Abstract: A method and apparatus for monitoring arterial properties, including systolic and diastolic pressure levels, of a subject is provided, in which a hardware processor receives and analyzes ballistocardiogram (BCG) data of the subject. A non-transient computer readable medium, accessible by the hardware processor, contains instructions that, when executed by the hardware processor, identify features of the BCG waveform and determine the arterial properties therefrom. For example, a diastolic pressure level may be determined from a time interval between the ‘I’ and ‘J’ peaks of the waveform and a systolic pressure level determined from the amplitude difference between the ‘J’ and ‘K’ peaks of the waveform in combination with the ‘I-J’ time interval or amplitude difference. A physical mechanism for the BCG data is disclosed that enables other arterial properties of the subject to be determined from the BCG data alone or from the BCG data in combination with other measurements.

Abstract: A three-dimensional folding self-driving flexible respiration monitoring sensor and the preparing method thereof is disclosed. In the present invention a first friction unit and a second friction unit are set on a bottom of the box, which comprise a substrate, a conductive electrode layer and a friction layer respectively; the second friction unit is fixed on the bottom of the box; a friction layer of the first friction unit faces a friction layer of the second friction unit; a back plate is set on a substrate of the first friction unit; a balloon is between the box and the back plate; an inlet tube connects the balloon and the box, which is on a side wall of the box; the conductive electrode layer of the first friction layer and the second friction layer are connected to the electrometer respectively. Micro-energy of the respiration is adopted to monitor the breathing.

Abstract: A catheter for measuring a fractional flow reserve includes a proximal shaft, a distal shaft coupled to a distal portion of the proximal shaft, and a pressure sensor coupled to the distal shaft. The proximal shaft includes a distal portion configured to extend through a stenosis in a vessel. The distal portion of the proximal shaft includes a radially expanded configuration having a first diameter and a radially collapsed configuration having a second diameter, wherein the first diameter is larger than the second diameter. The distal shaft includes a guidewire lumen configured to receive therein.

Abstract: A plethysmograph variability processor inputs a plethysmograph waveform having pulses corresponding to pulsatile blood flow within a tissue site. The processor derives plethysmograph values based upon selected plethysmograph features, determines variability values, and calculates a plethysmograph variability parameter. The variability values indicate the variability of the plethysmograph features. The plethysmograph variability parameter is representative of the variability values and provides a useful indication of various physiological conditions and the efficacy of treatment for those conditions.

Abstract: Subject matter disclosed herein relates to monitoring and/or controlling blood glucose levels in patients. In particular, times for obtaining metered blood glucose samples of a patient may be altered based, at least in part, on a blood glucose level of said patient observed from a blood glucose sensor.

Abstract: Adhesive pad systems that provide longer lasting adherence of the mounting unit to the host's skin are provided. Some systems include a reinforcing overlay that at least partially covers the adhesive pad. The reinforcing overlay may be removable without disturbing the sensor so that the overlay may be replaceable.

Abstract: An apparatus for measuring blood pressure, and a method for measuring blood pressure by using the same are disclosed. The disclosed method for measuring blood pressure comprises the steps of: calculating pulse wave transit time; measuring vascular compliance; and measuring systolic blood pressure and diastolic blood pressure by using the pulse wave transit time and the vascular compliance, wherein the vascular compliance can be measured respectively in at least two or more different hand shape poses.

Abstract: The ingestible event marker data framework provides a uniform, comprehensive framework to enable various functions and utilities related to ingestible event marker data (IEM data). The functions and utilities include data and/or information having an aspect of data derived from, collected by, aggregated by, or otherwise associated with, an ingestion event.

Abstract: A method for pulmonary testing includes, while a patient inspires through the testing device, injecting a test gas at a selected flowrate toward an open end of the testing device. The method also includes measuring a flow rate of the inspired gas, which comprises the test gas. The method further includes measuring a concentration of a selected test gas component in the inspired gas.

Abstract: A sensor assembly (256) for detecting at least one analyte in a body fluid and a method of assembly a sensor assembly (256) for detecting at least one analyte in a body fluid are disclosed. The sensor assembly (256) comprises: at least one body mount (212) configured for attachment to a body of a user; at least one electronics unit (186) attachable to the body mount (212), having at least one electronics component (208) for one or more of controlling the detection of the analyte or transmitting measurement data to another component; wherein the body mount (212) includes a locking mechanism (216) having at least one lever (218) pivotably mounted to the body mount (212), the lever (218) being configured to lock the electronics unit (186) to the body mount (212).

Abstract: In respiratory monitoring, a breathing cycle detector (44) detects a breath interval in airway pressure and/or flow data. A respiratory parameters estimator and validator (30) asynchronously fits the airway pressure and airway flow data to an equation of motion of the lungs relating airway pressure and airway flow to generate asynchronously estimated respiratory parameters for the breath interval, using a sliding time window that is not synchronized with the breath interval. The asynchronously estimated respiratory parameters for the breath interval are validated using at least one physiological plausibility criterion defined with respect to the breath interval. Responsive to failure of the validation, the airway pressure and airway flow data are synchronously fitted to the equation of motion of the lungs to generate synchronously estimated respiratory parameters for the breath interval. The synchronous fitting is performed in a time window aligned with the breath interval.

Abstract: A method and system is provided for pre-processing of an electroencephalography (EEG) signal for cognitive load measurement. The present application provides a method and system for pre-processing of electroencephalography signal for cognitive load measurement of a user, comprises of capturing the electroencephalography signal from the head of the user, detecting the plurality of system artifacts in the captured electroencephalography signal, detecting and removing noisy window from the captured electroencephalography signal, detecting an eye blink region and filtering out said detected eye blink region from the captured electroencephalography signal, utilizing the filtered electroencephalography signal for measuring the cognitive load of the user and subsequently computing different levels of mental workloads on the user using variation of spatial distribution of frontal scalp EEG electrodes for measured cognitive load.

Abstract: Methods and devices include automated coaching for management of glucose states by receiving a user's glucose levels using a continuous glucose monitoring (CGM) device, determining a time in range (TIR) value, determining a TIR state, receiving a glucose variability (GV) value, determining a GV state, determining a starting state based on the TIR state and the GV state, determining that the starting state corresponds to a non-ideal state, generating an optimized pathway to reach an ideal state based on one or more account vectors such as addressing self-management behavior including food, activity, and medication use. The optimized pathway may further be based on computer detection and classification of significant events of interest over time.

Abstract: There are provided systems and methods for performing mean arterial pressure (MAP) derived prediction of future hypotension. Such a system includes a hardware unit including a hardware processor and a system memory, a hypotension prediction software code stored in the system memory, and a sensory alarm. The hardware processor is configured to execute the hypotension prediction software code to receive MAP data of the living subject, and to transform the MAP data to one or more parameters predictive of a future hypotension event of the living subject. The hardware processor is further configured to execute the hypotension prediction software code to determine a risk score of the living subject corresponding to the probability of the future hypotension event based on at least some of the one or more parameters, and to invoke the sensory alarm if the risk score of the living subject satisfies a predetermined risk criteria.

Abstract: Disclosed herein are systems and methods for non-invasively monitoring blood glucose levels with a level of accuracy that is high enough to replace invasive methods such as finger prick devices and others. In some examples, glucose values are determined using a patient's electrocardiogram (ECG) signals. Additionally, glucose values may additionally be determined using an impedance spectroscopy based method and then combined with glucose values determined using an ECG waveform to output a blood glucose value.

Abstract: Systems and methods for measuring electrophysiological and electrochemical signals in a portion of a body of a subject are provided. The structure includes an array of electrochemical sensors made of miniaturized multi-layer graphene, an array of electrophysiological electrodes, an integrated front-end readout circuit, and narrow silicon shafts with metal spines. The sensor arrays offer significantly higher sensitivity than conventional methods and enable simultaneous, multi-site measurement of chemical and electrophysiological. The front-end circuit contains features that allow significant improvement in detection of the resulting electrochemical current produced by the electrochemical sensing electrodes. The silicone probes allow measurements deep in the body.

Abstract: There are provided systems and methods for performing mean arterial pressure (MAP) derived prediction of future hypotension. Such a system includes a hardware unit including a hardware processor and a system memory, a hypotension prediction software code stored in the system memory, and a sensory alarm. The hardware processor is configured to execute the hypotension prediction software code to receive MAP data of the living subject, and to transform the MAP data to one or more parameters predictive of a future hypotension event of the living subject. The hardware processor is further configured to execute the hypotension prediction software code to determine a risk score of the living subject corresponding to the probability of the future hypotension event based on at least some of the one or more parameters, and to invoke the sensory alarm if the risk score of the living subject satisfies a predetermined risk criteria.

Abstract: This relates to systems and methods for determining one or more physiological signals of a user using ambient light. The systems and methods can include one or more light sensors configured to measure light that has interacted with a user and one or more light sensors configured to measure ambient light. The gain of the one or more light sensors can be adjusted based on the levels of measured ambient light. For example, the gain of the one or more light sensors can be increased when ambient light levels are low (e.g., a low light environment), or the gain of the one or more light sensors can be decreased when ambient light levels are high (e.g., a bright light environment). In some examples, the systems can include a variable opacity element whose transmission properties (e.g., opacity and/or selected one or more wavelengths to pass through) can be varied.

Abstract: Systems, devices and methods are provided for inserting at least a portion of an in vivo analyte sensor, such as a dermal sensor, for sensing an analyte level in a bodily fluid of a subject. An applicator is positioned against a skin surface and a force is applied to the applicator causing at least a portion of a sharp and an in vivo analyte sensor to be positioned in the body of the subject. In particular, disclosed herein are embodiments of applicators designed to prevent premature sharp withdrawal and/or reduce the likelihood of improper sensor insertion. Also disclosed are embodiments of applicators including sharp modules having an angled sharp which can be configured to create an insertion path for a sensor.

Abstract: Described herein is an apparatus to detect fetal acidosis during labor. This apparatus, which is noninvasive to the fetus, has a pH sensor and at least one fetal tissue detector. When the apparatus is inserted into the vaginal canal of a patient during labor, the pH reading determined by the pH sensor correlates to the pH of the fetus's blood. The fetal tissue detector may be a pulse oximeter, which may allow for a user to obtain the pulse rate reading of a surface contacted by the pH sensor. This pulse rate reading may be compared to an external reading of a pulse rate of the patient to confirm whether the pH sensor is contacting the fetus. During travel through the vaginal canal, the pH sensor may be protected by a protective sheath with an area of weakness to allow exposure of the pH sensor when the fetus is reached.