Patents Examined by Michael G. Hartley
  • Patent number: 10557854
    Abstract: The present disclosure relates to compounds that are useful as near-infrared fluorescence probes, wherein the compounds include i) a ligand that binds to the active site of carbonic anhydrase, ii) a dye molecule, and iii) a linker molecule that comprises an amino acid, amide, ureido, or polyethylene glycol derivative thereof. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.
    Type: Grant
    Filed: March 16, 2017
    Date of Patent: February 11, 2020
    Assignee: On Target Laboratories, LLC
    Inventors: Sumith A Kularatne, Pravin Gagare, Ananda Kumar Kanduluru
  • Patent number: 10555970
    Abstract: The present invention provides compositions, systems, kits, and methods for preparation prior to a colonoscopy or other gastrointestinal procedure. In particular, the present invention provides a colon lavage system comprising an aqueous portion and a solid portion.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: February 11, 2020
    Inventor: Dale R. Bachwich
  • Patent number: 10556873
    Abstract: Substituted 1,4,7-triazacyclononane-N,N?,N?-triacetic acid and 1,4,7,10-tetraazacycicododecane-N,N?,N?,N??-tetraacetic acid compounds with a pendant amino or hydroxyl group, metal complexes thereof, compositions thereof, and methods of making and use in diagnostic imaging and treatment of cellular disorders.
    Type: Grant
    Filed: August 25, 2015
    Date of Patent: February 11, 2020
    Inventor: Hyun-Soon Chong
  • Patent number: 10548996
    Abstract: Radioactive hydrogels for the delivery of localized radiotherapy, methods of making the radioactive hydrogels, and methods of using the radioactive hydrogels are disclosed. A radioisotope may be conjugated to a high molecular weight molecule, which may be encapsulated in a microparticle, where the microparticle is then dispersed within a hydrogel. The radioactive hydrogel may prevent leakage of the radioisotope to provide radiotherapy to a surgical margin while minimizing damage to surrounding normal tissue.
    Type: Grant
    Filed: March 30, 2015
    Date of Patent: February 4, 2020
    Inventors: Abdel Kareem Azab, Pilar de la Puente, Feda Azab
  • Patent number: 10548992
    Abstract: The present disclosure concerns a medical image indicator. More particularly, it concerns the multipurpose medical image indicator including more than one of fluorophores and MRI contrast agent/CT contrast agent and method for manufacturing same. Responding to a demand for non-invasive and effective way of marking lesions, the present disclosure provides a method for manufacturing the multipurpose medical image indicator including a provision of rubber material fluid composition; a mixing of the rubber material fluid composition and fluorophores; and a transfiguring and drying of the mixture and the multipurpose medical image indicator manufactured according to the method. Further, the present disclosure provides a ligation device for endoscope including the multipurpose medical image indicator.
    Type: Grant
    Filed: April 7, 2015
    Date of Patent: February 4, 2020
    Inventors: Dae Kyung Sohn, Yong Doo Choi, Kwang Gi Kim
  • Patent number: 10543481
    Abstract: Methods of preparing fluorinated compounds by carboxylative fluorination using fluoride are contained herein. Fluorinated compounds are provided. Methods of using fluorinated compounds are contained herein.
    Type: Grant
    Filed: February 9, 2016
    Date of Patent: January 28, 2020
    Inventors: John T. Groves, Xiongyi Huang
  • Patent number: 10544167
    Abstract: The present disclosure relates to the field of synthetic pharmaceutical chemistry and biology. The disclosure provides a compound of Formula I and a process of preparation thereof. The disclosure further relates to methods and use of Formula I compounds as stimuli-responsive probes. Said Formula I compounds are employed for detecting and quantifying reactive oxygen species (ROS), and have related applications including but not limited fluorescence spectroscopy, diagnostics, treatment, imaging and biomedical applications.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: January 28, 2020
    Assignee: Jawaharlal Nehru Centre for Advanced Scientific Research
    Inventors: Govindaraju Thimmaiah, Nagarjun Narayanaswamy
  • Patent number: 10537647
    Abstract: This invention relates to, in part, methods and compositions that are useful for the diagnosis, treatment, or prevention of a blinding eye disease, including in the discovery of drugs that are efficacious against these diseases. Diseases include, for example, age related macular degeneration and reticular pseudodrusen disease, and the methods described herein include, for example, the method named delayed near infrared analysis (DNIRA).
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: January 21, 2020
    Assignee: Translatum Medicus Inc.
    Inventor: Shelley Romayne Boyd
  • Patent number: 10537622
    Abstract: Gas-filled microvesicles comprising an antigen bound thereto and to aqueous suspensions containing said microvesicles, for use in immunomodulating formulations, in particular as a vaccine. The antigen is covalently bound to a component of the microvesicles envelope. The microvesicles of the invention, comprising a molar excess of fatty acids in the stabilizing envelope, are particularly effective in the uptake by antigen-presenting cells, in particular dendritic cells.
    Type: Grant
    Filed: December 21, 2015
    Date of Patent: January 21, 2020
    Assignee: BRACCO SUISSE S.A.
    Inventors: Gilles Bioley, Philippe Bussat, Blaise Corthesy, Anne Lassus
  • Patent number: 10537650
    Abstract: The invention relates to novel multi-modality probes for imaging, tracking and analyzing stem cells and related biological samples, and methods of preparation and use thereof. The molecular probes of the invention are constructed, for example, by utilizing (a) the high selectivity of long hydrocarbon chains for binding to plasma membranes of cells, (b) a near-infrared (NIR) dye for optical imaging, and (c) a radionuclide for PET or SPECT imaging. The in vitro and in vivo data of the optical and radiolabeled probes demonstrated their utility for detecting the presence of stem cells with multiple imaging modalities.
    Type: Grant
    Filed: November 14, 2016
    Date of Patent: January 21, 2020
    Assignee: University of Massachusetts
    Inventors: Brian D. Gray, Mary Rusckowski, Koon Y. Pak
  • Patent number: 10538486
    Abstract: The present invention relates to a hydroxamic acid-based contrast agent containing an isotope of fluorine, which comprises a compound having a structure of Formula (III): wherein R1 represents radioactive fluorine-18 (18F) or isotope fluorine-19 (19F), and R2 represents hydroxyamine —(NH)OH. The hydroxamic acid-based contrast agent containing an isotope of fluorine provided in the present invention has the capability of selectively inhibiting histone deacetylase (HDAC) subtypes 8/6/3, and specifically targets to the focus of spinocerebellar ataxia with over-activation of HDAC. By labeling with the radioisotope fluorine-18, a positron emission tomography (PET) image is obtained with the hydroxamic acid-based contrast agent containing radioisotope fluorine-18, whereby spinocerebellar ataxia is effectively detected.
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: January 21, 2020
    Inventors: Mei-Hui Wang, Chia-Yu Hu, Mao-Chi Weng, Jyun-Hong Chen, Chun-Hung Yang, Hung-Man Yu
  • Patent number: 10525078
    Abstract: A solid dialysis A agent is provided, which is to be used in preparing a bicarbonate dialysis fluid, wherein: the solid dialysis A agent contains glucose, acetic acid and an acetate salt; at least a part of a mixture of the acetic acid with the acetate salt is an alkali metal diacetate; and the acetic acid/acetate salt molar ratio is adjusted to 1/0.5 to 1/2. This solid dialysis A agent makes it possible to prepare a bicarbonate dialysis fluid which has a total acetate ion concentration of 2 to less than 6 mEq/L. Further, the dialysis A agent exhibits excellent stability of ingredients and a reduced acetic acid odor.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: January 7, 2020
    Assignee: Tomita Pharmaceutical Co., Ltd.
    Inventors: Michiko Myose, Hiroshi Noguchi, Junya Kikuishi, Hideyuki Aoyama, Mina Hashimoto, Yusuke Yoshimoto
  • Patent number: 10526317
    Abstract: Compounds useful as labels with properties comparable to known fluorescent compounds. The compounds are conjugated to proteins and nucleic acids for biological imaging and analysis. Synthesis of the compounds, formation and use of the conjugated compounds, and specific non-limiting examples of each are provided.
    Type: Grant
    Filed: July 5, 2017
    Date of Patent: January 7, 2020
    Assignees: Pierce Biotechnology, Inc., Dyomics GmbH
    Inventors: Greg Hermanson, Peter T. Czerney, Surbhi Desai, Matthias S. Wenzel, Boguslawa R. Dworecki, Frank G. Lehmann, Marie Christine Nlend
  • Patent number: 10525149
    Abstract: Compositions and methods for assessing blood vessels and organs of the body are disclosed herein, specifically methods for assessing the vasculature of the eye.
    Type: Grant
    Filed: May 12, 2016
    Date of Patent: January 7, 2020
    Assignee: MediBeacon Inc.
    Inventors: Richard B. Dorshow, Thomas E. Rogers
  • Patent number: 10525150
    Abstract: A contrast agent having a contrast protein have contrast properties and at least one targeting moiety, wherein the at least one targeting moiety is operatively linked to or incorporated within the contrast protein. Methods for targeting contrast agents and for preparing such agents are included.
    Type: Grant
    Filed: May 16, 2016
    Date of Patent: January 7, 2020
    Assignee: Georgia State University Research Foundation, Inc.
    Inventors: Jenny J. Yang, Zhi-Ren Liu
  • Patent number: 10519171
    Abstract: The present invention relates to a process for the preparation of a solid form of the gadobenate dimeglumine compound that comprises obtaining a solution of the said compound in a suitable solvent A wherein the amount by weight of the water optionally present in the solution is at most equal to or lower than the amount by weight of the gadobenate dimeglumine comprised in the solution and adding the obtained solution to an organic solvent B, acting as an appropriate antisolvent and favoring the formation of a solid form of the gadobenate dimeglumine that can be collected by filtration.
    Type: Grant
    Filed: July 20, 2015
    Date of Patent: December 31, 2019
    Assignee: BRACCO IMAGING S.P.A.
    Inventors: Roberta Mazzon, Roberta Fretta, Pier Lucio Anelli
  • Patent number: 10519160
    Abstract: Provided herein are radiolabeled compounds useful for non-invasive imaging techniques. An exemplary radiolabeled compound provided herein is useful as a radiotracer for positron emission tomography. The present application also provides unlabeled compounds useful in methods of treating diseases of the central nervous system or disease of the peripheral nervous system. Methods for preparing radiolabeled compounds, preparing unlabeled compounds, and diagnostic methods using labeled or unlabeled compounds are also provided.
    Type: Grant
    Filed: July 17, 2015
    Date of Patent: December 31, 2019
    Assignee: The General Hospital Corporation
    Inventors: Genevieve Van de Bittner, Jacob M. Hooker
  • Patent number: 10517965
    Abstract: This present application relates to fluorescent tetrazine-containing compounds consisting of a single pi-system. For example, a compound of Formula (I): or a salt thereof, wherein: F is a fluorophore, L is a conjugated linker, and Tz is a substituted or unsubstituted tetrazine; wherein the linker bridges the Tz and F moieties in a single conjugated pi-system. Also provided herein are methods of using the compounds provided herein for biomedical imaging.
    Type: Grant
    Filed: May 6, 2014
    Date of Patent: December 31, 2019
    Assignee: The General Hospital Corporation
    Inventors: Labros Meimetis, Jonathan Carlson, Ralph Weissleder
  • Patent number: 10508127
    Abstract: The invention relates to a compound V for complexing metallic isotopes, comprising a chelator X and one or more targeting vectors conjugated with the chelator X, said targeting vectors having the structure -L1-R1-L2-R2-L3-R3, wherein R3 contains a bisphosphonate. A pharmaceutical consists of the compound V and a metallic isotope which is complexed with compound V.
    Type: Grant
    Filed: October 16, 2015
    Date of Patent: December 17, 2019
    Assignee: SCV GmbH
    Inventors: Frank Rösch, Marian Meckel
  • Patent number: 10500292
    Abstract: Prostate-specific membrane antigen (PSMA) binding compounds having radioisotope substituents are described, as well as chemical precursors thereof. Compounds include pyridine containing compounds, compounds having phenylhydrazine structures, and acylated lysine compounds. The compounds allow ready incorporation of radionuclides for single photon emission computed tomography (SPECT) and positron emission tomography (PET) for imaging, for example, prostate cancer cells and angiogenesis.
    Type: Grant
    Filed: January 8, 2018
    Date of Patent: December 10, 2019
    Assignee: The Johns Hopkins University
    Inventors: Martin G. Pomper, Ronnie Charles Mease, Ying Chen