Abstract: Disclosed are a system, methods and computer-readable medium products that provide safety constraints for an insulin-delivery management program. Various examples provide safety constraints for a control algorithm-based drug delivery system that provides automatic delivery of a drug based on sensor input. Glucose measurement values may be received at regular time intervals from a sensor. A processor may predict future glucose values based on prior glucose measurement values. The safety constraints assist in safe operation of the drug delivery system during various operational scenarios. In some examples, predicted future glucose values may be used to implement safety constraints that mitigate under-delivery or over-delivery of the drug while not overly burdening the user of the drug delivery system and without sacrificing performance of the drug delivery system. Other safety constraints are also disclosed.

Abstract: A drug delivery device is proposed which comprises: a housing defining an interior; a reservoir which is adapted to contain a drug or contains a drug, the reservoir being retained in the interior; and a closure part which is secured relative to the housing and has to be disconnected from the housing to get access to the reservoir within the interior, wherein the closure part is secured relative to the housing by a connection, wherein the connection comprises a welded connection, and wherein the welded connection is formed between two join partners, i.e. a first join partner and a second join partner. Further, a method for manufacturing a drug delivery device is disclosed as is a use associated with drug delivery devices.

Abstract: A device and a method for dispensing at least one substance to a patient is presented where the device has a movable first container containing a first substance having a first piston with a first piston rod, a movable second container containing a second substance having a second piston with a second piston rod, an injection device, and a conduit device for guiding the contents of the second container to the first container and the contents of the first container to the injection device, wherein the first and the second piston are each movable via at least one pre-tensioned spring element. A free end of the first piston rod and a free end of the second piston rod are releasably held by a common holding component, and the common holding component is designed in such a way that a movement of the common holding component results in a successive release of the first piston rod and the second piston rod.

Abstract: The objective of the present invention is for an object discharged from a discharge port to be less liable to form a jet flow, and less liable to cause injury to the central nervous system. A passage 11 for a cell is formed inside a needle body 10 of a puncture needle 1. A discharge port 15 for a cell is formed in a side surface 13b of a front end part 13 of the needle body 10. Furthermore, the needle body is a single tube provided with a passage for an object. Further, a discharge path 14 for a cell, oriented upward from the passage 11 toward the discharge port 15, is formed in the front end part 13. The discharge path 14 comprises a frustoconical part 14a and a columnar part 14b.

Abstract: A peripheral intravenous catheter assembly may include a low-drag septum. The septum may include a body having a distal end and a proximal end, which may be sealed. The septum may include a slot disposed within an outer surface of the body and oriented along a longitudinal axis of the body. The slot may include a distal end spaced apart from the distal end of the body, and a proximal end spaced apart from the proximal end of the body. An introducer needle may extend through the slot.

Abstract: The present disclosure relates to an injector device having a housing, a cartridge with a reservoir for medicament, a needle unit with a needle, and a needle sleeve rotatably mounted to the housing about an axis. Prior to use of the injector device the needle is sealed from the reservoir, and at least one of the needle unit and the cartridge is axially slidably mounted to the housing. The needle sleeve includes an engagement member arranged to engage the needle unit and/or the cartridge. The engagement member is adapted such that rotation of the needle sleeve moves the needle unit and/or the cartridge in an axial direction to move the needle into fluid communication with the reservoir.

Abstract: An injector device includes an elongate housing configured to receive container of medicament. The injector device also includes a needle sleeve mounted within the housing and moveable between an extended position in which the needle sleeve at least partially extends from the distal end of the housing, and a retracted position in which the needle sleeve is received further within the housing than in the extended position. The injector device also includes a release mechanism configured to control actuation of a piston rod. The release mechanism includes a rotatable member disposed within the housing and in cooperating engagement with the needle sleeve such that movement of the needle sleeve from the extended position to the retracted position causes the rotatable member to rotate within the housing from a first position to a second position.

Abstract: The present invention provides a drug injection device (100, 100?, 100?) comprising a first element (130) and a second element (102, 102?, 102?) configured to undergo movement relative to each other corresponding to an action performed on or by the drug injection device (100, 100?, 100?), wherein the first element (130) comprises serially disposed protrusions (133), and wherein the second element (102, 102?, 102?) comprises a second element base and a deflectable transducer (170, 170?, 170?). The deflectable transducer (170, 170?, 170?) defines a base portion attached to the second element base, and a deflectable portion (162) configured for sequentially cooperating with the plurality of protrusions (133), wherein a processor (165) is electrically connected with the deflectable transducer (170, 170?, 170?) to register activation signals.

Abstract: A catheter may include an inner liner, at least one support structure over the inner liner, and an outer jacket over the at least one support structure. In some examples, the catheter includes a tip jacket positioned over a distal portion of the outer jacket and extend beyond a distal-most part of the inner liner and a distal-most part of the outer jacket to define a single-layer catheter tip. In some examples, the at least one support structure may include a braid and a coil. The catheter may include a marker band over a distal portion of one of the braid or the coil. The other of the braid or the coil ends proximally of a proximal end of the marker band, such that the catheter includes a location with lower radial and/or flexural stiffness proximal of the marker band.

Abstract: A catheter assembly includes: a catheter; and an inner needle inserted through the catheter. The catheter includes: a catheter body; and a flexible portion that is located at a distal portion of the catheter body and forms a most distal portion of the catheter. An elastic modulus of the catheter body is greater than an elastic modulus of the flexible portion. The catheter has a mixed region in which the catheter body and the flexible portion overlap each other in a radial direction.

Abstract: A medical device is provided that includes a fine needle aspiration device and an incision device, which are inserted into a body with an endoscope. The fine needle aspiration device includes an injection needle and an injection needle tube, which surrounds the injection needle. A first limiting unit limits the length of the needlepoint of the injection needle protruding from the injection needle tube. A syringe is connected to the injection needle for tissue collection and medicine injection. A second limiting unit limits the connection between the injection needle and the syringe. The incision device includes a knife and a knife tube that surrounds the knife. A third limiting unit limits the length of the cutting edge of the knife protruding from the knife tube.

Abstract: A medical instrument or device, such as a catheter, has echogenic properties, in addition to or as an alternative to radiopaque properties, to facilitate detection of the medical instrument or device during medical procedures using suitable imaging methods, such as ultrasound imaging and/or x-ray imaging methods. In example embodiments, an example catheter has a relatively increased radiopacity and echogenicity to facilitate a clinician with detecting the catheter with ultrasound imaging and/or x-ray imaging methods to assist the clinician with the insertion, placement, and/or maintenance of the catheter, for example.

Abstract: Methods and devices for use and handling of intravenous and/or subcutaneous needles, and, more particularly, to safety devices for shielding needles or other sharp articles or devices that present a safety hazard are disclosed. In an embodiment, a needle protective sheath can include a top wall, a bottom wall, and a pair of side walls joining the top and bottom walls. A finger shield extends from the top wall at a front opening of the sheath and is attached to the top wall by a hinge portion. The finger shield can be rotated about the hinge portion to block the front opening so as to secure a needle within the sheath.

Abstract: A feedback mechanism for an injection device that is configured to deliver a medicament to a user is described. The feedback mechanism comprises an actuator and a fluid chamber having a restricted outlet. The actuator is adapted to urge fluid from the fluid chamber through the restricted outlet. The feedback mechanism also has an indicator that is adapted to provide feedback to the user after a predetermined volume of fluid has passed from the fluid chamber through the restricted outlet during use of the injection device.

Abstract: A plastic flange for a medical container, the plastic flange defining an opening, the opening being surrounded by a peripheral collar, the collar providing a support to a user's fingers, wherein the flange comprises connecting means for connecting the flange to an external surface of a tubular barrel of the medical container, and wherein the flange further comprises a remotely readable electronic component for remote identification of the medical container, the remotely readable electronic component being embedded into the plastic flange.

Abstract: A system for serially injecting liquids includes a syringe body, proximal and distal stopper members disposed in the syringe body, a first liquid in a distal chamber, a second liquid in a proximal chamber, a plunger member, and a needle hub assembly coupled to a distal needle interface of the syringe body. The plunger member includes a needle retention feature disposed in a plunger interior, an energy-storage member disposed in the plunger interior, and an energy-storage member latching member disposed in the plunger interior. The needle assembly includes a needle having a needle proximal end feature, a hub, and a needle latching member configured to couple the needle to the hub. Manipulating the plunger member to insert the proximal stopper member distally relative to the syringe body initially expels the first liquid, then the second liquid. The needle is at least partially retractable into plunger interior.

Abstract: Disclosed is a system for administrating fluids to a patient, such as an infant. The system comprises a container that defines a drip chamber, a source of nutritive fluid fluidically communicating with the drip chamber, and a tube connecting the drip chamber to the gastric cavity of a patient, the chamber including a membrane that is gas-permeable but that is resistant to fluid passage. The system allows fluids to be introduced to the patient and for gastric gases to be released while they are resistant to the leak and spillage.

Abstract: The present invention relates to an injection device that includes a housing having an axis, and a needle sleeve that is axially movably within the housing. Axial movement of the needle sleeve into the housing is configured to actuate an injection process. The needle sleeve includes a first part that is slidably mounted to the housing, and a second part that protrudes from the housing and is rotationally coupled to the first part. The needle sleeve includes a locking mechanism that is configured to prevent axial movement of the needle sleeve into the housing until the second part of the needle sleeve has been rotated relative to the first part of the needle sleeve.

Abstract: The objectives for the designs presented herein can be for a variably flexible and kink-resistant catheter for vascular applications. The designs benefit from good compressive and tensile stiffness. A braided wire support structure can be disposed around an inner liner and an outer layer having a plurality of outer jackets of variable durometer. A metallic reinforcing layer can be cut from a hypotube and be used as the primary structure for catheter stiffness, reducing the reliance on and number of jackets to transition stiffness changes along the length of the catheter. The metallic reinforcing layer can have one or more ribbon cut segments and one or more axial hole patterns laser cut into the hypotube to progressively evolve the stiffness from proximally regions with more column stiffness and distal regions with greater lateral flexibility. The polymer jackets can be reflowed to bond the structure together.

Abstract: An autoinjector and method of injection are described. A power spring causes rotation of a drive nut about the central axis of the autoinjector that, in turn, causes a middle screw to rotate in the same direction as the drive nut and also to move in the distal direction while pushing a center screw in the distal direction that pushes the syringe and needle. The center screw also pushes a plunger that pushes the fluid out of the syringe. After injection, a locked retract screw is freed and rotates in the same direction as the middle screw causing the syringe to retract the syringe into the housing.