Patents Examined by Michael P. Barker
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Patent number: 7393867Abstract: The present invention discloses and claims compounds of formula (I) and formula (II), as inhibitors of human casein kinase I? and methods for using said compounds for treating central nervous system diseases and disorders including mood disorders and sleep disorders. Pharmaceutical compositions comprising compounds of formula (I) or formula (II) and a method for the preparation of compounds of formula (I) or formula (II) are also disclosed and claimed.Type: GrantFiled: February 13, 2007Date of Patent: July 1, 2008Assignee: Aventis Pharmaceuticals Inc.Inventors: David Marc Fink, Yulin Chiang, Nicola Dawn Collar
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Patent number: 7390797Abstract: The present invention provides a novel fused indazole compound having an excellent JNK inhibitory action. More specifically, it provides a compound represented by the following formula, a salt thereof or a hydrate of them. Wherein Z11 and Z12 each independently represent a carbonyl group, a methylene group, etc.; represents a double bond or a single bond; R1a represents a hydrogen atom, etc.; the ring A represents a benzene ring, a naphthalene ring or a 5- to 10-membered aromatic heterocyclic ring, etc.; and R2a, R2b and R2c each independently represent (1) a hydrogen atom, (2) a halogen atom, (3) a nitro group, etc.Type: GrantFiled: February 21, 2003Date of Patent: June 24, 2008Assignee: Eisai Co., Ltd.Inventors: Norihito Ohi, Nobuaki Sato, Naohiro Kohmura
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Cyclohexyl(alkyl)-propanolamines, preparation method and pharmaceutical compositions containing same
Patent number: 7388031Abstract: The present invention relates to the compounds of formula (I): in which A is a group of formula (a) or (b) in which R represents a hydrogen or halogen atom, an —S(O)z(C1–C4)alkyl group, an —NHSO2(C1–C4)alkyl group, an —SO2NH(C1–C4)alkyl group, an —NHSO2phenyl-(C1–C4)alkyl group or an —NHSO2phenyl group, said phenyl possibly being substituted with a halogen atom, with a (C1–C4)alkyl group or with a (C1–C4)alkoxy group; R1 represents a hydrogen atom or a (C1–C4)alkyl group, a —CO(C1–C4)alkyl group, a phenyl-(C1–C4)alkyl group or a —COphenyl group, said phenyl also possibly being substituted with a halogen atom or with a (C1–C4)alkoxy group; R2 is a hydrogen atom or an —SO2(C1–C4)alkyl group, an —SO2phenyl-(C1–C4)alkyl group or an —SO2phenyl group; X completes a ring of 5 to 8 atoms, said ring being saturated or unsaturated, possibly being substituted with one or two (C1–C4)alkyl groups and bearing one or two carbonyl groups; n, m and z are, independently, 0, 1 or 2; R3 represents a hydrogen or halogenType: GrantFiled: November 30, 2001Date of Patent: June 17, 2008Assignee: Sanofi-AventisInventors: Philippe R. Bovy, Roberto Cecchi, Gilles Courtemanche, Tiziano Croci, Ambrogio Oliva, Nunzia Viviani -
Patent number: 7388023Abstract: Certain ?-amino acids that bind to the alpha-2-delta (?2?) subunit of a calcium channel are disclosed. These compounds and their pharmaceutically acceptable salts are useful in the treatment of a variety of psychiatric, pain and other disorders. Also disclosed are methods of making the ?-amino acids.Type: GrantFiled: December 7, 2006Date of Patent: June 17, 2008Assignee: Warner-Lambert Company LLCInventors: Peter Garth Blazecka, Joseph Richard Bozelak, Norman Lloyd Colbry, Timothy Thomas Curran, Annise Paige Goodman, Kevin E. Henegar, Garrett Hoge, Paul D. Johnson, Augustine Tobi Osuma, Mark Stephen Plummer, Jacob Bradley Schwarz, Derek Clinton Vrieze, Ji Zhang
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Patent number: 7384964Abstract: The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).Type: GrantFiled: August 18, 2004Date of Patent: June 10, 2008Assignee: Sloan-Kettering Institute for Cancer ResearchInventors: Samuel J. Danishefsky, Alexey Rivkin, Fumihiko Yoshimura, Ting-Chao Chou, Ana E. Gabarda, Huajin Dong, Kaida Wu, Malcolm A. S. Moore, David Dorn
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Patent number: 7384966Abstract: A compound of general structure I, wherein the compound is optionally in the form of an N-oxide or S-oxide or prodrug form and/or pharmaceutically acceptable salt thereof wherein: each of R1 to R9 is independently selected from hydrogen, hydroxyl, alkoxy, halo, mesyl, CX3 (X=halo), —O(CH2)nNYZ-, substituted or unsubstituted lower alkyl, substituted or unsubstituted heteroalkyl, substituted or unsubstituted aryl or heteroaryl, and substituted or unsubstituted aralkyl or heteroaralkyl; optionally R6 and R7 together form a dioxymethylene (—OCH2O—) unit and wherein n is 1 to 3 and Y and Z are independently selected from any of the following: C1-C6 straight chain, branched or cyclic substituted or unsubstituted alkyl group, Y and Z can be taken together to form a cyclic alkyl or hetereoalkyl group wherein in addition to N the hetereoalkyl group comprises a heteroatom selected from N, O or S.Type: GrantFiled: August 31, 2005Date of Patent: June 10, 2008Assignee: Pharminxo LimitedInventors: Malcolm Francis G. Stevens, Andrew David Westwell, Tracey Dawn Poole, Geoffrey Wells
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Patent number: 7384969Abstract: The invention relates to compounds of general formula (I): in which X1, X2, X3, X4, X5, Z1, Z2, Z3, Z4 and Z5, R, Y and n are as defined herein. Also disclosed and claimed are the preparative methods and application of said compounds in therapeutics.Type: GrantFiled: January 18, 2007Date of Patent: June 10, 2008Assignee: Sanofi-AventisInventors: Laurent Dubois, Yannick Evanno, Luc Even
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Patent number: 7378533Abstract: The present invention describes surfactants of formula (I), wherein R, RN, and m are defined herein, processes for their preparation, and methods for their decomposition.Type: GrantFiled: March 22, 2006Date of Patent: May 27, 2008Assignee: Sandia CorporationInventors: James R. McElhanon, Gregory M. Jamison, Timothy M. Long, Douglas A. Loy, Kamyar Rahimian, Blake A. Simmons, Chad L. Staiger, David R. Wheeler, Thomas Zifer
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Patent number: 7365087Abstract: This invention provides compounds of the formula: wherein A?, X and Y are defined in the specification. These compounds are useful as antibacterial agents.Type: GrantFiled: December 13, 2006Date of Patent: April 29, 2008Assignee: WyethInventors: Phaik-Eng Sum, David Brian How, Darrin William Hopper, Matthew Douglas Vera, Joshua James Sabatini
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Patent number: 7361680Abstract: The present invention provides novel indole derivatives useful to inhibit cancer or sensitize cancer cells to chemotherapeutic agents, radiation or other anti-cancer treatments.Type: GrantFiled: August 25, 2006Date of Patent: April 22, 2008Assignee: The Regents of the University of CaliforniaInventors: Dennis A. Carson, Howard B. Cottam, Lorenzo M. Leoni
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Patent number: 7361672Abstract: The invention is concerned with novel heteroarylacetamides of formula (I) Rd—C(O)—N(Re)—Rc—CH2—C(O)—N(Ra)(Rb)??(I) wherein Ra to Re are as defined in the description and in the claims, as well as physiologically acceptable salts thereof. These compounds inhibit the coagulation factor Xa and can be used as medicaments.Type: GrantFiled: December 13, 2005Date of Patent: April 22, 2008Assignee: Hoffmann-La Roche Inc.Inventors: Markus Boehringer, Katrin Groebke Zbinden, Wolfgang Haap, Hans Hilpert, Narendra Panday, Fabienne Ricklin
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Patent number: 7361658Abstract: 2-Acylaminothiazole derivatives or salts thereof which have a platelet increasing activity based on an excellent human c-mpl-Ba/F3 cell growth function and a function of accelerating formation of megakaryocytic colonies and which are useful for treating thrombocytopenia are provided.Type: GrantFiled: July 15, 2004Date of Patent: April 22, 2008Assignee: Astellas Pharma Inc.Inventors: Keizo Sugasawa, Yuji Koga, Kazuyoshi Obitsu, Takao Okuda, Koichiro Harada, Hideki Kubota, Fukushi Hirayama, Masaki Abe, Ken-ichi Suzuki
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Patent number: 7358393Abstract: The invention relates to ?-alanine amides of general formula (I), wherein: R1 represents hydrogen or C1-6 alkyl that is optionally substituted by hydroxy, amino, carboxy, carbamoyl, methylmercapto, guanidino, optionally substituted aryl or heteroaryl, and; R2 represents hydrogen or R1 and R2, together, form a group of formula —(CH2)n—, wherein n is 3 or 4. Said ?-alanine amides are produced without using an amino protective group by reacting the corresponding amine with a cyanoacetic ester in order to form an acetamide and by effecting a subsequent catalytic hydrogenation. The method is suited, in particular, for producing carcinine (?-alanyl-histamine, R?1 =imidazol-4-ylmethyl, R2=H), a naturally occurring pseudo dipeptide, which is used as an active ingredient having an antioxidative effect in medicaments and cosmetics.Type: GrantFiled: September 4, 2002Date of Patent: April 15, 2008Assignee: Lonza Ltd.Inventors: Paul Hanselmann, Stefan Hildbrand
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Patent number: 7358253Abstract: Provided are compounds of formula (I) which are useful in the treatment and/or prevention of diseases or disorders mediated by T lymphocytes and/or PKC, e.g. acute or chronic rejection of organ or tissue allo- or xenografts, graft versus host diseases, atherosclerosis, vascular occlusion due to vascular injury such as angioplasty, restenosis, obesity, syndrome X, impaired glucose tolerance, polycystic ovary syndrome, hypertension, heart failure, chronic obstructive pulmonary disease, CNS diseases such as Alzheimer disease or amyotrophic lateral sclerosis, cancer, infectious diseases such as AIDS, septic shock or adult respiratory distress syndrome, ischemia/reperfusion injury e.g. myocardial infarction, stroke, gut ischemia, renal failure or hemorrhage shock, or traumatic shock, e.g. traumatic brain injury. The compounds of formula I are also useful in the treatment and/or prevention of T-cell mediated acute or chronic inflammatory disease or disorders or autoimmune diseases e.g.Type: GrantFiled: October 12, 2006Date of Patent: April 15, 2008Assignee: Novartis AGInventors: Jean-Pierre Evenou, Peter Von Matt, Jürgen Wagner, Gerhard Zenke
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Patent number: 7358265Abstract: Compounds formula (IA) or (IB), wherein W represents HO(C?O)—, HONH(C?O)— or H(C?O)N(OH)—; X represents —O— or —S—; and R1, R2, and R3 are as defined in the description and claims, are inhibitors of matrix metalloproteinases, in particular MMP9 and/or MMP12.Type: GrantFiled: February 20, 2003Date of Patent: April 15, 2008Assignees: Vernalis (R&D) Ltd, Laboratories Serono S.A.Inventors: Andrew Paul Ayscough, Stephen John Davies, Gilles Pain, Jean-Yves Gillon
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Patent number: 7354938Abstract: Substituted pyrazoles are provided that are useful for the treatment of, for example, diabetes, obesity and metabolic syndrome.Type: GrantFiled: March 18, 2005Date of Patent: April 8, 2008Assignee: Amgen Inc.Inventors: Hiroyuki Goto, Makoto Kakutani, Jun Nishiu, Yasuhiro Ohe, Jay P. Powers, Shinji Yata, Hua Tu
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Patent number: 7351837Abstract: The present invention describes surfactants of formula (I), wherein R, RN, and m are defined herein, processes for their preparation, and methods for their decomposition.Type: GrantFiled: March 22, 2006Date of Patent: April 1, 2008Assignee: Sandia CorporationInventors: James R. McElhanon, Gregory M. Jamison, Timothy M. Long, Douglas A. Loy, Kamyar Rahimian, Blake A. Simmons, Chad L. Staiger, David R. Wheeler, Thomas Zifer
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Patent number: 7351841Abstract: A compound represented by the formula (1): wherein A is a nitrogen atom or CR4, B is an oxygen atom, a sulfur atom or NR9 (provided that when A is a nitrogen atom, B is not NH), R1 is a C2-14 aryl group, L1 is a bond, CR10R11, an oxygen atom, a sulfur atom or NR12, X is OR13 SR13 or NR14NR15, R2 is a hydrogen atom, a formyl group, a C1-10 alkyl group or the like, L2 is a bond or the like, L3 is a bond, CR17R18, an oxygen atom, a sulfur atom or NR19, L4 is a bond, CR20R21, an oxygen atom, a sulfur atom or NR22, Y is an oxygen atom, a sulfur atom or NR23, and R3 is a C2-14 aryl group, a tautomer, prodrug or pharmaceutically acceptable salt of the compound or a solvate thereof.Type: GrantFiled: December 6, 2005Date of Patent: April 1, 2008Assignee: Nissan Chemical Industries, Ltd.Inventors: Shingo Owada, Shunsuke Iwamoto, Kazufumi Yanagihara, Katsuaki Miyaji, Takanori Nakamura, Norihisa Ishiwata, Yutaka Hirokawa
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Patent number: 7348357Abstract: The present invention relates to compounds, to processes for preparing them, to pharmaceutical compositions comprising them, and to their use in the therapy and/or prophylaxis of diseases in people or animals, especially diseases of bacterial infection.Type: GrantFiled: July 28, 2003Date of Patent: March 25, 2008Assignee: Bayer HealthCare AGInventors: Nina Brunner, Christoph Freiberg, Thomas Lampe, Peter Nell, Ben Newton, Michael Otteneder, Josef Pernerstorfer, Jens Pohlmann, Guido Schiffer, Mitsuyuki Shimada, Niels Svenstrup, Rainer Endermann
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Patent number: 7348327Abstract: The present invention relates to new, potent DPP-IV enzyme inhibitors of the general formula (I), which contain fluorine atoms.Type: GrantFiled: March 4, 2003Date of Patent: March 25, 2008Assignee: Sanofi-AventisInventors: Peter Aranyi, Laszlo Balazs, Imre Bata, Sandor Batori, Eva Boronkay, Philippe Bovy, Karoly Kanai, Zoltan Kapui, Edit Susan, Tibor Szabo, Lajos T. Nagy, Katalin Urban-Szabo, Marton Varga