Abstract: A photoacoustic medical imaging device may include a substrate, an array of ultrasonic transducers on the substrate, at least one groove etched on the substrate, at least one optical fiber, and at least one facet. Each optical fiber is disposed in one of the grooves. Each facet is etched in one of the grooves and coated with a layer of metal having high infrared reflectivity. Each optical fiber is configured to guide infrared light from a light source through the fiber and toward the respective facet. The facet is configured to reflect the infrared light toward a target.

Abstract: Described herein are systems and methods for efficient and accurate, automated detection of a region of interest interior to the ribcage from an in vivo mammalian image. It is found that efficient, automated identification of the region of interest interior to the ribcage can be achieved by the use of both a bone distance mask and a surface distance mask. The technique solves the problem of accurate and fast identification of the region of interest for a wide range of sizes and shapes of mammals, e.g., small mammals such as mice.

Abstract: When estimating an arterial input function or a patient under study, cross-calibration factors are generated by comparing nuclear scan data of a radioactive material (e.g., F18) and measuring a sample of the radioactive material in a gamma counter. The derived cross-calibration factors are applied to venous samples collected from the patient during a nuclear scan after infusion with a radioactive tracer, to convert gamma values counted by the gamma counter into concentration values. The concentration values are used to optimize an initial estimated input function, thereby generating an arterialized input function.

Abstract: A method for identifying a stimulation target is provided, which uses microelectrode recording and electrical impedance tomography techniques together in a composite probe. The composite probe includes at least a microelectrode recording sensor and a plurality of microelectrodes, so that after the composite probe is guided and implanted to a depth suitable for the stimulation target based on microelectrode recording signals, tissue structures surrounding the composite probe are delineated by using the plurality of microelectrodes, and the boundary of the stimulation target and the precise location of the composite probe within the stimulation target are determined. Accordingly, the present invention provides a quick and accurate direction for surgeons, eliminating the problem of not knowing the exact location of the implanted probe within the stimulation target as in the case during deep brain stimulation surgeries.

Abstract: An ultrasonic probe includes a substrate, a diaphragm, a thin-film piezoelectric element, a communication passage, and an air hole. The substrate has first and second cavities thereon. The diaphragm is configured at the first cavity. The thin-film piezoelectric element is configured to the diaphragms. The communicating passage is configured in the substrate and extending from the first cavity to the second cavity. The air hole extends between the communicating passage to an outside of the substrate.

Abstract: A method, a software program and a system for processing MRT data of the human brain of a patient, wherein three-dimensional MRT data resolved in voxels of the patient's brain and the brains of a normative database of a plurality of neurologically healthy human individuals are available. The MRT data of the patient's brain are segmented for each voxel into portions of grey substance, white substance and liquor by means of a classification algorithm, wherein for comparison with corresponding data of the normative database the data are normalized before, after or synchronously into a standardized stereotactic space whereby one or more normalized tissue maps result that contain the proportions determined by the classification algorithm, and the tissue map or tissue maps of the patient's brain is or are subjected to a voxel-wise statistical comparison with the correspondingly normalized and segmented data of the normative database.

Abstract: Apparatus and methods are described that include ultrasound imaging devices, which may operate in a transmissive ultrasound imaging modality, and which may be used to detect properties of interest of a subject such as index of refraction, density and/or speed of sound. Devices suitable for performing high intensity focused ultrasound (HIFU), as well as HIFU and ultrasound imaging, are also described.

Abstract: Apparatus and methods are described that include ultrasound imaging devices, which may operate in a transmissive ultrasound imaging modality, and which may be used to detect properties of interest of a subject such as index of refraction, density and/or speed of sound. Devices suitable for performing high intensity focused ultrasound (HIFU), as well as HIFU and ultrasound imaging, are also described.

Abstract: Cerebral blood flow data during cognitive task execution is measured using a functional near infrared spectroscopy method, then characteristic amount extraction is performed after performing primitive analysis on the measured cerebral blood flow data. Then, by using the extracted characteristic amounts and a pre-built model for employing in determination of cognitive impairment, automatic determination is made into clinical diagnostic groups of normal (NC), mild cognitive impairment (MCI) and Alzheimer's disease (AD). It is thereby possible to perform cognitive impairment determination that is suitable for mass early stage screening of elderly people.

Abstract: Systems and methods for performing robotic endoscopic surgical procedures, according to a surgical plan prepared on a preoperative set of three dimensional images. The system comprises a surgical robot whose coordinate system is related to that of fluoroscope images generated intraoperatively, by using a three dimensional target having radio-opaque markers, attached in a predetermined manner to the robot or to another element to which the robot is attached, such as the spinal bridge or an attachment clamp. The robot is mounted directly or indirectly on a bone of the patient, thereby nullifying movement of the bone, or a bone tracking system may be utilized. The coordinate system of the intraoperative fluoroscope images may be related to the preoperative images, by comparing anatomical features between both image sets. This system and method enables the endoscope to be directed by the robot along the exact planned path, as determined by the surgeon.

Abstract: A system and method for reducing anxiety of a patient during medical scanning in a medical scanner which may produce significant levels of acoustic noise. A processor or control unit receives a measure of variation in a parameter of the scanner noise during the medical scanning. The processor then generates outputs to audio and video playback units that present an audio-video scenery to the patient during the scanning in accordance with the measure of variation in the parameter of the scanner noise. An image object in the video imagery is linked to the audio signal, so as to distract the patient's attention away from the scanner noise. The audio-video scenery may be switched according to an estimated scanner noise level. An effective distraction of the patient is obtained with a limited audio signal level which is far lower than the scanner noise.

Abstract: A drive apparatus for an ultrasonic device includes a transmission circuit for outputting a first through n-th (where n is an integer 2 or greater) drive signal to first through n-th driving electrode line belonging to the ultrasonic device, as well as a control unit for controlling the transmission circuit. In a case where the phase difference between an i-th (where i is an integer 1?i?n?1) drive signal and an i+1-th drive signal is a first phase difference, the transmission circuit outputs the first through n-th drive signals at a greater voltage amplitude than a case where the phase difference between the i-th drive signal and the i+1-th drive signal is a second phase difference greater than the first phase difference.

Abstract: A system and method for focusing ultrasound into a target tissue is disclosed. The method calculates a pressure field for an array of transducer elements to generate an unaberrated pressure field matrix and causes the transducer elements to apply focused ultrasound to generate a respective aberrated pressure field at a focus location in a target tissue and surrounding volume. MR-ARFI images are acquired of the focus location and surrounding volume, a magnitude of the aberrated pressure field is measured that is generated by the applied focused ultrasound at respective focus locations in the target tissue and surrounding volume based on the MR-ARFI images, an aberration for the transducer elements is determined from the pressure field matrix and the MR-ARFI images of the focus location and the surrounding volume using a magnitude least-squares method, and a corrective phase/amplitude adjustment is applied to the transducer elements based on the determined aberrations.

Abstract: A sensor attachment for use with three dimensional ultrasound mapping devices is presented. According to the invention, one or more sensors are attached to specific locations on the body, such as the nipple and sternum, the inventive sensor attachments enabling accurate recording of target information, including location and size; the present invention especially helpful in subsequent and comparative examinations. A method of use is also presented.

Abstract: A side-fire ultrasonic probe includes an alignment feature that, when used to connect the probe with a needle guide for intra-cavity medical procedures, enables alignment of a needle in an imaging plane of an ultrasonic transducer. The alignment feature is configured such that alignment of the needle within the imaging plane is accomplished when a protective sheath is disposed between the alignment feature and the needle guide. This configuration can be used with high frequency ultrasonic arrays having frequency distributions centered at about 20 MHz, and for medical procedures, such as biopsying organs or other bodily intra-cavity structures, and delivering intra-cavity therapies.

Abstract: Methods for registering a three-dimensional model of a body volume to a real-time indication of a sensor position that involve analyzing scanned and sensed voxels and using parameters or thresholds to identify said voxels as being either tissue or intraluminal fluid. Those voxels identified as fluid are then used to construct a real-time sensed three-dimensional model of the lumen which is then compared to a similarly constructed, but previously scanned model to establish and update registration.

Abstract: A portable ultrasonic diagnostic apparatus has an ultrasonic probe, and a main body including a display unit provided on a front surface of the main body. An input device is provided at a rear surface of the main body to receive user command information from a user, which allows the user to operate the portable ultrasonic diagnostic apparatus with a hand that is gripping the portable ultrasonic diagnostic apparatus. The apparatus may be used by moving the ultrasonic probe in contact with a surface of an object, sending ultrasonic signals from the object surface, receiving reflected ultrasonic signals from the object, and converting the ultrasonic signals into electrical signals.

Abstract: Provided is a photoacoustic apparatus capable of recognizing light quantity unevenness, which occurs on a surface of an analyte, and decreasing image unevenness resulted from the light quantity unevenness. A photoacoustic apparatus includes a light source configured to irradiate an analyte with light; an optical system configured to guide the light from the light source to the analyte; a detecting unit including a receiving element configured to receive an acoustic wave generated in the analyte by the light; a signal processing unit configured to acquire information about the inside of the analyte from a detected signal acquired from the detecting unit; an optical absorber configured to absorb the light from the light source; and a calculation unit configured to calculate an irradiation intensity distribution of the light on the basis of a detected signal acquired when the receiving element receives the acoustic wave generated from the optical absorber.

Abstract: The present invention provides an ultrasound-mediated drug delivery method for administering a compound to a targeted tissue, and the method at least comprises the following steps: First, an ultrasound apparatus is provided. The compound is then administered to the targeted tissue. A sonication is performed by the ultrasound apparatus to a blood vessel of the targeted tissue after the administration of the compound, and the sonication is capable of enhancing the permeability of the blood vessel to allow the administration of the compound to the targeted tissue. An ultrasound-mediated drug delivery system is also disclosed here.

Abstract: Methods and systems for sensing properties of an object or entity utilize non-resistive contact sensors alone or in combination with other sensors. The sensor data is utilized for detecting and visualizing properties of one or more biological or non-biological objects or entities.