Patents Examined by Mindy G Brown
  • Nitrogen fixation gene island suitable for expressing in prokaryotic and eukaryotic systems
    Patent number: 9290769
    Abstract: Provided is a nitrogen fixation gene island suitable for expressing in prokaryotic and eukaryotic systems, wherein the prokaryotic nitrogen fixation genes are modified using T7 promoters to make them suitable for eukaryotic expression.
    Type: Grant
    Filed: March 21, 2012
    Date of Patent: March 22, 2016
    Assignee: PEKING UNIVERSITY
    Inventors: Xia Wang, Jianguo Yang, Li Chen, Yun Yang, Yiping Wang
  • Method for preparing mutant capable of simultaneously utilizing glucose and xylose
    Patent number: 9284582
    Abstract: The present invention relates to a method for preparing a mutant E. coli strain, capable of simultaneously using glucose and xylose, by genetic engineering and evolutionary adaptation; the mutant E. coli prepared using the same; and a method for producing biofuels, biologically active ingredients, medicinal materials or base chemicals for the chemical industry using the mutant E. coli. Being capable of simultaneously using glucose and xylose, in contrast to wild-type E. coli, the mutant E. coli can be effectively applied to the enzymatic saccharification process of producing biofuels from a biomass.
    Type: Grant
    Filed: July 2, 2014
    Date of Patent: March 15, 2016
    Assignee: UNIST Academy-Industry Research Corporation
    Inventors: Sung Kuk Lee, Goo Hee Kim, Seong Hun Jeong, Suk Min Kim, Bae Young Choi
  • Vitro method for high throughput screening of genotoxic agents in eukaryotic cells
    Patent number: 9285358
    Abstract: The present invention relates to a novel method for high throughput detection of wide range of genotoxins in eukaryotic cells wherein the eukaryotic cell based tool combines the ability to detect a broad spectrum of genotoxic signaling events and a simple and reproducible assay technique. The present invention further comprises expression cassettes, vectors, and eukaryotic cell lines for the same.
    Type: Grant
    Filed: April 7, 2012
    Date of Patent: March 15, 2016
    Assignee: ANTHEM BIOSCIENCES PVT LTD
    Inventors: Ayyappan Nair, Madhuri Subbiah, Gunja Gupta, Lakshmi Rajakrishna, Pradeep Savanoor, Subbulakshmi Karthikeyan, Salini Krishnan Unni, Ganesh Sambasivam
  • Promoters for expressing genes in a fungal cell
    Patent number: 9284588
    Abstract: The present invention relates to isolated promoters and constructs, vectors, and fungal host cells comprising such promoters operably linked to polynucleotides encoding polypeptides. The present invention also relates to methods for producing such polypeptides.
    Type: Grant
    Filed: December 15, 2011
    Date of Patent: March 15, 2016
    Assignee: NOVOZYMES, INC.
    Inventors: Sandra Merino, Debbie Yaver
  • Kluyveromyces lactis yeast strain and methods for the production of sugars, ethanol, beta-galactosidase and biomass
    Patent number: 9279135
    Abstract: A Kluyveromyces lactis yeast strain comprising the sequence identified by SEQ ID NO: 1, and methods for the production of sugars (glucose and galactose), ethanol, ?-galactosidase and biomass is provided, in which the Kluyveromyces lactis yeast strain is cultured in the presence of a lactose-containing medium. The lactose-containing medium may be milk, whey, whey resulting from the preparation of butter, whey resulting after casein precipitation, milk permeate, whey permeate, acid whey and YPL culture medium.
    Type: Grant
    Filed: July 27, 2011
    Date of Patent: March 8, 2016
    Assignee: QUEIZUAR, S.L.
    Inventors: Angel Pereira Rodriguez, Manuel Becerra Fernandez, Maria Isabel Gonzalez Siso, Maria Esperanza Cerdan Villanueva
  • Engineered sequences to facilitate expression of antigens in and methods of use
    Patent number: 9260489
    Abstract: The present disclosure generally provides non-naturally-occurring polynucleotide sequences that facilitate high-level expression of one or more gene products (e.g., polypeptides, RNA) of interest in Neisseria meningitidis. Methods of use of such sequences, e.g., use in vaccine production, are also provided.
    Type: Grant
    Filed: August 30, 2012
    Date of Patent: February 16, 2016
    Assignee: Children's Hospital & Research Center Oakland
    Inventor: Rolando Pajon Feyt
  • Cellular depletion of biomolecular targets
    Patent number: 9243280
    Abstract: The present application relates to methods, compositions and systems for the specific, controllable degradation of targeted proteins. Typically, the target proteins have a function which has not yet been elucidated. The disclosure enables one to study the effect of degrading a targeted protein, which in turn, will lead to a characterization of its function. In one embodiment, the invention pertains to a composition comprising a construct wherein the construct includes a peptide including a degradation tag. The degradation tag includes a ClpX binding sequence appended to a protein, wherein the sequence is YALAA.
    Type: Grant
    Filed: February 23, 2012
    Date of Patent: January 26, 2016
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventor: Sean D. Moore
  • Methods and compositions for regulating RNA import into mitochondria
    Patent number: 9238041
    Abstract: Disclosed herein are methods of manipulating the processing, targeting, and/or internalization of a nucleic acid molecule. Also disclosed are recombinant and/or isolated nucleic acid molecules having a first nucleic acid sequence, which is a wild-type sequence or an altered sequence, directly or indirectly linked to a second nucleic acid sequence which is a mitochondria localization sequence, an RNA import sequence, or a combination thereof, and methods of using thereof.
    Type: Grant
    Filed: March 7, 2012
    Date of Patent: January 19, 2016
    Assignee: The Regents of the University of California
    Inventors: Michael A. Teitell, Carla M. Koehler, Geng Wang
  • Recombinant phage and methods
    Patent number: 9234227
    Abstract: This disclosure provided methods of cloning a phage genome. Also provided are methods of making a recombinant phage genome. In some embodiments the phage genome is engineered to comprise a heterologous nucleic acid sequence, for example a sequence comprising an open reading frame. In some embodiments the phage genome is cloned in a yeast artificial chromosome. Recombinant phage genomes and recombinant phage are also provided. In some embodiments the methods are high throughput methods such as methods of making a plurality of recombinant phage genomes or recombinant phage. Collections of recombinant phage genomes and recombinant phage are also provided.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: January 12, 2016
    Assignee: Sample6 Technologies, Inc.
    Inventors: Timothy Kuan Ta Lu, Michael Sandor Koeris, Brett Smith Chevalier, Jason Wyatt Holder, Gregory John McKenzie, Daniel Robert Brownell
  • Organ-specific feline endothelial cells and uses thereof
    Patent number: 9228173
    Abstract: The present invention relates to isolated organ-specific feline endothelial cells. Specifically, the present invention relates to established organ-specific feline endothelial cells. The present invention also relates to organ-specific feline endothelial cells derived from micro- and macro-vascularisation. The present invention also relates to methods for screening molecules, for studying pathologies and for producing pathogens using same.
    Type: Grant
    Filed: January 11, 2011
    Date of Patent: January 5, 2016
    Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE—CNRS, ECOLE NATIONALE VETERINAIRE D'ALFORT
    Inventors: Claudine Kieda, Maria Paprocka, Michele Mitterand, Nathalie Lamerant-Fayel, Henri-Jean Boulouis, Nadia Haddad, Martine Monteil
  • Fungi and products thereof
    Patent number: 9222096
    Abstract: The present invention provides substantially purified or isolated fungi of Nodulisporium spp. or Ascocoryne spp., plants infected with said fungi, organic compounds produced by said fungi, and related nucleic acids, polypeptides and methods.
    Type: Grant
    Filed: May 22, 2012
    Date of Patent: December 29, 2015
    Assignee: Agriculture Victoria Services PTY LTD
    Inventors: German Carlos Spangenberg, Timothy Ivor Sawbridge, Simone Jane Rochfort, Scott W. Mattner, Ross C. Mann
  • Alternative splice variant patterns of human telomerase reverse transcriptase (hTERT) in thyroid tumors to distinguish benign from malignant
    Patent number: 9222136
    Abstract: This invention relates, e.g., to a method for determining if a thyroid tumor in a subject is malignant, comprising determining in a sample from the subject the amount of TERT (telomerase reverse transcriptase) mRNA which lacks the ? sequence and the amount of TERT mRNA in the sample which comprises the ? sequence, wherein a preponderance (e.g., at least about 55%) of TERT mRNA in the sample which comprises the ? sequence indicates that the tumor is malignant, and wherein a preponderance of TERT mRNA which lacks the ? sequence indicates that the tumor is not malignant.
    Type: Grant
    Filed: December 5, 2008
    Date of Patent: December 29, 2015
    Assignee: The Johns Hopkins University
    Inventors: Martha Allen Zeiger, Jeanne Kowalski, Christopher Umbricht, Yongchun Wang
  • Polynucleotides having leader sequence function
    Patent number: 9222095
    Abstract: The present invention relates to isolated polynucleotides having leader sequence function. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods using the polynucleotides for production of polypeptides.
    Type: Grant
    Filed: June 23, 2011
    Date of Patent: December 29, 2015
    Assignee: NOVOZYMES A/S
    Inventors: Hiroaki Udagawa, Rikako Taira, Shinobu Takagi
  • Actinomycete integrative and conjugative element from sp. SE50/110 as plasmid for genetic transformation of related Actinobacteria
    Patent number: 9217154
    Abstract: The present invention is directed to an innate DNA sequence within the complete genome sequence of Actinoplanes sp. SE50/110 which resembles the structure of an actinomycete integrative and conjugative element (AICE). Related AICEs were used for establishing genetic manipulation tools for other bacteria in the past. In this document, we describe the unique features of the specific AICE found in Actinoplanes sp. SE50/110 which are clearly distinct from any other known AICE as a whole, but share minor parts with varying sequence similarity with other characterized AiCEs from other species.
    Type: Grant
    Filed: December 4, 2012
    Date of Patent: December 22, 2015
    Assignee: BAYER INTELLECTUAL PROPERTY GMBH
    Inventors: Andreas Klein, Klaus Selber, Hermann Wehlmann, Winfried Rosen, Alfred Pühler, Patrick Schwientek, Jörn Kalinowski, Udo Wehmeier
  • Polypeptides having cellobiohydrolase activitiy and polynucleotides encoding same
    Patent number: 9212354
    Abstract: The present invention provides isolated polypeptides having cellobiohydrolase activity and isolated polynucleotides encoding the polypeptides. The invention also provides nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods of producing and using the polypeptides.
    Type: Grant
    Filed: November 2, 2011
    Date of Patent: December 15, 2015
    Assignee: NOVOZYMES INC.
    Inventors: Ye Liu, Lan Tang, Junxin Duan
  • Methods for the diagnosis of bacterial vaginosis
    Patent number: 9200331
    Abstract: The present invention relates to methods for the diagnosis of bacterial vaginosis based on an analysis of a patient sample. For example, patient test samples are analyzed for the presence or absence of one or more lactobacilli and two or more pathogenic organisms. The presence or absence of one or more lactobacilli and two or more pathogenic organisms may be detected using PCR analysis of nucleic acid segments corresponding to each target organism. The quantity of the target organisms can then be used to determine a score which is indicative of a diagnosis of bacterial vaginosis.
    Type: Grant
    Filed: November 17, 2010
    Date of Patent: December 1, 2015
    Assignee: QUEST DIAGNOSTICS INVESTMENTS INCORPORATED
    Inventors: Erik P. Johnson, Dale A. Schwab
  • Methods for identifying modulators of murine double minute 2
    Patent number: 9200333
    Abstract: The disclosure is directed to methods of identifying compounds that modulate murine double-minute 2. More particularly, the disclosure is directed to methods of identifying compounds that modulate murine double-minute 2 neddylation activity.
    Type: Grant
    Filed: July 25, 2013
    Date of Patent: December 1, 2015
    Assignee: Indiana University Research and Technology Corporation
    Inventor: Lindsey Mayo
  • Synthetic gene for expressing Sm-14 in , methods for producing and purifying Sm-14 and the use thereof as a vaccine and diagnostic medium
    Patent number: 9193772
    Abstract: The production of recombinant proteins using a synthetic gene for increased expression of the protein in Pichia pastoris is disclosed. More specifically, disclosed is a process for producing a recombinant Sm14 protein of Schistosoma mansoni, by providing a synthetic gene for increased production of Sm14 protein, producing the gene and genetically manipulating the Pichia pastoris strain with the gene in order to produce a vaccine effectively. Improved methods are also provided for producing and purifying this protein from P. pastoris cells, which can be scaled for industrial production.
    Type: Grant
    Filed: September 13, 2011
    Date of Patent: November 24, 2015
    Assignees: ALVOS—CONSULTORIA, DESENVOLVIMENTO E COMERCIALIZAçÃO DE PRODUTOS BIOTECNOLÓGICOS S/A, FUNDAçÃO OSWALDO CRUZ
    Inventors: Miriam Tendler, Celso Raul Romero Ramos, Andrew J. G. Simpson
  • Genetic switches for butanol production
    Patent number: 9181566
    Abstract: The invention relates to suitable screening strategies for evaluating various candidate promoters for differential gene expression during the propagation and production phases of a fermentation process. The invention also relates to recombinant host cells that comprise identified promoter nucleic acid sequences and methods for producing fermentation products employing the same.
    Type: Grant
    Filed: December 28, 2012
    Date of Patent: November 10, 2015
    Assignee: BUTAMAX ADVANCED BIOFUELS LLC
    Inventors: Michael Dauner, Arthur Leo Kruckeberg, Robert A Larossa, Brian James Paul, Wonchul Suh, Joseph Frederich Tuminello
  • Diagnostic and treatment for chronic and acute phase myeloid leukemia
    Patent number: 9173963
    Abstract: Disclosed are methods of predicting responsiveness of a cancer cell to a tyrosine kinase inhibitor, and methods of predicting the risk of progression of a cancer cell to a more aggressive form. Also provided are methods of reducing proliferation or promoting differentiation of a cancer cell having reduced level of Numb or increased level of Msi. Further disclosed are methods of treating a mammalian subject having cancer and methods of assessing an agent for chemotherapeutic potential.
    Type: Grant
    Filed: May 14, 2010
    Date of Patent: November 3, 2015
    Assignee: Duke University
    Inventors: Tannishtha Reya, Hyog Y. Kwon, Takahiro Ito, Dong-Wook Kim, Vivian Oehler, Jerald Radich