Patents Examined by Michael T. Rozanski
  • Patent number: 11185597
    Abstract: In certain aspects, the invention relates to processes for using renally excretable optical agents to detect one or more tissues of the renal system of a surgical patient. In certain aspects, the invention relates to a kit including a biocompatible composition containing one or more optical agents and instructions for using the optical agent(s) in a process of the present invention.
    Type: Grant
    Filed: February 28, 2019
    Date of Patent: November 30, 2021
    Assignee: MediBeacon, Inc.
    Inventors: Richard B. Dorshow, Raghavan Rajagopalan, Dennis A. Moore, Scott T. Depierro
  • Patent number: 11116409
    Abstract: A device for detection of internal bleeding in a patient's body is provided. An optical interface for transmitting IR light through an area of a skin of a patient and to collect IR light from the area of the skin, is provided. In some embodiments the optical interface includes one or more delivery components and one or more collection components. The delivery component includes a plurality of first optical channels configured to transmit the IR light through a plurality of respective first sub-areas on the area of the skin, into an internal layer of the body. The collection component includes a plurality of second optical channels, configured to collect IR light from a plurality of respective second sub-areas on the area of the skin.
    Type: Grant
    Filed: May 1, 2019
    Date of Patent: September 14, 2021
    Inventors: Dean Nahman, Yaron Ilan, Ilan Ben Oren, Yaron Bar-Ilan, Shmuel Chen
  • Patent number: 11110052
    Abstract: Methods and devices for three-dimensional navigation of magnetic nanoparticles are provided. A method can comprise introducing high-anisotropy magnetic nanoparticles to a mammal and directing the high-anisotropy magnetic nanoparticles towards a target region of the mammal. Direction control is achieved by subjecting the high-anisotropy magnetic nanoparticles to an alternating signal comprising a uniform magnetic field pulse having a strength greater than a coercivity of the high-anisotropy magnetic nanoparticles and a magnetic gradient pulse having a highest strength that is less than the coercivity of the high-anisotropy magnetic nanoparticles and a location of a lowest strength at the target region of the mammal, and the direction of the uniform magnetic field pulse being in an opposite direction of the magnetic gradient pulse.
    Type: Grant
    Filed: May 21, 2019
    Date of Patent: September 7, 2021
    Inventors: Sakhrat Khizroev, Tiffanie Stewart, Abhignyan Nagesetti
  • Patent number: 11103156
    Abstract: An apparatus and method for determining bio-information of a target using an impulse radar are provided. The method may include generating a frame set by accumulating frames received at preset time intervals, determining a first magnitude spectrum of the frame set corresponding to a first frequency axis by performing a frequency conversion of frames included in the frame set in a sampler index axis direction, determining a second magnitude spectrum of the frame set corresponding to the first frequency axis and a second frequency axis by performing a frequency conversion of the first magnitude spectrum in a time axis direction, determining a third magnitude spectrum of the frame set by adding up values of the second magnitude spectrum for each second frequency, and determining a frequency indicating a peak in the third magnitude spectrum as a heartbeat frequency of the target.
    Type: Grant
    Filed: July 1, 2019
    Date of Patent: August 31, 2021
    Inventors: Hui Sup Cho, Young Jin Park
  • Patent number: 11089966
    Abstract: Devices and methods for non-invasive capillary blood pressure measurement are provided. An device can comprise a front end in contact with the body to compress and decompress the capillaries in the tissue, a pressure control module for regulating the contact pressure between the front end and the tissue, a pressure transducer coupled to the front end for measuring the contact pressure, a capillary sensing module for detecting the capillaries pulsations under the contact pressure modulation, and an algorithm for determining the capillaries pressures from the traces of capillary pulsation signals and the contact pressure signal. The methods include an oscillometric method for intermittent arterial and capillary blood pressure measurement and a volume-clamp method for continuous capillary blood pressure measurement.
    Type: Grant
    Filed: May 7, 2018
    Date of Patent: August 17, 2021
    Assignees: The Chinese University of Hong Kong, Massachusetts Institute of Technology
    Inventors: Ni Zhao, Jing Liu, Charles Sodini
  • Patent number: 11083836
    Abstract: A system for injecting fluid to a patient is provided. The system provides manual or automatic verification and identification of the fluid to be injected, prior to, during or after injection. The system includes: a fluid having at least one active compound and at least one tracer compound; an injector configured to deliver the fluid to the patient through a fluid path set; at least one sensor coupled to at least one of the syringe, the injector, or the patient, configured to measure at least one property of the tracer in the fluid, and a feedback path to adjust at least one injection parameter of the injector based on at least one measurement from the at least one sensor.
    Type: Grant
    Filed: November 25, 2014
    Date of Patent: August 10, 2021
    Inventor: Jacob Agris
  • Patent number: 11083438
    Abstract: First transmission information in which an optimum transmitting voltage and a transmitting waveform are associated with each other for each display mode, and second transmission information in which a plurality of transmitting voltage candidates and pulse-width modulation transmitting waveforms that are pulse-width-modulation controlled to respectively correspond to the plurality of transmitting voltage candidates are associated with each other for each display mode are used to extract a maximum transmitting voltage candidate that does not exceed an optimum transmitting voltage of a first display mode from a plurality of transmitting voltage candidates included in the second transmission information of a second display mode so as to determine a common transmitting voltage used in common for the first display mode and the second display mode based on the optimum transmitting voltage of the first display mode and/or the maximum transmitting voltage candidate.
    Type: Grant
    Filed: June 8, 2018
    Date of Patent: August 10, 2021
    Assignee: KONICA MINOLTA, INC.
    Inventors: Kazushi Ota, Akihiro Kawabata, Tomohito Sakai, Takashi Sakai
  • Patent number: 11071531
    Abstract: A system for performing a surgical procedure includes a bronchoscope, monitoring equipment coupled to the bronchoscope, a tracking system, a positioning assembly, and a biopsy tool. The biopsy tool includes an elongated flexible body extending from a proximal end to a distal end and a biopsy member formed on the distal end of the elongated flexible body. The biopsy member includes a tissue-receiving portion defining an opening including sharpened edges. The sharpened edges are disposed on the interior perimeter of the opening and are capable of cutting tissue. A biopsy tool is also provided.
    Type: Grant
    Filed: February 21, 2019
    Date of Patent: July 27, 2021
    Assignee: COVIDIEN LP
    Inventors: David M. Costello, Thomas P. Crowley, Thomas D. Magnuson
  • Patent number: 11074702
    Abstract: Methods for registering a three-dimensional model of a body volume to a real-time indication of a sensor position that involve analyzing scanned and sensed voxels and using parameters or thresholds to identify said voxels as being either tissue or intraluminal fluid. Those voxels identified as fluid are then used to construct a real-time sensed three-dimensional model of the lumen which is then compared to a similarly constructed, but previously scanned model to establish and update registration.
    Type: Grant
    Filed: October 2, 2018
    Date of Patent: July 27, 2021
    Assignee: COVIDIEN LP
    Inventor: Dorian Averbuch
  • Patent number: 11065645
    Abstract: A method for generating a mechanical wave, including generating a high amplitude mechanical pulse; coupling the mechanical pulse in a proximal end of a transmission member; propagating the mechanical pulse into the transmission member from the proximal end and a distal end thereof; and transmitting the mechanical pulse at the distal end.
    Type: Grant
    Filed: April 25, 2016
    Date of Patent: July 20, 2021
    Assignee: Les Solutions Medicales Soundbite Inc.
    Inventors: Martin Brouillette, Steven Dion, Louis-Philippe Riel
  • Patent number: 11064974
    Abstract: A patient interface system for scanning a volume of tissue protruding from a patient, the system comprising: a base including a planar portion configured to support the patient in a prone configuration, and a frustoconical portion extending from the planar portion and defining a base aperture configured to receive the volume of tissue; and a support assembly configured to couple to the base, including a frame and a membrane retained in tension within the frame at a peripheral portion of the membrane, wherein the membrane defines a membrane aperture configured to align with the base aperture, and wherein the membrane is configured to deflect into the frustoconical portion of the base in response to the patient's weight. The system can further include an electrical subsystem including a pressure sensor array configured to generate signals in response to a pressure distribution resulting from the patient's weight at the patient interface system.
    Type: Grant
    Filed: October 9, 2018
    Date of Patent: July 20, 2021
    Assignee: Delphinus Medical Technologies, Inc.
    Inventors: James Szpak, Nebojsa Duric, Peter Littrup, Roman Janer, Mike Tesic
  • Patent number: 11061093
    Abstract: A dynamic phantom for use with a functional magnetic resonance imaging (fMRI) device is described. In one example, the dynamic phantom includes an outer housing, an inner cylinder including a removable divider, and a gearbox that can rotate the cylinder, all of which are made from fMRI-compatible materials. The divider forms longitudinal compartments inside the cylinder that can each contain a contrast material. When the cylinder contains contrast materials having at least two different concentrations, and a space between the cylinder and the housing also contains a contrast material, rotation of the cylinder produces biomimetic hemodynamic signals that may be detected by the fMRI device.
    Type: Grant
    Filed: June 29, 2016
    Date of Patent: July 13, 2021
    Inventors: Lilianne Mujica-Parodi, Helmut Strey, Daniel Dedora
  • Patent number: 11039890
    Abstract: A system and method for tracking and determining characteristics of an inflatable medical instrument that is configured for interventional deployment. The system includes a guidewire that is positioned within a lumen of the inflatable medical instrument. The guidewire includes an optical fiber for a FORS system. The FORS system is configured to measure a shape of the guidewire during the interventional deployment of the inflatable medical instrument. A shape analysis module is configured to analyze the FORS data from the FORS system and determine characteristics of the inflatable medical instrument, including the diameter of the inflatable instrument, the pressurization of the instrument, whether the instrument has ruptured and the position of the inflatable instrument during an interventional procedure.
    Type: Grant
    Filed: June 8, 2016
    Date of Patent: June 22, 2021
    Inventors: Gregory Cole, Paul Thienphrapa, Molly Lara Flexman, David Paul Noonan, Neriman Nicoletta Kahya
  • Patent number: 11026706
    Abstract: Disclosed herein are ultrasound systems comprising a plurality of transducers configured to work in concert to produce a customizable beam profile through the additive effects of multiple pulses. As an example, uniform and wide beam profiles can be generated using transducer elements that cannot independently generate such beam profiles. Related methods, systems, and computer-readable media are all disclosed.
    Type: Grant
    Filed: November 20, 2017
    Date of Patent: June 8, 2021
    Assignees: University of Washington, SonoMotion Inc.
    Inventors: Adam D. Maxwell, Doug Corl
  • Patent number: 11026580
    Abstract: An OCT (Optical Coherence Tomography) handheld device is provided comprising: a housing configured for handheld OCT scanning during a surgical procedure, the housing comprising an OCT scanning end and a proximal end opposite the OCT scanning end; an OCT scanning device inside the housing, the OCT scanning device configured for one or more of OCT polarized scanning and Doppler OCT scanning from the OCT scanning end, the OCT scanning device further configured to receive and convey OCT light between the proximal end and an OCT analysing system; and a tip extending from the OCT scanning end, the tip being removably attached to the OCT scanning end, the tip configured to receive and collect the OCT light therethrough. The OCT handheld device is configured to be removably draped around the tip, for use in the surgical procedure.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: June 8, 2021
    Inventors: Siu Wai Jacky Mak, Ho Yiu Cheng, Fangxin Li, Harshul Varma
  • Patent number: 10993699
    Abstract: Techniques, systems, and devices are disclosed for ultrasound diagnostics using spread spectrum, coherent, frequency- and/or phase-coded waveforms.
    Type: Grant
    Filed: October 1, 2018
    Date of Patent: May 4, 2021
    Assignee: Decision Sciences International Corporation
    Inventor: Allan Wegner
  • Patent number: 10980421
    Abstract: An electromagnetic tomography system for gathering measurement data pertaining to a human head includes an image chamber unit, a control system, and a housing. The image chamber unit includes an antenna assembly defining a horizontally-oriented imaging chamber and including an array of antennas arranged around the imaging chamber. The antennas include at least some transmitting antennas and some receiving antennas. The control system causes the transmitting antennas to transmit a low power electromagnetic field that is received by the receiving antennas after passing through a patient's head in the imaging chamber. A data tensor is produced that may be inversed to reconstruct a 3D distribution of dielectric properties within the head and to create an image. The housing at least partially contains the antenna assembly and has a front entry opening into the imaging chamber. The head is inserted horizontally through the front entry opening and into the imaging chamber.
    Type: Grant
    Filed: March 27, 2018
    Date of Patent: April 20, 2021
    Assignee: EMTensor GmbH
    Inventor: Serguei Y. Semenov
  • Patent number: 10966693
    Abstract: A method of evaluating an image indicating a potential presence of a cancer lesion at a location within a prostate of a patient by transmitting light from an optical probe toward a location, receiving fluorescence spectra by the optical probe from the location, and generating a visual display of a diagnosis classification so as to confirm or contradict the existence of the cancer lesion at the location.
    Type: Grant
    Filed: July 9, 2018
    Date of Patent: April 6, 2021
    Inventors: Amir Tehrani, Edward A. Jasion
  • Patent number: 10945610
    Abstract: A fractionated photoacoustic flow cytometry (PAFC) system and methods for the in vivo detection of target objects in biofluidic systems (e.g., blood, lymph, urine, or cerebrospinal fluid) of a living organism is described. The fractionated system includes a fractionated laser system, a fractionated optical system, a fractionated acoustic system, and combinations thereof. The fractionated laser system includes at least one laser or laser array for pulsing a target object within the circulatory vessel with fractionated focused laser beams. The fractionated optical system separates one or several laser beams into multiple beams in a spatial configuration on the skin above the circulatory vessel of the living organism. The fractionated acoustic system includes multiple focused ultrasound transducers for receiving photoacoustic signals emitted by the target object in response to the fractionated laser beams.
    Type: Grant
    Filed: December 31, 2015
    Date of Patent: March 16, 2021
    Inventor: Vladimir Pavlovich Zharov
  • Patent number: 10945707
    Abstract: An ultrasonic transducer device includes a first substrate that is provided with a plurality of ultrasonic transducer elements arranged in a matrix, and a plurality of first wires via which the ultrasonic transducer elements are electrically connected to each other as a plurality of serial sets, and a second substrate that is provided to overlap the first substrate, and is provided with a plurality of second wires intersecting the first wires in a plan view from a thickness direction of the first substrate and third wires via which the first wires are electrically connected to the second wires.
    Type: Grant
    Filed: November 1, 2017
    Date of Patent: March 16, 2021
    Inventor: Jiro Tsuruno