Patents Examined by Michael G. Hartley
  • Patent number: 10047330
    Abstract: The present invention provides beverages and pharmaceutical compositions containing a deuterated alcohol according to Formula 1, and provides methods for their manufacture and use. The compositions of the invention are expected to ameliorate some of the negative side effects associated with the consumption of alcohol, such as hangover and facial flushing.
    Type: Grant
    Filed: August 14, 2017
    Date of Patent: August 14, 2018
    Assignee: Deuterla Beverages, LLC
    Inventors: Anthony W Czarnik, Jeffrey A McKinney
  • Patent number: 10047135
    Abstract: The present invention is directed to novel non-invasive diagnostic tools/compounds to image cancers, especially, melanoma, including metastatic melanoma in vivo. The present compounds exhibit enhanced uptake in cancerous cells and tissue and decreased renal uptake in kidney, evidencing favorable pharmacokinetics of compounds of the present invention. The compounds according to the present invention represent an advance in the diagnosis and treatment of melanoma, including metastatic melanoma using non-invasive molecular imaging techniques. The novel probes of the present invention are also useful for initiating therapy for melanoma as well as monitor patients' response to chemotherapy treatments and other interventions or therapies used in the treatment of melanoma/metastatic melanoma. Compounds according to the present invention may be used as diagnostic tools for a number of conditions and diseases states as well as therapeutic agents for treating such conditions and disease states.
    Type: Grant
    Filed: February 13, 2015
    Date of Patent: August 14, 2018
    Assignee: STC.UNM
    Inventor: Yubin Miao
  • Patent number: 10039844
    Abstract: A novel pyruvate kinase M2 (PKM2)-specific activator, [11C]DASA-23 and derivatives thereof, and methods for their rapid synthesis are provided. The probes are particularly useful in methods for the non-invasive positron emission tomography (PET) detection and imaging of PKM2 expression in subcutaneous and orthotopic tumors. [11C]DASA-23 cell uptake correlates with PKM2 protein expression in cultured tumor cells and orthotopic tumors are delineated from the surrounding normal brain tissue in vivo.
    Type: Grant
    Filed: December 2, 2015
    Date of Patent: August 7, 2018
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Timothy Witney, Michelle L. James, Sanjiv S. Gambhir
  • Patent number: 10039843
    Abstract: The present invention relates to paramagnetic solid lipid nanoparticles (pSLNs) comprising an amphiphilic paramagnetic metal chelating moiety selected from: a diazepine derivative of Formula I and a tetraazocyclododecane derivative of Formula (II): being said chelating moiety complexed to a paramagnetic metal ion selected from the group consisting of: Gd(III), Mn(II), Cr(III), Cu(II), Fe(III), Pr(III), Nd(III), Sm(III), Tb(III), Yb(III), Dy(III), Ho(III) and Er(III), or salts thereof. The invention further relates to the process for preparation of said solid lipid nanoparticles comprising amphiphilic complexes of paramagnetic metals (pSLNs) and to the use of pSLNs as MRI contrast agents in the diagnostic field.
    Type: Grant
    Filed: September 6, 2013
    Date of Patent: August 7, 2018
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Chiara Brioschi, Claudia Cabella, Simona Ghiani, Alessandro Maiocchi, Luigi Miragoli, Massimo Visigalli
  • Patent number: 10034651
    Abstract: Compositions, including composition for use in radiographic calibration and quality assurance include glass micro bubbles, epoxy, CaCo3, MgO, and Polyethylene. Embodiments of the composition may be used in calibration devices or phantoms. Calibration devices or phantoms constructed of embodiments of the composition may be used in methods of calibrating a radiographic device for imaging of brain tissue.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: July 31, 2018
    Assignee: Gammex, Inc.
    Inventor: Cristel Baiu
  • Patent number: 10029022
    Abstract: Provided is a radioactive labeled compound capable of detecting a secondary mutation of an epidermal growth factor receptor, where the compound is represented by Formula (1) or a pharmaceutically acceptable salt thereof, where Y, L1, R1 and R2 are as defined.
    Type: Grant
    Filed: April 28, 2016
    Date of Patent: July 24, 2018
    Assignees: Kyoto University, ARKRAY, Inc.
    Inventors: Hideo Saji, Hiroyuki Kimura, Hirokazu Matsuda, Shuichi Nakanishi
  • Patent number: 10029021
    Abstract: As a substance used as a contrast agent for a method of nuclear magnetic resonance analysis or a method of magnetic resonance imaging, a substance with high selectivity and high sensitivity was demanded. According to the present invention, when a polymer having, in a side chain thereof, a sequence of a 1H—13C—15N, 1H—15N—13C or 1H—13C—13C bond, that is, a structure labeled with stable isotopes of 13C and 15N, is used, the abundance of such a sequence in one molecule can be increased, and hence, high selectivity and higher sensitivity can be attained when used as a contrast agent.
    Type: Grant
    Filed: May 22, 2013
    Date of Patent: July 24, 2018
    Inventors: Teruyuki Kondo, Yasuhiro Aoyama, Hisatsugu Yamada, Yoshinori Hasegawa, Hidehito Tochio, Yu Kimura, Masahiro Shirakawa, Fuminori Sugihara, Tetsuya Matsuda, Shinsuke Sando, Masato Minami, Fumio Yamauchi, Tetsuya Yano, Hidetoshi Tsuzuki
  • Patent number: 10022459
    Abstract: A medical tissue-marker which enables the identification of a location even from the outside of an organ, can remain topical over a long period, and enables the easy identification of a marked location within the whole organ; also a manufacturing method for the medical tissue-marker. The medical tissue-marker includes a vesicle formed by the synthesis of a phospholipid and a near infrared fluorescent dye, and an emulsion formed by the synthesis of the phospholipid and an X-ray contrast medium, and has agglomerated clusters wherein the vesicle and the emulsion are contained in a hydrophilic solvent and a plurality of capsules are formed by use of an emulsifier.
    Type: Grant
    Filed: May 31, 2012
    Date of Patent: July 17, 2018
    Inventors: Hideki Hayashi, Hirosuke Hatayama, Masanori Fujinami, Taro Toyota
  • Patent number: 10022462
    Abstract: The present invention generally relates to methods and system for the synthesis of imaging agents, and precursors thereof. The methods may exhibit improved yields and may allow for the large-scale synthesis of imaging agents, including imaging agents comprising a radioisotope (e.g., 18F). Various embodiments of the invention may be useful as sensors, diagnostic tools, and the like. In some cases, methods for evaluating perfusion, including myocardial perfusion, are provided. Synthetic methods of the invention have also been incorporated into an automated synthesis unit to prepare and purify imaging agents that comprise a radioisotope. In some embodiments, the present invention provides a novel methods and systems comprising imaging agent 1, including methods of imaging in a subject comprising administering a composition comprising imaging agent 1 to a subject by injection, infusion, or any other known method, and imaging the area of the subject wherein the event of interest is located.
    Type: Grant
    Filed: February 15, 2017
    Date of Patent: July 17, 2018
    Assignee: Lantheus Medical Imaging, Inc.
    Inventors: Richard R. Cesati, Edward H. Cheesman, Joel Lazewatsky, Heike S. Radeke, Enrico Mongeau, Dianne D. Zdankiewicz, Marybeth Devine
  • Patent number: 10022460
    Abstract: The invention provides, inter alia, improved lipid formulations used to generate lipid-encapsulated gas microspheres, and methods of their use.
    Type: Grant
    Filed: May 23, 2017
    Date of Patent: July 17, 2018
    Assignee: Lantheus Medical Imaging, Inc.
    Inventors: Simon P. Robinson, Robert W. Siegler, David C. Onthank, Nhung Tuyet Nguyen
  • Patent number: 10016518
    Abstract: An imaging agent comprising a conjugate of an oligosaccharide moiety with an imaging moiety. The oligosaccharide is Lewis A or Lewis B or a mimetic thereof, or a pharmaceutically acceptable salt or PEGylated form of Lewis A or Lewis B or its mimetics. Lewis A and Lewis B and its mimetics are also provided for use in the therapeutic treatment of inflammatory diseases, autoimmune diseases and cancer.
    Type: Grant
    Filed: August 15, 2013
    Date of Patent: July 10, 2018
    Inventors: Daniel Anthony, Benjamin Guy Davis, Guillaume Bort
  • Patent number: 10016465
    Abstract: A cured non-polymeric gel including a plurality of non-polymeric cross-links. The non-polymeric cross-links result from curing an oil or oil composition at selected curing conditions to achieve a desired amount of cross-linking to form the non-polymeric get. The desired amount of cross-linking is selected based on a desired rate of degradation of the gel after the gel is implanted. The oil or oil composition comprises one or more of eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), or alphalinolenic acid (ALA).
    Type: Grant
    Filed: October 10, 2014
    Date of Patent: July 10, 2018
    Inventors: Roger Labrecque, Philip McNamara, Joseph Ferraro, Lisa Rogers, Paul Martakos, Theodore Karwoski, Steve A. Herweck, Keith M. Faucher, Thomas M. Swanick
  • Patent number: 10016529
    Abstract: Biomaterials, implants made therefrom, methods of making the biomaterial and implants, methods of promoting bone or wound healing in a mammal by administering the biomaterial or implant to the mammal, and kits that include such biomaterials, implants, or components thereof. The biomaterials may be designed to exhibit osteogenic, osteoinductive, osteoconductive, and/or osteostimulative properties.
    Type: Grant
    Filed: June 10, 2015
    Date of Patent: July 10, 2018
    Assignee: Globus Medical, Inc.
    Inventors: Archana Bhat, Vipin Kunjachan, Chris Geisler, Allison Adams, Christine Grimes
  • Patent number: 10016520
    Abstract: A compound represented by formula (I) is provided, wherein in formula (I), R1 and R2 each independently represents hydrogen, O—R3 or S—R4, at least one of R1 and R2 is O—R3 or S—R4, and R3 and R4 are independently a C1 to C10 alkyl group, such that the C1 to C10 alkyl group is non-substituted or substituted with at least one selected from the group consisting of —OH, —NH2, halogen, ester, ether, and carboxylic acid, and M being a metal or a metal-containing compound. The compound represented by formula (I) is shown to have higher specificity to tumor cells, and is therefore suitable for carrying anti-cancer drugs and/or nuclear imaging agents.
    Type: Grant
    Filed: January 9, 2017
    Date of Patent: July 10, 2018
    Assignee: SeeCure Taiwan Co., Ltd.
    Inventors: Wei-Chung Chang, Kun-Hsin Lee, Kai-Chi Chang, Ping-Fan Chen, Min-Huei Huang, Hung-Yuan Huang, Ning Tsao
  • Patent number: 10010630
    Abstract: A formulation for preparing gas-filled microvesicles which comprises a phospholipid and a mixture of saturated and unsaturated fatty acids. The gas-filled microvesicles having a stabilizing layer comprising said composition show an increased stability with respect to microvesicles containing only a saturated or an unsaturated fatty acid.
    Type: Grant
    Filed: December 19, 2013
    Date of Patent: July 3, 2018
    Assignee: BRACCO SUISSE S.A.
    Inventors: Anne Lassus, Philippe Bussat, Thierry Bettinger
  • Patent number: 10010629
    Abstract: The present disclosure provides lipid-probe compounds, and compositions comprising the compounds. A subject lipid-probe compound is useful for various imaging applications, which are also provided.
    Type: Grant
    Filed: July 22, 2015
    Date of Patent: July 3, 2018
    Assignee: The Regents of the University of California
    Inventors: Carolyn Ruth Bertozzi, Andreas Stahl, Amy Helene Fluitt, Elena A. Dubikovskaya, Allison Cohen
  • Patent number: 10011820
    Abstract: Three-dimensional tissue constructs are described, which may be created by isolating adipose-derived stromal vascular fraction (SVF) cells, plating the cells onto a polymer scaffold, and culturing the plated scaffold in a culture of DMEM with approximately 10% FBS.
    Type: Grant
    Filed: October 1, 2012
    Date of Patent: July 3, 2018
    Inventors: Amanda J. LeBlanc, James B. Hoying, Stuart K. Williams
  • Patent number: 10006913
    Abstract: Heteroaryldihydropyrimidine (HAP)-based fluorescent stains (compounds), as well as uses of such stains as diagnostic reagents, viral-tracking agents, and/or tools for drug discovery are described. The present invention relates to heteroaryldihydropyrimidine (HAP)-based fluorescent stains (compounds), as well as uses of such stains as diagnostic reagents, viral-tracking agents, and/or tools for drug discovery.
    Type: Grant
    Filed: March 20, 2014
    Date of Patent: June 26, 2018
    Assignee: Indiana University Research and Technology Corporation
    Inventors: Adam Zlotnick, Lichun Li, Michael S. Van Nieuwenhze, William W. Turner
  • Patent number: 10004818
    Abstract: Methods and compositions utilizing ether and alkyl phospholipid ether analog compounds for treating cancer and imaging, monitoring, and detecting cancer stem cells in humans.
    Type: Grant
    Filed: April 15, 2016
    Date of Patent: June 26, 2018
    Assignee: CELLECTAR, Inc.
    Inventors: Jamey P. Weichert, Anatoly Pinchuk, Irawati Kandela, Marc Longino, William R. Clarke
  • Patent number: 10004816
    Abstract: The present invention relates to X-ray examinations and to the improvement of patient safety during such. More specifically the invention relates to X-ray diagnostic compositions having low concentrations of iodine and an optimized amount of electrolytes. The invention further relates to methods of X-ray examinations wherein a body is administered with an X-ray diagnostic composition comprising a low concentration of iodine and irradiated with a radiation dose.
    Type: Grant
    Filed: January 10, 2013
    Date of Patent: June 26, 2018
    Assignee: GE HEALTHCARE AS
    Inventors: Ben Newton, Mikkel Thaning, Dirk-Jan in't Veld, Karina Langseth, Paul Michael Evans