Patents Examined by Nathan A. Bowers
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Patent number: 12163113Abstract: Described herein is a cell culture device and methods of use in three-dimensional cell co-cultures and for use in studying paracrine signaling in vitro.Type: GrantFiled: November 6, 2020Date of Patent: December 10, 2024Assignee: Rutgers, The State University of New JerseyInventors: Martin L. Yarmush, Anil Shrirao, Rene S. Schloss, Ileana Marrero-Berrios
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Patent number: 12157877Abstract: The subject technology relates to a cell retention device and method for use in a perfusion cell culture system where the cell retention device includes a hollow-fiber filter having an average pore size ranging from about 0.5 to about 20 ?m and having the ability to operate under perfusion cell culture conditions for up to 35 days without being clogged or losing its product sieving ability by more than 20%.Type: GrantFiled: April 13, 2017Date of Patent: December 3, 2024Assignee: Boehringer Ingelheim International GmbHInventors: Jonathan Coffman, Scott Godfrey, Samantha Wang
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Patent number: 12152227Abstract: The invention relates to a a single-use flexible bioreactor bag comprising a rigid multiport plate sealed to a side wall of said bioreactor bag, wherein said multiport plate comprises a plurality of ports. The invention further relates to a method of manufacturing the bag and to a method of installing the bag in a rigid support vessel.Type: GrantFiled: April 17, 2019Date of Patent: November 26, 2024Assignee: GLOBAL LIFE SCIENCES SOLUTIONS USA LLCInventors: Michael Jason Miller, Hanna-Leena Saukkonen
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Patent number: 12146891Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.Type: GrantFiled: July 18, 2019Date of Patent: November 19, 2024Assignee: Labrador Diagnostics LLCInventors: James R. Wasson, John Kent Frankovich, Elizabeth A. Holmes, Timothy Smith, Michael Chen, Daniel Young
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Patent number: 12146130Abstract: Aspects of the invention include methods of removing carbon dioxide (CO2) from a CO2 containing gas. In some instances, the methods include contacting CO2 containing gas with a bicarbonate buffered aqueous medium under conditions sufficient to produce a bicarbonate rich product. Where desired, the resultant bicarbonate rich product or a component thereof may then be stored or further processed, e.g., combined with a divalent alkaline earth metal cation, under conditions sufficient to produce a solid carbonate composition. Aspects of the invention further include systems for practicing the methods, as well as products produced by the methods.Type: GrantFiled: June 2, 2020Date of Patent: November 19, 2024Assignee: Blue Planet Systems CorporationInventors: Brent R. Constantz, Mark Bewernitz, Jacob Schneider, Chris Camire
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Patent number: 12138226Abstract: Nutritional formulas comprising long-chain polyunsaturated fatty acids (LC-PUFAs) are provided, along with methods and devices for preparing and/or administering nutritional formulas. In some embodiments, a percentage of the LC-PUFAs in the nutritional formula are in the form of monoglycerides and/or free fatty acids. In some embodiments, the nutritional formulas do not comprise added lipase. Also provided are methods for providing nutrition to a subject, methods for improving fat absorption, methods for improving cognitive ability, methods for preventing chronic lung disease, and methods for reducing the length of time a patient requires total parenteral nutrition.Type: GrantFiled: June 29, 2022Date of Patent: November 12, 2024Assignee: ALCRESTA THERAPEUTICS, INC.Inventors: Alexey L. Margolin, Robert Gallotto, Bhami Shenoy
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Patent number: 12139702Abstract: A well for electrically stimulating at least one cell. The well includes a bottom portion and comprises an adaptive electrode arrangement for introducing an electric field into the well. The adaptive electrode arrangement includes a pair of electrodes disposed within the well. Each electrode of the pair of electrodes has a distal end and is independently and axially displaceable relative to the other electrode and the bottom portion of the well. The distal end of each electrode of the pair of electrodes is in contact with the bottom portion of the well, ensuring a uniform and constant electric field is applied within the well.Type: GrantFiled: September 30, 2022Date of Patent: November 12, 2024Assignee: AMGEN INC.Inventors: Chuck Z. Li, Brandon Zachary Sarich, Phillip Ng
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Patent number: 12134757Abstract: Described herein is a beads-free bioprocessor as an automated and cost-effective T cell processing and manufacturing platform. T cells are a core component in CAR T cell therapies for cancer treatment, but are difficult to manufacture to scale in clinically relevant quantities. The 3D bioprocessor provides an alternative device that is scalable, beads-free, easy-to-use, and cost-effective for using CAR T cell therapy in cancer immunotherapy. Besides CAR T cell application, this platform technology has potential for many other applications such as cancer cell isolation.Type: GrantFiled: September 26, 2022Date of Patent: November 5, 2024Assignees: Southwest Research Institute, The Trustees Of The University Of PennsylvaniaInventors: Jian Ling, Kreg A. Zimmern, Michael C. Milone
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Patent number: 12134758Abstract: Systems, methods and kits are described for culturing one or more biological cells in a microfluidic device, including provision of nutrients and gaseous components configured to enhance cell growth, viability, portability, or any combination thereof. In some embodiments, culturing a single cell may produce a clonal population in the microfluidic device.Type: GrantFiled: May 12, 2022Date of Patent: November 5, 2024Assignee: BRUKER CELLULAR ANALYSIS, INC.Inventors: Randall D. Lowe, Jr., Kristin G. Beaumont, Aathavan Karunakaran, Natalie C. Marks, Jason M. McEwen, Mark P. White, J. Tanner Nevill, Gang F. Wang, Andrew W. McFarland, Daniele Malleo, Keith J. Breinlinger, Xiao Guan, Kevin T. Chapman
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Patent number: 12122992Abstract: A large-flux in-situ filtration device for marine microorganism based on a multi-channel circulation distributor is provided, comprising an energy and control module, a circulation distribution module, a filtration module, a pump module, a filtration volume measurement module, a pipeline connection, and a main body support frame. The circulation distribution module may include a multi-channel circulation distributor, a deep-sea servo motor, etc. The filtration module may include a plurality of filter film holders. The pump module may include a stainless steel gear pump, a deep-sea drive motor, etc. The filtration volume measurement module may include a water meter, a camera, and an LED light.Type: GrantFiled: March 7, 2023Date of Patent: October 22, 2024Assignee: ZHEJIANG UNIVERSITYInventors: Shuo Liu, Zhiyong Sun, Yu Zhang, Shanmin Zhou, Jingyang Li, Yang Shi, Yong Cai, Jiwei Tian, Xiao Zhang, Yu Xin
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Patent number: 12121023Abstract: A system for the hypothermic transport of biological samples, such as tissues, organs, or body fluids. The system includes a self-purging preservation apparatus to suspend a sample in preservation fluid and perfuse a tissue with preservation fluid. The self-purging preservation apparatus is placed in an insulated transport container having a cooling medium. When assembled, the system allows for transport of biological samples for extended periods of time at a stable temperature.Type: GrantFiled: July 15, 2024Date of Patent: October 22, 2024Assignee: Paragonix Technologies, Inc.Inventors: Lisa Maria Anderson, Jared Alden Judson
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Patent number: 12116558Abstract: High capacity, low cost devices for use in growing monocultures of novel, previously unknown microbial species contain adhesive layers with wells covered by nanoporous membranes. The devices are placed in natural environments for cultivation of unknown microbial species.Type: GrantFiled: April 12, 2021Date of Patent: October 15, 2024Assignee: Northeastern UniversityInventor: Slava Epstein
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Patent number: 12096765Abstract: A system for the hypothermic transport of biological samples, such as tissues, organs, or body fluids. The system includes a self-purging preservation apparatus to suspend a sample in preservation fluid and perfuse a tissue with preservation fluid. The self-purging preservation apparatus is placed in an insulated transport container having a cooling medium. When assembled, the system allows for transport of biological samples for extended periods of time at a stable temperature.Type: GrantFiled: May 28, 2024Date of Patent: September 24, 2024Assignee: PARAGONIX TECHNOLOGIES, INC.Inventors: Lisa Maria Anderson, Jared Alden Judson
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Patent number: 12097497Abstract: A cell accommodating chip is adapted for use in a screening apparatus for searching for a predetermined cell based on optical information emitted from a substance on the cell accommodating chip and selectively collecting the cell searched for. The cell accommodating chip includes a substrate composed of a light-transmitting material, and a plurality of wells capable of accommodating cells, the plurality of wells being provided on at least one of main faces of the substrate. A surface of the cell accommodating chip having the plurality of wells is coated with a specific polymer having a crosslinked structure.Type: GrantFiled: September 28, 2018Date of Patent: September 24, 2024Assignee: YAMATO SCIENTIFIC CO., LTD.Inventors: Mariko Matsunaga, Ken Tsukii, Kenichi Kimura, Toru Takahashi, Jie Xu, Takayuki Matsumoto, Kohta Igarashi
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Patent number: 12098357Abstract: Inoculating systems/devices, methods for inoculating a target, and coating methods are disclosed. An example inoculating system may include an inoculating member having a transfer region and a handle region. A pre-determined quantity of viable microorganisms may be disposed on the transfer region. The inoculating member may be configured to transfer the pre-determined quantity of viable microorganisms to a target during an inoculation operation without having to rehydrate the pre-determined quantity of viable microorganisms prior to the inoculating operation.Type: GrantFiled: December 15, 2022Date of Patent: September 24, 2024Assignee: STRATIX LABS CORPORATIONInventors: Joshua Erickson, Mark Mulvahill, Maya Burroughs
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Patent number: 12084645Abstract: The invention discloses a hollow profile wall segment (1) for a bioreactor or mixer support vessel (2;2a;2b), comprising a base profile (3) with two parallel wide sides (4,5), two narrow sides (6,7) and at least one heat exchange channel (8) extending in a longitudinal direction of the base profile through an interior space (9) in the base profile, wherein the hollow profile wall segment is adapted to be joined with similar hollow profile wall segments to form a side wall (12) of a bioreactor or mixer support vessel (2) and wherein each narrow side comprises at least one coupling member (10,11;11a;150) capable of securing the hollow profile wall segment side by side with similar hollow profile wall segments.Type: GrantFiled: May 11, 2017Date of Patent: September 10, 2024Assignee: CYTIVA SWEDEN ABInventors: Klaus Gebauer, Thomas Erik Arctaedius, Patrick Jonsson, Andreas Marcstrom
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Patent number: 12085583Abstract: Systems and methods are provided for sample processing. A device may be provided, capable of receiving the sample, and performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing multiple assays. The device may comprise one or more modules that may be capable of performing one or more of a sample preparation, sample assay, and detection step. The device may be capable of performing the steps using a small volume of sample.Type: GrantFiled: May 13, 2021Date of Patent: September 10, 2024Assignee: Labrador Diagnostics LLCInventors: Elizabeth A. Holmes, Michael Chen, Pey-Jiun Ko
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Patent number: 12077739Abstract: Embodiments described herein generally provide for the expansion of cells in a cell expansion system using an active promotion of a coating agent(s) to a cell growth surface in some embodiments. A coating agent may be applied to a surface, such as the cell growth surface of a hollow fiber in a bioreactor, by controlling the movement of a fluid in which a coating agent is suspended, by changing flow rates, by changing flow directions, by rotation of the bioreactor, and/or combinations thereof.Type: GrantFiled: February 16, 2023Date of Patent: September 3, 2024Assignee: Terumo BCT, Inc.Inventors: Nathan D. Frank, Brian J. Nankervis, Dennis J. Hlavinka, Thomas G. Dilorenzo
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Patent number: 12077800Abstract: The disclosure provides a system and a process for injecting and uniformly distributing a liquid into a fermentation broth in a bioreactor for maintaining stable condition within the fermentation broth. The system includes a downcomer section which contains two or more circular pipe conduits extending from a wall of the downcomer to the center vertical axis line of the downcomer. Liquid injection apertures are arranged along the circular pipe conduit and are non-uniformly spaced apart from the center vertical axis of the downcomer to the wall of the downcomer. The apertures further alternate and are offset between the top and bottom surfaces of the circular pipe conduit. The process of the disclosure involves using the system described above for carrying out a fermentation process for converting a C1-substrate to at least one product such as ethanol.Type: GrantFiled: June 16, 2022Date of Patent: September 3, 2024Assignee: LanzaTech, Inc.Inventors: Paul Alvin Sechrist, Bjorn Daniel Heijstra, Joshua Jeremy Conolly
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Patent number: 12073924Abstract: The disclosure features methods that include obtaining a vibrational spectrum of a solution in a biological manufacturing system, analyzing the vibrational spectrum using a first chemometrics model to determine a value of a first quality attribute associated with the solution, analyzing the vibrational spectrum using a second chemometrics model to determine a value of a second quality attribute associated with the solution, and adjusting at least one parameter of a purification unit of the biological manufacturing system based on at least one of the values of the first and second quality attributes.Type: GrantFiled: December 7, 2021Date of Patent: August 27, 2024Assignee: Genzyme CorporationInventors: Dhanuka Pulasthi Wasalathanthri, Jagdish C. Tewari, Xuezhen Kang, Marina Hincapie, Shawn L. Barrett, Julie Susanne Pollock