Abstract: Vessel perfusion and myocardial blush are determined by analyzing fluorescence signals obtained in a static region-of-interest (ROI) in a collection of fluorescence images of myocardial tissue. The blush value is determined from the total intensity of the intensity values of image elements located within the smallest contiguous range of image intensity values containing a predefined fraction of a total measured image intensity of all image elements within the ROI. Vessel (arterial) peak intensity is determined from image elements located within the ROI that have the smallest contiguous range of highest measured image intensity values and contain a predefined fraction of a total measured image intensity of all image elements within the ROI. Cardiac function can be established by comparing the time differential between the time of peak intensity in a blood vessel and that in a region of neighboring myocardial tissue both pre and post procedure.

Abstract: A medical manipulator system that includes a joint, a first sensor that detects an amount of rotational motion of the joint, an actuator that drives the joint via a wire, a second sensor that detects an amount of operation of the actuator based on a rotation angle of the actuator, an input device, and a controller. The controller generates a control signal based on: an operation mode in which the control signal is generated by a transfer function that receives an input target value of the rotation angle of the joint and the amount of operation of the actuator, and a calibration mode in which the transfer function is adjusted based on comparing to a predetermined threshold value the amount of rotational motion of the joint and the amount of operation of the actuator. The controller then transmits the generated control signal to the actuator to drive the joint.

Abstract: A patient tracking device for insertion into an oral cavity includes a sensor housing comprising a first surface shaped to correspond to a pallet within the oral cavity. At least a portion of the first surface affixes the sensor housing to the oral cavity. An electromagnetic sensor is coupled to the sensor housing.

Abstract: A diagnostic imaging catheter is disclosed, which is capable of preventing a solution from an internal space of a hub from flowing into a portion communicating with the internal space of the hub and to which the signal lines such as the optical fiber and the electric signal cable are electrically or optically connected. The optical diagnostic catheter includes a rotatable drive shaft, an elongated sheath configured to be inserted into a biological lumen, a hub that includes a port connected to the sheath for supplying the solution, a connector portion that includes an optical connector accommodated in an internal space of the hub and optically connected to an external optical connector, a first seal portion that prevents the solution from the port from flowing into a first connection portion, and a second seal portion that prevents the solution from the port from flowing into a second connection portion.

Abstract: The devices and methods generally relate to vibratable sensors for measuring ambient fluid pressure, in particular implantable sensors. The devices and methods are suited to implantation within the body to monitor physiological conditions, such as portal and/or hepatic venous blood pressure, and allow frequent, remote interrogation of venous pressure. The sensor devices are relatively small compared to conventional devices for measuring fluid pressure and can be implanted in the portohepatic venous system, whereas conventional devices are too large. The small size of the device is accomplished by using a thick sensor membrane, compared to conventional devices, and by limiting the size of additional elements of the device relative to the size of the sensor membrane. The thicker sensor member also obviates the need for multiple sensor arrays and maintains the accuracy and robustness of the sensor device. A data capture, processing, and display system provides a pressure measurement reading.

Abstract: A medical instrument includes a printed ultrasound sensor, a surface, at least one non-conductive material, and at least one pair of contacts. The ultrasound sensor includes an array of ultrasound transducers printed on a non-conductive surface of the medical instrument. The medical instrument contains multiple conductive and nonconductive layers. The at least one pair of contacts are electrically coupled to the ultrasound sensor and operably coupled to the conductive layer, the conductive layer coupled to a measurement device, which converts electrical signals from the ultrasound sensor into images displayed on a display unit. The location of the medical instrument can be visualized in real time on the display unit.

Abstract: A non-invasive, transcutaneous, real-time viral detection device that is configured for self-administration, e.g., at a user's home. In one embodiment, and after positioning the device relative to the human body part (e.g., the user's finger), light sources in the device are activated (excited), and resulting data captured. In particular, a set of Raman spectra are collected from a configured set of emitters and detectors in the device and delivered to a nearby receiver, preferably wirelessly. The receiver filters and de-convolves the Raman spectra producing a data set representative of the constituent elements in the user's tissue of interest. The data set is applied against a statistical classifier, e.g., a neural network that has been trained to recognize and distinguish the absence or presence of viral components, e.g., C-19, or its associated blood-borne acute phase reactants.

Abstract: A method of navigating and positioning an endovascular device in a vasculature is disclosed. Initially, a system including an endovascular device and at least one transducer is inserted into the lumen of a patient. An acoustic signal is then transmitted within the lumen. A reflected signal is pre-processed to extract one or more acoustic features. The one or more acoustic features are processed using a computer readable set of rules to produce an output related to guidance of the instrument within a blood vessel or a position of the instrument within the blood vessel.

Abstract: A patient tracking device for insertion into a body cavity includes a flexible conformable sensor housing having a sensor cavity therein. The housing conforms to the body cavity when inserted therein. A sensor is disposed within the housing.

Abstract: To implement a single-chip ultrasonic imaging solution, on-chip signal processing may be employed in the receive signal path to reduce data bandwidth and a high-speed serial data module may be used to move data for all received channels off-chip as digital data stream. The digitization of received signals on-chip allows advanced digital signal processing to be performed on-chip, and thus permits the full integration of an entire ultrasonic imaging system on a single semiconductor substrate. Various novel waveform generation techniques, transducer configuration and biasing methodologies, etc., are likewise disclosed. HIFU methods may additionally or alternatively be employed as a component of the “ultrasound-on-a-chip” solution disclosed herein.

Abstract: For radial sampling in magnetic resonance imaging (MRI), a rescaling factor is determined from k-space data for each coil. The rescale factor is inversely proportional to the streak energy in the k-space data. The k-space data from the coils is rescaled for reconstruction, such as weighting the k-space data by the rescale factor in a data consistency term of iterative reconstruction. The rescale factor is additionally or alternatively used to determine a correction field for correction of intensity bias applied to intensities in the image-object space after reconstruction. These approaches may result in a diagnostically useful bias-corrected image with reduced streak artifact while benefiting from the efficient computation (i.e., computer operates to reconstruct more quickly).

Abstract: One or more launch fixture (650)s for optical shape sensing (OSS), the one launch fixture (650) or each launch fixture (650) being configured to receive and secure an optical fiber within a flexible OSS enabled instrument. A docking device (670) is provided for securing the launch fixture (650)(s) onto a launch fixture base (660). The docking device (670) may include one or more launch fixture (650) slots on one side of the docking device (670), or one or more launch fixture (650) slots on each of two opposing sides of the docking device (670).

Abstract: A surgical system includes a surgical tool, a tracking system configured to obtain tracking data indicative of positions of the surgical tool relative to an anatomical feature, an acoustic device, and a computer system programmed to control the acoustic device to provide acoustic feedback to a user based on the tracking data.

Abstract: A system of robotic surgery includes components capable of drilling a bore in the cranium of a patient in connection with craniotomy and other cranial surgeries. A perforator associated with such system is controlled by suitable computer-implemented instructions to maintain the perforator tip along a desired trajectory line while moving the perforator bit at locations proximal to such perforator tip in a circular motion, thereby imparting a conical oscillation to the perforator bit relative to the trajectory line. The angle at which the perforator bit is oscillated relative to such trajectory line results in the bore formed in the cranium having a diameter larger than the bit diameter, and the larger diameter and related conical oscillation is selected so as to reduce frictional force opposing withdrawal of the bit from the situs of the bore, thereby reducing the risk of jamming of the bit during its associated operations.

Abstract: A system and method perform a registration such as for a surgical navigation system by fitting a plurality of anatomical points as received to a digital model and developing a map having a corresponding confidence level indicating a degree of certainty. As additional anatomical points are received, they are continually matched to the digital model and the confidence level continually updated. The confidence level is output in any form, such as a score, a color code, or other metric. The output may include a graphical representation e.g. overlaid on an image from the digital model. The output may be a heat map overlaid on the image. The heat map may indicate an overall confidence level, and/or may indicate a plurality of confidence levels at various locations on the digital model. The overlay may provide an indication as to one or more suggested probe points to increase the level.

Abstract: A robotic acoustic probe for application with an interventional device (60). The robotic acoustic probe employs an acoustic probe (20) including a imaging platform (21) having a device insertion port (22) defining a device insertion port entry (23) and device insertion port exit (24), and further including an acoustic transducer array (25) are disposed relative the device insertion port exit (24). The robotic acoustic probe further employs a robotic instrument guide (40) including a base (41) mounted to the imaging platform (21) relative to the device insertion port entry (23), and an end-effector (45) coupled to the base (41) and transitionable between a plurality of poses relative to a remote-center-of-motion (49). The end-effector (45) defines an interventional device axis (48) extending through the device insertion port (22), and the remote-center-of-motion (49) is located on the interventional device axis (48) adjacent the device insertion port exit (24).

Abstract: Provided is an ultrasonic probe having a buffer structure capable of preventing internal components from being damaged by an external impact. The ultrasonic probe includes a transducer module transmitting and receiving an ultrasonic wave, a case which has an opened one side and is configured to accommodate the transducer module, a lens provided at the one side of the case, and a protective member accommodated in the case and positioned to face at least one surface of the transducer module, wherein the protective member protrudes further forward compared to the piezoelectric layer.

Abstract: A biopsy device is provided comprising a tubular member, a hollow shaft and an elongated fiber body. The hollow shaft may have a distal end and a shaft, wherein a laterally (sidewardly) facing notch is formed in the distal portion of the shaft. The elongated fiber body may include at least one optical fiber, preferably at least two optical fibers, with a distal end. The tubular member is movable relative to the shaft, between a first position in which the notch is covered by the tubular member, and a second position in which the notch is not covered by the tubular member. The fiber body is movable within the shaft, between a first position in which the distal end of the optical fiber is located at the distal end of the shaft with the elongated fiber body extending through the notch, and a second position in which the distal end of the at least one optical fiber is located proximally to the notch.

Abstract: A method of detecting subject respiratory motion and non-respiratory motion includes: transmitting a transmitted signal toward a subject, the transmitted signal being an ultrasound wave, the transmitted signal reflecting off the subject to produce a reflected signal; receiving the reflected signal and converting a form of the reflected signal from ultrasound wave to electrical; comparing the reflected signal to at least a first reference signal to determine at least a first reference phase signal indicative of a first phase difference between the first reference signal and the reflected signal, the at least a first reference signal being associated with the transmitted signal; and analyzing the first reference phase signal for respiratory motion of the subject and non-respiratory motion, the non-respiratory motion including at least one of non-respiratory motion of the subject or motion of an entity other than the subject.

Abstract: Arrangements described herein relate to systems, apparatuses, and methods for managing gel on a subject to provide gel on a first area of the subject, including controlling a transducer to move to a second area of the subject and controlling the transducer to move the gel to the first area from the second area.