Patents Examined by Natalia Harkaway
  • Patent number: 4440774
    Abstract: Novel substituted imidazoles of the formula ##STR1## and methods for their preparation are disclosed. These imidazoles, and their salts, exhibit pharmacological activity which includes antihypertensive activity and .beta.-adrenergic blocking activity.
    Type: Grant
    Filed: April 20, 1981
    Date of Patent: April 3, 1984
    Assignee: Merck & Co., Inc.
    Inventor: John J. Baldwin
  • Patent number: 4420619
    Abstract: The invention relates to urea and amido compounds of the formula ##STR1## which have a powerful action on tumors, and to processes for their preparation and pharmaceutical preparations containing such compounds.
    Type: Grant
    Filed: March 25, 1981
    Date of Patent: December 13, 1983
    Assignee: Ciba-Geigy Corporation
    Inventor: Adrian Marxer
  • Patent number: 4420476
    Abstract: Herein is disclosed benzofuro[3,2-c]pyrazol-3-amine derivatives, therapeutically acceptable acid addition salts thereof, processes for their preparation, methods of using the derivatives and pharmaceutical compositions. The derivatives are useful for producing analgesia in a mammal. In addition, some of the derivatives are useful for inhibiting gastric acid secretion, convulsions, anxiety and aggression, and producing muscle relaxation, hypnosis and sedation in a mammal.
    Type: Grant
    Filed: May 24, 1982
    Date of Patent: December 13, 1983
    Assignee: Averst McKenna & Harrison, Inc.
    Inventors: Adolf Philipp, Ivo Jirkovsky, Rene Martel
  • Patent number: 4420324
    Abstract: 5-Amino-1-phenylpyrazole-4-carboxylic acid esters of the formula ##STR1## where R.sup.1 is methyl, trifluoromethyl, chlorine or bromine, R.sup.2 is chlorine, bromine, iodine or akylsulfonyl, R.sup.3 is hydrogen, chlorine or bromine, or is methoxy in the 5-position, in which case R.sup.1 and R.sup.2 are chlorine, whilst R.sup.2 is hydrogen if R.sup.3 is chlorine in the 3-position, and R.sup.4 is methyl, and herbicides containing these compounds.
    Type: Grant
    Filed: November 18, 1981
    Date of Patent: December 13, 1983
    Assignee: BASF Aktiengesellschaft
    Inventors: Karl Eicken, Peter Plath, Bruno Wuerzer
  • Patent number: 4419361
    Abstract: 1-Phenoxy-1-imidazol-1-yl-4-fluoro-butane derivatives of the formula ##STR1## in which B is --CO- or --CH(OH)--,X is hydrogen or fluorine,Z each independently is halogen, alkyl, nitro, cyano, alkoxy-carbonyl or optionally substituted phenyl, andn is 0, 1, 2 or 3,or an acid or metal salt adduct thereof, which possess fungicidal properties.
    Type: Grant
    Filed: November 16, 1981
    Date of Patent: December 6, 1983
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wolfgang Kramer, Karl H. Buchel, Jorg Stetter, Paul-Ernst Frohberger, Wilhelm Brandes, Hans Scheinpflug
  • Patent number: 4418072
    Abstract: The invention relates to diastereoisomeric 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanol and methods for its preparation. Also included in the invention are compositions containing said diastereoisomeric 1-(4-chlorophenoxy)-1-(1-imidazolyl)-3,3-dimethyl-2-butanol and methods for the use of said compound and compositions as antimycotic agents.
    Type: Grant
    Filed: March 25, 1981
    Date of Patent: November 29, 1983
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wolfgang Kramer, Karl H. Buchel, Ingo Haller, Manfred Plempel
  • Patent number: 4418073
    Abstract: N-Acylated N-methyl-carbamic acid O-pyrazol-4-yl esters of the formula ##STR1## in which R represents an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aralkyl or aryl radical,Z represents an acyl radical,l represents 1 or 2,m represents 1 or 2 andn represents zero or 1,which possess pesticidal activity.
    Type: Grant
    Filed: June 8, 1981
    Date of Patent: November 29, 1983
    Assignee: Bayer Aktiengesellschaft
    Inventors: Fritz Maurer, Ingeborg Hammann, Bernhard Homeyer, Wolfgang Behrenz
  • Patent number: 4415739
    Abstract: 4-Benzoyl-5-hydroxypyrazoles useful as herbicidal active ingredients, their intermediate or stabilizers against heat, oxidation or ultraviolet light are produced by a condensation of a pyrazolone, tetrachloromethane and a benzene compound in the presence of an aluminium halide, followed by a hydrolysis reaction with industrial advantages.
    Type: Grant
    Filed: July 20, 1982
    Date of Patent: November 15, 1983
    Assignee: Ishihara Sangyo Kaisha Ltd.
    Inventors: Takahiro Haga, Tetsuji Nishikawa, Toshio Nakajima, Kohji Minamida, Masaru Maeda
  • Patent number: 4410707
    Abstract: The preparation of 3-amino-1-phenylpyrazol-5-one by heating phenylhydrazine and a lower cyanoacetic acid alkyl ester in a polar solvent, using a lower alcoholate of an alkali metal as the condensation agent, leads to particularly high yields and quality, if the phenylhydrazine and 1 to 1.2 moles of the alcoholate are initially taken, the cyanoacetic ester is metered in and the reaction is carried out at 105.degree. to 140.degree. C., volatile alcohols which have been liberated from the ester and, if appropriate, from the alcoholate being distilled off at the reaction temperature. It is advantageous to employ the phenylhydrazine in an excess of up to about 200 mole % and to select, as the polar solvent, an alcohol or ether having a boiling point above 105.degree. C.
    Type: Grant
    Filed: July 21, 1981
    Date of Patent: October 18, 1983
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Wolfgang Tronich, Wolfgang Rieper, Peter Bohme
  • Patent number: 4409234
    Abstract: Novel pyrazoloindazole derivatives of the formula ##STR1## wherein R.sub.1 is a hydrogen atom, halogen atom, a hydroxyl group, a lower alkyl group, a lower alkoxyl group or benzyloxyl group; R.sub.2 is a hydrogen atom, a halogen atom, a lower alkyl group or phenyl group (provided R.sub.1 and R.sub.2 are not hydrogen at the same time); and X.sup..crclbar. is a halide ion, a hydroxide ion, a methanesulfonate ion, a p-toluene sulfonate ion, a sulfate ion, a nitrate ion, a carbonate ion, an acetate ion, a benzoate ion or a salicylate ion, a process for preparing the derivatives, and a pharmaceutical composition containing the same are disclosed. The derivatives have good bronchodilating action for human without exhibiting substantially bad effects on the functioning of heart, and therefore, they are useful as a drug.
    Type: Grant
    Filed: June 3, 1982
    Date of Patent: October 11, 1983
    Assignee: Chugai Seiyaku Kabushiki Kaisha
    Inventors: Yasuo Fujimura, Sadao Tanaka, Isao Matsunaga, Yasuyuki Shiraki, Yugo Ikeda, Tamotsu Yamazaki, Yasuhiro Ohba, Shun-ichi Hata, Minoru Shindo, Kazushige Sakai
  • Patent number: 4407813
    Abstract: Pyrazoline derivatives having the formula ##STR1## wherein R.sup.1 represents hydrogen atom, a lower alkyl group, phenyl group or a halogen-substituted phenyl group; R.sup.2 represents hydrogen atom or phenyl group which can have halogen substituents; X represents oxygen or sulfur atom; Y and Z respectively represent hydrogen atom, a halogen atom, a lower alkyl group, a lower alkoxy group, nitro-group, trifluoromethyl group, a lower alkylthio group, an acyl group, nitrile group or a lower alkyl sulfonyl group.
    Type: Grant
    Filed: August 13, 1981
    Date of Patent: October 4, 1983
    Assignee: Nissan Chemical Industries Ltd.
    Inventors: Kiyomi Ozawa, Yasuyuki Nakajima, Makoto Tsugeno, Shigeru Ishii, Masataka Hatanaka
  • Patent number: 4407808
    Abstract: 3-Nitro-2-substituted aminopyrroles are histamine H.sub.2 -receptor antagonists. The 2- position substituent is a fully-unsaturated heterocyclyl alkyl group preferably with alkyl group interrupted by sulfur or oxygen. The 4- and 5- positions of the pyrrole ring can also be substituted.
    Type: Grant
    Filed: January 28, 1982
    Date of Patent: October 4, 1983
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Michael L. Roantree, Rodney C. Young
  • Patent number: 4406688
    Abstract: A herbicidal compound having the following formula ##STR1## wherein n is 0 or 1; a herbicidal composition comprising said compound as an active ingredient; a process for producing said composition; and a herbicidal method employing said compound.
    Type: Grant
    Filed: October 22, 1981
    Date of Patent: September 27, 1983
    Assignee: Mitsubishi Petrochemical Co., Ltd.
    Inventors: Kazuhiko Konno, Atsushi Goh, Kazuhito Miyoshi, Kaoru Ikeda
  • Patent number: 4404213
    Abstract: Derivatives of certain pyridyliminomethylbenzenes, useful as fungicides.
    Type: Grant
    Filed: April 12, 1982
    Date of Patent: September 13, 1983
    Assignee: Shell Oil Company
    Inventors: Pieter Ten Haken, Shirley B. Webb
  • Patent number: 4401821
    Abstract: Herbicides containing a pyrazole derivative of the formula ##STR1## where R.sup.1 denotes hydrogen, formyl, acetyl, propionyl, chloroacetyl, dichloroacetyl, methoxyacetyl, methoxycarbonyl, or phenoxycarbonyl which is unsubstituted or mono- or polysubstituted by halogen, R.sup.2 denotes phenyl which is unsubstituted or mono- or polysubstituted by fluorine, chlorine, bromine, methyl, methoxy, cyano, nitro, trifluoromethyl, trifluoromethoxy or methoxycarbonyl, R.sup.2 further denotes a 5- to 6-membered, heterocyclic aromatic ring which is unsubstituted or substituted by methyl or chlorine and which contains 1 or 2 hetero-atoms X, X being independently oxygen, sulfur or nitrogen, or R.sup.2 denotes .alpha.-naphthyl or .beta.-naphthyl, and R.sup.3 denotes methyl, ethyl or isopropyl, or a salt of such a pyrazole derivative, a process for combating unwanted plant growth with the active ingredients and methods of manufacturing the herbicides.
    Type: Grant
    Filed: July 2, 1981
    Date of Patent: August 30, 1983
    Assignee: BASF Aktiengesellschaft
    Inventors: Peter Plath, Wolfgang Rohr, Bruno Wuerzer
  • Patent number: 4400387
    Abstract: Indolizine derivatives represented by the general formula: ##STR1## wherein R represents a straight- or branched-chain alkyl radical having from 1 to 8 carbon atoms, or a phenyl group non-substituted or bearing one or two substituents, which may be the same or different, selected from halogen atoms, for example fluorine, chlorine and bromine and from lower alkyl and alkoxy groups, for example methyl and methoxy and X.sub.1, X.sub.2 and X.sub.3, which may be the same or different, each represent hydrogen, chlorine, bromine or methoxy with the proviso that when they are identical X.sub.1, X.sub.2 and X.sub.3 are not simultaneously hydrogen.They possess an inhibitory activity with respect to the action of xanthine oxidase and of adenosine deaminase as well as an uricosuric action and can be used in the treatment of physiological disturbances consequent upon an excess of uric acid, upon disorders of the immunization system and as antiparasitic agents.
    Type: Grant
    Filed: June 30, 1980
    Date of Patent: August 23, 1983
    Assignee: S. A. Labaz-Sanofi N.V.
    Inventors: Gilbert Rosseels, Pierre Nokin
  • Patent number: 4396548
    Abstract: Pyrazoline derivatives of the formula ##STR1## wherein Z represents a radical of the formula ##STR2## or of the formula ##STR3## and R, R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.8, R.sub.9 and R.sub.10 represent specific substituents and An.sup..crclbar. represents the equivalent of a colorless anion, a process for the production of these compounds and their use as fluorescent brightening agents.
    Type: Grant
    Filed: June 23, 1980
    Date of Patent: August 2, 1983
    Assignee: Ciba-Geigy Corporation
    Inventor: Kurt Weber
  • Patent number: 4394512
    Abstract: Compounds of the general formula ##STR1## wherein R represents an alkyl group of 1 to 3 carbon atoms or the group N(R.sub.2).sub.2, in which R.sub.2 represents a hydrogen atom, an alkyl group of 1 to 3 carbon atoms, or an acyl group of 1 to 3 carbon atoms, and R.sub.1 has the same meaning as R or is a hydrogen atom, are new and are suitable as chromogens for measuring H.sub.2 O.sub.2 formation in enzymatic reactions.
    Type: Grant
    Filed: January 23, 1981
    Date of Patent: July 19, 1983
    Assignee: Boehringer Mannheim GmbH
    Inventor: Hans-Georg Batz
  • Patent number: 4393217
    Abstract: This disclosure describes novel substituted phenyl-5-aminopyrazoles useful as anxiolytic and/or anti-depressant agents.
    Type: Grant
    Filed: January 12, 1981
    Date of Patent: July 12, 1983
    Assignee: American Cyanamid Company
    Inventors: John P. Dusza, Jay D. Albright
  • Patent number: 4388319
    Abstract: The compounds are N,N'-substituted thioureas, ureas and guanidines which are H-2 histamine receptor inhibitors. A compound of this invention is N-cyano-N'-[2-((4-methyl-5-imidazolyl)methylthio)ethyl]-N"-[2-(2-thiazolyl methylthio)ethyl]guanidine.
    Type: Grant
    Filed: December 11, 1980
    Date of Patent: June 14, 1983
    Assignee: Smith Kline & French Laboratories Limited
    Inventors: Graham J. Durant, Charon R. Ganellin