Abstract: A control system for administration of a drug comprises a drug administration actuator for administering the drug to a patient at a controllable dosage; a monitor for measuring an effect of the drug on the patient; and a controller configured to determine a control signal to the drug administration actuator; wherein the controller is configured to implement a closed loop model-predictive control scheme comprising, for each of a series of time steps, minimizing a cost function subject to one or more constraints to determine the control signal, the cost function based at least in part on a reference level and the monitor measurement; wherein the control signal is used as an input to an auxiliary model to estimate at least one concentration level of the drug in the patient; and wherein the constraints comprise at least one constraint on the estimate of the concentration level of the drug.

Abstract: A balloon catheter may include a shaft having a distal side and a proximal side and a balloon provided at the distal side of the shaft. The balloon may have a plurality of wings in a deflated state, with each of the wings having a projection on an outer surface in a wrapped state, and each of the projections having a projecting direction, which is opposite to a wrapping direction of the wing. In a cross section that is perpendicular to a long axis direction of the balloon, a base of the projection may have a base first end part farther from a tip of the wing and a base second end part closer to the tip of the wing, and a tip of the projection may be closer to a base of the wing with respect to a line passing through the base first end part which is perpendicular to a line passing through the base first end part and the base second end part.

Abstract: The present invention generally provides a device for inserting needles and alleviating the discomfort associated with needle insertion. In certain embodiments, the device is suited for injecting butterfly needles and particularly butterfly needles that are attached to infusion tubing. The patient or caregiver loads a butterfly needle with tubing attached into the base of the drive plunger. The needle with tubing attached is retracted into the housing of the device by retracting the inner plunger. Once retracted, the device is activated and ready to administer a needle into the tissue of a patient. The device is then placed on the location of the skin where injection is desired. The surface that contacts the skin may be textured and may include a contact switch that causes the device to vibrate when slight pressure is applied through contact with the skin.

Abstract: Embodiments herein relate to an implantable device comprising a casing, a semi-permeable membrane plug at or near a first end of the casing, a piston, beads, and an opening for release of the beads from the implantable device within a body of a human or an animal; wherein the implantable device is configured to be implanted within the body of the human or the animal during delivery of the beads into the body of the human or the animal; wherein the beads comprise a core and a shell with the core being enclosed by the shell and the beads contain a drug; and wherein the implantable device is configured to produce a desired flow rate of elution of the drug from the implantable device when the implantable device is implanted within the body of the human or the animal.

Abstract: The present disclosure relates to systems and methods for controlling physiological glucose concentrations in a patient using a closed loop artificial pancreas. The systems and methods may utilize a controller with control logic operative to execute a multi-model predictive controller algorithm to determine a medication dose to the patient.

Abstract: An apparatus for delivering a metered stream of saliva solution includes a delivery tube for drawing a saliva solution from a solution source; a pumping and metering device connected to the delivery tube for pumping saliva solution from the solution source through the delivery tube and delivering the solution to a user mouth, the delivery tube having a delivery tube upstream segment for extending from the solution source to the device, and a delivery tube downstream segment extending from the device to a delivery tube free end for placement in a user mouth; and a mouthpiece mounted to the delivery tube free end for engaging and securely retaining the delivery tube free end within a user mouth until released.

Abstract: A non-surgical method of delivering a liquid radioactive solution from a source to a recipient comprising the steps of: determining a desired recipient level of radioactivity and recipient volume of the radioactive solution to be delivered to the recipient, providing a first valve having a waste position and a recipient position, providing a bolus conduit, a waste conduit and a recipient conduit, each conduit having a valve end being connected to said first valve, so that the first valve can establish a waste flow path in the waste position and a recipient flow path in the recipient position, the recipient flow path being different from said waste flow path, the bolus conduit comprising a measuring section and an internal volume, the internal volume being approximately equal to the desired recipient volume of the radioactive solution to be delivered to the recipient, arranging said first valve in the waste position, transporting a first amount of said radioactive solution through said waste flow path, the fir

Abstract: This passive safety device comprises an inner needle shield having a proximal end configured to be sealed to a tip of an injection device, a distal portion configured to be pricked by a needle in a pre-use position and pierced by the needle in an injection position, and an energy storage portion configured to accumulate energy as the passive safety device passes from the pre-use position to the injection position and release energy as the passive safety device passes from the injection position to a safety position. The passive safety device further comprises a sleeve surrounding the proximal end, an outer needle shield having a proximal end slidably attached to the sleeve so that the outer needle shield is movable relative to the sleeve, and a lock configured to lock the outer needle shield in the safety position.

Abstract: A connecting structure for medical use includes a male assembly 1 and a female connector 2. The male assembly 1 includes a male connector 10 and a threadedly engageable cylinder 20. A male luer portion 11 of the male connector 10 and a female luer portion 2a of the female connector 2 are joined by turning the threadedly engageable cylinder 20 in a tightening direction in a state where a female screw 21a of the threadedly engageable cylinder 20 and an engageable protrusion 2c of the female connector 2 are threadedly engaged with each other. A torque limiting mechanism 50 is disposed between an operation cylinder 30 mounted on an outer periphery of the threadedly engageable cylinder 20 and the threadedly engageable cylinder 20. Engageable teeth 51 are formed in an inner periphery of one end portion of the operation cylinder 30 over an entire periphery. A slit 54 is formed in one end portion of the threadedly engageable cylinder 20.

Abstract: Methods and systems are disclosed wherein temperature in a device such as an ambulatory infusion pump is monitored during inductive charging of the device such that temperature-sensitive contents or components, such as, for example, insulin, particular circuitry and/or other components are not damaged. Temperature can be monitored in the device at one or more locations during inductive charging. If the temperature breaches one or more predetermined thresholds and/or is rising at a rate greater than one or more predetermined thresholds, charging can be suspended or provided at reduced power to prevent the temperature from further rising and damaging the contents and/or components of the device. One or more alerts associated with these events may also be triggered so that the user is aware of the situation and may take corrective action.

Abstract: A hand-held, portable inhalator device is disclosed. The device has a mouthpiece with a chamber operatively coupled to a medication inlet and a fluid outlet. A trigger is configured to dispense medication from a medication source through the medication inlet and into the chamber after a threshold level of positive pressure is achieved within the chamber of the mouthpiece and maintained for a threshold period of time.

Abstract: A stabilized coronary sinus catheter system having a proximal section and a distal section with a memory shape portion, and a tip, distal of the memory shape portion. A handle having a body, a tip deflection actuator, a memory shape portion deployment actuator, and an axis. The tip is in line with the axis and the tip deflection actuator is at a first position. The tip is deflected out of alignment with the axis when the tip deflection actuator is at a second position. A third position is a delivery configuration where the memory shape portion and the tip are in line with the axis. The memory shape portion deployment actuator is at a first location. A deployed configuration allows the memory shape portion to form a predetermined shape conforming to the shape of the coronary sinus when the memory shape portion deployment actuator is at a second location.

Abstract: A delivery device for delivering a gel or liquid pharmaceutical to a treatment site, the delivery device including a body extending from a delivery tip, the body defining a cavity for retaining a pharmaceutical or a pre-assembled cartridge holding the pharmaceutical; and a driver for mechanically discharging the pharmaceutical from the cartridge to the delivery tip. The driver may be adapted to release a consistent flow of the pharmaceutical. In addition, the delivery device may be biased into a release configuration.

Abstract: The present disclosure relates to a syringe safety cap and a safety syringe including the same. One aspect of the present disclosure provides a syringe safety cap including a base portion having a mounting portion to be mounted on a cylinder of a syringe, a link portion rotatably connected to the base portion, a first elastic portion configured to provide a rotational force so that the link portion rotates with respect to the base portion, a safety cover portion rotatably connected to the link portion, detachably fixed to the base portion, and configured to, when detached from the base portion and rotating, surround an injection needle of the syringe, and a second elastic portion configured to provide a rotational force so that the safety cover portion rotates with respect to the link portion.

Abstract: A breathing mask which is convenient for enteral nutrition using a nasogastric feeding tube when the mask is in use may be provided. The breathing mask may include at least one nasogastric tube port. The port may allow a nasogastric tube to pass through the mask without substantially affecting the seal or pressure of the mask while accommodating enteral feeding. In addition, the breathing mask may incarnate the human-centered design to reduce discomfort in patients and is favorable for therapy and rehabilitation.

Abstract: The present disclosure relates to an injector device comprising: a housing having a distal end and a proximal end; a medicament cartridge disposed within the housing; a needle unit comprising a needle, the needle unit being disposed in the distal end of the housing; and a button disposed in the proximal end of the housing, the button being configured to move the cartridge onto the needle unit to fluidly connect the needle with the cartridge when, in use, the button is pressed from an initial position into a depressed position.

Abstract: A one-piece catheter (30) and manufacturing method therefor are disclosed. The catheter (30) includes a catheter tube (33) and an adapter (31). The catheter catheter tube (33) includes a tip (331) at one end and an end portion (332) at another other end. The adapter (31) can be configured for receiving a septum (402). The adapter (31) includes a narrow opening. The end portion (332) of the catheter tube (33) is connected to the adapter (31) at the narrow opening for fluid communication between the catheter tube (33) and the adapter (31). The catheter tube (33) and adapter (31) are formed as a one-piece element that is preferably injection molded in a single-shot process. Additional elements, such as one or more retention tabs (313) for attaching to a base can be formed on the catheter (30). The one-piece catheter (30) can be made by a single-shot injection molding process. Additional structures, such as a base can be attached to the catheter (30) by a second-shot injection molding process.

Abstract: A fluid injector system for delivering a multi-phase fluid injection to a patient and methods of fluid delivery is disclosed. Methods of creating and using a multi-aspect fluid path impedance model of the injector system are used. Modeling and adjustment of factors that affect impedance and prevent or reduce backflow, reduce the likelihood of fluid flow rate spikes and provide more accurate flow rates and mixing ratios of fluids may be repeated or happen essentially continuously during an injection. The adjustments may be determined before the injection or determined and/or adjusted during the injection. The determination may include sensor feedback commonly used in injectors such as pressure and position feedback as well as other sensors. In all cases, the user can be notified of adjustments through on-screen notices and/or through the recordation of the injection data by a control device of the injector at the conclusion of the injection.

Abstract: Systems, devices, and methods for detaching an implantable device from a delivery system are disclosed herein. One aspect of the present technology, for example, is directed toward an elongated shaft having an inner surface that defines a lumen that extends distally from the proximal portion to an opening at a distal terminus of a distal portion. In some embodiments the distal portion includes an inner polymer structure having a first portion and a second portion positioned distal of the first portion along the length of the inner polymer structure. The first portion can have a first stiffness and the second portion can have a second stiffness less than the first stiffness. The distal portion can further include an outer polymer structure disposed around the inner polymer structure and a coil wound around the inner polymer structure and disposed within the outer polymer structure.

Abstract: A system for delivery of gas to a tissue, comprises: a first container containing the gas, an applicator having a distal end arranged to deliver the gas to the tissue, a second container containing a purging gas; and a flow control system for controlling flow of gas. The system also comprises a three-port valve having a first port for receiving the gas from the first container, a second port for receiving the purging gas from the second container, and a third port in fluid communication with the applicator. The valve is switchable between a first state at which the first port fluidly connects to the third port, and a second state at which the second port fluidly connects to the third port.