Patents Examined by Michael Shippen
  • Patent number: 6284929
    Abstract: The invention relates to compounds of the general formula in which R1 to R7 are, independently, H, methyl or ethyl, R8+R9 together form methylene (—CH2—) or a single bond, or R1+R2 together form —(CH2)n—, with n being 3 or 4, or R3+R5 or R5+R7 represent methylene or a single bond; and the presence of at least one cyclopropane ring in the molecule is compulsory and the side chain can be saturated or contains one double bond in position &agr;,&bgr; or &bgr;,&ggr;, a process for the manufacture of these compounds, compounds used to perform the process and the use of these compounds as an odorant or as an ingredient of an odorant composition.
    Type: Grant
    Filed: October 5, 2000
    Date of Patent: September 4, 2001
    Assignee: Givaudan Roure (International) SA
    Inventors: Jerzy A. Baigrowicz, Georg Frater
  • Patent number: 4943679
    Abstract: A process for the N-.omega.-trifluoroacetylation of a saturated aliphatic monocarboxylic .alpha.,.omega.-diamino acid. A saturated aliphatic monocarboxylic .alpha.,.omega.-diamino acid of the formula: ##STR1## wherein R represents a straight-chain or branched-chain C.sub.1 -C.sub.6 alkylene radical, is contacted with a C.sub.1 -C.sub.6 straight-chain or branched-chain alkyl trifluoroacetate.
    Type: Grant
    Filed: January 25, 1988
    Date of Patent: July 24, 1990
    Assignee: Rhone-Poulenc Chimie
    Inventors: Paul Aviron-Violet, Christian Gervals
  • Patent number: 4474980
    Abstract: There is described a process for the preparation of 2,2-dimethyl-cyclopropanecarboxylates carrying in position 3 a halosubstituted dienic substituent.Said compounds are intermediates for the synthesis of pyrethroid insecticides.
    Type: Grant
    Filed: November 29, 1982
    Date of Patent: October 2, 1984
    Assignee: Montedison S.p.A.
    Inventors: Enrico Bosone, Franco Gozzo
  • Patent number: 4349567
    Abstract: Cyclopropanecarboxylic acid esters of the formula ##STR1## wherein R.sub.1 is hydrogen, halogen, methyl, trifluoromethyl or methoxy, and X.sub.1 and X.sub.2 are each halogen.A process for producing the above compounds and their use in pest control, as well as .alpha.-haloethynyl-3-phenoxy-benzyl alcohols.
    Type: Grant
    Filed: August 4, 1980
    Date of Patent: September 14, 1982
    Assignee: Ciba-Geigy Corporation
    Inventors: Peter Ackermann, Jozef Drabek, Saleem Farooq, Laurenz Gsell, Odd Kristiansen, Rudolf Wehrli
  • Patent number: 4346234
    Abstract: Sodium salt of mercaptopropionylglycine of formula: ##STR1## This salt is prepared by reacting 2-mercaptopropionylglycine with sodium-2-ethylhexanoate.It is a very active protector of the hepatic cell and it can be also efficaciously used as a mucolytic agent by inhalation or in the form of suppositories.
    Type: Grant
    Filed: April 29, 1980
    Date of Patent: August 24, 1982
    Inventor: Pietro Gargani
  • Patent number: 4336266
    Abstract: The invention relates to vinylcyclopropanecarboxylic acid 3-phenoxy-.alpha.-vinylbenzyl esters of the formula ##STR1## wherein each of X.sub.1 and Y is fluorine, chlorine or bromine, processes for the manufacture of these compounds and their use in pest control.
    Type: Grant
    Filed: March 3, 1981
    Date of Patent: June 22, 1982
    Assignee: Ciba-Geigy Corporation
    Inventors: Jozef Drabek, Peter Ackermann, Saleem Farooq, Laurenz Gsell, Odd Kristiansen
  • Patent number: 4336402
    Abstract: A process for the preparation of N-alkyl-monosubstituted carbamic acid esters by reacting an unsubstituted carbamic acid ester and an aliphatic primary amine at a suitable pressure and reaction temperature in the presence of a monohydric aliphatic alcohol and preferably in the presence of a strongly basic tertiary amine as catalyst. Optionally an inert co-solvent in addition to the alcohol may be employed.
    Type: Grant
    Filed: July 30, 1980
    Date of Patent: June 22, 1982
    Assignee: Atlantic Richfield Company
    Inventors: Samuel J. Falcone, John J. McCoy
  • Patent number: 4335253
    Abstract: A process for the preparation of dihalovinyl compounds of the formula ##STR1## wherein each Hal is fluorine, chlorine or bromine, R.sup.1 is an optionally substituted hydrocarbyl group, R.sup.2 is a methyl group or a hydrogen atom, or R.sup.1 and R.sup.2 together with the carbon atom to which they are attached form cycloalkylidene group, which process comprises treating a trihalo compound of the formula ##STR2## wherein Hal, R.sup.1 and R.sup.2 have the above meanings and R.sup.3 is a hydrogen atom or ##STR3## in which M is an alkali atom, with PHal.sub.3.
    Type: Grant
    Filed: May 22, 1981
    Date of Patent: June 15, 1982
    Assignee: Shell Oil Company
    Inventor: Petrus A. Kramer
  • Patent number: 4330675
    Abstract: A compound of formula: ##STR1## wherein one of R.sup.1 and R.sup.2 represents a group of formula:W--(CF.sub.2).sub.m --where W represents an atom of hydrogen, fluorine or chlorine and m has the value one or two, and the other of R.sup.1 and R.sup.2 represents an atom of fluorine, chlorine or bromine, or a group of formula: ##STR2## where each of X, Y and Z independently represents an atom of hydrogen, fluorine or chlorine, and Q represents the hydroxy group, a lower alkoxy group containing up to six carbon atoms or the chlorine or bromine atom.
    Type: Grant
    Filed: July 24, 1979
    Date of Patent: May 18, 1982
    Assignee: Imperial Chemical Industries Limited
    Inventor: Roger K. Huff
  • Patent number: 4328241
    Abstract: Phenylguanidine derivatives are provided having the structure ##STR1## wherein R.sup.1 is lower alkyl, cycloalkylalkyl, or phenylalkyl; R.sup.2 is lower alkyl, phenyl or benzyl; and R.sup.3 is lower alkyl, cycloalkylalkyl, lower alkenylalkyl, dihalovinylalkyl, dihalobutadienyl or phenylalkyl; and n is 1 to 5. These compounds are useful as anthelmintic agents.
    Type: Grant
    Filed: July 20, 1981
    Date of Patent: May 4, 1982
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: Rudiger D. Haugwitz, Barbara V. Maurer
  • Patent number: 4328027
    Abstract: The di-triethylamine salt of N,N'-bis-carboethoxymethyl-N,N'-bis-phosphonomethylurea is disclosed herein, having utility in regulating the natural growth or development of plants.
    Type: Grant
    Filed: April 16, 1981
    Date of Patent: May 4, 1982
    Assignee: Stauffer Chemical Company
    Inventors: Lawrence L. Buren, George B. Large
  • Patent number: 4323704
    Abstract: Novel compounds of the formula ##STR1## wherein A is methylene, ethylene or ethylidene; R.sub.1 is --C.tbd.CH or --CH.dbd.CH.sub.2 ; R.sub.2 is hydrogen or COR wherein R is hydroxy, a straight or branched alkoxy group of from 1 to 8 carbon atoms, --NR.sub.4 R.sub.5 wherein each of R.sub.4 and R.sub.5 is hydrogen or a straight or branched lower alkyl group of from 1 to 4 carbon atoms or ##STR2## wherein R.sub.6 is hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl or p-hydroxybenzyl; R.sub.a is hydrogen, ##STR3## alkylcarbonyl wherein the alkyl moiety has from 1 to 4 carbon atoms and is straight or branched, alkoxycarbonyl wherein the alkoxy moiety has from 1 to 4 carbon atoms and is straight or branched or ##STR4## wherein R.sub.7 is selected from hydrogen, a straight or branched lower alkyl group of from 1 to 4 carbon atoms, benzyl and p-hydroxybenzyl; and R.sub.b has the same meaning as defined for R.sub.a except R.sub.b is not ##STR5## and R.sub.a and R.sub.
    Type: Grant
    Filed: January 16, 1981
    Date of Patent: April 6, 1982
    Assignee: Merrell Toraude et Compagnie
    Inventors: Brian W. Metcalf, Michel Jung, Charles Danzin
  • Patent number: 4321409
    Abstract: A process for producing a conjugated diene monoester by reacting a gaseous mixture comprising a conjugated diene, a carboxylic acid and oxygen as reactive components, in which the fraction of said conjugated diene is preferably 12-60 mole % and the fraction of oxygen is preferably 5-30 mole %, in the gas phase in the presence of a catalyst, characterized by carrying out the reaction in the presence of a catalyst which comprises, as active components, (a) palladium, (b) at least one member selected from the group consisting of magnesium, calcium, barium, cerium, lanthanum, tungsten, copper, zinc, cadmium, boron, thallium, molybdenum, tin, lead, phosphorous, arsenic and selenium and (c) at least one alkali metal carboxylate, or a catalyst which comprises, as active components, these three components (a), (b) and (c) together with (d) at least one alkali metal halide.
    Type: Grant
    Filed: December 14, 1979
    Date of Patent: March 23, 1982
    Assignee: Japan Synthetic Rubber Co., Ltd.
    Inventors: Yoshinori Yoshida, Hironobu Shinohara
  • Patent number: 4320142
    Abstract: Compounds of formula (I) are pesticides active against arthropods. ##STR1## wherein R.sup.1, R.sup.2, and R.sup.3 are H, alkyl, alkoxy, halo, CN or CF.sub.3 or two are linked to form a 3 or 4 carbon atom group;X is O or NA where A is H or alkyl;R is H or alkyl;R.sup.4 is H or optionally substituted alkyl, aryl, aralkyl, alkenyl or alkynyl; andR.sup.5 is --CB. R.sup.6 where B is O, S or NR.sup.7 where R.sup.7 is H, alkyl, alkoxy, or optionally substituted aryl or aralkyl;R.sup.6 is H, R.sup.8, OR.sup.8, SR.sup.8 or NR.sup.9 R.sup.10 where R.sup.8 is alkyl, alkenyl or optionally substituted aryl, aralkyl or aryloxyalkyl; and R.sup.9 and R.sup.10 are H, alkyl or optionally substituted aryl or aralkyl;The invention also comprises processes for the preparation of compounds (I), formulations containing them, and their use as pesticides.
    Type: Grant
    Filed: May 15, 1980
    Date of Patent: March 16, 1982
    Inventors: Malcolm H. Black, Alexander D. Frenkel, Peter T. Roberts
  • Patent number: 4317919
    Abstract: In the oxidation of a substituted aromatic compound such as p-xylene using a heavy metal catalyst promoted by bromine the effluent gases from the oxidation contain methyl bromide and are treated for the recovery of bromine. A variety of methods are described whereby the bromine may be recovered, preferably in a form suitable for reuse in the oxidation process.
    Type: Grant
    Filed: December 19, 1979
    Date of Patent: March 2, 1982
    Assignee: Imperial Chemical Industries Limited
    Inventors: Peter J. Jones, David J. Royall
  • Patent number: 4312989
    Abstract: The use of amine boranes to inhibit the inflammation process is disclosed. These boranes, which are boron analogs of .alpha.-amino acids, effectively block the following: general inflammation, induced arthritis, and the writhing reflex associated with inflammation pain. The inflammation associated with pleurisy is also inhibited. The boron analogs are shown in vitro to inhibit the release of lysosomal enzymes from liver and polymorphonuclear neutrophils (PMNs). Further, prostaglandin synthesis is blocked by these compounds at a low concentration, viz, 10.sup.-6 M.Liver oxidative phosphorylation processes are also uncoupled by these compounds, but PMN migration is unaltered at 10.sup.-4 M. The elevation of cyclic adenosine monophosphate in PMNs correlates positively with in vivo antiarthritic activity. Studies in rodents demonstrate that these boron analogs may be used at safe therapeutic doses. Several compounds per se are included within the scope of the invention.
    Type: Grant
    Filed: August 21, 1979
    Date of Patent: January 26, 1982
    Assignee: The United States of America as represented by the Secretary of the Army
    Inventors: Bernard F. Spielvogel, Andrew T. McPhail, Iris H. Hall
  • Patent number: 4307243
    Abstract: Conversion of esters (R.sup.1)(R.sup.2)C(C Hal.sub.3)OX, X being-P Hal.sub.2, --C(O)OR.sup.3 or ##STR1## R.sup.1, R.sup.3 and R.sup.4 being optionally substituted hydrocarbyl groups and R.sup.2 methyl or hydrogen, with zinc in acetic acid gives a very high yield of a dihalovinyl compound (R.sup.1)(R.sup.2)C.dbd.C Hal.sub.2, e.g., of the ethyl ester of the parent acid of pyrethroid insecticides.
    Type: Grant
    Filed: March 25, 1980
    Date of Patent: December 22, 1981
    Assignee: Shell Oil Company
    Inventors: Petrus A. Kramer, Pieter A. Verbrugge
  • Patent number: 4307244
    Abstract: Novel penten-2-yl derivatives of the formula in the trans form ##STR1## wherein R is selected from the group consisting of hydrogen and acetyl and to a novel process for the preparation of methyl 2,2-dimethyl-3-(2'-methyl-propenyl)-cyclopropane-1,1-dicarboxylate which is an intermediate for chrysanthemic acid.
    Type: Grant
    Filed: August 11, 1980
    Date of Patent: December 22, 1981
    Assignee: Roussel Uclaf
    Inventors: Jacqueline Ficini, Jean-Pierre Genet
  • Patent number: 4307246
    Abstract: From a mixture of isoleucine and leucine in a ratio by weight of at least 3:7, the isoleucine is precipitated in an anhydrous solvent, particularly methyl ethyl ketone, using concentrated sulphuric acid. The precipitate is separated and freed from sulphuric acid, for example by neutralisation with barium hydroxide after elimination of the solvent. Industrial production of marketable isoleucine from a mixture still containing leucine.
    Type: Grant
    Filed: August 29, 1980
    Date of Patent: December 22, 1981
    Assignee: Societe D'Assistance Technique pour Produits Nestle S.A.
    Inventors: Raymond Bertholet, Pierre Hirsbrunner
  • Patent number: 4305958
    Abstract: This invention relates to the compounds: N-(mercaptoacy)-cysteine represented by the following formula wherein Z is selected from the group consisting of CH.sub.3 --CH<, (CH.sub.3).sub.2 C<, (CH.sub.2).sub.2 < and CH.sub.2 <, acting as agents for the liquefaction of sputum, intermediate therefor and a process for manufacture thereof.
    Type: Grant
    Filed: February 24, 1977
    Date of Patent: December 15, 1981
    Assignee: Santen Pharmaceutical Co., Ltd.
    Inventors: Tadashi Fujita, Masayuki Oya, Hideo Takashina, Tadashi Iso