid formulation comprising (a) a controlled release component comprising a core comprising levodopa, wherein the core is coated with a layer of a muco-adhesive polymer and externally coated with a layer of an enteric polymer; and (b) an immediate release component comprising carbidopa and levodopa.
Type:
Grant
Filed:
October 4, 2022
Date of Patent:
June 6, 2023
Assignee:
Impax Laboratories, LLC
Inventors:
Ann Hsu, Liang Dong, Amy Ding, Suneel Gupta
Abstract: Disclosed herein are compositions and methods for delivering cannabidiol to subject in need of hypertension treatment. The disclosed compositions are orally delivered. Further disclosed are kits comprising the disclosed compositions as part of a method of delivering the cannabidiol-containing compositions.
Type:
Grant
Filed:
July 5, 2022
Date of Patent:
June 6, 2023
Assignee:
POVIVA CORP.
Inventors:
John Docherty, Christopher Andrew Bunka
Abstract: The present invention provides an emulsified gel composition comprising a physiologically active substance, water, a gelling agent, an anti-peeling agent, and a surfactant having an HLB value of 18 to 20, in which the gelling agent is a nonionic water-soluble polymer, and the anti-peeling agent is one or more compounds selected from the group consisting of sucrose, sorbitol, polyethylene glycol, glycerin, a (meth)acrylic-based polymer compound, and a polyoxyethylene hydrogenated castor oil.
Type:
Grant
Filed:
November 29, 2021
Date of Patent:
May 30, 2023
Assignee:
HISAMITSU PHARMACEUTICAL CO.. INC.
Inventors:
Shinya Matsumura, Toshihiro Nakanishi, Yasuhisa Kose
Abstract: The invention provides particles, compositions including the particles, and methods of making the particles using electrospray. In certain embodiments, the particles allow for high concentrations of a therapeutic or diagnostic agent to be delivered at low viscosity. Particles may also exhibit beneficial properties with respect to stability.
Type:
Grant
Filed:
November 22, 2017
Date of Patent:
May 23, 2023
Assignee:
Elektrofi, Inc.
Inventors:
Chase Coffman, Lyndon Charles, Paul Brown, Daniel Benjamin Dadon, Lisa Liu, Cory Robinson
Abstract: Water-dispersible pharmaceutical compositions of hydroxychloroquine sulfate in powder or granule form are provided that allow for ease of preparation of measured-dose, liquid suspensions that are palatable and suitable for pediatric administration. The compositions in granular or powder form are efficiently dissolvable in water and can be provided encapsulated within a two-piece releasable hard capsule or a packet or pouch for easy release. An ion-pairing agent is present in the formulation of the composition that masks the bitter taste of the hydroxychloroquine sulfate, significantly reducing the need for addition of a sweetening agent. Methods are provided for preparing the water-dispersible pharmaceutical compositions of hydroxychloroquine sulfate and for preparing palatable weight-based pediatric doses.
Type:
Grant
Filed:
October 11, 2018
Date of Patent:
May 16, 2023
Assignee:
Research Triangle Institute
Inventors:
Elliott Richard Pauli, Hemant N. Joshi, Anvit S. Vasavada
Abstract: Provided, inter alia, are methods for treating an epilepsy disorder using a 5HT receptor agonist, or a pharmaceutically acceptable salt thereof.
Type:
Grant
Filed:
November 8, 2019
Date of Patent:
May 16, 2023
Assignee:
The Regents of the University of California
Abstract: The present invention is directed to a polymer of Formula (IV): wherein A, X, Q, Y, Z, m1; m2, m3, k1; and k2 are as described herein and wherein the monomer units of the polymer are the same or different. The present invention also relates to a monomer of Formula (III), wherein R?, X1, Y1, Z1, m4, m5, and m6 are as described herein, and a polymeric network comprising two or more monomers of Formula (III). The present invention also relates to a hydrogel comprising any of the polymers and monomers described herein, a capsule comprising the hydrogel, and a method of delivering a therapeutic agent to a subject using the capsule.
Abstract: A method of treating vaginal dryness by administering a vaginal care composition, which includes an effective amount of a vaginal care agent, to vaginal tissue of a user experiencing vaginal dryness. The vaginal care agent may be selected to specifically treat symptoms of vaginal dryness exhibited by the introitus and/or labia, based on the transcriptomic data of skin cells obtained therefrom. In some instances, the vaginal care composition may be applied to introitus and/or labia with a suitable implement configured for such use.
Type:
Grant
Filed:
October 27, 2020
Date of Patent:
April 25, 2023
Assignee:
THE PROCTER & GAMBLE COMPANY
Inventors:
Travis Kyle Hodgdon, Leo Timothy Laughlin, II, Samantha Chen-Yee Wang, Robert Lloyd Binder
Abstract: Provided herein is technology relating to lipid compositions containing bioactive fatty acids and particularly, but not exclusively, to compositions and methods related to the production and use of structured lipid compositions containing sciadonic and/or pinoleic acid alone or in combination with other bioactive fatty acids including, but not limited to, eicosapentaenoic acid, docosahexaenoic acid, conjugated linoleic acid, and non-?-oxidizable fatty acid analogues such as tetradecylthioacetic acid.
Abstract: The present invention provides a composition and method for preventing or healing injured nipples or areolas in mammalian females utilizing components of water, peppermint oil and poloxamer in a synergistic ratio.