Patents Examined by Nizal Chandrakumar
  • Selective inhibitors of ubiquitin specific protease 7, the pharmaceutical compositions thereof and their therapeutic applications
    Patent number: 9328093
    Abstract: The present invention concerns the discovery of new selective inhibitors of ubiquitin specific proteases, their process of preparation and their therapeutic use.
    Type: Grant
    Filed: September 17, 2014
    Date of Patent: May 3, 2016
    Assignee: HYBRIGENICS SA
    Inventors: Roman Lopez, Frederic Colland
  • Preparation method, agricultural composition and applications of natural brassinolide analogs
    Patent number: 9326506
    Abstract: The present invention provides extraction methods and uses of brassinolide analogs extracted from a plant, including the uses for the promotion of growth, resistance to low temperature and salt tolerance of a plant. Furthermore, the present invention also provides agricultural compositions comprising the brassinolide analogs.
    Type: Grant
    Filed: August 28, 2012
    Date of Patent: May 3, 2016
    Assignee: CHENGDU NEWSUN CROPSCIENCE CO., LTD
    Inventor: Qiming He
  • Polymorphs of cocrystals of p-Coumaric acid:nicotinamide
    Patent number: 9314459
    Abstract: Polymorphs, Forms II and III, of cocrystals of p-coumaric acid and nicotinamide in a 1:1 molar ratio. Pharmaceutical compositions containing Forms II or III, processes for making such forms, and methods of treatment with such Forms.
    Type: Grant
    Filed: January 28, 2015
    Date of Patent: April 19, 2016
    Assignee: AMRI SSCI, LLC
    Inventors: Melanie Janelle Bevill, Nate Schultheiss
  • Antibacterial agents: aryl myxopyronin derivatives
    Patent number: 9315495
    Abstract: The invention provides compounds of formula la, lb and Ic: [Formula Ia, Ib, and Ic] and salts thereof, wherein variables are as described in the specification, as well as compositions comprising a compound of formula Ia-Ic, methods of making such compounds, and methods of using such compounds, e.g., as inhibitors of bacterial RNA polymerase and as antibacterial agents.
    Type: Grant
    Filed: June 19, 2013
    Date of Patent: April 19, 2016
    Assignees: Rutgers, The State University of New Jersey, Provid Pharmaceuticals Inc.
    Inventors: Richard H. Ebright, Yon W. Ebright, Juan Shen, James Bacci, Anne-Cecile Hiebel, William Solvibile, Christopher Self, Gary Olson
  • Chiral intermediate, process for producing the same and its use in the manufacture of tolterodine, fesoterodine, or the active metabolite thereof
    Patent number: 9309215
    Abstract: The compound of formula (I): is provided. It may be produced by subjecting a compound of formula (IV) to a reduction reaction wherein R represents hydrogen, straight or branched C1-C6 alkyl. This compound is a valuable intermediate which may be used in the synthesis of fesoterodine, tolterodine, its active metabolite, and related compounds.
    Type: Grant
    Filed: April 21, 2014
    Date of Patent: April 12, 2016
    Assignee: UCB PHARMA GMBH
    Inventor: Claus Meese
  • Preparation of oxycodone base form 14-hydroxycodeinone sulfate
    Patent number: 9309257
    Abstract: Synthetic methods are provided for preparation of oxycodone and salts thereof with an improved impurity profile. Thebaine is converted to 14-hydroxycodeinone sulfate intermediate to minimize a 7,8-dihydro-8,14-dihydroxycodeinone impurity. Efficient methods for conversion of oxycodone base to oxycodone hydrochloride are provided to minimize 14-hydroxycodeinone impurity in the final product.
    Type: Grant
    Filed: August 21, 2014
    Date of Patent: April 12, 2016
    Assignee: Cody Laboratories, Inc.
    Inventors: Zinovy Itov, Vladimir F. Kuznetsov, Iouri Voitsekhovski
  • Imidazopyridine derivatives as modulators of TNF activity
    Patent number: 9309243
    Abstract: A series of imidazo[1,2-a]pyridine derivatives of formula (I), being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders.
    Type: Grant
    Filed: July 5, 2013
    Date of Patent: April 12, 2016
    Assignee: UCB Biopharma SPRL
    Inventors: Jonathan Mark Bentley, Daniel Christopher Brookings, Julien Alistair Brown, Thomas Paul Cain, Praful Tulshi Chovatia, Anne Marie Foley, Ellen Olivia Gallimore, Laura Jane Gleave, Alexander Heifetz, Helen Tracey Horsley, Martin Clive Hutchings, Victoria Elizabeth Jackson, James Andrew Johnson, Craig Johnstone, Boris Kroeplien, Fabien Claude Lecomte, Deborah Leigh, Martin Alexander Lowe, James Madden, John Robert Porter, Joanna Rachel Quincey, Laura Claire Reed, James Thomas Reuberson, Anthony John Richardson, Sarah Emily Richardson, Matthew Duncan Selby, Michael Alan Shaw, Zhaoning Zhu
  • Benzopyran and benzoxepin PI3K inhibitor compounds and methods of use
    Patent number: 9309265
    Abstract: Benzopyran and benzoxepin compounds of Formulas I and II, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including p110 alpha and other isoforms of PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formulas I and II for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: April 12, 2016
    Assignees: Genentech, Inc., Hoffmann-La Roche Inc.
    Inventors: Steven Do, Richard Goldsmith, Tim Heffron, Aleksandr Kolesnikov, Steven Staben, Alan G. Olivero, Michael Siu, Daniel P. Sutherlin, Bing-Yan Zhu, Paul Goldsmith, Tracy Bayliss, Adrian Folkes, Neil Pegg
  • Borate moiety-contained linker and bio-sensing element containing the same
    Patent number: 9309268
    Abstract: A borate moiety-contained linker and a bio-sensing element containing the same are disclosed. The borate moiety-contained linker can be used to modify a sensing molecule and connect the sensing molecule to a substrate to form the bio-sensing element.
    Type: Grant
    Filed: December 4, 2014
    Date of Patent: April 12, 2016
    Assignee: NATIONAL CHIAO TUNG UNIVERSITY
    Inventors: Yaw-Kuen Li, Mo-Yuan Shen, Yu-Ju Pien
  • Line leaf inula flower lactone A and methods for preparing and using the same for treating myocarditis
    Patent number: 9303006
    Abstract: Preparation and application of line leaf inula flower lactone A for treating myocarditis having a structure of The compound shows positive therapeutic activity against Coxsackie virus and significant dose dependent correlation. The line leaf inula flower lactone A prevents disease in mouse models of experimental autoimmune myocarditis and onset of the process by intraperitoneal injection of a dose of 20 mg/kg/d. When increased to 100 mg/kg/d, the line leaf inula flower lactone A shows positive therapeutic effect on EAM. Line leaf inula flower lactone A is used as the sole active ingredient and combined with a conventional pharmaceutical carrier in a drug for treating myocarditis, and the pharmaceutical composition may be in the form of tablets, dispersible tablets, mouth collapse tablets, retard tablets, capsule, soft capsule, dropping pill, granules, injection, powder injection, or aerosol.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: April 5, 2016
    Assignee: SHANXI ZHENDONG PILOT BIOLOGICAL SCIENCE AND TECHNOLOGY CO., LTD.
    Inventors: Weidong Zhang, Lei Shan, Huizi Jin, Juan Su, Huiliang Li, Yunheng Shen, Xike Xu, Runhui Liu
  • Process for producing solid amino acid
    Patent number: 9302980
    Abstract: The problem to be solved by the present invention is to easily and efficiently produce an amino acid having 2 to 7 carbon atoms as a high-purity solid without complicated operation, which is useful as a synthetic intermediate for medicines or agrochemicals. The present invention is characterized in comprising a step of precipitating solid amino acid with high purity. In the present invention, the by-produced salt composed of the sulfonic acid and the amine was removed to the mother liquor by reacting an amine with a sulfonic acid salt of amino acid in an aprotic polar solvent, or by reacting a sulfonic acid with an amine salt of amino acid in an aprotic polar solvent. The sulfonic acid salt of amino acid, for example, may be produced by reacting a N-(tert-butoxycarbonyl) amino acid with a sulfonic acid, or by reacting an amino acid tert-butyl ester with a sulfonic acid.
    Type: Grant
    Filed: January 21, 2013
    Date of Patent: April 5, 2016
    Assignee: KANEKA CORPORATION
    Inventors: Masatoshi Ohnuki, Akira Nishiyama
  • Methods useful in the synthesis of halichondrin B analogs
    Patent number: 9303039
    Abstract: In general, the present invention features improved methods useful for the synthesis of analogs of halichondrin B, such as eribulin and pharmaceutically acceptable salts thereof (e.g., eribulin mesylate).
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: April 5, 2016
    Assignee: Eisai R&D Management Co., Ltd.
    Inventors: Huiming Zhang, Bryan M. Lewis
  • Preparation of 3,5-dioxo hexanoate ester in two steps
    Patent number: 9296718
    Abstract: The invention discloses a method for the preparation of tert-butyl 6-chloro-3,5-dioxohexanoate from Meldrum's acid derivative and its use for the preparation of tert-butyl (4R,6S)-(6-hydroxymethyl-2,2-dimethyl-1,3-dioxan-4-yl)acetate (BHA), Rosuvastatin and Atorvastatin.
    Type: Grant
    Filed: August 28, 2014
    Date of Patent: March 29, 2016
    Assignee: Lonza Ltd
    Inventors: Christian Noti, Guixian Hu, Barry Jackson
  • Therapeutic compounds
    Patent number: 9296728
    Abstract: The invention provides compounds of formula (I) or a salt thereof as described herein. The invention also provides pharmaceutical compositions comprising a compound of formula (I), processes for preparing compounds of formula (I), intermediates useful for preparing compounds of formula (I) and therapeutic methods for treating cancer or treating autoimmune diseases or preventing transplant rejection using compounds of formula (I).
    Type: Grant
    Filed: January 18, 2013
    Date of Patent: March 29, 2016
    Assignee: Regents of the University of Minnesota
    Inventors: Venkatram R. Mereddy, Lester R. Drewes, Mohammed Abrar Alam, Sravan K. Jonnalagadda, Shirisha Gurrapu
  • Crystalline forms of an 8-azabicyclo[3.2.1]octane compound
    Patent number: 9290491
    Abstract: The invention provides a crystalline sulfate salt of 3-endo-(8-{2-[cyclohexylmethyl-((S)-2,3-dihydroxy-propionyl)amino]ethyl}-8-aza-bicyclo[3.2.1]oct-3-yl)benzamide or a solvate thereof. The invention also provides pharmaceutical compositions comprising such crystalline salt forms, methods of using such crystalline salt forms to treat diseases associated with mu opioid receptor activity, and processes useful for preparing such crystalline salt forms.
    Type: Grant
    Filed: July 16, 2014
    Date of Patent: March 22, 2016
    Assignee: Theravance Biopharma R&D IP, LLC
    Inventors: Sean M. Dalziel, Leticia M. Preza, Miroslav Rapta, Pierre-Jean Colson
  • Methods for making and using novel semi-synthetic small molecules for the treatment parasitic disease
    Patent number: 9290474
    Abstract: Small molecule therapeutics for the treatment of parasitic diseases, in particular, semi-synthetic derivatives of the fungally-derived natural product merulin A for the treatment of African Sleeping Sickness.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: March 22, 2016
    Assignee: The Regents of the University of California
    Inventors: Roger R Linington, Gabriel Navarro, Khanitha Pudhom, James McKerrow
  • Aniline type compounds
    Patent number: 9282741
    Abstract: The present invention relates to a crystalline form of 2-(3-chloro-2-pyridyl)-N-[2-methyl-4-chloro-6-[(diethyl-?4-sulfanylidene)carbamoyl]phenyl]-5-(trifluoromethyl)pyrazole-3-carboxamide. The present invention also relates to a method for controlling invertebrate pest, which method comprises contacting the invertebrate pest or their food supply, habitat, breeding grounds or their locus with a pesticidally effective amount of a crystalline form of 2-(3-chloro- 2-pyridyl)-N-[2-methyl-4-chloro-6-[(diethyl-?4-sulfanylidene)carbamoyl]phenyl]-5-(trifluoromethyl)pyrazole-3-carboxamide.
    Type: Grant
    Filed: April 13, 2015
    Date of Patent: March 15, 2016
    Assignee: BASF SE
    Inventors: Karsten Koerber, Prashant Deshmukh, Florian Kaiser, Michael Rack, Timo Frasetto, Gemma Zünd, Markus Kordes, Marco Naujok
  • Phenylpyrrole derivative
    Patent number: 9284324
    Abstract: Provided are novel compounds that are useful in the prevention or treatment of such diseases as dementia, Alzheimer's disease, attention-deficient hyperactivity disorder, schizophrenia, epilepsy, central convulsion, obesity, diabetes mellitus, hyperlipidemia, narcolepsy, idiopathic hypersomnia, behaviorally induced insufficient sleep syndrome, sleep apnea syndrome, circadian rhythm disorder, parasomnia, sleep related movement disorder, insomnia, and depression, or allergic rhinitis, or pharmaceutically acceptable salts of such compounds.
    Type: Grant
    Filed: December 7, 2012
    Date of Patent: March 15, 2016
    Assignee: TAISHO PHARMACEUTICAL CO., LTD
    Inventors: Toshio Nakamura, Seiji Masuda
  • Nicotinic receptor compounds
    Patent number: 9284322
    Abstract: Provided herein are compounds and methods of preparation of compounds that are capable of functioning as agonists or antagonists of a nicotinic receptor. Also provided are pharmaceutical compositions comprising one or more of these compounds, which may further comprise one or more additional therapeutic agents. Further provided are methods of treatment of various conditions that may be responsive to such activity at the nicotinic receptors, such as nicotine dependence.
    Type: Grant
    Filed: February 6, 2015
    Date of Patent: March 15, 2016
    Assignee: Research Triangle Institute
    Inventors: Frank Ivy Carroll, Pauline Wanjiku Ondachi
  • Line leaf inula flower lactone A and methods for preparing and using the same for treating multiple sclerosis
    Patent number: 9278948
    Abstract: Preparation and application of line leaf inula flower lactone A in the multiple sclerosis, having a structure of Line leaf inula flower lactone A has therapeutic effects on experimental autoimmune encephalomyelitis (EAE) model, and is used to develop drug for treating multiple sclerosis (MS). Line leaf inula flower lactone A drug is a combination containing the active ingredient of line leaf inula flower lactone A and conventional pharmaceutically carrier, and may be in forms of tablets, dispersible tablets, mouth collapse tablets, retard tablets, capsule, soft capsule, dropping pill, granules, injection, powder injection, or aerosol. The pharmaceutical composition is used for treating multiple sclerosis, has tremendous developing potentiality because of its high value of clinical application.
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: March 8, 2016
    Assignee: Shanxi Zhendong Pilot Biological Science And Technology Co., Ltd.
    Inventors: Weidong Zhang, Lei Shan, Juan Su, Huizi Jin, Huiliang Li, Yunheng Shen, Xike Xu, Runhui Liu