Patents Examined by Nicky Chan
  • Patent number: 5409952
    Abstract: A compound of the formula (I) ##STR1## in which: R.sub.1 represents a hydrogen atom, a lower alkyl group, a hydroxy group or a lower alkoxy group,R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8 and R.sub.11 are as defined in the description.Medicaments.
    Type: Grant
    Filed: October 27, 1993
    Date of Patent: April 25, 1995
    Assignee: Adir et Compagnie
    Inventors: Jean D. Brion, Guillaume Le Baut, Francoise Zammatio, Alain Pierre, Ghanem Atassi, Larbi Belachmi
  • Patent number: 5409951
    Abstract: Novel compounds of formula I ##STR1## wherein R.sup.1 is independently hydrogen, hydroxy, alkyl with 1 to 6 carbon atoms, acyloxy groups with 1 to 6 carbon atoms, alkyloxy with 1 to 6 carbon atoms or from 1 to 5 sugar moleties; and R.sup.2 is independently hydrogen, or alkyl with 1 to 6 carbon atoms.The compounds are producible by aerobic cultivation on suitable nutrient media under suitable conditions of a strain of the fungus Ascochyta sp., subsequent recovery of the active component from the fermentation medium, and optionally modifying the active compound to obtain a compound of the desired formula I.Disclosed is also microorganisms capable of producing said compounds, compositions containing said compounds, and the use of such compositions for controlling fungi in valuable crops, animals, including birds and mammals, and in the preservation of wood, paints and edible products.
    Type: Grant
    Filed: July 22, 1993
    Date of Patent: April 25, 1995
    Assignee: Novo Nordisk A/S
    Inventors: Ruby I. Nielsen, Frank W. Rasmussen
  • Patent number: 5409950
    Abstract: Compounds are described of the formula ##STR1## wherein R.sub.1 represents a hydrogen atom, a hydroxyl group or a group selected from --OCOCH.dbd.CHCH(CH.sub.3)(CH.sub.2).sub.3 CH.sub.3, --OCOCH.dbd.CHC(CH.sub.3).dbd.CHCH(CH.sub.3)--CH.sub.2 CH.sub.3, or --OCO--X--CH.sub.2 CH(CH.sub.3)CH.sub.2 CH.sub.3 [where X is --CH.dbd.CHCH(CH.sub.3)--, --CH.sub.2 CH(OH)CH(CH.sub.3)--, --CH.dbd.CHC(OH)(CH.sub.3)--, --CH.sub.2 CH(OH)CH.sub.2 -- or --CH.sub.2 CH.sub.2 CH(CH.sub.3)--)];R.sub.2 represents a hydrogen atom or a hydroxyl group;R.sub.3 represents a group selected from --C(.dbd.CH.sub.2)CH(OR.sub.7)CH(CH.sub.3)CH.sub.2 Ph (where R.sub.7 is a hydrogen atom or an acetyl group), --C(CH.sub.3).dbd.CHCH(CH.sub.2 R.sub.8)CH.sub.2 Ph (where R.sub.8 is a hydrogen or a hydroxyl group), --C(CH.sub.2 OH).dbd.CHCH(CH.sub.3)CH.sub.2 Ph, --C(.dbd.CH.sub.2)CH(OH)CH(CH.sub.2 OH)CH.sub.2 Ph, --C(.dbd.CH.sub.2)CH(NHCOCH.sub.3)CH(CH.sub.3)CH.sub.2 Ph, --C(CH.sub.2 NHCOCH.sub.3).dbd.CHCH(CH.sub.3)CH.sub.2 Ph or ##STR2## R.sub.4, R.
    Type: Grant
    Filed: October 26, 1993
    Date of Patent: April 25, 1995
    Assignee: Glaxo Group Limited
    Inventors: Michael J. Dawson, Allan Baxter, Robert M. Tait, Nigel S. Watson, David Noble, Alan Shuttleworth, Howard G. Wildman, Michael V. Hayes
  • Patent number: 5405976
    Abstract: Dyes comprising an inner salt of a compound of the formula:Q.sup.1 =Z-Q.sup.2wherein:Q.sup.1 is a 4-(benz[b]-4H-pyrylium)methylidene, 4-(benz[b]-4H-thiopyrylium)methylidene or 4-(benz[b]-4H-selenopyrylium)methylidene grouping;Z is a 1,3-(2-hydroxy-4-oxo-2-cyclobutylidene) hydroxide or 1,3-(2-hydroxy-4,5-dioxo-2-cyclopentylidene) hydroxide ring; andQ.sup.2 is a 4-(benz[b]-4H-pyran-4-ylidene)methyl, 4-(benz[b]-4H-thiopyran-4-ylidene)methyl or 4-(benz[b]-4H-selenopyran-4-ylidene)methyl grouping;wherein at least one of the groupings Q.sup.1 and Q.sup.
    Type: Grant
    Filed: September 24, 1993
    Date of Patent: April 11, 1995
    Assignee: Polaroid Corporation
    Inventors: Stephen J. Telfer, Robert P. Short, Stephen G. Stroud, Anthony J. Puttick, Socorro Ramos, Michael J. Zuraw
  • Patent number: 5403941
    Abstract: A process for the preparation of mono-fatty acid or hydroxymono-fatty acid esters of isopropylidene derivatives of a polyglycerol is disclosed. A C6-C22 fatty acid or -hydroxy fatty acid is reacted with isopropylideneglycerol glycidyl ether or diisopropylidenetriglycerol glycidyl ether in a molar ratio of 0.5:1 to 1:0.5 at temperatures of 373473 K. in the presence of a catalyst. The monoisopropylidenediglycerol mono-fatty acid ester or monoisopropylidenediglycerol hydroxy mono-fatty acid ester or diisopropylidenetetraglycerol mono-fatty acid ester or diisopropylidenetetraglycerol hydroxy mono-fatty acid ester obtained is optionally purified by distillation, fractional distillation and/or ion exchange.
    Type: Grant
    Filed: April 12, 1993
    Date of Patent: April 4, 1995
    Assignee: Deutsche Solvay-Werke GmbH
    Inventors: Gerald Jakobson, Werner Siemanowski
  • Patent number: 5401860
    Abstract: Polyethercyclicpolyols are prepared by thermally condensing a polyol having at least three hydroxyl groups of which at least two of the hydroxyl groups are vicinal, precursors of the polyol, cyclic derivatives of the polyol, or mixtures thereof, and controlling process conditions to avoid substantial undesirable degeneration. Lower molecular weight polyethercyclicpolyols are copolymerized with epoxy resins to form higher molecular weight polyethercyclicpolyols.
    Type: Grant
    Filed: May 26, 1993
    Date of Patent: March 28, 1995
    Assignee: Shell Oil Company
    Inventors: George C. Blytas, Harry Frank
  • Patent number: 5399722
    Abstract: A novel process is described for preparing tert-butyl (3R, 5S ) 6-hydroxy-3,5-O-isopropylidene-3,5-dihydroxyhexanoate of the formula I ##STR1## which is a valuable structural element for preparing inhibitors of HMG-CoA reductase.
    Type: Grant
    Filed: June 30, 1993
    Date of Patent: March 21, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Gerhard Beck, Joachim-Heiner Jendralla, Kurt Kesseler
  • Patent number: 5399724
    Abstract: Novel acyclic terpene compounds useful as intermediates for producing sarcophytol A which have an anti-carcinogenic promotor activity and anti-tumor activity, which compounds are shown by the following general formula (I): ##STR1## [wherein R.sup.1 is a hydrogen atom, 1-alkoxyalkyl group, tetrahydrofuryl group, tetrahydropyranyl group or acyl group; R.sup.2 is a group of formula: --CHO, --CH.sub.2 OR.sup.3 or ##STR2## (wherein R.sup.3 is a hydrogen atom, 1-alkoxyalkyl group, tetrahydrofuryl group, tetrahydropyranyl group or acyl group; and R.sup.4 is C.sub.1 to C.sub.4 alkyl group) with the proviso that R.sup.1 and R.sup.3 do not represent the same substituents simultaneously; when R.sup.1 is a hydrogen atom, R.sup.3 is not acetyl group or tetrahydropyranyl group; and when R.sup.2 is a group of formula: ##STR3## R.sup.1 is not a hydrogen atom).
    Type: Grant
    Filed: September 28, 1993
    Date of Patent: March 21, 1995
    Assignee: Mitsubishi Kasei Corporation
    Inventors: Hisao Takayanagi, Yasunori Kitano, Yasuhiro Morinaka
  • Patent number: 5399545
    Abstract: Substituted benzyl carbamates of formula I ##STR1## wherein R is halogen, trifluoromethyl, cyano, nitro or C.sub.1 -C.sub.3 haloalkoxy;Z is hydrogen or halogen; orZ and R together in 2- and 3-position of the phenyl ring form the group --OCF.sub.2 O--;R.sub.1 is C.sub.1 -C.sub.5 alkyl; wherein in caseR and Z together in 2- and 3-position of the phenyl ring form the group --OCF.sub.2 --,R.sub.2 and R.sub.3 are each independently of the other hydrogen, methyl or ethyl; and in case R is halogen, trifluoromethyl, cyano, nitro or C.sub.1 -C.sub.3 haloalkoxy,R.sub.2 is methyl or ethyl; and R.sub.3 is hydrogen, methyl or ethyl;X is oxygen, sulfur, --SO-- or --SO.sub.2 --;Y is hydrogen, halogen, C.sub.1 -C.sub.3 alkyl, C.sub.1 -C.sub.3 haloalkyl, C.sub.1 -C.sub.3 alkoxy or cyano; andn is 0, 1 or 2;and the diastereoisomers thereof, have pre- and postemergence herbicidal properties. The preparation of these compounds and the use thereof as herbicides are described.
    Type: Grant
    Filed: October 22, 1993
    Date of Patent: March 21, 1995
    Assignee: Ciba-Geigy Corporation
    Inventor: Hermann Rempfler
  • Patent number: 5395951
    Abstract: The invention discloses novel triterpene derivatives of azadirachtin of the formulae 2 to 11 of the drawings and a process for isolating new triterpene derivatives of azadirachtin from the various parts of the neem plant(Azadirachta indica A-Juss), which process comprises grinding the parts of the neem plant to get a powder, extracting the powder with a binary immiscible solvent consisting of one polar and another non-polar solvent in a ratio of 1:2 to obtain an extract, filtering the extract to get a filtrate having two layers, one layer containing lipids and the other layer containing the new triterpene derivatives of azadirachtin and water soluble constituents including sugars, separating the layers by known methods, concentrating the layer containing the new triterpenes of the formulae 2-11 including derivatives of azadirachtin and water soluble salts, treating the resultant concentrate with a polar solvent and if necessary, warm the concentrate having the solvent, and filtering/decanting the resultant so
    Type: Grant
    Filed: November 17, 1992
    Date of Patent: March 7, 1995
    Assignee: Council of Scientific & Industrial Research
    Inventors: Bhimsen A. Nagasampagi, Supada R. Rojatkar, Mandakini M. Kulkarni, Vimal S. Joshi, Vidya S. Bhat, Mukund G. Sane, Nagaraj R. Ayyangar
  • Patent number: 5393514
    Abstract: Fluorescent pH indicator compounds which exhibit an increase in fluorescence intensity with decreasing pH. The indicators are derivatives of rhodamine and sulforhodamine type dyes and are particularly useful for measuring pH in acidic environments such as carbon dioxide production by microorganisms and pH of certain acidic intracellular compartments.
    Type: Grant
    Filed: December 6, 1993
    Date of Patent: February 28, 1995
    Assignee: Becton, Dickinson and Company
    Inventors: J. Bruce Pitner, Randal A. Hoke
  • Patent number: 5391570
    Abstract: Certain aminomethyl-benzodioxanes and benzopyrans are useful serotonergic agents. They possess anxiolytic properties with few of the side effects often associated with dopaminergic agents.
    Type: Grant
    Filed: October 14, 1993
    Date of Patent: February 21, 1995
    Assignee: Bristol-Myers Squibb
    Inventors: John D. Catt, Ronald J. Mattson
  • Patent number: 5387701
    Abstract: A process for preparing 4-hydroxymethyltetrahydropyran comprises reacting tetrahydrofurans of the general formula I ##STR1## where R.sup.1 is hydrogen, C.sub.1 - to C.sub.6 -alkyl or --CO--R.sup.2, andR.sup.2 is hydrogen or C.sub.1 - to C.sub.6 -alkyl,at from 0.degree. to 400.degree. C. and from 0.001 to 400 bar in the presence of acidic catalysts.
    Type: Grant
    Filed: September 30, 1993
    Date of Patent: February 7, 1995
    Assignee: BASF Aktiengesellschaft
    Inventors: Hans-Juergen Weyer, Rolf Fischer, Werner Schnurr, Norbert Goetz, Thomas Kuekenhoehner
  • Patent number: 5387700
    Abstract: A process for producing chlorosulfate and sulfamate esters of 2,3:4,5-bis-O-(1-methylethylidene)-.beta.-D-fructopyranose and (1-methylcyclohexyl)methanol is disclosed. The process involves a two step procedure involving in the first step reacting of an alcohol with sulfuryl chloride in the presence of a tertiary or heterocyclic amine base in a solvent selected from the group consisting of toluene, t-butyl methyl ether or tetrahydrofuran to produce a chlorosulfate intermediate, which is preferably stabilized by an aqueous wash and/or treatment with a base, and in the second step reacting of the resulting intermediate with an amine in a solvent selected from the group consisting of t-butyl methyl ether, tetrahydrofuran and lower alkanol.
    Type: Grant
    Filed: August 12, 1993
    Date of Patent: February 7, 1995
    Assignee: McNeilab, Inc.
    Inventors: Cynthia A. Maryanoff, Lorraine Scott, Kirk L. Sorgi
  • Patent number: 5384327
    Abstract: Sulfamate derivatives having the following formula (I): ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, and R.sub.6 are as herein defined, have been found to exhibit anticonvulsant activity and are thus useful in the treatment of conditions such as epilepsy. Further, the present invention encompasses pharmaceutical compositions containing a compound of formula (I) as well as methods for their use and novel intermediates are disclosed.
    Type: Grant
    Filed: December 22, 1992
    Date of Patent: January 24, 1995
    Assignee: McNeilab, Inc.
    Inventors: Michael J. Costanzo, Bruce E. Maryanoff
  • Patent number: 5384415
    Abstract: A process for the preparation of a brominated compound which comprises the step of reacting at least one compound selected from the group consisting of a chloroformate, a chlorosulfite and a chlorophosphite with a brominating agent for a time sufficient to obtain at least one brominated compound. In particular, an alcohol is converted into a chloroformate, chlorosulfite or a chlorophosphite, which is then brominated to obtain the desired product. In another embodiment, a brominating agent is reacted with a reactant selected from the group consisting of thionyl chloride, phosgene and phosphorous oxychloride, followed by contacting the reaction product obtained with an alcohol to be brominated.
    Type: Grant
    Filed: May 28, 1993
    Date of Patent: January 24, 1995
    Assignee: Rhone-Poulenc Chimie
    Inventors: Jean-Manuel Mas, Pascal Metivier
  • Patent number: 5384414
    Abstract: Benzopyran derivatives of the formula: ##STR1## wherein R.sup.1a is hydrogen, C1-4 alkyl or C1-4 alkoxy; or two R.sup.1a taken together with 7th- and 8th-carbon to which they are attached form a C6 carbocyclic ring;R.sup.2a is hydrogen, C1-4 alkyl or C1-4 alkoxy;R.sup.3a is hydrogen, C2-4 acyl or benzoyl;na is 1-3;Ya is C1-7 alkylene, C2-7 alkenylene or C2-7 alkynylene;Ma isi) bond orii) a group of the formula: --Da--Ba--;Da isi) --O-- orii) --S--;Ba isi) C1-4 alkylene orii) a group of the formula: ##STR2## Za is i) bond,ii) --OCO--,iii) CONR.sup.9a --,iv) --COO--,v) --NR.sup.9a CO--,vi) --O-- orvii) --NH--CO--NH--;Wa is a group of the formula: --W1a--Aa--W2 a--;Aa isi) bond orii) a group of the formula: --Ea-- .circle.Ga --;Ea isi) bond,ii) --O-- oriii) --S--;.circle.Ga is C4-10 carbocyclic or heterocyclic ring; or C4-10 carbocyclic or heterocyclic ring substituted by one to three C1-4 alkyl, C1-4 alkoxy, halogen, a group of the formula: --COOR.sup.
    Type: Grant
    Filed: August 18, 1993
    Date of Patent: January 24, 1995
    Assignee: Ono Pharmaceutical Co., Ltd.
    Inventors: Shuichi Ohuchida, Masaaki Toda, Tsumoru Miyamoto
  • Patent number: 5384077
    Abstract: Described are novel reversible photochromic naphthopyran compounds, examples of which are compounds substituted at the 3 position of the pyran ring with (i) an aryl substituent and (ii) a phenyl substituent having a 5- or 6-member heterocyclic ring fused at the number 3 and 4 carbon atoms of the phenyl substituent. Also described are organic host materials that contain or that are coated with such compounds. Articles such as ophthalmic lenses or other plastic transparencies that incorporate the novel naphthopyran compounds or combinations thereof with complementary photochromic compounds, e.g., spiro(indoline) type compounds, are also described.
    Type: Grant
    Filed: June 21, 1993
    Date of Patent: January 24, 1995
    Assignee: Transitions Optical, Inc.
    Inventor: David B. Knowles
  • Patent number: 5384416
    Abstract: The novel 2R,4S-2-ethyl-4-[(4-phenoxyphenoxy)methyl]dioxolan of formula I ##STR1## can be used as a pesticide. It is used to control especially insects in fruit and citrus crops.
    Type: Grant
    Filed: September 21, 1993
    Date of Patent: January 24, 1995
    Assignee: Ciba-Geigy Corporation
    Inventors: Friedrich Karrer, Hans-Peter Buser, Gerardo Ramos, Alfred Rindlisbacher, Luigi M. Venanzi, Thomas R. Ward
  • Patent number: 5380882
    Abstract: The invention relates to compounds of formula I ##STR1## wherein A is a radical of formula ##STR2## R.sub.1 and R.sub.2 are each independently of the other hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, halogen or a radical of formula ##STR3## wherein X is --O--, --CH.sub.2 --, --C(CH.sub.3).sub.2 -- or --SO.sub.2 --, and R.sub.3 and R.sub.4 are each independently of the other hydrogen, C.sub.1 -C.sub.4 alkyl or phenyl, as well as compositions comprising these compounds.The compositions are particularly suitable for making integrated circuits.
    Type: Grant
    Filed: March 30, 1993
    Date of Patent: January 10, 1995
    Assignee: Ciba-Geigy Corporation
    Inventor: Alfred Steinmann