Patents Examined by Neil N Turk
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Patent number: 10393659Abstract: The present disclosure provides an instrument and methods for detecting an analyte, comprising a light source capable of generating excitation light for exciting a plurality of luminescence labels, an excitation beam path extending between said light source and said analyte, a detector capable of detecting light emitted from said luminescence label, an emission beam path extending between said analyte and said detector, a filter carrier carrying two or more pairs of filter portions, each pair being related to one luminescence label and comprising a first filter portion for transmitting excitation light and a second filter portion for transmitting emitted light, wherein said first filter portion of one pair is said second filter portion of another pair, and wherein said filter portions are arranged in a manner that a respective one of said pairs can be brought in an operative condition in which said first filter portion is in said excitation beam path and said second filter portion is in said emission beam patType: GrantFiled: September 15, 2016Date of Patent: August 27, 2019Assignee: Roche Molecular Systems, Inc.Inventor: Alan Furlan
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Patent number: 10345240Abstract: The invention combines recent advances in barcode technology with portable wireless communication devices to engineer a simple and low-cost chip-based multiplex wireless detection system. The system can analyze multiple targets of interest simultaneously in minutes and is applicable to detection of pathogens or contaminants in a wide range of fields including medicine, agriculture and the environment.Type: GrantFiled: December 11, 2013Date of Patent: July 9, 2019Assignee: THE GOVERNING COUNCIL OF THE UNIVERSITY OF TORONTOInventors: Warren Che Wor Chan, Kevin Ming
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Patent number: 10338000Abstract: There is provided a sensor fiber including an electrically insulating material having a fiber length. At least one transduction element is disposed along at least a portion of the fiber length and is arranged for exposure to an intake species. A photoconducting element is in optical communication with the transduction element. At least one pair of electrically conducting electrodes are in electrical connection with the photoconducting element. The pair of electrodes extend the fiber length.Type: GrantFiled: September 24, 2013Date of Patent: July 2, 2019Assignees: Massachusetts Institute of Technology, FLIR Systems, IncorporatedInventors: Alexander Gumennik, Alexander Mark Stolyarov, Brent Richard Schell, Chong Hou, Guillaume Romain Lestoquoy, Fabien Sorin, William Richard McDaniel, II, Yoel Fink, Aimee Rose, John Dimitris Joannopoulos
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Patent number: 10324020Abstract: Embodiments are directed to an apparatus that includes a fluidic structure and optical components. The fluidic structure includes a transparent channel through which objects in an analyte fluid can travel along respective paths during operation of the apparatus. The optical components are configured to provide measurement light to the objects traveling through the transparent channel. The fluidic structure is configured to reversibly engage with a host structure. The host structure includes a source of the measurement light and electronics to receive and process output light emanating from the objects traveling in the channel. The fluidic structure makes an air-tight seal when engaged with the host structure.Type: GrantFiled: December 23, 2013Date of Patent: June 18, 2019Assignee: Palo Alto Research Center IncorporatedInventors: David M. Johnson, Noble M. Johnson, Michael I. Recht, Joerg Martini, Tim Curley, Peter Kiesel, Martin Sheridan
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Patent number: 10302649Abstract: We describe apparatuses, systems, method, reagents, and kits for conducting assays as well as process for their preparation. They are particularly well suited for conducting automated sampling, sample preparation, and analysis in a multi-well plate assay format. For example, they may be used for automated analysis of particulates in air and/or liquid samples derived therefrom in environmental monitoring.Type: GrantFiled: December 21, 2006Date of Patent: May 28, 2019Assignee: Meso Scale Technologies, LLCInventors: Charles M. Clinton, Eli N. Glezer, Bandele Jeffrey-Coker, Sandor L. Kovacs, Sudeep M. Kumar, George Sigal, Carl Stevens, Michael Vock
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Patent number: 10265700Abstract: A diabetes test system for measuring blood glucose levels is provided, which includes a glucose meter, at least one diabetic test strip, and a container or pouch for storing the diabetes test strips and protecting them during transport. Methods of packaging diabetes test strips are also provided. The glucose meter includes software for detecting the validity of the at least one diabetic test strip, and a communication device that transmits data relating to the blood glucose level of the user to an external device. A secure packaging system for diabetes test strips which eliminates gray market sales of such test strips is also provided.Type: GrantFiled: February 1, 2017Date of Patent: April 23, 2019Inventor: Samuel Messinger
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Patent number: 10266463Abstract: Apparatuses, systems and methods for extracting isoprene using minimum capital investment, operating cost, and relatively corrosion free environment are disclosed herein. Embodiments of the invention are directed to producing pure isoprene and gasoline quality raffinate (free or sulfur and acetylenes) which are of value in manufacturing rubbers and other polymers.Type: GrantFiled: April 7, 2015Date of Patent: April 23, 2019Assignee: GTC Technology US LLCInventors: Venkata K. Ramanujam, Michael McCaulley, Joseph C. Gentry
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Patent number: 10254225Abstract: Biosensor including a device base having a sensor array of light sensors and a guide array of light guides. The light guides have input regions that are configured to receive excitation light and light emissions generated by biological or chemical substances. The light guides extend into the device base toward corresponding light sensors and have a filter material. The device base includes device circuitry electrically coupled to the light sensors and configured to transmit data signals. The biosensor also includes a shield layer having apertures that are positioned relative to the input regions of corresponding light guides such that the light emissions propagate through the apertures into the corresponding input regions. The shield layer extends between adjacent apertures and is configured to block the excitation light and the light emissions incident on the shield layer between the adjacent apertures.Type: GrantFiled: December 9, 2014Date of Patent: April 9, 2019Assignee: ILLUMINA, INC.Inventors: Cheng Frank Zhong, Hod Finkelstein, Boyan Boyanov, Dietrich Dehlinger, Darren Segale
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Patent number: 10247699Abstract: The invention describes a detection system (1) for analytical separation processes, particularly for electrophoresis, characterized by an optoelectronic sensor layer (5) made from organic semiconductor materials extending along the carrier layer (2) for the sample to be tested, for detecting the separated sample.Type: GrantFiled: November 21, 2007Date of Patent: April 2, 2019Assignee: ASMAG-Holding GmbHInventor: Max Sonnleitner
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Patent number: 10241233Abstract: A method for characterizing an interaction between a first particle and a second particle is provided. The method includes the steps of: (i) providing an optical trap system including a photonics-based trap, a light source, and a camera; (ii) optically trapping, using the photonics-based trap, the first particle; (iii) obtaining a first measurement of a trap stiffness of the photonics-based trap; (iv) introducing the second particle to the optically trapped particle; (v) incubating the first and second particles under conditions suitable for an interaction between the first and second particles; (vi) obtaining a second measurement of the trap stiffness of the photonics-based trap after the incubation; and (vii) determining, using the first measurement of trap stiffness and the second measurement of trap stiffness, a property of the interaction between the first particle and the second particle.Type: GrantFiled: August 12, 2015Date of Patent: March 26, 2019Assignee: CORNELL UNIVERSITYInventors: David Erickson, Pilgyu Kang
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Patent number: 10201331Abstract: A biopsy tissue sample transport device and method of using thereof including a tissue storage assembly having a sample container, having a holding structure to hold a tissue sample, the holding structure having a sample access opening formed in a sidewall; a housing that receives the tissue storage assembly, the housing comprising an assembly insertion opening through which the tissue storage assembly is inserted into the housing; a sealing member configured to engage and substantially seal the sample access opening of the holding structure of the sample container of the tissue storage assembly; and a lid to engage and substantially seal the assembly insertion opening of the housing.Type: GrantFiled: June 24, 2013Date of Patent: February 12, 2019Assignee: Leica Biosystems Nussloch GmbHInventors: Jo Fleming, Charles E. Clemens, David Berardelli
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Patent number: 10184891Abstract: A biochip device comprising a substrate constituted by at least one plate of material forming a multimode planar waveguide and carrying chromophore elements suitable for emitting fluorescence in response to excitation by guided waves having an evanescent portion, the device being characterized in that it includes coupling means for coupling excitation light with the waveguide in the form of guided waves, the coupling means being substantially non-directional.Type: GrantFiled: December 28, 2011Date of Patent: January 22, 2019Assignee: GENEWAVEInventors: Claude Weisbuch, Lucio Martinelli, Henri Benisty, Christof Schafauer, Gabriel Sagarzazu, Thierry Gacoin, Mélanie Bedu
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Patent number: 10180441Abstract: The invention relates to a microplate reader and a respective method, wherein the microplate reader comprises at least one measuring device and a holding device for accommodating at least one microplate and for positioning the samples-containing wells of this(these) microplate(s) in relation to the at least one measuring device. The at least one measuring device is used for detecting light which is emitted by samples in wells of a microplate inserted in this microplate reader and/or which is influenced by samples transilluminated by light in wells of a microplate inserted in this microplate reader. The microplate reader comprises a control unit for controlling the temperature of a gas atmosphere surrounding the wells containing the samples of microplates used in this microplate reader.Type: GrantFiled: September 30, 2015Date of Patent: January 15, 2019Assignee: TECAN TRADING AGInventors: Florian Reiner, Harald Gebethsroither, Josef Grassl
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Patent number: 10156524Abstract: A device for use in the detection of binding affinities, the device comprising a planar waveguide (2) arranged on a substrate (3), and further comprising an optical coupler (41) having a predetermined length for coupling coherent light (1) of a predetermined wavelength into the planar waveguide (2) such that a parallel beam of coherent light propagates through the planar waveguide (2) with an evanescent field (11) of the coherent light propagating along an outer surface (21) of the planar waveguide (2). The outer surface (21) of the planar waveguide (2) comprises binding sites thereon capable of binding target samples to the binding sites such that light of the evanescent field (11) is diffracted by target samples bound to the binding sites. The binding sites are arranged along a plurality of predetermined straight lines (7) running parallel to one another with a constant distance between adjacent straight lines.Type: GrantFiled: December 3, 2013Date of Patent: December 18, 2018Assignee: Hoffmann-La-Roche Inc.Inventor: Christof Fattinger
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Patent number: 10132821Abstract: The present invention provides a processing station for automatically processing a biological sample, a system for automated real-time inventory control of consumables within a biological sample handling or assay instrument, a high throughput random access automated instrument for processing biological samples, an automated instrument for processing or analysis of a sample, and processes for automated mucoid detection and elimination. Methods of using the disclosed instruments, mucoid detection processes, and systems to process and/or analyze samples are also disclosed.Type: GrantFiled: February 26, 2016Date of Patent: November 20, 2018Assignee: GEN-PROBE INCORPORATEDInventors: Rolf Silbert, David Opalsky, David Aaron Buse, Robert J. Rosati, Olev Tammer, Richard Capella, Matthias Merten
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Patent number: 10011481Abstract: The present invention provides an electronic nose device based on chemically sensitive field effect transistors. In particular, the sensors of the electronic nose device are composed of non-oxidized, functionalized silicon nanowires which can detect volatile organic compounds with very high sensitivity. Methods of use in diagnosing diseases including various types of cancer are disclosed.Type: GrantFiled: July 24, 2008Date of Patent: July 3, 2018Assignee: Technion Research and Development Foundation Ltd.Inventor: Hossam Haick
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Patent number: 9987194Abstract: Described in one aspect is a multi-cell or multi-chambered container for sealing various materials such as therapeutic or diagnostic agents, animal or human tissue, tissue samples, specimens, blood, genetic material, or any other material. The container includes seals formed by folding the wall of the elongate body transverse to the interior of the elongate body and maintaining the folded wall portions adjacent one another or joining them together. In another aspect, the container disclosed may be made according to a method involving creating multiple seals at various locations along the elongate body thus creating sealed voids or cells between the seals within the elongate body.Type: GrantFiled: August 26, 2015Date of Patent: June 5, 2018Assignee: Muffin IncorporatedInventors: William J. Havel, Neal E. Fearnot, Peter S. McKinnis, Richard B. Sisken, Charles Leland Baxter
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Patent number: 9968927Abstract: The present disclosure relates to an integrated chip having an integrated optical bio-sensor, and an associated method of fabrication. In some embodiments, the integrated optical bio-sensor has a sensing device arranged within a semiconductor substrate. An optical waveguide structure is located over a first side of the semiconductor substrate at a position over the sensing device. A dielectric structure is disposed onto the optical waveguide structure at a position that separates the optical waveguide structure from a sample retention area configured to receive a sample solution.Type: GrantFiled: May 22, 2015Date of Patent: May 15, 2018Assignee: Taiwan Semiconductor Manufacturing Co., Ltd.Inventors: Yi-Shao Liu, Emerson Cheng, Yi-Hsien Chang, Chun-Ren Cheng, Ching-Ray Chen, Alex Kalnitsky, Allen Timothy Chang
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Patent number: 9968868Abstract: Provided is a pore water extraction kit for extracting pore water in a seabed sediment. More specifically, provided is a pore water extraction kit of a seabed sediment for more easily extracting pore water separated from a sediment through a centrifugal separator tube.Type: GrantFiled: November 6, 2015Date of Patent: May 15, 2018Assignee: KOREA INSTITUTE OF GEOSCIENCE AND MINERAL RESOURCESInventors: Yuri Kim, Jong-Hwa Chun
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Patent number: 9969937Abstract: A process for producing coke that may include: heating a coker feedstock to a coking temperature to produce a heated coker feedstock; feeding the heated coker feedstock to a coking drum; feeding a coking additive, such as at least one hydroconversion or hydrocracking catalyst, to the coking drum; and subjecting the heated coker feedstock to thermal cracking in the coking drum to crack a portion of the coker feedstock to produce a cracked vapor product and produce a coke product.Type: GrantFiled: September 18, 2013Date of Patent: May 15, 2018Assignee: Lummus Technology Inc.Inventor: Ahmad Faegh