Patents Examined by Mina Haghighatian
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Patent number: 12042559Abstract: The present disclosure is directed to floating gastroretentive dosage forms with prolonged gastric residence time. The disclosure also provides rapidly expanding sustained release or combined immediate release and sustained release formulations comprising drugs that require targeted release in the proximal gastrointestinal tract for maximum therapeutic benefit. The rapidly expanding floating gastroretentive dosage forms comprise a permeable elastic membrane providing desired characteristics for drug release and mechanical strength to maintain tablet integrity.Type: GrantFiled: August 8, 2023Date of Patent: July 23, 2024Inventors: Kanji Meghpara, Jaydeep Vagashiya, Navnit H. Shah, Dipen Desai, Wantanee Phuapradit, Harpreet Kaur Sandhu, Siva Ram Kiran Vaka, Namdev B. Shelke, Ashish Chatterji
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Patent number: 12029821Abstract: Vesicles, including exosomes, having a coating of a hydrophilic, neutral polymer such as PEG have an increased ability to form a suspension or colloid compared to uncoated vesicles. This enables the coated vesicles to be used to form aerosol droplets such that a liquid formulation containing vesicles can be used in a nebulizer for inhaled administration thereof. Such coated vesicles are also able to pass through mucus and can deliver their cargo into lung cells. Exosomes from mesenchymal stem cells can deliver additional proteins, miRs, mRNAs and other nucleic acid sequences to lung cells providing a regenerative gene therapy for CF, COPD lung cancer and other lung diseases.Type: GrantFiled: August 9, 2019Date of Patent: July 9, 2024Assignee: OMNISPIRANT LIMITEDInventor: Gerard Bernard McCauley
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Patent number: 12029709Abstract: The present disclosure relates to an inhalable formulation, suitable for use in a dry powder inhaler, for the delivery of epinephrine, or a pharmaceutically acceptable salt or derivative thereof. The inhalable formulation further comprises a solid carrier and results in a stable formulation with useful physical properties for delivery to the lungs of a subject in need of epinephrine.Type: GrantFiled: August 11, 2022Date of Patent: July 9, 2024Assignee: De Motu Cordis Pty LtdInventors: John Fraser, Sean Mark Dalziel, Teresa Iley, Jonathan Brazier, Patrick Joseph Lynch, John Fredatovich, Benjamin Barnaby Trout
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Patent number: 12029216Abstract: A plant growth regulator contains thiophene acetic acid. A method of regulating growth of plants includes preparing a plant growth regulator comprising thiophene acetic acid and applying the plant growth regulator. Shoot regeneration from tomato cotyledon explants in vitro is enhanced in the presence of the antibiotic timentin. Timentin degrades into thiophene acetic acid (TAA) over time. Thiophene acetic acid (TAA) performs particularly well as a plant growth regulator. TAA was surprisingly found to enhance root and shoot formation and growth in explants, and in particular in cotyledon explants. TAA is also advantageous in that it may be used to enhance growth in whole plants.Type: GrantFiled: August 28, 2023Date of Patent: July 9, 2024Assignee: United Arab Emirates UniversityInventors: Suja George, Khaled M. A. Amiri, Mohammed Rafi, Maitha Aldarmaki, Mohamed ElSiddig, Mariam Al Nuaimi
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Patent number: 12023309Abstract: Pharmaceutical compositions having enhanced active component permeation properties are described.Type: GrantFiled: June 8, 2022Date of Patent: July 2, 2024Assignee: AQUESTIVE THERAPEUTICS, INC.Inventors: Alexander Mark Schobel, Stephanie Marie Varjan, Stephen Paul Wargacki
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Patent number: 12016978Abstract: According to the invention there is provided inter alia a process for the manufacture of a solid object having a surface comprising a layered coating of cationic and anionic polymer wherein the outer coating layer comprises an anticoagulant entity, comprising the steps of: i) treating a surface of the solid object with a cationic polymer; ii) treating the surface with an anionic polymer; iii) optionally repeating steps i) and ii) one or more times; iv) treating the surface with a cationic polymer; and v) treating the outermost layer of cationic polymer with an anticoagulant entity, thereby to covalently attach the anticoagulant entity to the outermost layer of cationic polymer; wherein, the anionic polymer is characterized by having (a) a total molecular weight of 650 kDa-10,000 kDa; and (b) a solution charge density of >4 ?eq/g; and wherein, step ii) is carried out at a salt concentration of 0.25 M-5.0 M.Type: GrantFiled: July 22, 2022Date of Patent: June 25, 2024Assignee: CARMEDA ABInventors: Per Antoni, Malin Eriksson, Anna Gällhagen, Eva Koch, Daniel Nyström, Christian Porsch-Grahm, Helena Göransson
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Patent number: 12011515Abstract: The invention concerns a method of making a synthetic, biodegradable, bone graft comprising a three-dimensional porous structure; a formulation of constituents for use in said method; a synthetic, biodegradable bone graft produced by said method; and a method of surgery comprising use of said bone graft.Type: GrantFiled: March 21, 2019Date of Patent: June 18, 2024Assignee: 3D-BGS (UK) LIMITEDInventor: Zhidao Xia
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Patent number: 11993578Abstract: Embodiments provide a harmful organism control agent containing a pyrazole-3-carboxylic acid amide derivative or a salt thereof as an active ingredient, having an excellent harmful organism controlling effect. A pyrazole-3-carboxylic acid amide derivative represented by general formula [I]: (wherein, R1, R2, R3, R4, and R5 represent a hydrogen atom, halogen atom, C1-C6 alkyl group or the like, R6 represents a C1-C12 alkyl group, C1-C12 haloalkyl group or the like, R7 and R8 represent a hydrogen atom, C1-C12 alkyl group or the like) or an agriculturally acceptable salt thereof, and a harmful organism control agent containing the pyrazole-3-carboxylic acid amide derivative or an agriculturally acceptable salt thereof as an active ingredient.Type: GrantFiled: May 9, 2018Date of Patent: May 28, 2024Assignee: KUMIAI CHEMICAL INDUSTRY CO., LTD.Inventors: Akira Kinpara, Ryo Ishikawa, Keiji Toriyabe, Katsuya Kato, Masao Nakatani, Akira Takanezawa, Takeshi Matsuda
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Patent number: 11985972Abstract: Biocidal coatings include flake shaped particles that are deposed with a vertical orientation to form a coating which is biocidal to pathogens including viruses, bacteria, biofilms, fungi, microbes, algae, and other pathogens. In some embodiments, the pathogen membrane becomes lacerated when contacting the blade shaped flake particle. In other embodiments, a flake shaped particle which is a semiconductor generates radicals, or hydroxyls, or oxidizers, which transit to pathogens, and stress or deactivate the pathogens. In still more embodiments, this generation of radicals, hydroxyls, or oxidizers by the semiconductive flake shaped particle is increased with light irradiation.Type: GrantFiled: March 17, 2022Date of Patent: May 21, 2024Inventor: Allen Howard Engel
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Patent number: 11986491Abstract: The present invention provides pharmaceutical compositions comprising an iodine-containing compound and a steroid, useful for treating a clinical symptom in a patient's airway (e.g., nose, lung, and sinus), as well as methods for using the same.Type: GrantFiled: June 22, 2011Date of Patent: May 21, 2024Assignee: IVIEW THERAPEUTICS, INC.Inventors: Bo Liang, Belachew Tessema, Joseph A. Capriotti, Michael C. Samson, Wei Song
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Patent number: 11980188Abstract: The present invention relates to compounds of Formula (I), wherein R1, R2, R3, R4 and G are as defined herein. The invention further relates to herbicidal compositions which comprise a compound of Formula (I), to their use for controlling weeds, in particular in crops of useful plants.Type: GrantFiled: March 11, 2019Date of Patent: May 14, 2024Assignee: SYNGENTA PARTICIPATIONS AGInventors: Alan Joseph Hennessy, Elizabeth Pearl Jones, Shuji Hachisu, Nigel James Willetts, Suzanna Dale, Alexander William Gregory, Ian Thomas Tinmouth Houlsby, Yunas Bhonoah, Julia Comas-Barcelo
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Patent number: 11980689Abstract: Disclosed herein are formulations of imatinib or a phenylaminopyrimidine derivative compound for aerosolization and use of such formulations for inhaled aerosol administration of imatinib or a phenylaminopyrimidine derivative compound for the prevention or treatment of various fibrotic, carcinogenic, vascular and viral infectious diseases, including diseases associated with the lung, heart, kidney, liver, eye, central nervous system and surgical sites. In some embodiments, formulations and delivery options described herein allow for efficacious local delivery of imatinib or a phenylaminopyrimidine derivative compound or salt thereof. Compositions include all formulations, kits, and device combinations described herein. Methods include inhalation procedures, indications and manufacturing processes for production and use of the compositions described. Also included are methods for identifying compounds and indications that may benefit by reformulation and inhalation administration.Type: GrantFiled: September 22, 2020Date of Patent: May 14, 2024Assignee: AVALYN PHARMA INC.Inventor: Mark William Surber
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Patent number: 11976014Abstract: The invention relates to the technical field of agricultural planting, in particular to a controlled-release bacterial fertilizer for peanuts and a preparation method of the special controlled-release bacterial fertilizer. The special controlled-release bacterial fertilizer is composed of an inner layer and an outer layer; after the outer layer is released completely, the inner-layer network structure gradually absorbs water and preserves moisture, and has good slow release and controlled release properties, thereby achieving the gradual release of the inner layer, high fertilizer utilization rate, exerting the efficacy of the microbial agent and facilitating the large-area promotion.Type: GrantFiled: July 20, 2020Date of Patent: May 7, 2024Assignee: Biotechnology Research Center, Shandong Academy of Agricultural SciencesInventors: Jialei Zhang, Xinguo Li, Shubo Wan, Feng Guo, Jianguo Wang, Zheng Zhang, Gao Chen, Chaohui Tang, Sha Yang, Zhenying Peng, Jingjing Meng
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Patent number: 11963529Abstract: Methods and systems for enhancing production of adenosine triphosphate (ATP) in living organisms are provided. An example method includes generating structurally altered gas molecules from water. The structurally altered gas molecules have a higher probability of attraction of electrons into areas adjunct to the structurally altered gas molecules than molecules of the water. The method further includes infusing the structurally altered gas molecules into a living organism. Upon being infused, the structurally altered gas molecules cause an increase of production of the ATP in the living organism.Type: GrantFiled: October 4, 2023Date of Patent: April 23, 2024Assignees: H2Plus LLC, H2Plus Operations, LLCInventors: Gene Dedick, Jared Roberts
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Patent number: 11959065Abstract: Provided are bioactive compositions and metabolites derived from Bacillus and particularly Bacillus megaterium cultures responsible for controlling pests as well as their methods of use for controlling pests. Further provided are pesticidal Bacillus megaterium strains.Type: GrantFiled: June 9, 2022Date of Patent: April 16, 2024Assignee: PRO FARM GROUP, INC.Inventors: Ratnakar Asolkar, Ana Lucia Cordova-Kreylos, Margarita Rodriguez, Carly Todd, Debora Wilk, Pamela G. Marrone
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Patent number: 11957815Abstract: An artificial tissue construct for nerve repair and regeneration includes a biocompatible and biodegradable nerve guidance matrix comprising a plurality of biopolymers that include chitosan, gelatin, collagen and hyaluronic acid. A cross-linker includes glutaraldehyde. The nerve guidance matrix is formed as a three-dimensional scaffold polyelectrolyte complex (PEC). A subconfluent and grown monolayer of at least one of human mesenchymal stem cells, mesenchymal stem cells, differentiated Schwann cells and neuronal cells is on the biocompatible and biodegradable nerve guidance matrix for direct implantation or delivery. A method of making the artificial tissue construct is disclosed.Type: GrantFiled: November 12, 2020Date of Patent: April 16, 2024Assignee: DATT LIFE SCIENCES PRIVATE LIMITEDInventors: Rajan Datt, Siddharth Pandey, Poonam Meena, Mukesh Kumar, Nitin Khatri, Rakesh Kumar Nagar
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Patent number: 11951198Abstract: A method for strengthening and repairing keratin fibers including providing a caustic as well as an acidic crosslinking composition, wherein the caustic crosslinking composition comprises an at least bi-functional Brönsted-base and the acidic crosslinking composition comprises an at least bi-functional organic acid, and a cosmetically acceptable carrier; applying the caustic as well as the acidic crosslinking composition to keratin fibers; and optionally mixing the caustic crosslinking composition into a commercially available hair coloring or hair bleaching composition.Type: GrantFiled: February 11, 2020Date of Patent: April 9, 2024Assignee: LIW PATENT COMPANY LIMITED BY GUARANTEEInventor: Sabine Wagner
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Patent number: 11944655Abstract: The invention is directed to a microcapsule and the method to obtain it. The microcapsule comprises a core in the form of a lipid sphere coated by a protein film, wherein the lipid sphere comprises sporulated microorganisms and at least one lipid wall material, and the protein film is a mix of carbohydrate, protein material and water. The method to obtain this microcapsule includes the stages of mixing sphere components, mixing protein film components, homogenizing the protein film and the subsequent coating of the lipid sphere by means of fluidization with the protein film.Type: GrantFiled: September 30, 2020Date of Patent: April 2, 2024Assignee: Alpina Productos Alimenticios, S.A.Inventors: Bernadette Francisca Klotz Ceberio, Maria Ximena Quintanilla Carvajal
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Patent number: 11944640Abstract: The invention relates to pharmaceutical compositions comprising a zinc2+ salt and a ?-polyglutamic acid carrier, and, optionally, an NF-kB inhibitor as a tumor-sensitizing agent, and methods for using such compositions to treat tumors in patients. Methods include administering a liquid dosage form or a solid dosage form of a therapeutically effective amount of a Zn(II) salt and a ?-polyglutamic acid carrier to a patient in need thereof. Methods of treating a broad spectrum of human tumors, including tumors with a drug-resistant phenotype, using the disclosed compositions are provided. Tumors that respond to the pharmaceutical compositions disclosed herein include neuroendocrine (neuroblastoma), gastric, uterine, and lung tumors.Type: GrantFiled: October 31, 2017Date of Patent: April 2, 2024Assignee: XYLONIX PTE. LTD.Inventor: Jinhyuk Fred Chung
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Patent number: 11937602Abstract: Antimicrobial compositions including at least one acid and at least one anionic surfactant are provided. In particular, food contact antimicrobial compositions including at least one acid and at least one anionic surfactant provide efficacious virucidal activity, including against Norovirus, having acceptable use solution pH that do not require use of personal protective equipment (PPE), are surface compatible and do not leave residues on treated surfaces. Methods of cleaning a surface with the compositions are also provided and may beneficially eliminate the need to rinse the antimicrobial compositions after use.Type: GrantFiled: September 26, 2018Date of Patent: March 26, 2024Assignee: ECOLAB USA INC.Inventors: Wendy Lo, Derrick Anderson, Erik Olson, Catherine Hanson, Junzhong Li, David D. McSherry, Stacy Fawbush, Kaitlin Lake, Gerard Hinrichs, Joshua Luedtke, Richard Staub