Patents Examined by Natalia Harkaway
  • Patent number: 4322536
    Abstract: A new improved process for producing pyridinaldehydes and hydrazone derivatives thereof, for example, pyridinaldehyde-phenylhydrazones, is described. This comprises reacting an aminomethylpyridine with an aldehyde or a ketone to give a compound of the formula ##STR1## isomerizing the compound (III), in the presence of suitable catalysts, to a compound of the formula ##STR2## and converting the compound (V), in the presence of an acid and optionally in the presence of a hydrazine, into a pyridinaldehyde or a pyridinaldehyde-hydrazone. It is possible to produce by the process according to the invention pyridinaldehydes and pyridinaldehyde-hydrazones in a simple manner, under mild ecologically favorable conditions and in good to very good yields.
    Type: Grant
    Filed: June 30, 1980
    Date of Patent: March 30, 1982
    Assignee: Ciba-Geigy Corporation
    Inventors: Rolf Bader, Dieter Reinehr
  • Patent number: 4322413
    Abstract: Heterocyclic phosphoric acid derivatives of the formula ##STR1## where R, R.sup.1, R.sup.2, R.sup.3, X and Y have the meanings given in the disclosure. The compounds are suitable for combating pests from the class of insects, Acarina and nematodes.
    Type: Grant
    Filed: January 6, 1981
    Date of Patent: March 30, 1982
    Assignee: BASF Aktiengesellschaft
    Inventors: Annegrit Baumann, Karl Kiehs, Gerhard Hamprecht, Arno Lange, Heinrich Adolphi
  • Patent number: 4322430
    Abstract: Amino-substituted-4,5,6,7-tetrahydro-1H (or 2H)-indazoles, useful as prolactin inhibitors and in treatment of Parkinson's Syndrome.
    Type: Grant
    Filed: February 19, 1981
    Date of Patent: March 30, 1982
    Assignee: Eli Lilly and Company
    Inventors: Nicholas J. Bach, Edmumd C. Kornfeld
  • Patent number: 4322541
    Abstract: Compounds having the formula ##STR1## wherein R.sub.3 and R.sub.5 each is independently hydrogen or alkyl are useful intermediates for the preparation of mercaptoacylamino acids having hypotensive activity.
    Type: Grant
    Filed: August 22, 1980
    Date of Patent: March 30, 1982
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: George C. Rovnyak
  • Patent number: 4321397
    Abstract: A 3-aminobenzoic acid or a 3-aminobenzenesulfonic acid, when reacted with a 4-aminoantipyrine in aqueous medium in the presence of hydrogen peroxide forms a novel colored dye which is believed to be a charge-transfer complex of free radicals formed from the 3-aminoaromatic acid and the 4-aminoantipyrine. The dye and the process by which it is produced are useful in analytical procedures for hydrogen peroxide, as well as in enzymatic analyses involving the formation of hydrogen peroxide.
    Type: Grant
    Filed: February 20, 1980
    Date of Patent: March 23, 1982
    Assignee: Millipore Corporation
    Inventors: Paul T. Nix, Spencer M. Fields
  • Patent number: 4318913
    Abstract: The invention relates to compounds of the formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in whichR.sub.1 and R.sub.2 represent hydrogen, an aliphatic or cycloaliphatic group, or R.sub.1 and R.sub.2 together with the nitrogen atom form a 5 to 10 membered heterocyclic ring:Alk represents a straight or branched alkylene chain;Q represents furan, thiophen or benzene ring which is incorporated into the rest of the molecule;X represents --CH.sub.2 --, ##STR2## --O-- or --S-- whereR.sub.6 represents hydrogen or methyl;n represents zero, 1 or 2;m represents 2, 3 or 4;R.sub.3 represents hydrogen, a substituted or unsubstituted aliphatic or aryl group and;R.sub.4 and R.sub.5, which may be the same or different, each represent hydrogen, a substituted or unsubstituted aliphatic, aryl, or together with the nitrogen atom form a heterocyclic group.
    Type: Grant
    Filed: April 26, 1979
    Date of Patent: March 9, 1982
    Assignee: Glaxo Group Limited
    Inventors: John W. Clitherow, John Bradshaw, John W. M. Mackinnon, Barry J. Price, Michael Martin-Smith, Duncan B. Judd
  • Patent number: 4316033
    Abstract: Alkoxysilylbenzotriazoles are provided and method for making such materials. These alkoxysilanes have been found useful as UV stabilizers and as adhesion promoters for silicone top coat compositions which can be applied onto thermoplastic organic polymers to impart improved abrasion resistance and UV stabilization thereto.
    Type: Grant
    Filed: May 30, 1980
    Date of Patent: February 16, 1982
    Assignee: General Electric Company
    Inventor: Ta-Yen Ching
  • Patent number: 4316039
    Abstract: New and valuable pyrazole derivatives having a good herbicidal action, herbicides containing these compounds as active ingredients, and processes for controlling the growth of unwanted plants with these compounds.
    Type: Grant
    Filed: August 25, 1980
    Date of Patent: February 16, 1982
    Assignee: BASF Aktiengesellschaft
    Inventors: Peter Plath, Bruno Wuerzer, Wolfgang Rohr
  • Patent number: 4316040
    Abstract: Substituted pyrazole ether derivatives, and salts thereof, having a herbicidal action, herbicides containing these compounds as active ingredients, and processes for controlling the growth of unwanted plants with these compounds.
    Type: Grant
    Filed: January 14, 1981
    Date of Patent: February 16, 1982
    Assignee: BASF Aktiengesellschaft
    Inventors: Peter Plath, Wolfgang Rohr, Bruno Wuerzer, Rainer Becker
  • Patent number: 4315938
    Abstract: Compounds of the formula ##STR1## wherein R.sub.2 is hydrogen, chlorine, bromine, formyl, acetyl, alkyl of 1 to 4 carbon atoms, nitro, cyano or --CH.sub.2 --A;whereA is (alkyl of 1 to 2 carbon atoms)-amino; di(alkyl of 1 to 2 carbon atoms)-amino, where one of the alkyl moieties may have a terminal hydroxyl substituent attached thereto; or a 5-, 6- or 7-membered saturated, nitrogen-containing heterocycle which is attached to the methylene group through the nitrogen atom and may have a hydroxyl or hydroxymethyl substituent attached to a ring carbon atom, and the 6-membered heterocycle may contain oxygen as an additional ring heteroatom in the p-position;R.sub.3 is hydrogen, fluorine, chlorine, bromine, methyl or methoxy; andR.sub.4 is hydrogen or alkyl of 1 to 3 carbon atoms;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as antidepressants.
    Type: Grant
    Filed: June 30, 1980
    Date of Patent: February 16, 1982
    Assignee: Boehringer Ingelheim Gmbh
    Inventors: Claus Schneider, Karl-Heinz Weber, Gerhard Walther, Karin Boke, Wolf D. Bechtel
  • Patent number: 4314844
    Abstract: This invention relates to novel substituted imidazoles of the formula: ##STR1## wherein R.sup.1 is a trifluoromethyl group, a halogen atom, an unsubstituted aryl group, a substituted aryl group, a heteroaromatic group, or a substituted heteroaromatic group;R.sup.2 and R.sup.3 are selected from a hydrogen atom, a halogen atom and a trifluoromethyl group, provided R.sup.2 and R.sup.3 are not concurrently halogen; andM is a hydrogen atom, an alkali or alkaline earth metal atom, a substituted carbonyl group, or other hydrolytically labile group.These compounds and compositions containing them exhibit herbicidal activity. Fungicidal activity of compounds of the invention is also shown.
    Type: Grant
    Filed: January 10, 1980
    Date of Patent: February 9, 1982
    Assignee: Rohm and Haas Company
    Inventors: Colin Swithenbank, Ted T. Fujimoto
  • Patent number: 4315008
    Abstract: O-Ethyl-S-n-propyl-O-(1-substituted-pyrazol-4-yl)-(thiono)-thiolphosphoric acid esters of the formula ##STR1## wherein R is alkyl, cycloalkyl or phenyl, andX is oxygen or sulphur, which possess arthropodicidal and nematicidal properties.
    Type: Grant
    Filed: November 19, 1979
    Date of Patent: February 9, 1982
    Assignee: Bayer Aktiengesellschaft
    Inventors: Fritz Maurer, Ingeborg Hammann, Bernhard Homeyer
  • Patent number: 4314067
    Abstract: Polymerizable monomeric compounds corresponding to the general formula ##STR1## wherein R is H or CH.sub.3, U designates a cyclic or acyclic ureido or thioureido group and L designates a selected linking structure. The linking structure L may contain one or more oxy (ether), amino, amido, or carbonyl groups provided that any carbonyl group (CO) present is not directly attached to U or to an ethylenic carbon atom nor is such ethylenic carbon atom directly attached to a nitrogen atom.
    Type: Grant
    Filed: March 6, 1978
    Date of Patent: February 2, 1982
    Assignee: Air Products and Chemicals, Inc.
    Inventors: Frederick L. Herman, Dale D. Dixon
  • Patent number: 4312880
    Abstract: Imidazolyl-enol ethers of the formula ##STR1## in which Ar is an optionally substituted aryl radical,R is an alkyl group, andX is an oxygen atom or a methylene radial,or acid or metal salt addition products thereof which possess fungicidal properties.
    Type: Grant
    Filed: July 17, 1980
    Date of Patent: January 26, 1982
    Assignee: Bayer Aktiengesellschaft
    Inventors: Wilfried Draber, Karl H. Buchel, Paul-Ernst Frohberger, Wilhelm Brandes
  • Patent number: 4312990
    Abstract: Compounds having the formula ##STR1## wherein R.sub.1 is hydrogen, alkyl, aryl, arylalkyl or a hydrolyzable acyl protecting group;R.sub.2 is hydrogen, alkyl or trifluoromethyl;R.sub.3 and R.sub.4 each is independently hydrogen, halogen, trifluoromethyl, alkylamino, furylmethylamino, phenylamino, thienylmethylamino, alkoxy, aryloxy, benzylthio, arylthio, benzyl, benzoyl, hydroxy, cyano or arylmethoxy;R.sub.5 is hydrogen, alkyl or arylalkyl; andn is 0, 1 or 2, have hypotensive activity.
    Type: Grant
    Filed: September 11, 1980
    Date of Patent: January 26, 1982
    Assignee: E. R. Squibb & Sons, Inc.
    Inventor: Rudiger D. Haugwitz
  • Patent number: 4312870
    Abstract: 2-Aryl-pyrazolo[4-3-c]quinolin-3-ones, e.g. those of the formula ##STR1## and pharmaceutically acceptable acyl derivatives or salts thereof, are psychoactive agents useful in the treatment of anxiety or depression.
    Type: Grant
    Filed: May 16, 1980
    Date of Patent: January 26, 1982
    Assignee: Ciba-Geigy Corporation
    Inventor: Naokata Yokoyama
  • Patent number: 4310664
    Abstract: Pyridine-4-aldehyde phenylhydrazones are prepared by catalytic hydrogenation of 4-cyano-pyridine under normal pressure or almost normal pressure in the presence of phenylhydrazine or nuclear-substitution products thereof, in an aqueous medium in the absence of organic solvents, at a pH value between 9 and 12, preferably between 9.5 and 11, and in a temperature range from 0.degree. to 60.degree. C.
    Type: Grant
    Filed: June 26, 1980
    Date of Patent: January 12, 1982
    Assignee: Bayer Aktiengesellschaft
    Inventors: Heinz Giesecke, Alfred Brack
  • Patent number: 4310521
    Abstract: Aspirin-isopropylantipyrine (N-3'a-propylphenazonyl-2-acetoxybenzamide) of the following formula ##STR1## and its pharmaceutical use. This compound can be prepared by reacting 1-phenyl-2-methyl-3-aminomethyl-4-isopropylpyrazolone of the formula ##STR2## with a member selected from the group consisting of acetylsalicylic acid and a reactive acid derivative thereof, and is useful as an analgetic, antipyretic and anti-inflammatory agent.
    Type: Grant
    Filed: November 7, 1980
    Date of Patent: January 12, 1982
    Assignee: Toho Pharmaceutical Co., Ltd.
    Inventor: Shinichiro Aonuma
  • Patent number: 4309552
    Abstract: 4-Nitro-1,2-hydrocarbyl pyrazolidines are prepared by a novel route from 1,2-disubstituted hydrazines and 1,3-di-(secondary amino)-2-nitropropanes and reduced to the corresponding 4-amino-1,2-hydrocarbyl pyrazolidines, which latter compounds are intermediates in the preparation of certain pharmaceutical benzamides.The novel 4-nitro-1,2-hydrocarbyl pyrazolidines have the formula: ##STR1## wherein R.sup.1 and R.sup.2 are selected from loweralkyl, lowercycloalkyl or phenyl-loweralkyl and may be the same or different.
    Type: Grant
    Filed: August 7, 1980
    Date of Patent: January 5, 1982
    Assignee: A. H. Robins Company, Inc.
    Inventors: Young S. Lo, Harry R. Munson, Jr.
  • Patent number: 4308278
    Abstract: 4-[(3,4-Dialkoxyphenyl)alkyl]-2-imidazolidinone derivatives having the formula I ##STR1## wherein R.sup.1 stands for a cycloalkyl group containing from 3 to 6 carbon atoms or benzyl group;R.sup.2 stands for hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms;R.sup.3 stands for hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms;R.sup.4 stands for hydrogen atom, or an alkyl group containing from 1 to 4 carbon atoms or an alkoxycarbonyl group containing from 1 to 4 carbon atoms; andR.sup.5 stands for hydrogen atom or an alkoxycarbonyl group containing from 1 to 4 carbon atoms,are prepared by(a) reducing a hydantoin derivative having the general formula II, wherein R.sup.1 and R.sup.2 are as defined above, with lithium aluminum hydride in a neutral organic solvent, or(b) hydrogenating catalytically an 1,3-dihydro-2H-imidazol-2-one derivative having the general formula III, wherein R.sup.1 and R.sup.3 are as defined above, while the meaning of R.sup.
    Type: Grant
    Filed: November 1, 1979
    Date of Patent: December 29, 1981
    Assignee: Gyogyszerkutato Intezet
    Inventors: Geza Schneider, Ferenc Andrasi, Pal Berzsenyi, Arpad Lazar, Sandor Elek, Istvan Elekes, Istvan Polgari