Abstract: The present invention is related to the field of devices for introducing and extracting media from the body, more specifically to the devices for introducing media into the body by means of intravascular access, and in particular, provides a puncture device for accessing the vascular system comprised of: a needle having a tubular body, with said tubular body having a distal end and a proximal end, a cutting edge in the distal end of said tubular body, and an expansion of the external diameter having a bulb shape next, in distal-proximal direction, to said cutting edge. In this way, a puncture device is provided for accessing the vascular system that solves the problem of allowing the echograph monitoring of the needle, but whose fabrication implies a reduction in the technical difficulty for its obtention, while it avoids the accidental perforation of the distal wall of the vessel of interest.

Abstract: A drug coated balloon includes a balloon body and a drug loaded coating layer. The drug loaded coating layer includes a first drug loaded coating component having at least two controllable sustained release drugs with different drug release kinetics, and a second drug loaded coating component including an active drug. The second drug loaded coating component is dispersed among the controllable sustained release drugs and couples the controllable sustained release drugs on the balloon body. The first and second drug loaded coating components are both non-hydrophilic compositions. The drug coated balloon provides sufficient initial drug loading dosage to the lesion site, and has adjustable drug release rate, thereby allowing the drug coated balloon to provide bioactive drugs to the treatment site at different stages of the cascade reaction of vascular restenosis, providing the controllable long-acting therapeutic drugs, and improving the overall vascular drug release efficacy.

Abstract: A medical device may include: a shaft configured to be inserted into a body lumen of a subject; a handle at a proximal end of the shaft, the handle including an adjustment mechanism configured to be transitioned from a first configuration, in which the shaft has a first stiffness, to a second configuration, in which the shaft has a second stiffness. The first stiffness may be different from the second stiffness.

Abstract: Disclosed herein is a catheter placement system with a stiffening system and associated methods thereof. The catheter placement system can include a needle, catheter (e.g. rapid insertion central catheter), one or more guidewires, and a stiffening system, configured to place the catheter while containing portions of the catheter placement system that contact the patient within a sterile environment. Advantageously, the catheter placement system can provide all tools necessary for accessing a vasculature, dilating the insertion site and placing the catheter within a single device, mitigating repeated insertion of multiple tools and reducing the risk of introducing pathogens or the like. Further, the overall time required to place the catheter is reduced, reducing patient down time and improving patient outcomes.

Abstract: A proximal-femur intraosseous release device includes a release mechanism. A primary fixing mechanism is provided at one end of the release mechanism, the primary fixing mechanism includes a first shell, and a second shell, a first triangular block and a second triangular block are arranged inside the first shell; the second shell is screwed to the first shell through threads, a bottom of the second shell is rotatably connected with the first triangular block, the first triangular block is slidably connected with the first shell, a bottom surface of the first triangular block is an inclined surface, the second triangular block is located at a bottom of the first triangular block, a top surface of the second triangular block is an inclined surface, and a through hole matched with the second triangular block is formed in the first shell.

Abstract: A device for draining cysts includes a catheter system configured to deploy an absorbent material, including but not limited to a foam, into a cyst. The absorbent material advantageously absorbs fluid contained within the cyst, for example fluid that may remain following aspiration, reducing the potential for cyst recurrence. In various embodiments, the absorbent material may be bioabsorbable, radiolucent, echogenic, drug eluting, or a combination thereof. In some embodiments the device may further include or be coupled to a vacuum source which applies negative pressure to the cyst during foam delivery, thereby reduce the overall size and/or profile of the cyst.

Abstract: A device having a bone screw with a body, an outer thread and a proximal screw head. A fluid-permeable conduit is disposed in the body, begins at the head and opens out into a fluid outlet opening that is spaced apart from the head in the distal direction. An axial groove extends from the fluid outlet opening to the screw head. The base of the groove is deeper than the base of the outer thread. A cap detachably connects with the screw head, in which a fluid-permeable conduit is disposed, which opens out into the conduit of the bone screw. A hose for feeding fluid is connected or connectable in a fluid-permeable manner with the inlet opening on the cap so that a pharmaceutical fluid is pressable out of the fluid outlet opening through the hose, through the conduit of the cap and through the conduit of the bone screw.

Abstract: A communication device arranged for transmitting information from a medicament delivery device is presented. The communication device includes at least one translation detection arrangement, configured to detect a translation of at least one physical part of the medicament delivery device by utilization of a resilience and an electrical conductivity for at least one spring of the medicament delivery device. The communication device also includes at least one change of state detection unit, configured to detect at least one change of state for the medicament delivery device based on the detected translation. The communication device further includes at least one activation unit, configured to activate the at least one change of state detection unit based on the at least one detected translation. The communication device also includes at least one transmission unit configured to provide a wireless transmission of information related to the at least one change of state to an external receiving device.

Abstract: Disclosed are rapidly insertable central catheters (“RICCs”) including assemblies and methods thereof. In some embodiments, a RICC assembly includes a RICC and an introducer. The RICC includes a soft catheter tube having an introducing aperture that opens into a primary lumen of the RICC. The introducer includes an introducer catheter including a hard catheter tube having an introducing hole that opens into a single lumen of the introducer catheter. When the RICC assembly is in a ready-to-deploy state thereof, the introducer catheter is disposed in the primary lumen of the RICC such that a distal end of the introducer catheter extends past a distal end of the RICC. In addition, an introducer needle of the introducer is disposed in the introducer catheter through both the introducing aperture and the introducing hole such that a beveled tip of the introducer needle extends past the distal end of the introducer catheter.

Abstract: The invention provides a medical instrument with angle adjustment device, including a guidewire output portion, a guidewire guide portion, an adjustment control portion and traction wires. The guidewire output portion is bendable relative to the guidewire guide portion. The guidewire output portion is provided with a guidewire output hole. One end of each traction wire is connected to a proximal end of the guidewire output portion, and the other end of the traction wire is connected to a bending control member of the adjustment control portion. The adjustment control portion controls a bending angle of the guidewire output portion through the traction wire. The ends of the plurality of traction wires are evenly distributed along the guidewire output portion. The positions and quantity of traction wires are set to enable a medical instrument having a distal end with an adjustable bending degree to adjust angles in various directions as required.

Abstract: The present disclosure relates to a drive subassembly for a drug delivery device, the drive subassembly comprising a housing and a plunger, wherein the plunger is adapted to be rotated between a locked position, in which the plunger is prevented from advancing, and a released position, in which the plunger is advancable, wherein at least one restraining component is provided to restrain rotation of the plunger from the locked position towards the released position.

Abstract: An apparatus includes a housing, an energy storage member, a carrier, a medicament container, and a delivery control mechanism. The housing defines a gas chamber configured to receive pressurized gas from the energy storage member to pressurize the gas chamber. The carrier has a proximal surface that defines a portion of the gas chamber. The medicament container is coupled to the carrier and has a distal end portion coupled to a delivery member. The medicament container contains at least 5 mL of medicament and includes an elastomeric member that seals the medicament within the medicament container. The delivery control mechanism is coupled to a proximal end portion of the medicament container and includes a flow restriction member for regulating a pressure supplied by the gas chamber and entering into the medicament container that acts on the elastomeric member.

Abstract: A phacoemulsification cutting tip, including a rigid tubular portion and a flexible and expandable tip portion located distal to the rigid tubular portion. The flexible and expandable tip portion presents an axial length and an unexpanded radius and is formed such that the axial length shortens while the unexpanded radius increases when differential pressure due to an occlusion of an opening of the flexible tip portion exists.

Abstract: Devices and methods for filling a medicament cartridge of a pump, including a user-wearable, ambulatory infusion pump. A device for supporting a medicament cartridge can comprise a body portion resembling a tray, with recesses disposed therein to support one or more of a cartridge body, cartridge tubing, interconnect fitting, and vial adapter. The recesses of the tray may be shaped to correspond to that component intended to be placed in its respective recess so to provide a visual indication to a user how to couple and align the various components necessary to fill the cartridge.

Abstract: Elongate blood flash flow paths can be detrimental to the operation of catheter placement systems by delaying the indication time, reducing the efficacy of the vacuum, or increasing the chance of clotting. Catheter placement systems with reduced blood flash fluid paths include blood flash indicators having a proximally slidable syringe barrel and plunger that is fixedly attached to the system housing. By reversing the operation of the blood flash indicator syringe, the clinician maintains the advantages of a visual and tactile feedback while shortening the blood flow path between the needle tip and syringe barrel. Catheter placement systems also include a needle interface structure configured to further shorten the blood flash fluid path.

Abstract: The present invention relates to a movement disorder monitor, and a method of measuring the severity of a subject's movement disorder. The present invention additionally relates to a treatment delivery system for treating a subject in response to changes in the severity of a subject's symptoms. The present invention further provides for a system and method, which can accurately quantify symptoms of movement disorders, utilizing continuously obtained kinetic information to be analyzed, accurately distinguishing between symptoms of movement disorders and activities of daily living, relating quantified symptoms to a standard clinical rating scale, and correlating a subject's symptoms with certain physiological and environmental factors. The present invention still further provides for home monitoring of symptoms in subjects with these movement disorders in order to capture the complex fluctuation patterns of the disease over the course of days, weeks, months, or years.

Abstract: A system for delivery of molecular hydrogen (H2) into a bodily orifice of a subject, such as the vagina or anus/rectum, to provide therapeutic effect.

Abstract: Devices and methods for administering a medication in fluid form, the systems and methods including a basal flow path and a bolus flow path in parallel to the basal flow path. The bolus flow path includes a combined piston pump and rotatable valve. The piston pump is configured to prevent partial dosing of a bolus dose.

Abstract: An implantable access device for accessing the vascular system of a human or animal body, particularly subcutaneously implantable access port, comprising: a port body with at least one outlet opening connected or connectable to a catheter for accessing the vascular system of the human or animal body; a needle entrance with at least one inlet opening for receiving a needle, wherein the needle entrance is connected to the port body and movable relative to the port body between a first, unactuated operating condition and a second, actuated operating condition; and a flexible socket arranged between the port body and the needle entrance and at least covering the area where the needle entrance moves relative to the port body to prevent tissue growth in this area.

Abstract: A portable insulin pump can integrate and display data from a continuous glucose monitor (CGM) to allow a user to more readily determine whether any interaction with the pump is necessary. Data from the CGM can automatically be transmitted to the pump and can be displayed for user analysis or automatically analyzed to present recommendations to the user based on combined data from the CGM and the pump.