Abstract: A process for the preparation of a salt of clavulanic acid, wherein clavulanic acid in solution in a wholly or partly water-imiscible organic solvent is contacted in a region of high turbulence and/or shear stress, with a salt precursor compound to form a solution of the salt of clavulanic acid in an aqueous phase, then the organic solvent and aqueous phases are physically separated during a separation step, followed by a further processing step in which the said salt of clavulanic acid is isolated from solution as a solid.

Abstract: Process for the purification of 5H-dibenz?b,f!a-zepine, which comprises evaporating 5H-dibenz?b, f!azepine under reduced pressure from a reaction mixture obtained by catalytic dehydrogenation of 10,11-dihydro-5H-dibenz-?b,f!azepine in the 1st step and depositing it as a solid, suspending the deposited product in an aromatic hydrocarbon in the 2nd step and then isolating pure 5H-dibenz?b,f!azepine.

Abstract: Disclosed are thiocyanomethyloxy(or thiocyanomethylthio)-1,2,3-benzatriazin-4(3H)-one compounds corresponding to one of the formulae: ##STR1## wherein Z represents oxygen or sulfur; X represents --C1, --F, --I, C.sub.1 -C.sub.7 straight or branched chain alkyl, C.sub.1 -C.sub.7 straight or branched chain alkoxy, --CF.sub.3, --OCF.sub.3, --CN, --COOR wherein R is C.sub.1 -C.sub.7 straight or branched chain alkyl and n is an integer of from 0-4.These compounds have been found to exhibit antimicrobial and marine antifouling activity in industrial and commercial applications and compositions containing these compounds are so employed.

Abstract: The invention provides 1-cyclopropyl-6-fluoro-1,4- dihydro-8-methoxy-7-(3-methyl-1-piperazinyl)-4-oxo-3- quinolinecarboxylic acid sesquihydrate with excellent stability represented by a following formula (1), ##STR1## and process for producing the same.

Abstract: Derivatives of 2,3-benzodiazepine are substituted by one or two halogen atom(s) and have the general formula ##STR1## These derivatives are non-competitive AMPA antagonists and are used in pharmaceutical compositions.

Abstract: Compounds of the general formula I ##STR1## where the A radicals are, independently of one another, ##STR2## where the rings B and C can also, independently of one another, be substituted by C.sub.1 -C.sub.4 -alkyl, C.sub.1 -C.sub.4 -alkoxy, nitro, hydroxysulfonyl, benzoyl or a fused-on benzo ring,R is hydrogen or methyl, and the two hydrogen atoms on the nitrogens Can be replaced by copper, nickel, vanadyl, magnesium, AlCl or zinc,are suitable as IR-absorbers.

Abstract: The present invention relates to new 2-Phenyl-1-?4-(amino-1-yl-alk-1-ynyl)benzyl!-1H-indol-5-ol compounds which are useful as estrogenic agents, as well as pharmaceutical compositions and methods of treatment utilizing these compounds, which have the general structure below.

Abstract: Crystalline sodium 2.alpha.-methyl-2.beta.-(1,2,3-triazol-1-yl) -methylpenam-3.alpha.-carboxylate-1,1-dioxide monohydrate (crystalline tazobactam sodium monohydrate) obtainable by adding to a concentrated aqueous solution of sodium 2.alpha.-methyl-2.beta.-(1,2,3-triazol-1-yl)-methylpenam-3.alpha.-carboxyl ate-1,1-dioxide (tazobactam sodium) a solvent selected from acetone and ethanol in an amount corresponding to a solvent to water ratio of between about 95:5 and 99:1 v/v and crystallizing the desired product from the solvent mixture. The crystalline tazobactam sodium monohydrate exhibits a high .beta.-lactamase inhibitory activity in combination with .beta.-lactam antibiotics.

Abstract: Hydroxygallium phthalocyanine crystals having intense diffraction peaks at Bragg angles (2.theta..+-.0.2.degree.) of 7.5.degree., 9.9.degree., 12.5.degree., 16.3.degree., 18.6.degree., 25.1.degree. and 28.3.degree. in Cuk.alpha. characteristic X-ray diffractometry, a process for producing the same, and an electrophotographic photoreceptor containing the same are disclosed. The hydroxygallium phthalocyanine crystals are obtained by once preparing impurity-free hydroxygallium phthalocyanine having intense X-ray diffraction peaks at specific Bragg angles, followed by a solvent treatment for crystal transformation, in which the impurity-free crystals are prepared by using excess phthalocyanine ring-forming compound in the synthesis of starting gallium phthalocyanine or by removing insoluble matter from the acid paste of starting gallium phthalocyanine.

Abstract: Compounds of formulaA(B).sub.x, (I),whereinx is an integer from 1 to 4,A is the radical of a chromophore of the quinacridone, anthraquinone, perylene, indigo, quinophthalone, isoindolinone, isoindoline, dioxazine, phthalocyanine or azo series, which radical contains x N-atoms attached to B, preferably with at least one directly adjacent or conjugated carbonyl group,B is a group of formula ##STR1## and, if x is 2, 3 or 4, may also be one, two or three hydrogen atoms. The symbols Q, R.sub.1, R.sub.2, R.sub.3, R.sub.4, X, Y, Z, m und n, are as defined in claim 1.These carbamate group-containing soluble chromophores are distinguished by outstanding solid state fluorescence in the UV range as well as the by ease with which they can be converted to the corresponding pigments in the substrate in which they are incorporated.

Abstract: New compounds of formula: ##STR1## wherein A-B, X, Y, R and n are as defined in the description. The geometric isomers, racemate and optical isomers thereof and the addition salts with pharmaceutically acceptable acids, and medicinal products containing the same are useful for treating psychotic disorders, depression, Parkinson's disease, memory disorders and disorders associated with drug abuse.

Abstract: A process for preparing a tertiary amine-N-oxide which comprises reacting a tertiary amine with a peroxide in the presence of a catalyst comprising an oxide containing silicon and titanium atoms. According to the process of the present invention, a tertiary amine-N-oxide can be obtained in a high yield, and since the catalyst can easily be separated from the reaction mixture, the tertiary amine-N-oxide can be obtained in a high purity without the contamination by the catalyst.

Abstract: The invention relates to aminoalkyl-substituted 5,6-dihydro-dibenz[b,e]azepine-6,11-dione-11-oximes, to processes for their preparation and to their use as antiretroviral agents.

Abstract: There is here disclosed a method for preparing an alkoxyphthalocyanine represented by the formula (1): ##STR1## wherein each of Rs is independently a secondary alkyl group having 3 to 20 carbon atoms, Met is a divalent metal atom or an oxy metal, and the substitution positions of -ORs are the 1- or 4-position, the 5- or 8-position, the 9- or 12 position, and the 13- or 16-position, which comprises the steps of heating a mixture of 3-alkoxyphthalonitrile and an organic base in an alcohol to 90.degree.-120.degree. C., adding a metal derivative at the same temperature, and then carrying out reaction, or alternatively the step of reacting a mixture of a 1,3-diimino-4-alkoxyisoindoline and a metal derivative in the presence or absence of an organic base in an aliphatic alcohol having 6 or more carbon atoms. In addition, the ratio of isomers of the alkoxyphthalocyanine can be controlled by regulating the addition time of the organic base.

Abstract: The compound (R) (-)-4-amino-5-chloro-N-(2-pyrrolidinylmethyl)-2,3-dihydrobenzo[b]furan-7-c arboxamide; the S isomer thereof, and pharmaceutical compositions containing the same.

Abstract: The present invention pertains to boron containing thiouracil derivatives, their method of preparations, and their use in the therapy of malignant melanoma using boron neutron capture therapy.

Abstract: To prepare the compound (I), a lithiation of the compound (II) is performed, an aldehyde (IV) is reacted with the compound (III) formed, leading to the secondary alcohol (V) which is subjected to a reduction leading to the compound (VI), which is then subjected to a hydrolysis (of the dioxolane group)/cyclization/dehydration reaction. The procedure may be followed by a nucleophilic substitution reaction of the chlorine. The compounds (a) below exhibit antitumor activity. ##STR1## R=C.sub.1 -C.sub.3 alkyl; Ar=aromatic or polycyclic aromatic group; R.sub.1 and r.sub.2 =H or C.sub.1 -C.sub.3 alkyl; and n=2 to 4. No drawing.

Abstract: An organ preservation solution, particularly valuable in the preservation of mammalian hearts intended for transplantation, in aqueous solution, at least about 3% by weight of polypropylene glycol having an average molecular weight of at least about 15,000 daltons and being free of material retained by 10 micron filtration, a buffer buffering the pH of the solution perfusate to a value in the range of about 7.1 to about 7.5, and an impermeant composition for retarding the passage of water across cell membranes of an organ treated with the solution.

Abstract: A silver halide photographic emulsion is described, comprising junction-type silver halide crystal grains composed of cubic, rectanguloid, or tetradecadedral silver halide crystals as a first type of silver halide crystal, having projection-joined to at least one of the six (100) faces of said first type of silver halide crystal a second type of silver halide crystal having a different halogen composition from the halogen composition of the surface of the first type of silver halide crystal. A silver halide photographic material containing the foregoing photographic emulsion is also described.

Abstract: The present invention is directed to a process of precipitating for use in photography a high aspect ratio tabular grain emulsion employing a dispersing medium containing a gelatino-peptizer comprised of less than 30 micromoles of methionine per gram and at least a 0.5 molar concentration of chloride ion. A wide range of chloride ion concentrations in the tabular grains can be achieved while avoiding the use of tabular grain thickening ripening agents and synthetic peptizers.