Abstract: A fluid detection panel and a fluid detection device are disclosed. The fluid detection panel includes a fluid-driven substrate, a filter structure and a sensor. The filter structure is configured to filter light emitted by a light source; the fluid-driven substrate comprises a detection area, and is configured to enable a liquid sample to move to the detection area; the sensor is configured to receive light which is emitted by the light source and sequentially passes the filter structure and the detection area.

Abstract: An image capturing apparatus for capturing an image of a workpiece held on a chuck table includes a camera, an objective lens having a minute hole defined centrally therein and disposed in facing relation to the workpiece held on the chuck table, an optical fiber having an end inserted in the minute hole in the objective lens, a light source optically coupled to another end of the optical fiber, and a beam splitter disposed in the optical fiber for branching off returning light reflected by the workpiece held on the chuck table. The image capturing apparatus further includes a calculating section for calculating a value representing a height or a thickness of the workpiece on the basis of the returning light branched off by the beam splitter, and a focusing mechanism for focusing the objective lens on the workpiece on the basis of the value calculated by the calculating section.

Abstract: The present disclosure is directed to a system and a method for compensating non-linear response characteristics in measuring the shape of an object using phase-shifting deflectomerty. More particularly, the present disclosure is directed to a method for compensating non-linear response characteristics in phase-shifting deflectometry including steps of: generating a pattern by a pattern generating portion and projecting the same to a measurement object; obtaining an image of a deformed pattern reflected from the measurement object by a detector; linearizing non-linear responses on the basis of a look up table considering non-linear response characteristics of the pattern generating portion and the detector by a compensation means; and compensating phase-shifting amounts generated due to non-linear response characteristics by the compensation means.

Abstract: Disclosed are devices and methods for analyzing an analyte, such as white blood cells in liquid samples.

Abstract: Systems and methods for assessing strain in structural components are disclosed. Structural components may have geometric patterns of diffraction cavities within the structural component, with the diffraction cavities in the geometric pattern each having a cavity width and being spaced from each other by a cavity spacing distance. The method may include projecting beams of electromagnetic (EM) energy through the structural component to the geometric pattern of diffraction cavities to create diffracted beams of EM energy that are reflected from or transmitted through the geometric pattern of diffraction cavities and have diffracted wavelengths indicating changes in the cavity spacing distances due to strain caused when the structural component is exposed to environmental conditions, detecting the diffracted wavelength of the diffracted beams, and correlating the diffracted wavelengths of the diffracted beams to the strain in the structural components.

Abstract: A sensor system includes a self-mixing interferometry sensor; a drive circuit configured to apply a modulated drive signal to an input of the self-mixing interferometry sensor; a mixer circuit configured to mix a modulated output of the self-mixing interferometry sensor with a local oscillator signal that is orthogonal to the modulated drive signal over a period of time; an integrator circuit configured to integrate an output of the mixer circuit over the period of time; and a processor configured to determine, using an output of the integrator circuit, at least one of a round-trip propagation time of electromagnetic radiation emitted by the self-mixing interferometry sensor and reflected back into the self-mixing interferometry sensor by an object or medium, or a velocity of the object or medium.

Abstract: An overlay error measurement structure includes a lower-layer pattern disposed over a substrate, and an upper-layer pattern disposed over the lower-layer pattern and at least partially overlapping with the lower-layer pattern. The lower-layer pattern includes a plurality of first sub-patterns extending in a first direction and being arranged in a second direction crossing the first direction. The upper-layer pattern includes a plurality of second sub-patterns extending in the first direction and being arranged in the second direction. At least one of a pattern pitch and a pattern width of at least one of at least a part of the first sub-patterns and at least a part of the second sub-patterns varies along the second direction.

Abstract: A measurement method for a grooved axially symmetric body involves detecting the geometry of the peripheral surface of the axially symmetric body, reconstructing a virtual profile corresponding at least to the profile of the lateral flanks of a plurality of recesses or grooves of the peripheral surface of the grooved axially symmetric body, generating a plurality of virtual rounded bodies of a predetermined size and placed each at a tangent to a corresponding pair of lateral sides and making one or more measurements using a centre or another point belonging to said virtual rounded bodies as a reference point.

Abstract: There is described an interferometer for use in an optical locker. The interferometer comprises at least two transparent materials having different thermal path length sensitivities. The interferometer is configured such that an input beam is split by the interferometer into first and second intermediate beams, which recombine to form an output beam, the first and second intermediate beams travelling along respective first and second intermediate beam paths which do not overlap. At least one of the intermediate beam paths passes through at least two of the transparent materials. A length of each intermediate beam path which passes through each transparent material is selected such that an optical path difference between the first and second intermediate beam path is substantially independent of temperature.

Abstract: A sample slide (100) for use in a spectrometer (501), wherein the sample slide comprises a plurality of sample-receiving portions (111-114) provided on a sample side (115) of the slide, and a plurality of beam-receiving portions (121-124) provided on a beam-receiving side (125) of the slide, each beam-receiving portion being arranged opposite a respective sample-receiving portion, and wherein each beam-receiving portion is configured to act as an internal reflection element (IRE). A device (300) for use with a spectrometer (501) comprises a stage (330) configured to receive a sample slide (100); and a moving mechanism (360) configured to move the sample slide relative to a sample-measuring location (320) of the device. Associated methods for preparing a sample and measuring a sample are also disclosed.

Abstract: An optical module 1 includes: a mirror unit 2 including a base 21, a movable mirror 22, and a fixed mirror 16; a beam splitter unit 3 that is disposed on one side of the mirror unit 2 in a Z-axis direction; a light incident unit 4 that causes measurement light L0 to be incident to the beam splitter unit 3; a first light detector 6 that is disposed on the one side of the beam splitter unit 3 in the Z-axis direction, and detects interference light L1 of measurement light which is emitted from the beam splitter unit 3; a support 9 to which the mirror unit 2 is attached; a first support structure 11 that supports the beam splitter unit 3; and a second support structure 12 that is attached to the support 9 and supports the first light detector 6.

Abstract: A method for controlling an optical substance detection device, wherein the optical substance detection device includes a light sensing device, includes: when it is detected that the optical substance detection device is subjected to an impact, acquiring an impact force and an impact direction when the optical substance detection device is subjected to the impact; calculating a light sensing displacement deviation value according to a predetermined data model and in combination with the impact force and the impact direction; and performing light sensing correction according to the light sensing displacement deviation value.

Abstract: The present invention provides systems, devices, and methods for point-of-care and/or distributed testing services. The methods and devices of the invention are directed toward automatic detection of analytes in a bodily fluid. The components of the device can be modified to allow for more flexible and robust use with the disclosed methods for a variety of medical, laboratory, and other applications. The systems, devices, and methods of the present invention can allow for effective use of samples by improved sample preparation and analysis.

Abstract: An example of a flow cell includes a substrate, a plurality of chambers defined on or in the substrate, and a plurality of depressions defined in the substrate and within a perimeter of each of the plurality of chambers. The depressions are separated by interstitial regions. Primers are attached within each of the plurality of depressions, and a capture site is located within each of the plurality of chambers.

Abstract: Systems and methods for automated laser microdissection are disclosed including automatic slide detection, position detection of cutting and capture lasers, focus optimization for cutting and capture lasers, energy and duration optimization for cutting and capture lasers, inspection and second phase capture and/or ablation in a quality control station and tracking information for linking substrate carrier or output microdissected regions with input sample or slide.

Abstract: In a hose connector fitting, an outer circumferential surface of a socket is crimped toward a radially inner side thereof within a crimping range along an axis direction of the socket in the state where a hose is inserted into an annular space between an outer circumferential portion of a nipple and an inner circumferential portion of the socket. A shape measuring device includes: a sensor and a rotational moving unit that detect distance data from a reference position to the surface of the socket over a zone including at least the entire crimping range; a shape data generating unit that generates shape data representative the three-dimensional shape of the socket surface based on the detected distance data; and a measurement data calculating unit that calculates measurement data about the crimping state of the socket based on the shape data.

Abstract: A microfluidic analyzer includes optical sources and optical detectors, the sources generating optical beams, and a multi-chamber fluid cell mounted for relative movement of the fluid cell and the beams to selectively align fluid chambers with beam paths for obtaining optical-response measurements. The cell is configured to reduce differential optical-response measurement between fluid chambers not attributed to a differential analyte in chamber fluids. A controller (1) generates actuator control signals to produce the relative movement of the fluid cell and beams through a sequence of measurement positions, (2) for each measurement position, obtains a set of detector output values, and (3) applies processing to the detector output values to obtain differential optical-response measurements for characterizing a differential analyte between chamber fluids of the cell.

Abstract: An interferometer detection system, including a beam splitter receiving a collimated light signal and splitting the signal into a first light signal and a second light signal. The system includes a first mirror receiving and reflecting the first light signal along a first path. The system includes a second mirror receiving and reflecting the second light signal along a second path via a transparent material. The system includes a 2D photosensor array configured to receive from the beam splitter the reflected first light signal merged with the reflected second light signal double passing through the transparent material and configured to generate an interference fringe pattern. A non-sinusoidal interference fringe pattern indicates geometrical variation between a wavefront of the reflected first light signal along the first path and a wavefront of the reflected second light signal double passing through the transparent material along the second path.

Abstract: An optical gyroscope includes, in part, an optical switch, a pair of optical rings and a pair of photodetectors. The optical switch supplies a laser beam. The first optical ring delivers a first portion of the beam in a clockwise direction during the first half of a period, and a first portion of the beam in a counter clockwise direction during the second half of the period. The second optical ring delivers a second portion of the beam in a counter clockwise direction during the first half of the period, and a second portion of the beam in a clockwise direction during the second half of the period. The first photodetector receives the beams delivered by the first and second optical rings during the first half of the period. The second photodetector receives the beams delivered by the first and second optical rings during the second half of the period.

Abstract: Methods and apparatus for measuring a thickness of a coating on an moving object are provided. Light is directed toward the object at a predetermined location on the object such that a portion of the light interacts with the object. A 1D and/or 2D maximum intensities for at least one wavelength channel is captured that is produced by the portion of the light interacting with the object. A measured average intensity of the wavelength channel and/or intensities and their arithmetic derivatives of multi wavelength channel geometries is converted into 1D (averaged) and/or 2D thickness values. Based on these values an acceptability of the coating is evaluated and thickness calculated.