Patents Examined by Michael P Cohen
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Patent number: 12257268Abstract: The present invention provides a polysaccharide carbon nanogel exhibiting antitumor efficacy prepared by carbonizing the polysaccharide utilizing dry heating. The polysaccharide carbon nanogel comprises a graphene-like nanosheet and a polysaccharide, which are complexed to form a cross-linked supramolecular structure. The polysaccharide carbon nanogels has an exceptional polyphenolic structure and high antimetastatic activity, which can become a promising anti-tumor drug.Type: GrantFiled: February 7, 2022Date of Patent: March 25, 2025Assignee: NATIONAL TAIWAN OCEAN UNIVERSITYInventors: Chih-Ching Huang, Ju-Yi Mao, Chen-Yow Wang
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Patent number: 12256741Abstract: Antimicrobial preservative compositions that can be incorporated in products to be preserved are disclosed herein. The disclosed compositions include immobilized biocidal enzymes, such as cross-linking enzymes or active enzymes falling into the zymogen-class, for the purpose of modifying amino acid residues on a protein or binding a molecule of interest to a protein. The compositions include enzymes that are immobilized on a polymeric solid support, which improve the shelf life of the enzyme and protect the enzyme from auto-cross-linking or other deterioration over extended storage periods. Also disclosed are methods of increasing the self-like of products, such as personal care, household and industrial products, by incorporating an effective amount of the disclosed compositions into the product.Type: GrantFiled: March 5, 2020Date of Patent: March 25, 2025Assignee: Curie Co. Inc.Inventors: Erika Milczek, Simone Costa, William Shindel
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Patent number: 12245591Abstract: Disclosed herein are antimicrobial materials comprising a carbohydrate-templated microgel and a plurality of metal ions complexed thereto. The carbohydrate-templated microgel comprises a network copolymer molecule comprising a monoacrylate monomer, a crosslinking monomer, and a ligand monomer and wherein the microgel is prepared by the copolymerization of the monoacrylate monomer, the crosslinking monomer, and the ligand monomer in the presence of a carbohydrate or a carbohydrate derivative. The microgels have antimicrobial activity and allow for implementation of multiple, simultaneous mechanisms of antimicrobial action.Type: GrantFiled: February 5, 2020Date of Patent: March 11, 2025Assignee: THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSASInventors: Susanne Striegler, Babloo Sharma
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Patent number: 12233157Abstract: The invention provides methods and polymer compositions for treating ocular disorders, where the methods and compositions comprise polymer that can form a hydrogel in the eye of a subject. The hydrogel is formed by reaction of (i) a nucleo-functional polymer that is a biocompatible polymer, such as a thiolated hyaluronic acid polymer, containing a plurality of thio-functional groups —R1—SH wherein R1 is hydrolyzable and (ii) an electro-functional polymer that is a biocompatible polymer, such as a poly(ethylene glycol) polymer, containing at least one thiol-reactive group.Type: GrantFiled: July 24, 2024Date of Patent: February 25, 2025Assignee: PYKUS THERAPEUTICS, INC.Inventors: Tomasz Pawel Stryjewski, James Anthony Stefater, III, Laurence A. Roth, Kelsey-Ann Leslie
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Patent number: 12226511Abstract: Cosmetic formulation with deodorant activity for topical application including vitamin E or an ester thereof, starch, sodium bicarbonate, zinc oxide and a cosmetically acceptable carrier is disclosed. The vitamin E ester is preferably alpha-tocopherol acetate, n-propionate or linoleate and the vitamin E or ester thereof and is present in an amount of 5-40% by weight of the weight of the formulation.Type: GrantFiled: May 4, 2020Date of Patent: February 18, 2025Assignee: HULKA S.R.L.Inventor: Giorgio Panin
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Patent number: 12226498Abstract: The present invention relates to a sensory emulsifying composition, in particular for cosmetic use, capable of obtaining a liquid oil-in-water-type emulsion comprising at least one cyclodextrin in the form of solid particles, said particles having a volumetric average particle size d(4,3), measured by laser granulometry, of between 2 and 20 ?m, preferably between 3 and 12 ?m, and more preferably between 4 and 8 ?m, and at least one emulsifier of natural origin selected from water-in-oil emulsifiers, having a hydrophilic-lipophilic balance (HLB) of less than 8.Type: GrantFiled: December 4, 2019Date of Patent: February 18, 2025Assignee: Roquette FreresInventor: Léon Mentink
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Patent number: 12220473Abstract: This invention relates to oral care compositions, for example comprising a salt of a basic amino acid having a pH in solution of less than 7.5, an abrasive having a pH in solution of less than 7.5, and a fluoride ion source, and an acid selected from the group consisting of: a carboxylic acid (e.g., citric acid, lactic acid, glycolic acid, acetic acid, succinic acid, or fumaric acid), and an inorganic acid, wherein the inorganic acid is not phosphoric acid or sulfuric acid (e.g., wherein the inorganic acid is hydrochloric acid or sodium acid pyrophosphate), and to methods of using and of making these compositions.Type: GrantFiled: February 7, 2023Date of Patent: February 11, 2025Assignee: Colgate-Palmolive CompanyInventors: Yun Xu, Stacey Lavender, Luciana Rinaudi Marron, Zoe Scoullos, Manish Mandhare
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Patent number: 12208068Abstract: The invention also relates to processes for producing abuse deterrent pharmaceutical compositions comprising highly pure amphetamine and amphetamine-class compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds, and to methods of manufacturing, delivering, and using the amphetamine compounds resulting from the synthesis of chiral and racemic amphetamine derivatives by stereospecific, regioselective cuprate addition reaction with aziridine phosphoramidate compounds.Type: GrantFiled: March 31, 2023Date of Patent: January 28, 2025Assignee: Pharmapotheca A Inc.Inventors: Karl Popp, Harold Meckler
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Patent number: 12201695Abstract: The disclosure relates generally to polyglutamated antifolates, formulations containing liposomes filled with the polyglutamated antifolates, methods of making the polyglutamated antifolates and liposome containing formulations, and methods of using the polyglutamated antifolates and liposome containing formulations to treat hyerproliferative disorders (e.g., cancer) and disorders of the immune system (e.g., an autoimmune disease such as rheumatoid arthritis).Type: GrantFiled: December 7, 2021Date of Patent: January 21, 2025Assignee: L.E.A.F. HOLDINGS GROUP LLCInventors: Clet Niyikiza, Victor Mandla Moyo
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Patent number: 12194136Abstract: A method, and formulations for the method, for the treatment of hair loss is herein described. Typically, the method involves applying an exosome-based skincare product to skin affected by hair loss, such as the skin of the scalp. The exosome-based skincare product contains exosomes produced by and excreted from human umbilical mesenchymal stem cells cultured in vitro under specific conditions and then contained within a solvent. The hair loss may be caused by androgenic alopecia, alopecia areta, or telogen effulvium.Type: GrantFiled: January 26, 2023Date of Patent: January 14, 2025Inventor: Jordan Robert Plews
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Patent number: 12194137Abstract: A biological hair shape change composition including a macromolecular component, a small molecular component and an alkali agent component is provided. The macromolecular component includes a protease belonging to the class of alkaline proteases, and the small molecular component includes a peptide with reduction activity. Both the macromolecular component and the small molecular component are obtained from a fermentation product of Bacillus licheniformis and a keratin and/or keratin polymer-containing medium. Molecular weights of ingredients in the macromolecular component are greater than or equal to 3 kDa and are 3-1000 kDa, and molecular weights of ingredients in the small molecular component are less than 3 kDa and are 0.01-2.99 kDa.Type: GrantFiled: October 28, 2021Date of Patent: January 14, 2025Assignee: INDUSTRIAL TECHNOLOGY RESEARCH INSTITUTEInventors: Yin-Lung Han, Chieh-Lun Cheng, Kai-Chun Fan, Pei-Jyuan Gao, Bo-Han Chen
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Patent number: 12194129Abstract: Leave-on oral care compositions having good spreadability and improved retention property are provided for promoting Gum Health of a user. Leave-on oral care compositions can comprise a hyaluronic acid or a salt thereof, a polyacrylic acid as a mucoadhesive polymer, and an additional polymer.Type: GrantFiled: December 6, 2023Date of Patent: January 14, 2025Assignee: The Procter & Gamble CompanyInventors: Ross Strand, Yang Su, Yunming Shi, Thanigaivel Shanmugam, Guannan Wang, Xiaoxiao Li
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Patent number: 12195531Abstract: Compositions and methods for targeted delivery of active agents to cells are provided. The compositions comprise a wholly or partially double-stranded synthetic DNA carrier, and an active agent intercalated in double-stranded portions of the DNA carrier. The DNA carrier may also be linked to a targeting agent. The compositions are useful for delivering an active agent into a targeted cell type, for example a cytotoxic agent.Type: GrantFiled: September 12, 2019Date of Patent: January 14, 2025Assignees: CODE BIOTHERAPEUTICS, INC., Lankenau Institute of Medical ResearchInventors: Robert C. Getts, James Kadushin, Mindy George-Weinstein, Jacquelyn Gerhart, Emanuela Dylgjeri, Kelly Rhodes
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Patent number: 12178883Abstract: The disclosure relates generally to polyglutamated antifolates, formulations containing liposomes filled with alpha or D-gamma polyglutamated antifolates, methods of making the polyglutamated antifolates and liposome containing formulations, and methods of using polyglutamated antifolates and liposome containing formulations to treat hyerproliferative disorders (e.g., cancer) and disorders of the immune system (e.g., an autoimmune disease such as rheumatoid arthritis).Type: GrantFiled: December 7, 2021Date of Patent: December 31, 2024Assignee: L.E.A.F. HOLDINGS GROUP LLCInventors: Clet Niyikiza, Victor Mandla Moyo
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Patent number: 12178882Abstract: The disclosure relates generally to polyglutamated antifolates, formulations containing liposomes filled with alpha or D-gamma polyglutamated antifolates, methods of making the polyglutamated antifolates and liposome containing formulations, and methods of using polyglutamated antifolates and liposome containing formulations to treat hyerproliferative disorders (e.g., cancer) and disorders of the immune system (e.g., an autoimmune disease such as rheumatoid arthritis).Type: GrantFiled: December 7, 2021Date of Patent: December 31, 2024Assignee: L.E.A.F. HOLDINGS GROUP LLCInventors: Clet Niyikiza, Victor Mandla Moyo
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Patent number: 12178796Abstract: A drug-loaded nanofiber membrane includes a first fiber, a second fiber, and a drug. The drug is dispersed into the first fiber. The first fiber includes poly(lactic-co-glycolic acid) copolymer (PLGA copolymer), and the second fiber includes poly(p-dioxanone) (PDO).Type: GrantFiled: September 6, 2021Date of Patent: December 31, 2024Assignee: SHENZHEN GUANGYUAN BIOMATERIAL CO., LTD.Inventors: Zhichao Han, Shanshan Xu, Jia'en Wu
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Patent number: 12178210Abstract: Described herein are systems and methods for attracting insects to a trap or surface containing insecticide. One embodiment described herein is an insect attractant releasing system comprising a quantity of a volatile insect attractant where the attractant is released at a defined rate and has a particular product lifetime under field conditions. In another embodiment, the attractant releasing system is integrated into an apparatus having insecticide immobilized on one or more surfaces where attracted insects can crawl or land and contact the insecticide, which subsequently kills the insects.Type: GrantFiled: June 7, 2021Date of Patent: December 31, 2024Assignee: Suterra, LLCInventors: Ignacio de Alfonso Marzal, Zachary Ryan Clark, Scott Richard Lindbloom, Wesley Albert Matson
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Patent number: 12171733Abstract: A bactericidal and virucidal pharmaceutical composition for use on epithelial tissues such as pulmonary, nasal and oral tissues, which comprises a non-steroidal anti-inflammatory drug (NSAID) in a concentration between 5 and 500 mM and a salt, being the NSAID preferably solubilized in a hypertonic saline solution applicable in therapies for viral infections of the Herpes simplex type. The composition can be used in therapies for herpes simplex viral infections, be used as a bactericidal mouthwash, or be vehiculated to the lung by using a nebuliser, for cystic fibrosis.Type: GrantFiled: January 26, 2024Date of Patent: December 24, 2024Assignee: Quimica Luar SRLInventors: Luis Alberto Argañarás, Adrian Javier Muñoz, Roxana Valeria Alasino, Ariel Gustavo Garro, Dante Miguel Beltramo
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Patent number: 12171225Abstract: Biocide compositions efficacious for biofilm control, including treatment and/or prevention, comprising the synergistic combination of biocide(s) with a source of hydronium ions are disclosed. Methods of deactivating, removing and/or preventing biofilms with the compositions are also provided.Type: GrantFiled: May 28, 2021Date of Patent: December 24, 2024Assignee: ECOLAB USA INC.Inventors: Junzhong Li, Joshua Luedtke, Jesse David Hines, John Paul Koehl, Richard Staub
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Patent number: 12161686Abstract: Compositions are disclosed herein that comprise a mixture of at least one Albizia extract and a Magnolia extract. In some embodiments, the composition comprises a mixture of at least one Albizia extract enriched for one or more macrocyclic alkaloids and at least one Magnolia extract enrich for one or more lignans.Type: GrantFiled: December 19, 2022Date of Patent: December 10, 2024Assignee: Unigen, Inc.Inventors: Ping Jiao, Mi sun Oh, Mei Feng Hong, Qi Jia