Abstract: Novel substituted imidazoles of the formula ##STR1## and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit pharmacological activity which includes antihypertensive activity and .beta.-adrenergic blocking activity.

Abstract: Herein is disclosed benzofuro[3,2-c]pyrazol-3-amine derivatives, therapeutically acceptable acid addition salts thereof, processes for their preparation, methods of using the derivatives and pharmaceutical compositions. The derivatives are useful for producing analgesia in a mammal. In addition, some of the derivatives are useful for inhibiting gastric acid secretion, convulsions, anxiety and aggression, and producing muscle relaxation, hypnosis and sedation in a mammal.

Abstract: The invention relates to urea and amido compounds of the formula ##STR1## which have a powerful action on tumors, and to processes for their preparation and pharmaceutical preparations containing such compounds.

Abstract: 5-Amino-1-phenylpyrazole-4-carboxylic acid esters of the formula ##STR1## where R.sup.1 is methyl, trifluoromethyl, chlorine or bromine, R.sup.2 is chlorine, bromine, iodine or akylsulfonyl, R.sup.3 is hydrogen, chlorine or bromine, or is methoxy in the 5-position, in which case R.sup.1 and R.sup.2 are chlorine, whilst R.sup.2 is hydrogen if R.sup.3 is chlorine in the 3-position, and R.sup.4 is methyl, and herbicides containing these compounds.

Abstract: 1-Phenoxy-1-imidazol-1-yl-4-fluoro-butane derivatives of the formula ##STR1## in which B is --CO- or --CH(OH)--,X is hydrogen or fluorine,Z each independently is halogen, alkyl, nitro, cyano, alkoxy-carbonyl or optionally substituted phenyl, andn is 0, 1, 2 or 3,or an acid or metal salt adduct thereof, which possess fungicidal properties.

Abstract: N-Acylated N-methyl-carbamic acid O-pyrazol-4-yl esters of the formula ##STR1## in which R represents an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl or aryl radical,Z represents an acyl radical,l represents 1 or 2,m represents 1 or 2 andn represents zero or 1,which possess pesticidal activity.

Abstract: The invention relates to diastereoisomeric 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanol and methods for its preparation. Also included in the invention are compositions containing said diastereoisomeric 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanol and methods for the use of said compound and compositions as antimycotic agents.

Abstract: 4-Benzoyl-5-hydroxypyrazoles useful as herbicidal active ingredients, their intermediate or stabilizers against heat, oxidation or ultraviolet light are produced by a condensation of a pyrazolone, tetrachloromethane and a benzene compound in the presence of an aluminium halide, followed by a hydrolysis reaction with industrial advantages.

Abstract: The preparation of 3-amino-1-phenylpyrazol-5-one by heating phenylhydrazine and a lower cyanoacetic acid alkyl ester in a polar solvent, using a lower alcoholate of an alkali metal as the condensation agent, leads to particularly high yields and quality, if the phenylhydrazine and 1 to 1.2 moles of the alcoholate are initially taken, the cyanoacetic ester is metered in and the reaction is carried out at 105.degree. to 140.degree. C., volatile alcohols which have been liberated from the ester and, if appropriate, from the alcoholate being distilled off at the reaction temperature. It is advantageous to employ the phenylhydrazine in an excess of up to about 200 mole % and to select, as the polar solvent, an alcohol or ether having a boiling point above 105.degree. C.

Abstract: Novel pyrazoloindazole derivatives of the formula ##STR1## wherein R.sub.1 is a hydrogen atom, halogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxyl group or benzyloxyl group; R.sub.2 is a hydrogen atom, a halogen atom, a lower alkyl group or phenyl group (provided R.sub.1 and R.sub.2 are not hydrogen at the same time); and X.sup..crclbar. is a halide ion, a hydroxide ion, a methanesulfonate ion, a p-toluene sulfonate ion, a sulfate ion, a nitrate ion, a carbonate ion, an acetate ion, a benzoate ion or a salicylate ion, a process for preparing the derivatives, and a pharmaceutical composition containing the same are disclosed. The derivatives have good bronchodilating action for human without exhibiting substantially bad effects on the functioning of heart, and therefore, they are useful as a drug.

Abstract: Pyrazoline derivatives having the formula ##STR1## wherein R.sup.1 represents hydrogen atom, a lower alkyl group, phenyl group or a halogen-substituted phenyl group; R.sup.2 represents hydrogen atom or phenyl group which can have halogen substituents; X represents oxygen or sulfur atom; Y and Z respectively represent hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, nitro-group, trifluoromethyl group, a lower alkylthio group, an acyl group, nitrile group or a lower alkyl sulfonyl group.

Abstract: 3-Nitro-2-substituted aminopyrroles are histamine H.sub.2 -receptor antagonists. The 2- position substituent is a fully-unsaturated heterocyclyl alkyl group preferably with alkyl group interrupted by sulfur or oxygen. The 4- and 5- positions of the pyrrole ring can also be substituted.

Abstract: A herbicidal compound having the following formula ##STR1## wherein n is 0 or 1; a herbicidal composition comprising said compound as an active ingredient; a process for producing said composition; and a herbicidal method employing said compound.

Abstract: Derivatives of certain pyridyliminomethylbenzenes, useful as fungicides.

Abstract: Herbicides containing a pyrazole derivative of the formula ##STR1## where R.sup.1 denotes hydrogen, formyl, acetyl, propionyl, chloroacetyl, dichloroacetyl, methoxyacetyl, methoxycarbonyl, or phenoxycarbonyl which is unsubstituted or mono- or polysubstituted by halogen, R.sup.2 denotes phenyl which is unsubstituted or mono- or polysubstituted by fluorine, chlorine, bromine, methyl, methoxy, cyano, nitro, trifluoromethyl, trifluoromethoxy or methoxycarbonyl, R.sup.2 further denotes a 5- to 6-membered, heterocyclic aromatic ring which is unsubstituted or substituted by methyl or chlorine and which contains 1 or 2 hetero-atoms X, X being independently oxygen, sulfur or nitrogen, or R.sup.2 denotes .alpha.-naphthyl or .beta.-naphthyl, and R.sup.3 denotes methyl, ethyl or isopropyl, or a salt of such a pyrazole derivative, a process for combating unwanted plant growth with the active ingredients and methods of manufacturing the herbicides.

Abstract: Indolizine derivatives represented by the general formula: ##STR1## wherein R represents a straight- or branched-chain alkyl radical having from 1 to 8 carbon atoms, or a phenyl group non-substituted or bearing one or two substituents, which may be the same or different, selected from halogen atoms, for example fluorine, chlorine and bromine and from lower alkyl and alkoxy groups, for example methyl and methoxy and X.sub.1, X.sub.2 and X.sub.3, which may be the same or different, each represent hydrogen, chlorine, bromine or methoxy with the proviso that when they are identical X.sub.1, X.sub.2 and X.sub.3 are not simultaneously hydrogen.They possess an inhibitory activity with respect to the action of xanthine oxidase and of adenosine deaminase as well as an uricosuric action and can be used in the treatment of physiological disturbances consequent upon an excess of uric acid, upon disorders of the immunization system and as antiparasitic agents.

Abstract: Pyrazoline derivatives of the formula ##STR1## wherein Z represents a radical of the formula ##STR2## or of the formula ##STR3## and R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.8, R.sub.9 and R.sub.10 represent specific substituents and An.sup..crclbar. represents the equivalent of a colorless anion, a process for the production of these compounds and their use as fluorescent brightening agents.

Abstract: Compounds of the general formula ##STR1## wherein R represents an alkyl group of 1 to 3 carbon atoms or the group N(R.sub.2).sub.2, in which R.sub.2 represents a hydrogen atom, an alkyl group of 1 to 3 carbon atoms, or an acyl group of 1 to 3 carbon atoms, and R.sub.1 has the same meaning as R or is a hydrogen atom, are new and are suitable as chromogens for measuring H.sub.2 O.sub.2 formation in enzymatic reactions.

Abstract: This disclosure describes novel substituted phenyl-5-aminopyrazoles useful as anxiolytic and/or anti-depressant agents.

Abstract: The compounds are N,N'-substituted thioureas, ureas and guanidines which are H-2 histamine receptor inhibitors. A compound of this invention is N-cyano-N'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]-N"-[2-(2-thiazolyl methylthio)ethyl]guanidine.