Abstract: A tissue factor (TF)-targeted antibody-drug conjugate (ADC) and a method for preparing the ADC. The ADC is capable of binding to TF antigen with high specificity, and has high affinity, low immunogenicity, high cytotoxicity, and significant anti-tumor activity.
Type:
Grant
Filed:
October 27, 2022
Date of Patent:
May 6, 2025
Assignees:
FUDAN UNIVERSITY, SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES, SHANGHAI MIRACOGEN INC.
Inventors:
Ke Yu, Jingkang Shen, Tao Meng, Lanping Ma, Xuesai Zhang, Qingrou Li, Qing Lin
Abstract: Anti-RSV antibodies with neutralizing potency against RSV subtype A and RSV subtype B are provided, as well as methods for their identification, isolation, generation, and methods for their preparation and use are provided.
Abstract: Antibodies that bind the apple 3 domain of human coagulation Factor XI and inhibit activation of FXI by coagulation factor XIIa as well as activation of FIX by FXIa are described.
Type:
Grant
Filed:
April 18, 2023
Date of Patent:
April 15, 2025
Assignees:
Merck Sharp & Dohme LLC, Adimab, LLC
Inventors:
Zhu Chen, Kenneth Ellsworth, James Milligan, Elizabeth Oldham, Dietmar Seiffert, Bianka Prinz, Vaishnavi Ganti, Mohammad Tabrizifard
Abstract: The invention relates to a high purity Coagulation Factor Xa (FXa or activated Coagulation Factor X) preparation and an activation and purification process to obtain said FXa of high purity and high degree of activation without addition of proteinaceous activators during manufacturing.
Type:
Grant
Filed:
July 8, 2019
Date of Patent:
April 15, 2025
Assignee:
OCTAPHARMA AG
Inventors:
Juergen Roland Roemisch, Katharina Pock, Petra Schulz, Silvio Wuschko, Michael Andesner, Andrej Muranyi
Abstract: Provided herein are compositions and methods relating to improved assays for establishing Alzheimer's disease. Further provided herein are compositions and methods comprising improved antibodies for assays including immunoassays.
Abstract: The present invention is based on the finding that administration of polypeptides comprising at least one immunoglobulin single variable domains against vWF to human TTP patients provides a significant decrease in the time to response. The invention provides a polypeptide comprising at least one immunoglobulin single variable domain (ISVD) against von Willebrand Factor (vWF) for use in treating a vWF-related disease in a human in need thereof. The invention further relates to dosage unit forms, kits and medical uses for treating TTP.
Abstract: Described herein are novel and improved antibodies that bind human fibrin or fibrinogen ?C domain and methods of use thereof. In certain aspects, described herein are methods of inhibiting microglial activation. In certain aspects, described herein are pharmaceutical compositions comprising the antibodies that bind fibrin or fibrinogen ?C domain. In certain aspects, the antibodies and methods described herein are used for treatment of degenerative neuronal disorders that involve inflammatory demyelination.
Type:
Grant
Filed:
March 11, 2024
Date of Patent:
April 8, 2025
Assignee:
Therini Bio, Inc.
Inventors:
Jeffrey Stavenhagen, Olga Gasiorowska, Mathias Rickert, Paul Fredrick Widboom, Joseph Robert Warfield
Abstract: Provided herein are modified immunoglobulins comprising an amyloid reactive peptide joined to an antibody, as well as humanized antibodies that bind to human amyloid fibrils and antibody-peptide fusion proteins. Also provided herein are methods of treating amyloid-based diseases by administering a modified immunoglobulin, humanized antibody, or antibody-peptide fusion protein.
Type:
Grant
Filed:
May 9, 2024
Date of Patent:
April 1, 2025
Assignees:
Attralus, Inc, University of Tennessee Research Foundation
Inventors:
Jonathan S. Wall, James S. Foster, Spencer Guthrie
Abstract: Provided are methods for assessing T cell receptor ? chain complementary determining region 3 (TCR? CDR3) sequences. In certain embodiments, the methods comprise assessing TCR? CDR3 sequences determined from a sample obtained from a subject having or suspected of having a tick bite for the presence or absence of one or more TCR? CDR3 sequences set forth in the present disclosure. According to some embodiments, at the time of the assessing, the subject is seronegative for Lyme disease and/or has one or more non-specific symptoms consistent with Lyme disease. Also provided are methods comprising administering a Lyme disease therapy to a subject identified as comprising T cells that express a T cell receptor ? chain (TCR?) comprising a TCR? CDR3 sequence set forth in the present disclosure.
Type:
Grant
Filed:
July 31, 2020
Date of Patent:
April 1, 2025
Assignee:
Adaptive Biotechnologies Corporation
Inventors:
Harlan S. Robins, Thomas M. Snyder, Mark Klinger, Jonathan M. Carlson, Julia Greissl
Abstract: The present disclosure is generally directed to compositions that include antibodies, e.g., monoclonal, antibodies, antibody fragments, etc., that specifically bind a SIRPA polypeptide, e.g., a mammalian SIRPA or human SIRPA, and use of such compositions in preventing, reducing risk, or treating an individual in need thereof.
Type:
Grant
Filed:
April 5, 2024
Date of Patent:
March 25, 2025
Inventors:
Andrew Pincetic, Wei-Hsien Ho, Patricia Culp, Arnon Rosenthal
Abstract: The present disclosure provides methods inducing immune tolerance in a human, comprising administering to the human an effective amount of a composition or a chimeric protein comprising a clotting factor and an Fc region.
Type:
Grant
Filed:
December 1, 2017
Date of Patent:
March 25, 2025
Assignees:
BIOVERATIV THERAPEUTICS INC., SWEDISH ORPHAN BIOVITRUM AB
Inventors:
Jennifer Dumont, Nisha Jain, Stefan Lethagen
Abstract: Multispecific proteins that bind and specifically redirect NK cells to lyse a target cell of interest are provided without non-specific activation of NK cells in absence of target cells. The proteins have utility in the treatment of disease, notably cancer or infectious disease.
Type:
Grant
Filed:
October 29, 2018
Date of Patent:
March 18, 2025
Assignee:
INNATE PHARMA
Inventors:
Laurent Gauthier, Nadia Anceriz, Ariane Morel, Benjamin Rossi
Abstract: The present invention relates to methods and agents for preventing the establishment of HIV-1 latent reservoirs or for reducing the size of the reservoirs. Specifically, the disclosure provides methods and agents for preventing the establishment of HIV-1 latent reservoirs or for reducing the size of the reservoirs, the methods comprising administering to the subject a therapeutically effective amount of an isolated anti-HIV antibody, and administering to the subject two or more viral transcription inducers in effective amounts to induce transcription of an HIV provirus in the cells. Further provided are antibodies and viral transcription inducers used in the methods.
Type:
Grant
Filed:
May 28, 2020
Date of Patent:
February 25, 2025
Assignee:
The Rockefeller University
Inventors:
Michel Nussenzweig, Ariel Halper-Stromberg, Ching-Lan Lu
Abstract: The disclosure provides engineered polypeptides that specifically bind to human complement component C5 and/or serum albumin. The disclosure also provides fusion proteins comprising such engineered polypeptides, wherein such fusion proteins may be multivalent and multi-specific fusion proteins. The disclosure further provides nucleic acid molecules that encode such engineered polypeptides or fusion proteins, and methods of making such engineered polypeptides or fusion proteins. The disclosure further provides pharmaceutical compositions that comprise such engineered polypeptides or fusion proteins, and methods of treatment using such engineered polypeptides or fusion proteins.
Type:
Grant
Filed:
October 7, 2022
Date of Patent:
February 11, 2025
Assignee:
Alexion Pharmaceuticals, Inc.
Inventors:
Bridget Puffer, Julian Chandler, Nimish Gera, Douglas L. Sheridan, Siddharth Jindal, Paul P. Tamburini
Abstract: Materials and methods for identifying and using MHC molecule variants for activating self-reactive T cells in a peptide-specific manner, and their use to focus autoimmune cellular responses against diseases such as cancers and persisting viral infections, are described.
Type:
Grant
Filed:
September 1, 2020
Date of Patent:
February 11, 2025
Assignee:
Mayo Foundation for Medical Education and Research
Abstract: Described herein are compositions and methods for signaling and antigen-presenting bifunctional receptors (SABRs) comprising one or more antigen presenting domains; and one or more signal transduction domains, wherein the one or more antigen presenting domains comprise a binding fragment of a major histocompatibility complex (MHC) molecule. Various immunological functions of the SABRs are also described.
Type:
Grant
Filed:
September 5, 2018
Date of Patent:
February 11, 2025
Assignee:
California Institute of Technology
Inventors:
Alok V Joglekar, Michael T Leonard, Michael T Bethune, David Baltimore
Abstract: Provided herein are antibodies that specifically bind to human tissue factor (TF), anti-TF antibody-drug conjugates (ADCs), and compositions comprising the antibodies or ADCs. Also provided herein are methods of making and using the antibodies or ADCs, such as therapeutic and diagnostic methods.
Type:
Grant
Filed:
July 29, 2022
Date of Patent:
February 4, 2025
Assignee:
ICONIC THERAPEUTICS LLC
Inventors:
Jan-Willem Theunissen, Andrew D. Avery, Allen G. Cai, Anthony Byron Cooper, Thi-Sau Migone
Abstract: Cord blood or peripheral blood NK cells are prepared from whole blood mononuclear cells without the need to isolate CD34+ hematopoietic stem cells or NK cells, and without the need for a feeder layer. Advantageously, the methods presented herein use an enrichment process that uses antiCD16 agonist antibodies, antiCD3 antibodies, and N-803. Moreover, contemplated processes are suitable for adaptation into a fully automated production process (GMP in a box).
Type:
Grant
Filed:
February 20, 2020
Date of Patent:
February 4, 2025
Assignee:
ImmunityBio, Inc.
Inventors:
Rohit Duggal, Ranjeet Sinha, Wenzhao Li, Jason Isaacson, Karl Marquez, Patrick Soon-Shiong