Abstract: Compounds useful for the treatment of pain in accord with the following structural diagram, wherein R1, R2 and R3 are any of a number of groups as defined in the specification and pharmaceutical compositions and methods of treatment utilising such compounds.
Type:
Grant
Filed:
August 23, 2006
Date of Patent:
March 25, 2008
Assignee:
AstraZeneca AB
Inventors:
Marc Chapdelaine, Lucius Kemp, John McCauley
Abstract: Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.
Type:
Grant
Filed:
March 31, 2006
Date of Patent:
March 18, 2008
Assignee:
Hoffmann-La Roche Inc.
Inventors:
Paul Gillespie, Robert Alan Goodnow, Jr., Qiang Zhang
Abstract: Aminocyclohexyl ether compounds are disclosed. The compounds of the present invention may be incorporated in compositions and kits. The present invention also discloses uses for the compounds and compositions, including the treatment of arrhythmia.
Type:
Grant
Filed:
March 30, 2006
Date of Patent:
March 18, 2008
Assignee:
Cardiome Pharma Corp.
Inventors:
Gregory N. Beatch, Bertrand M. C. Plouvier, Tao Sheng, Michael J. A. Walker, Richard A. Wall, Sandro L. Yong, Jeff Jiqun Zhu, Alexander B. Zolotoy
Abstract: The present invention is directed to novel tetracyclic heteroatom containing derivatives, pharmaceutical compositions containing them, their use in the treatment of disorders mediated by one or more sex steroid hormone receptors and processes for their preparation.
Abstract: This invention features compounds of formula (I): pharmaceutical compositions of the compounds, and methods of using the compounds for the treatment of, inter alia, IL-12-related diseases and disorders.
Type:
Grant
Filed:
November 10, 2004
Date of Patent:
March 4, 2008
Assignee:
Synta Pharmaceuticals Corp.
Inventors:
Mitsunori Ono, Lijun Sun, Yumiko Wada, Teresa Przewloka, Hao Li, Howard P. Ng, Zachary Demko
Abstract: A targetted production method for benzothiazole-4,7-dione and benzoxazole-4,7-dione derivatives, mono-substituted in the 5 or 6 position with an amino group, itself optionally substituted.
Type:
Grant
Filed:
June 24, 2004
Date of Patent:
February 26, 2008
Assignee:
Societe de Conseils de Recherches et d'Applications (S.C.R.A.S.)
Abstract: Heterocyclic amides of formula (1) and pharmaceutically acceptable salts or pro-drugs thereof wherein variable groups are as described herein; which possess glycogen phosphorylase inhibitory activity and accordingly have value in the treatment of disease states associated with increased glycogen phosphorylase activity are described. Processes for the manufacture of said heterocyclic amide derivatives and pharmaceutical compositions containing them are also described.
Type:
Grant
Filed:
November 30, 2006
Date of Patent:
February 19, 2008
Assignee:
AstraZeneca AB
Inventors:
Andrew Stocker, Paul Robert Owen Whittamore
Abstract: A compound of formula (I): or a salt, solvate and chemically protected form thereof, wherein: R5 is an optionally substituted C5-20 aryl or C4-20 alkyl group; A is selected from the group consisting of: wherein X and Y are selected from the group consisting of: O and CR3; S and CR3; NH and CR3; NH and N; O and N; S and N; N and S; and N and O, and where the dotted lines indicate a double bond in the appropriate location, and where Q is either N or CH; R3 is selected from H, F, Cl and optionally substituted C1-4 alkyl, C1-4 alkoxy, C5-7 aryl and C5-7 aryl-C1-4 alkyl groups; R4 is selected from H, F, Cl and optionally substituted C1-4 alkyl, C1-4 alkoxy, C5-7 aryl and C5-7 aryl-C1-4 alkyl groups; R6 is selected from H, F, Cl and optionally substituted C1-4 alkyl, C1-4 alkoxy, C5-7 aryl and C5-7 aryl-C1-4 alkyl groups; D is selected from: B is selected from the group consisting of: where RN? is selected from H and C1-4 alkyl; where one of RP3 and RP4 is —Cm alkylene-R2 and t
Type:
Grant
Filed:
February 11, 2005
Date of Patent:
February 5, 2008
Assignee:
Pharmagene Laboratories Limited
Inventors:
Alexander William Oxford, Richard Jon Davis, Robert Alexander Coleman, Kenneth Lyle Clark, David Edward Clark, Neil Victor Harris, Garry Fenton, George Hynd, Keith Alfred James Stuttle, Jonathan Mark Sutton, Mark Richard Ashton, Edward Andrew Boyd, Shirley Ann Brunton
Abstract: The invention relates to compounds of formula (I) processes for their preparation, pharmaceutical compositions containing them and to their use in medicine, particularly use in the amelioration of a clinical condition for which a Factor Xa inhibitor is indicated.
Type:
Grant
Filed:
October 11, 2006
Date of Patent:
February 5, 2008
Assignee:
Glaxo Group Limited
Inventors:
Chuen Chan, Julie Nicole Hamblin, Henry Anderson Kelly, Nigel Paul King, Andrew McMurtrie Mason, Vipulkumar Kantibhai Patel, Stefan Senger, Gita Punjabhai Shah, Nigel Stephen Watson, Helen Elisabeth Weston, Caroline Whitworth, Robert John Young
Abstract: In one embodiment, the present application relates to a process of making a compound of formula I: and to certain intermediate compounds that are made within the process of making the compound of formula I.
Type:
Grant
Filed:
June 15, 2004
Date of Patent:
February 5, 2008
Assignee:
Schering Corporation
Inventors:
Anantha Sudhakar, Vilas Dahanukar, Ilia A. Zavialov, Cecilia Orr, Hoa N. Nguyen, Juergen Weber, Ingyu Jeon, Minzhang Chen, Michael D. Green, George S. Wong, Jeonghan Park, Tetsuo Iwama
Abstract: Process for the synthesis of (2S)-indoline-2-carboxylic acid of formula (I): Application in the synthesis of perindopril and its pharmaceutically acceptable salts.
Abstract: An isomer, enantiomer, diastereoisomer or tautomer of a compound, represented by formula I: wherein wherein A, B, R2, R3, M1, M2, M3, M4, Y1 and Z are as defined in claim 1, or a salt thereof, as an inhibitor of HCV NS5B polymerase.
Type:
Grant
Filed:
April 17, 2006
Date of Patent:
January 29, 2008
Assignee:
Boehringer Ingelheim International GmbH
Inventors:
Marc-André Poupart, Pierre Louis Beaulieu, Jean Rancourt
Abstract: The invention relates to substituted aryl-substituted heterocycles and to the physiologically tolerated salts and physiologically functional derivatives thereof, to process for their preparation and to their use as medicaments. Compounds of the Formula I in which the radicals have the stated meanings, the N-oxides thereof, and the physiologically tolerated salts thereof, and process for the preparation thereof are described. The compounds bring about for example a weight reduction in mammals and are suitable for example for the prevention and treatment of obesity and diabetes.
Type:
Grant
Filed:
January 25, 2005
Date of Patent:
January 15, 2008
Assignee:
Sanofi-Aventis Deutschland GmbH
Inventors:
Lothar Schwink, Siegfried Stengelin, Thomas Boehme, Matthias Gossel, Gerhard Hessler, Petra Stahl
Abstract: Pyrrole-oxindole derivatives useful as progesterone receptor antagonists, and methods for preparing the same, are provided. Pharmaceutical compositions containing these derivatives are described, as is the use thereof in contraception and hormone-related conditions.
Type:
Grant
Filed:
July 6, 2005
Date of Patent:
January 8, 2008
Assignee:
Wyeth
Inventors:
Andrew Fensome, Casey Cameron McComas, Edward George Melenski, Michael Anthony Marella, Jay Edward Wrobel, Gary Sondermann Grubb
Abstract: The present invention relates to novel compounds of the general formula (I) and salts and physiologically functional derivatives thereof, wherein Z is NH, or CH2 if Y is SO2 Y is C?O, C?S, or SO2 if Z is CH2; A is phenyl or indolyl, N-methyl-indolyl R1 is —CN, wherein the bond between CR3 and CR7 is a single or double bond; m is 0 or 1; n is 0 or 1; p is 0 or 1; and to their use as medicaments.
Abstract: The present invention is directed to phenylalanine derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme (“DP-IV inhibitors”) and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
Type:
Grant
Filed:
November 26, 2003
Date of Patent:
December 18, 2007
Assignee:
Merck & Co., Inc.
Inventors:
Joseph L. Duffy, Robert J. Mathvink, Ann E. Weber, Jinyou Xu
Abstract: Novel Process and Intermediates. A process for preparing a compound of formula (I) where R4 and R5 are as defined in the specification; and R6 is hydrogen or a protecting group, which process comprises cyclisation of a compound of formula (II) where R4 and R5 and R6 are as defined in relation to formula (I), and R7 is nitrogen protecting group, and removing the group R7, and thereafter if desired, removing any protecting group R6.
Type:
Grant
Filed:
September 29, 2003
Date of Patent:
December 11, 2007
Assignee:
AstraZeneca AB
Inventors:
Michael Butters, Paul Schofield, Andrew Stocker
Abstract: Novel polycyclic compounds having the structural formula (I) below: are formulated into pharmaceutical compositions suited for administration in human or veterinary medicine (in dermatology, and also in the fields of cardiovascular diseases, immune diseases and/or diseases associated with lipid metabolism), or, alternatively, into cosmetic compositions.
Type:
Grant
Filed:
September 20, 2006
Date of Patent:
December 11, 2007
Assignee:
Galderma Research & Development
Inventors:
Laurence Clary, Pascal Collette, Michel Rivier, Andre Jomard
Abstract: The invention relates to cyclic benzimidazoles of formula 1, in which the substituents and symbols have the meanings indicated in the description. The compounds have gastric secretion inhibiting and excellent gastric and intestinal protective action properties.
Type:
Grant
Filed:
April 2, 2004
Date of Patent:
December 11, 2007
Assignee:
Altana Pharma AG
Inventors:
Wilm Buhr, M. Vittoria Chiesa, Peter Jan Zimmermann
Abstract: Methods of synthesizing nicotine analogs and derivatives are described. The methods are particularly useful for the regioselective production of enantiomerically pure nicotine anlogs having substituents at the C4 position. Intermediates useful for the synthesis of such compounds are also described.
Type:
Grant
Filed:
August 11, 2006
Date of Patent:
December 4, 2007
Assignee:
North Carolina State University
Inventors:
Laura S. King, Emilie Smith, Daniel L. Comins