Abstract: The sulfonation of arylphosphines, i.e. mono-, di-, oligo- and polyphosphines, which contain at least one aromatic radical capable of being sulfonated, is carried out in the presence of a Lewis acid at 0.degree. to 80.degree. C. The process avoids side-reactions, in particular the formation of phosphine oxides. In treating the sulfonation mixture, the Lewis acid can be removed together with the sulfuric acid.

Abstract: Compounds of the structure ##STR1## where W is selected from ##STR2## where Q is oxygen or sulfur, R.sup.6 and R.sup.7 are hydrogen or alkyl, or R.sup.6 and R.sup.7, together with the nitrogen atoms to which they are attached, define a radical of formula ##STR3## Z is --CH.sub.2 --, oxygen, sulfur, or --NR.sup.9, L.sup.1 and L.sup.2 are selected from a valence bond, alkylene, propenylene, and propynylene; R.sup.1 and R.sup.2 are independently selected from alkyl, alkoxy, haloalkyl, halogen, cyano, amino, alkoxycarbonyl, and dialkylaminocarbonyl; Y is selected from oxygen, >NR.sup.10, and ##STR4## L.sup.3 is selected from alkylene of one to three carbon atoms, propenylene, propynylene, ##STR5## and R.sup.3, R.sup.4, and R.sup.5 are hydrogen or alkyl of one to four carbon atoms inhibit the synthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.

Abstract: There are described formazan dyes of the formula ##STR1## where m and n are each 1 or 2,Kat is the equivalent of a cation,Me is copper or nickel,X is oxygen or a radical of the formula CO-O or SO.sub.2 -O,Y is vinyl or a radical of the formula C.sub.2 H.sub.4 -Q, wherein Q is a group that is detachable under alkaline reaction conditions,E is a fiber-reactive radical,the rings A and B may be substituted and benzofused, andthe ring C may be substituted,the use thereof for dyeing or printing hydroxyl- or nitrogen-containing organic substrates, novel aminophenols and a process for preparing same.

Abstract: There are disclosed novel compounds that can be used to derive therefrom a fragment that corresponds to an A-ring which is to he combined with fragments which respectively correspond to C- and D-rings in synthetic formation of vitamin D.sub.3 derivatives by cleaving the 7,8-bondings by means of oxidizing agents following any known process. According to the invention, there is provided an industrially efficient and effective method of manufacturing above compounds that utilizes allylic hydroxylation to add an oxygen function group to position C(1), a method which is completely different from any existing synthetic methods.

Abstract: A process for the production of a highly concentrated fatty alcohol sulfate paste comprising the steps of: (1) forming a crude sulfonation product by reacting a mixture of an inert gas and sulfur dioxide with a mixture comprised of: (a) an unsaturated fatty alcohol of the formula IR.sup.1 --OH (I)wherein R.sup.1 is a linear unsaturated hydrocarbon radical having from 16 to 22 carbon atoms and 1, 2, or 3 double bonds, (b) a saturated fatty alcohol of the formula IIR.sup.2 --OH (II)wherein R.sup.2 is a linear or branched saturated hydrocarbon radical having from 12 to 22 carbon atoms; wherein the molar ratio of sulfur trioxide/fatty alcohol mixture is from 0.95:1 to 1.3:1 and (2) neutralizing, at a temperature of from 50.degree. C. to 90.degree. C., said crude sulfonation product with a quantity of aqueous base sufficient to form a water-containing fatty alcohol sulfate paste product having a solids content of from 60% to 70% by weight and a viscosity of less than 10 Pa.s at 60.degree. C.

Abstract: This invention relates to compounds of Formula I and the stereoisomers and pharmaceutically acceptable salts thereof ##STR1## wherein R is alkyl, alkenyl, alkynyl, or cycloalkylalkyl;R.sup.1 is alkyl;R.sup.2 is hydrogen, alkyl;R.sup.6 is alkyl;n is 1 to 5;p is 0 to 6;x is 0 or 2; andR.sup.4 and R.sup.5 are independently hydrogen or alkyl or together with N form a cycloalkylamine.The compounds of Formula I are leukotriene B.sub.4 antagonists and are useful as anti-inflammatory agents and in treating disease conditions mediated by LTB.sub.4.

Abstract: A composition of matter, comprising a cannabinol compound having the structure ##STR1## wherein, Q is --C(R.sup.1) (Y.sup.1)--(CH.sub.2).sub.n ----Z.sup.1 ; R.sup.1 is --H or --CH.sub.3 ; Y.sup.1 is --CH.sub.3 or Y.sup.2 ; Y.sup.2 is --N.sub.3 or --NCS; n is 4 or 6; Z.sup.1 is --H, when Y.sup.1 is Y.sup.2, or is Z.sup.2, when Y.sup.1 is --CH.sub.3 ; and Z.sup.2 is --N.sub.3 or --NCS.This composition has good binding affinity to the cannabinoid receptor and therefore, is useful as a receptor probe.

Abstract: Disclosed is a process for recovering maltol from water-insoluble source material containing maltol, comprising extracting the maltol with a hot aqueous solution containing a solute which increases the immiscibility between said source material and said solution.

Abstract: Certain 3-(phenyl, chroman-2-yl, benzofuran-5-yl or benzoxazol-5-yl)-2-(hydroxy or mercapto)propionic acid derivatives and analogs are useful as hypoglycemic and hypocholesterolemic agents.

Abstract: Crystalline calcium pseudomonate or a hydrate thereof, in particular the dihydrate. Processes for the preparation of these salts and their use in human and veterinary medicine and as a growth promoter in animals are described.

Abstract: Compounds of the formula ##STR1## wherein X is O or CH.sub.2 ; Y is O, --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, --C.tbd.C--, or --OCH.sub.2 C.sub.6 H.sub.4 --;Z is --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH-- or --C.tbd.C--;f, h, k, m and t, independently, are 0 or 1;n is an integer from 1 to 12;R.sup.1 is hydrogen, lower alkyl, lower alkenyl, cycloalkyl, or aralkyl; and A is B or --O--B, wherein B is a mono-, di- or tricyclic aromatic or heteroaromatic moiety substituted by the group --COR.sup.2, --(O).sub.t --(W).sub.s --COR.sup.2 or --(CH.dbd.CH).sub.p COR.sup.2 and which may also contain up to 4 additional substituents selected, independently, from the group consisting of halogen, cyano, lower alkyl, lower alkoxy, sulfonamido, alkanoyl, aroyl, --(Q).sub.k --(W).sub.s' --E or --(Q).sub.k --(W).sub.s" --C.sub.6 H.sub.4 --(W).sub.s'" --E, provided that no more than one of said substituents is --(Q).sub.k --(W).sub.s' --E or --(Q).sub.k --(W).sub.s" --C.sub.6 H.sub.4 --(W).sub.s'" --E, and wherein E is COR.sup.

Abstract: New N-Arylalkylderivatives of 2-aminomethyl-2,3-dihydro-1,4-benzodioxine and its (+)- and (-)- enantiomers represented by general formula (I), where R.sub.1, R.sub.2 and R.sub.3 represent H, or R.sub.1 and R.sub.2 represent H and R.sub.3 represent H or R.sub.1 and R.sub.2 represent methoxy and R.sub.3 represents H and their pharmaceutically acceptable organic or inorganic acid addition salts exhibit in pharmacological tests pronounced hypotensive activity as a result of their calcium channel blocking and alpha.sub.1 -adrenergic blocking activity and pronounced antithrombotic action. In a form of pharmaceutical preparations, they are suitable for the treatment and prevention of cardiovascular diseases and other disorders.

Abstract: 2-Amino-4-oxo-4H-benzopyrans I ##STR1## (m=0, 1 or 2; R.sup.1 -R.sup.4 have the meanings stated in the description) and the salts of I, and herbicides which contain 2-(4-hetaryloxy)- and 2-(4-aryloxy)-phenoxyacetic acid derivatives and/or cyclohexenone derivatives as herbicidal active ingredients and 2-amino-4-oxo-4H-benzopyrans I' as antidotes.

Abstract: According to the invention, a new process has been found for the preparation of 2,2-difluoro-benzo[1,3]-dioxole-carbaldehydes of the formula (I) ##STR1## in which benzo[1,3]dioxole-carbaldehydes are chlorinated, the 2,2-dichloro-dichloromethylbenzo[1,3]dioxoles formed, which are likewise new, are partly fluorinated to give the 2,2-difluoro-dichloromethyl-benzo[1,3]dioxoles, which are likewise new, and these are then reacted with urotropin to give the desired compounds.

Abstract: Novel fluorinated 1,3-benzo- and 1,3-pyrido-dioxoles of formula (I): ##STR1## in which A is C-R.sup.4 or N,X is hydrogen, fluorine, chlorine or bromine andR.sup.1 to R.sup.4 can be identical to or different from one another and are each hydrogen, halogen, C.sub.1 -C.sub.6 -alkyl, C.sub.1 -C.sub.6 -alkoxy, halogeno-C.sub.1 -C.sub.6 -alkyl, C.sub.6 -C.sub.10 -aryl, CHO, COOH, COCl, CN, OH, NCO, COO--C.sub.1 -C.sub.6 -alkyl, NO.sub.2, NH.sub.2, NH--C.sub.1 -C.sub.6 -alkyl, N(C.sub.1 -C.sub.6 -alkyl).sub.2, SO.sub.2 Cl, SO.sub.3 H, SO.sub.3 Na or SO.sub.3 K,it also being possible for two adjacent radicals from the series R.sup.1 to R.sup.4 together to be an optionally substituted --CH.dbd.CH--CH.dbd.CH-- bridge, processes for their preparation and their use for the preparation of plant protection agents.

Abstract: A process of preparing intermediates useful in making compounds with retinoic acid-like activity is disclosed. The intermediates are halogenated chromans and thiochromans of the formula shown below and are prepared by the alkylation of a phenol or thiophenol with an alkene compound (the starting materials shown in the formula below), cyclization and halogenation. ##STR1## In the formula the symbols have the following meanings: R.sub.1 and R.sub.2 are C.sub.1 to C.sub.4 alkyl, R.sub.3 is H or C.sub.1 to C.sub.4 alkyl, X is oxygen or sulfur, Y is a leaving group, and Z is chlorine, bromine or iodine.

Abstract: Process for the preparation of 3'-aminopropyl 2-sulfatoethyl sulfone in high yield, which comprises reacting allylamine with mercaptoethanol in aqueous sulfuric acid in a one-pot process at temperatures from about 25.degree. C. to the boiling point of the reaction mixture in the presence of free-radical initiators which are soluble in the reaction medium, oxidizing the reaction mixture thus obtained with hydrogen peroxide in the presence of catalytic amounts of a compound of a transition metal of the periodic table of elements as oxidation catalyst to give 3'-aminopropyl 2-hydroxyethyl sulfone hemisulfate, adding further sulfuric acid until the total amount of sulfuric acid in the mixture is at least 1 mol, relative to the allylamine used, and esterifying the 3'-aminopropyl 2-hydroxyethyl sulfone hemisulfate obtained after oxidation by evaporation to dryness or with sulfuric acid or oleum or chlorosulfonic acid in solution.

Abstract: A process for purifying esters of tetrahydropyran-4-carboxylic acid of the formula I ##STR1## where R.sup.1 to R.sup.3 are each C.sub.1 -C.sub.4 -alkyl, and R.sup.2 and R.sup.3 are each additionally hydrogen, from mixtures produced in the reaction of butyrolactones of the formula II ##STR2## where R.sup.2 and R.sup.3 have the abovementioned meanings, and R.sup.4 is hydrogen, alkyl of 1-6 carbons or acyl of the formula --CO--R.sup.2, with alcohols of the formula R.sup.1 OH in the presence of oxide catalysts, by distillation, which entailsa) removing overhead, in a first column with 5-25 theoretical plates with a distillate pressure of 700-1100 mbar and a distillate temperature of 50.degree.-80.degree. C.

Abstract: Polyethercyclicpolyols are prepared by thermally condensing a polyol having at least three hydroxyl groups of which at least two of the hydroxyl groups are vicinal, precursors of the polyol, cyclic derivatives of the polyol, or mixtures thereof, and controlling process conditions to avoid substantial undesirable degeneration. Lower molecular weight polyethercyclicpolyols are polycondensed with phenolic hydroxyl-containing compounds to form higher molecular weight polyethercyclicpolyols.

Abstract: A process for the preparation of alkyl sulfate powders, which entails spraying an aqueous solution or dispersion of alkyl sulfates into a head part of a spraying tower through single-component nozzles under pressure sufficient to form a spray mist, and drying the resulting spray mist in co-current manner using an inert gas at a temperature sufficient to afford a powder having a bulk density of at least 300 g/l.