Patents Examined by Mina Haghighatian
  • Patent number: 10342830
    Abstract: This document provides methods and materials for treating lung conditions induced by inhalable insulin therapy. For example, compositions including a dried amnion tissue preparation and/or a dried stem cell preparation as well as methods for using such compositions to treat inhalable insulin induced lung conditions are provided.
    Type: Grant
    Filed: December 30, 2015
    Date of Patent: July 9, 2019
    Inventor: Gary M. Petrucci
  • Patent number: 10342938
    Abstract: A pulmonary drug delivery system is disclosed, including a breath-powered, dry powder inhaler, and a cartridge for delivering a dry powder formulation. The inhaler and cartridge can be provided with a drug delivery formulation comprising, for example, a diketopiperazine and an active ingredient, including, peptides and proteins such as insulin and glucagon-like peptide 1 for the treatment of endocrine disease, for example, diabetes and/or obesity.
    Type: Grant
    Filed: June 14, 2016
    Date of Patent: July 9, 2019
    Assignee: MannKind Corporation
    Inventors: Chad C. Smutney, Benoit Adamo, John M. Polidoro, P. Spencer Kinsey, Dennis Overfield, Carl R. Sahi, Christine Billings, Mark T. Marino
  • Patent number: 10321681
    Abstract: A plant supporting formulation which is also suitable for use as a delivery vehicle, or a component of a delivery vehicle, for the delivery of one or more phytologically beneficial substances to a plant, and for enhancing the translocation of such delivered substance(s) in or on the plant, the formulation comprising a micro-emulsion constituted by a dispersion of vesicles or microsponges of a fatty acid based component in an aqueous carrier, the fatty acid based component comprising at least one long chain fatty acid based substance selected from the group consisting of free fatty acids and derivatives of free fatty acids. The dispersion is preferably characterized in that at least 50% of the vesicles or microsponges are of a diametrical size of between 50 nm and 5 micrometer. The dispersion is further also characterized in that the micro-emulsion has a zeta potential of between ?25 mV and ?60 mV.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: June 18, 2019
    Assignee: NORTH-WEST UNIVERSITY
    Inventor: Anne Frederica Grobler
  • Patent number: 10314839
    Abstract: The present invention provides a composition comprising an opioid agonist, and a polymer-antagonist conjugate. The polymer-antagonist conjugate preferably does not hydrolyze upon administration to a patient, and does not bind to the opioid receptors. The covalent bond between the polymer and the antagonist in the conjugate is broken over a defined period of time to release the antagonist into the formulation. The released antagonist attenuates the liking of the agonist, thereby eliminating the incentive to the diversion of the medicines.
    Type: Grant
    Filed: October 20, 2015
    Date of Patent: June 11, 2019
    Assignee: Elysium Therapeutics, Inc.
    Inventor: Thomas E. Jenkins
  • Patent number: 10299476
    Abstract: The invention relates to a novel class of (S)-3?-substituted-abscisic acid derivatives and (±)-3?-substituted-abscisic acid derivatives, and methods of synthesizing the derivatives.
    Type: Grant
    Filed: September 5, 2017
    Date of Patent: May 28, 2019
    Assignee: VALENT BIOSCIENCES LLC
    Inventors: Gary T. Wang, Daniel F. Heiman, Gregory D. Venburg, Eiki Nagano, Marci Surpin, Joseph H. Lustig
  • Patent number: 10301295
    Abstract: The present invention relates to a compound of formula (I) wherein: wherein R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11 and G are as defined herein; and wherein the compound of formula (I) is optionally present as an agrochemically acceptable salt thereof. These compounds are thought to be suitable for use as herbicides. The invention therefore also relates to a method of controlling weeds, especially grassy monocotyledonous weeds, in crops of useful plants, comprising applying a compound of formula (I), or a herbicidal composition comprising such a compound, to the plants or to the locus thereof.
    Type: Grant
    Filed: October 13, 2015
    Date of Patent: May 28, 2019
    Assignee: SYNGENTA PARTICIPATIONS AG
    Inventors: Shuji Hachisu, Alan Joseph Hennessy, Jeffrey Steven Wailes, Nigel James Willetts, Christopher John Mathews, Janice Black, Suzanna Jane Dale
  • Patent number: 10287615
    Abstract: The present invention relates to a process for selectively producing sophorolactone without use of organic solvent, comprising the steps of: —pre-cultivating cells of a Candida species capable of producing sophorolactone, in absence of an oily substrate until a stationary growth phase is obtained, —cultivating said pre-cultivated cells in an aqueous medium in the presence of at least one fermentable sugar and substrate; the reaction mixture of sugar, substrate and pre-cultivated cells being present in an amount and conditions such that the cells metabolize the sugar and substrate thereby forming sophorolactone and fatty acid, —continuously feeding said substrate to said cells thereby suppressing the formation of fatty acid and keeping fatty acid levels in the reaction mixture below 10 g/l, resulting in the crystallization of at least part of the sophorolactone present in the reaction mixture, —warming the reaction mixture to a temperature between 60° C. and 90° C.
    Type: Grant
    Filed: June 6, 2012
    Date of Patent: May 14, 2019
    Assignee: ECOVER CO-ORDINATION CENTER N.V.
    Inventors: Dirk Develter, Steve Fleurackers
  • Patent number: 10285915
    Abstract: A strip of material for the delivery of an oral care active is disclosed. The strip of material includes a structural elastic-like film backing layer including a strainable network having a first region and a second region formed of substantially the same material composition, the first region providing a first, elastic-like resistive force to an applied axial elongation, and the second region providing a second distinctive resistive force to further applied axial elongation, thereby providing at least two stages of resistive forces in use; and an oral care composition disposed on the film, the oral care composition including an oral care active.
    Type: Grant
    Filed: October 17, 2013
    Date of Patent: May 14, 2019
    Assignee: The Procter & Gamble Company
    Inventors: Paul Albert Sagel, Jean Jianqun Zhao, Lan Ngoc Nguyen
  • Patent number: 10285916
    Abstract: A strip of material for the delivery of an oral care active is disclosed. The strip of material includes a structural elastic-like film backing layer including a strainable network having a first region and a second region formed of substantially the same material composition, the first region providing a first, elastic-like resistive force to an applied axial elongation, and the second region providing a second distinctive resistive force to further applied axial elongation, thereby providing at least two stages of resistive forces in use; and an oral care composition disposed on the film, the oral care composition including an oral care active.
    Type: Grant
    Filed: October 26, 2015
    Date of Patent: May 14, 2019
    Assignee: The Procter & Gamble Company
    Inventors: Paul Albert Sagel, Jean Jianqun Zhao, Lan Ngoc Nguyen
  • Patent number: 10285404
    Abstract: Herbicidal concentrate compositions containing glyphosate salts and tank mix compositions containing a combination of glyphosate salt and dicamba salt herbicides are described. A method of preparing a tank mix composition comprising a glyphosate component and a dicamba component is also described. The method includes combining a glyphosate concentrate composition, a dicamba composition comprising one or more salts of dicamba and dilution water to form the tank mix composition. The glyphosate concentrate composition comprises a glyphosate salt selected from the group consisting of the monoethanolamine salt, the potassium salt, and mixtures thereof at a glyphosate loading of at least about 240 grams acid equivalent per liter (g a.e./l), and the pH of a 5 wt. % acid equivalent dilution of the glyphosate concentrate composition is from about 5 to about 6.5.
    Type: Grant
    Filed: February 27, 2014
    Date of Patent: May 14, 2019
    Assignee: Monsanto Technology LLC
    Inventors: John Hemminghaus, Alison MacInnes
  • Patent number: 10278395
    Abstract: This invention is directed to the preparation and applications of internally and/or externally functionalized environmentally benign nanoparticles (EbNPs), which are produced by a three step procedure: (1) synthesis of native EbNPs, (2) functionalization with active agents, and (3) additional surface property customization via one or more modifier(s).
    Type: Grant
    Filed: March 10, 2014
    Date of Patent: May 7, 2019
    Assignee: North Carolina State University
    Inventors: Orlin D. Velev, Alexander P. Richter
  • Patent number: 10265406
    Abstract: The present application relates to a pharmaceutical composition comprising biocompatible nanoparticles or nanoparticles aggregates which allows the appropriate delivery of said biocompatible nanoparticles or nanoparticles aggregates to a target site in a subject in need thereof. The composition indeed allows an accumulation of the biocompatible nanoparticles or nanoparticles aggregates it comprises into the targeted tissue of the subject of at least 4 milligram (mg) nanoparticles or nanoparticles aggregates per gram (g) of targeted tissue when at least 0.1 g of the pharmaceutical composition per kilogram (kg) of body weight is injected intravenously (IV) or intraarterially (IA) into said subject.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: April 23, 2019
    Assignee: NANOBIOTIX
    Inventors: Agnes Pottier, Laurent Levy, Matthieu Germain
  • Patent number: 10266408
    Abstract: A metal-organic compound containing polymer matrix includes a polymer and a three-dimensional metal-organic framework includes a polydentate organic linker. The metal-organic compound containing polymer matrix is configured to continuously produce nitric oxide when exposed to a physiological fluid including a nitric oxide-releasing compound via a catalytic reaction catalyzed by the three-dimensional metal-organic framework.
    Type: Grant
    Filed: January 15, 2015
    Date of Patent: April 23, 2019
    Assignee: COLORADO STATE UNIVERSITY RESEARCH FOUNDATION
    Inventors: Melissa M. Reynolds, Benjamin P. Reynolds
  • Patent number: 10251881
    Abstract: Embodiments of the invention relate to particles of active substances, methods for preparing the particles, formulations containing the particles, and metered dose inhalers containing such particles or formulations. In one embodiment, a composition of an aerosol formulation is provided and contains a particulate active substance of non-micronized, solid particles having a mass median aerodynamic diameter of less than 10 ?m suspended in a hydrofluorocarbon fluid vehicle at a concentration within a range from about 0.2% w/v to about 5% w/v. The aerosol formulation exhibits a flocculation volume of about 85% or greater about 1 minute after mixing the particulate active substance and the hydrofluorocarbon fluid vehicle. The particulate active substance contains an alkaloid ergotamine, pharmaceutically acceptable salts thereof, analogues thereof, or derivatives thereof.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: April 9, 2019
    Assignee: Nektar Therapeutics
    Inventors: Andreas Kordikowski, Stephen Ernest Walker, Peter York
  • Patent number: 10251394
    Abstract: This disclosure relates to the field of molecules having pesticidal utility against pests in Phyla Arthropoda, Mollusca, and Nematoda, processes to produce such molecules, intermediates used in such processes, compositions containing such molecules, and processes of using such molecules and compositions against such pests. These molecules and compositions may be used, for example, as acaricides, insecticides, miticides, molluscicides, and nematicides. This document discloses molecules having the following formula (“Formula One”).
    Type: Grant
    Filed: January 18, 2017
    Date of Patent: April 9, 2019
    Assignee: Dow AgroSciences LLC
    Inventors: Thomas Barton, Xin Gao, Jim Hunter, Paul R. LePlae, Jr., William C. Lo, Joshodeep Boruwa, Raghuram Tangirala, Gerald B. Watson, John Herbert
  • Patent number: 10251825
    Abstract: A composition comprising a compound having a Formula I: wherein T is derivative of a terpene and R is a derivative of a neurotransmitter amino acid. Pharmaceutical formulations for topical use as insect repellents including the terpenes and terpene esters in form of the pharmaceutically acceptable salt or base are provided. A process for preparing the composition and the formulations are also provided.
    Type: Grant
    Filed: July 28, 2017
    Date of Patent: April 9, 2019
    Inventors: Iryna Kravchenko, Mariia Nesterkina, Sergiy Lozovsky
  • Patent number: 10252210
    Abstract: Methods for reducing particulates in the air are disclosed. In some embodiments, the method comprises spraying a composition having an effective amount of a zwitterionic polymer, a compressed gas propellant, and an aqueous carrier in to the air. The composition agglomerates particulates upon contacting particulates in the air thereby reducing particulates in the air.
    Type: Grant
    Filed: May 10, 2011
    Date of Patent: April 9, 2019
    Assignee: The Procter & Gamble Company
    Inventors: Chisomaga Ugochi Nwachukwu, Alan Edward Sherry
  • Patent number: 10251891
    Abstract: A liquid pharmaceutical compositions comprising Aprepitant is preferably prepared as an oral suspension dosage form for the prevention and control of acute and delayed chemotherapy induced nausea and vomiting, and/or for prevention of postoperative nausea and vomiting.
    Type: Grant
    Filed: October 25, 2016
    Date of Patent: April 9, 2019
    Assignee: InnoPharma, Inc.
    Inventors: Udaya Toti, Shyamprasad Mukundan, Sasank Chaitanya Kunadharaju, Tushar Hingorani, Kumaresh Soppimath, Satish Pejaver, Navneet Puri
  • Patent number: 10246402
    Abstract: The present invention concerns the use as perfuming ingredient (of the fruity type) of a compound of formula in the form of any one of its stereoisomers or of a mixture thereof, and wherein R1 represents a C1-3 alkyl or alkenyl group, R2 represents a methyl or ethyl group, R3 represents a C1-4 alkyl or alkenyl group, and the compound (I) has from 8 to 12 carbon atoms.
    Type: Grant
    Filed: March 21, 2018
    Date of Patent: April 2, 2019
    Assignee: Firmenich SA
    Inventors: Christian Vial, Roger Leslie Snowden
  • Patent number: 10244755
    Abstract: Safeners for herbicides are suitable for increasing the microbicidal activity of fungicides.
    Type: Grant
    Filed: September 14, 2015
    Date of Patent: April 2, 2019
    Assignee: BAYER CROPSCIENCE AKTIENGESELLSCHAFT
    Inventors: Reiner Fischer, Peter Dahmen, Ulrike Wachendorff-Neumann