Abstract: A new improved process for producing pyridinaldehydes and hydrazone derivatives thereof, for example, pyridinaldehyde-phenylhydrazones, is described. This comprises reacting an aminomethylpyridine with an aldehyde or a ketone to give a compound of the formula ##STR1## isomerizing the compound (III), in the presence of suitable catalysts, to a compound of the formula ##STR2## and converting the compound (V), in the presence of an acid and optionally in the presence of a hydrazine, into a pyridinaldehyde or a pyridinaldehyde-hydrazone. It is possible to produce by the process according to the invention pyridinaldehydes and pyridinaldehyde-hydrazones in a simple manner, under mild ecologically favorable conditions and in good to very good yields.
Abstract: Heterocyclic phosphoric acid derivatives of the formula ##STR1## where R, R.sup.1, R.sup.2, R.sup.3, X and Y have the meanings given in the disclosure. The compounds are suitable for combating pests from the class of insects, Acarina and nematodes.
Type:
Grant
Filed:
January 6, 1981
Date of Patent:
March 30, 1982
Assignee:
BASF Aktiengesellschaft
Inventors:
Annegrit Baumann, Karl Kiehs, Gerhard Hamprecht, Arno Lange, Heinrich Adolphi
Abstract: Compounds having the formula ##STR1## wherein R.sub.3 and R.sub.5 each is independently hydrogen or alkyl are useful intermediates for the preparation of mercaptoacylamino acids having hypotensive activity.
Abstract: A 3-aminobenzoic acid or a 3-aminobenzenesulfonic acid, when reacted with a 4-aminoantipyrine in aqueous medium in the presence of hydrogen peroxide forms a novel colored dye which is believed to be a charge-transfer complex of free radicals formed from the 3-aminoaromatic acid and the 4-aminoantipyrine. The dye and the process by which it is produced are useful in analytical procedures for hydrogen peroxide, as well as in enzymatic analyses involving the formation of hydrogen peroxide.
Abstract: The invention relates to compounds of the formula (I) ##STR1## and physiologically acceptable salts, hydrates and bioprecursors thereof, in whichR.sub.1 and R.sub.2 represent hydrogen, an aliphatic or cycloaliphatic group, or R.sub.1 and R.sub.2 together with the nitrogen atom form a 5 to 10 membered heterocyclic ring:Alk represents a straight or branched alkylene chain;Q represents furan, thiophen or benzene ring which is incorporated into the rest of the molecule;X represents --CH.sub.2 --, ##STR2## --O-- or --S-- whereR.sub.6 represents hydrogen or methyl;n represents zero, 1 or 2;m represents 2, 3 or 4;R.sub.3 represents hydrogen, a substituted or unsubstituted aliphatic or aryl group and;R.sub.4 and R.sub.5, which may be the same or different, each represent hydrogen, a substituted or unsubstituted aliphatic, aryl, or together with the nitrogen atom form a heterocyclic group.
Type:
Grant
Filed:
April 26, 1979
Date of Patent:
March 9, 1982
Assignee:
Glaxo Group Limited
Inventors:
John W. Clitherow, John Bradshaw, John W. M. Mackinnon, Barry J. Price, Michael Martin-Smith, Duncan B. Judd
Abstract: Alkoxysilylbenzotriazoles are provided and method for making such materials. These alkoxysilanes have been found useful as UV stabilizers and as adhesion promoters for silicone top coat compositions which can be applied onto thermoplastic organic polymers to impart improved abrasion resistance and UV stabilization thereto.
Abstract: New and valuable pyrazole derivatives having a good herbicidal action, herbicides containing these compounds as active ingredients, and processes for controlling the growth of unwanted plants with these compounds.
Type:
Grant
Filed:
August 25, 1980
Date of Patent:
February 16, 1982
Assignee:
BASF Aktiengesellschaft
Inventors:
Peter Plath, Bruno Wuerzer, Wolfgang Rohr
Abstract: Substituted pyrazole ether derivatives, and salts thereof, having a herbicidal action, herbicides containing these compounds as active ingredients, and processes for controlling the growth of unwanted plants with these compounds.
Type:
Grant
Filed:
January 14, 1981
Date of Patent:
February 16, 1982
Assignee:
BASF Aktiengesellschaft
Inventors:
Peter Plath, Wolfgang Rohr, Bruno Wuerzer, Rainer Becker
Abstract: Compounds of the formula ##STR1## wherein R.sub.2 is hydrogen, chlorine, bromine, formyl, acetyl, alkyl of 1 to 4 carbon atoms, nitro, cyano or --CH.sub.2 --A;whereA is (alkyl of 1 to 2 carbon atoms)-amino; di(alkyl of 1 to 2 carbon atoms)-amino, where one of the alkyl moieties may have a terminal hydroxyl substituent attached thereto; or a 5-, 6- or 7-membered saturated, nitrogen-containing heterocycle which is attached to the methylene group through the nitrogen atom and may have a hydroxyl or hydroxymethyl substituent attached to a ring carbon atom, and the 6-membered heterocycle may contain oxygen as an additional ring heteroatom in the p-position;R.sub.3 is hydrogen, fluorine, chlorine, bromine, methyl or methoxy; andR.sub.4 is hydrogen or alkyl of 1 to 3 carbon atoms;and non-toxic, pharmacologically acceptable acid addition salts thereof. The compounds as well as their salts are useful as antidepressants.
Type:
Grant
Filed:
June 30, 1980
Date of Patent:
February 16, 1982
Assignee:
Boehringer Ingelheim Gmbh
Inventors:
Claus Schneider, Karl-Heinz Weber, Gerhard Walther, Karin Boke, Wolf D. Bechtel
Abstract: This invention relates to novel substituted imidazoles of the formula: ##STR1## wherein R.sup.1 is a trifluoromethyl group, a halogen atom, an unsubstituted aryl group, a substituted aryl group, a heteroaromatic group, or a substituted heteroaromatic group;R.sup.2 and R.sup.3 are selected from a hydrogen atom, a halogen atom and a trifluoromethyl group, provided R.sup.2 and R.sup.3 are not concurrently halogen; andM is a hydrogen atom, an alkali or alkaline earth metal atom, a substituted carbonyl group, or other hydrolytically labile group.These compounds and compositions containing them exhibit herbicidal activity. Fungicidal activity of compounds of the invention is also shown.
Abstract: O-Ethyl-S-n-propyl-O-(1-substituted-pyrazol-4-yl)-(thiono)-thiolphosphoric acid esters of the formula ##STR1## wherein R is alkyl, cycloalkyl or phenyl, andX is oxygen or sulphur, which possess arthropodicidal and nematicidal properties.
Type:
Grant
Filed:
November 19, 1979
Date of Patent:
February 9, 1982
Assignee:
Bayer Aktiengesellschaft
Inventors:
Fritz Maurer, Ingeborg Hammann, Bernhard Homeyer
Abstract: Polymerizable monomeric compounds corresponding to the general formula ##STR1## wherein R is H or CH.sub.3, U designates a cyclic or acyclic ureido or thioureido group and L designates a selected linking structure. The linking structure L may contain one or more oxy (ether), amino, amido, or carbonyl groups provided that any carbonyl group (CO) present is not directly attached to U or to an ethylenic carbon atom nor is such ethylenic carbon atom directly attached to a nitrogen atom.
Abstract: Imidazolyl-enol ethers of the formula ##STR1## in which Ar is an optionally substituted aryl radical,R is an alkyl group, andX is an oxygen atom or a methylene radial,or acid or metal salt addition products thereof which possess fungicidal properties.
Type:
Grant
Filed:
July 17, 1980
Date of Patent:
January 26, 1982
Assignee:
Bayer Aktiengesellschaft
Inventors:
Wilfried Draber, Karl H. Buchel, Paul-Ernst Frohberger, Wilhelm Brandes
Abstract: Compounds having the formula ##STR1## wherein R.sub.1 is hydrogen, alkyl, aryl, arylalkyl or a hydrolyzable acyl protecting group;R.sub.2 is hydrogen, alkyl or trifluoromethyl;R.sub.3 and R.sub.4 each is independently hydrogen, halogen, trifluoromethyl, alkylamino, furylmethylamino, phenylamino, thienylmethylamino, alkoxy, aryloxy, benzylthio, arylthio, benzyl, benzoyl, hydroxy, cyano or arylmethoxy;R.sub.5 is hydrogen, alkyl or arylalkyl; andn is 0, 1 or 2, have hypotensive activity.
Abstract: 2-Aryl-pyrazolo[4-3-c]quinolin-3-ones, e.g. those of the formula ##STR1## and pharmaceutically acceptable acyl derivatives or salts thereof, are psychoactive agents useful in the treatment of anxiety or depression.
Abstract: Pyridine-4-aldehyde phenylhydrazones are prepared by catalytic hydrogenation of 4-cyano-pyridine under normal pressure or almost normal pressure in the presence of phenylhydrazine or nuclear-substitution products thereof, in an aqueous medium in the absence of organic solvents, at a pH value between 9 and 12, preferably between 9.5 and 11, and in a temperature range from 0.degree. to 60.degree. C.
Abstract: Aspirin-isopropylantipyrine (N-3'a-propylphenazonyl-2-acetoxybenzamide) of the following formula ##STR1## and its pharmaceutical use. This compound can be prepared by reacting 1-phenyl-2-methyl-3-aminomethyl-4-isopropylpyrazolone of the formula ##STR2## with a member selected from the group consisting of acetylsalicylic acid and a reactive acid derivative thereof, and is useful as an analgetic, antipyretic and anti-inflammatory agent.
Abstract: 4-Nitro-1,2-hydrocarbyl pyrazolidines are prepared by a novel route from 1,2-disubstituted hydrazines and 1,3-di-(secondary amino)-2-nitropropanes and reduced to the corresponding 4-amino-1,2-hydrocarbyl pyrazolidines, which latter compounds are intermediates in the preparation of certain pharmaceutical benzamides.The novel 4-nitro-1,2-hydrocarbyl pyrazolidines have the formula: ##STR1## wherein R.sup.1 and R.sup.2 are selected from loweralkyl, lowercycloalkyl or phenyl-loweralkyl and may be the same or different.
Abstract: 4-[(3,4-Dialkoxyphenyl)alkyl]-2-imidazolidinone derivatives having the formula I ##STR1## wherein R.sup.1 stands for a cycloalkyl group containing from 3 to 6 carbon atoms or benzyl group;R.sup.2 stands for hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms;R.sup.3 stands for hydrogen atom or an alkyl group containing from 1 to 4 carbon atoms;R.sup.4 stands for hydrogen atom, or an alkyl group containing from 1 to 4 carbon atoms or an alkoxycarbonyl group containing from 1 to 4 carbon atoms; andR.sup.5 stands for hydrogen atom or an alkoxycarbonyl group containing from 1 to 4 carbon atoms,are prepared by(a) reducing a hydantoin derivative having the general formula II, wherein R.sup.1 and R.sup.2 are as defined above, with lithium aluminum hydride in a neutral organic solvent, or(b) hydrogenating catalytically an 1,3-dihydro-2H-imidazol-2-one derivative having the general formula III, wherein R.sup.1 and R.sup.3 are as defined above, while the meaning of R.sup.
Type:
Grant
Filed:
November 1, 1979
Date of Patent:
December 29, 1981
Assignee:
Gyogyszerkutato Intezet
Inventors:
Geza Schneider, Ferenc Andrasi, Pal Berzsenyi, Arpad Lazar, Sandor Elek, Istvan Elekes, Istvan Polgari