Patents Examined by Nizal Chandrakumar
  • Production method for compound comprising amino group and/or hydroxyl group
    Patent number: 9278905
    Abstract: Disclosed is a method for producing a compound having an amino group and/or a hydroxyl group from a substrate compound having an atomic group containing CO or CS by eliminating such atomic group. The substrate compound, having an atomic group containing CO or CS (for example, an amide, a carbamate, or the like), is allowed to react with a compound expressed by formula (I) below, at a temperature of 120° C. or lower, preferably in the presence of an ammonium salt, to eliminate such atomic group containing CO or CS. In formula (I) A may not be present, and in a case where A is present, A represents an alkyl group having 1 to 6 carbon atoms. H2N-A-NH2??(I).
    Type: Grant
    Filed: March 4, 2013
    Date of Patent: March 8, 2016
    Assignee: Kyushu University, National University Corporation
    Inventors: Takashi Ohshima, Hiroyuki Morimoto, Yuhei Shimizu
  • Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors
    Patent number: 9278950
    Abstract: The present disclosure describes bicyclic aromatic carboxamide derivatives, as well as their compositions and methods of use. The compounds inhibit the activity of the Pim kinases, and are useful in the treatment of diseases related to the activity of Pim kinases including, e.g., cancer and other diseases.
    Type: Grant
    Filed: January 14, 2014
    Date of Patent: March 8, 2016
    Assignees: Incyte Corporation, Incyte Holdings Corporation
    Inventors: Yun-Long Li, David M. Burns, Hao Feng, Chu-Biao Xue, Anlai Wang, Jun Pan
  • Process for manufacturing 5-chloromethyl-2,3-pyridine dicarboxylic acid anhydrides
    Patent number: 9278977
    Abstract: A process for manufacturing 5-chloromethyl-2,3-pyridine dicarboxylic acid anhydrides (I) wherein Z is hydrogen or halogen; Z1 is hydrogen, halogen, cyano or nitro; comprising the steps of (i) reacting a compound of formula (II), wherein the symbols have the meaning given in formula (I), with a chlorinating agent, optionally in the presence of a radical initiator in a solvent selected from halogenated hydrocarbons, and (ii) crystallizing the compound (I) formed in step (i) from a solvent selected from chlorobenzene, 1,2-dichlorobenzene, 1,3-dichlorobenzene, 1,4-dichlorobenzene, dichloroethane, trichloromethane, dichloromethane, toluene, xylenes, ethyl acetate, methyl tert.-butyl ether, and mixtures thereof. Compounds (I) are useful intermediates in the synthesis of herbicidal imidazolinones.
    Type: Grant
    Filed: March 20, 2014
    Date of Patent: March 8, 2016
    Assignee: BASF SE
    Inventors: Frederik Menges, Joachim Gebhardt, Michael Rack, Michael Keil, Rodney F. Klima, David Cortes, Robert Leicht, Helmut Zech, Jochen Schroeder
  • Heteroaryl-ketone fused azadecalin glucocorticoid receptor modulators
    Patent number: 9273047
    Abstract: The present invention provides heteroaryl ketone fused azadecalin compounds and methods of using the compounds as glucocorticoid receptor modulators.
    Type: Grant
    Filed: September 16, 2014
    Date of Patent: March 1, 2016
    Assignee: Corcept Therapeutics, Inc.
    Inventors: Hazel Hunt, Tony Johnson, Nicholas Ray, Iain Walters
  • TRPV1 antagonists including dihydroxy substituent and uses thereof
    Patent number: 9273043
    Abstract: The disclosure relates to Compounds of Formula (I) and pharmaceutically acceptable derivatives thereof, where R1, R4, R8, R9, and m are as defined herein, compositions comprising an effective amount of a Compound of Formula (I) or a pharmaceutically acceptable derivative thereof, and methods for treating or preventing a condition such as pain, pain associated with osteoarthritis, osteoarthritis, UI, an ulcer, IBD, and IBS, comprising administering to an animal in need thereof an effective amount of a Compound of Formula (I) or a pharmaceutically acceptable derivative thereof.
    Type: Grant
    Filed: June 21, 2012
    Date of Patent: March 1, 2016
    Assignees: Purdue Pharma L.P., Shionogi & Co., Ltd.
    Inventors: Noriyuki Kurose, Laykea Tafesse
  • Lichesterinic acid and the derivatives of same as pigmentation inhibitors
    Patent number: 9265706
    Abstract: The invention relates to the cosmetic use of a compound chosen from the compounds of formula (A) and the salts of same as an agent for depigmenting the skin and/or keratinous appendages.
    Type: Grant
    Filed: April 18, 2013
    Date of Patent: February 23, 2016
    Assignees: Centre National de la Recherche Scientifique—CNRS, Universite de Rennes 1, Centre Hospitalier Universitaire Pontchaillou
    Inventors: Joel Boustie, Marie-Dominique Galibert-Anne, Francoise Lohezic-le Devehat, Marylene Chollet-Krugler, Sophie Tomasi, Nicolas Mouchet, Beatrice Legouin-Gardadennec
  • Compositions and methods for treating cancer
    Patent number: 9266901
    Abstract: Provided herein, inter alia, are compositions and methods useful for treating hyperproliferative diseases, including cancer and non-malignant hyperproliferative diseases.
    Type: Grant
    Filed: October 2, 2014
    Date of Patent: February 23, 2016
    Assignee: The Regents of The University of Califronia
    Inventors: Richard J. Pietras, Michael E. Jung, Diana C. Marquez-Garban, Gang Deng
  • Indolizinone based derivatives as potential phosphodiesterase 3 (PDE3) inhibitors and a process for the preparation thereof
    Patent number: 9249139
    Abstract: The present invention provides compounds of general formula A useful as potential phosphodiesterase3 (PDE3) inhibitory agents and a process for the preparation thereof. The derivatives of formula A can be employed as therapeutics in human and veterinary medicine, where they can be used, for example, for the treatment and prophylaxis of the following diseases: heart failure, dilated cardiomyopathy, platelet inhibitors, cancer and obstructive pulmonary diseases.
    Type: Grant
    Filed: January 30, 2014
    Date of Patent: February 2, 2016
    Assignee: Council of Scientific & Industrial Research
    Inventors: Budde Mahendar, Saidulu Mattapally, Mettu Ravinder, Sanjay Kumar Banerjee, Vaidya Jayathirtha Rao
  • Tris(hetero)arylpyrazoles and use thereof
    Patent number: 9249148
    Abstract: The present invention relates to new tri(hetero)aryl pyrazoles, methods for their preparation, their use for treating and/or preventing diseases as well as their use in the preparation of drugs for treating and/or preventing diseases, in particular retroviral diseases in humans and/or animals.
    Type: Grant
    Filed: August 16, 2013
    Date of Patent: February 2, 2016
    Assignee: AICURIS GMBH & CO. KG
    Inventors: Steffen Wildum, Burkhard Klenke, Astrid Wendt
  • Compounds for the treatment of conditions associated with DGAT1 activity
    Patent number: 9242971
    Abstract: The present invention relates to novel crystalline forms of salts of 2-((1R,4R)-4-(4-(5-(benzo[d]oxazol-2-ylamino)pyridin-2-yl)phenyl)cyclohexyl)acetic acid and their use in the treatment or prevention of a condition or a disorder associated with DGAT1 activity in animals, particularly humans.
    Type: Grant
    Filed: February 24, 2015
    Date of Patent: January 26, 2016
    Assignee: NOVARTIS AG
    Inventors: Christina Capacci-Daniel, Marilyn Delacruz, Baoqing Gong, Akash Jain, Yansong Lu, Lijun Zhang
  • Pharmaceutical or cosmetic composition for treating alopecia
    Patent number: 9241888
    Abstract: The present invention relates to a cosmetic or pharmaceutical composition for treating alopecia, and in general for counteracting excessive hair loss, comprising as an active ingredient a compound of formula (I) R—N1-spermidine, or 1,4-butane-diamine,N-(3-aminopropyl)-N1—R. The compounds of general formula (I) are active in accordance with the objects of the present invention, and also sufficiently stable to allow effective application for topical use on the scalp without potentially being transformed into a different substance, which is no longer active, as a result of oxidation.
    Type: Grant
    Filed: July 26, 2013
    Date of Patent: January 26, 2016
    Assignee: Giuliani S.P.A.
    Inventors: Giammaria Giuliani, Ralf Paus, Anna Benedusi, Barbara Marzani, Sergio Baroni
  • Substituted bicyclic heteroaryl compounds
    Patent number: 9242967
    Abstract: Disclosed are azaindazole compounds of Formula (I): or a pharmaceutically acceptable salt thereof, wherein: X is O and Y is N; or X is S and Y is CH; Z is CR2 or N; Q is a heteroaryl; and R1 is defined herein. Also disclosed are methods of using such compounds in the treatment of at least one CYP17 assoC1ated condition, such as, for example, cancer, and pharmaceutical compositions comprising such compounds.
    Type: Grant
    Filed: January 16, 2015
    Date of Patent: January 26, 2016
    Assignee: Bristol-Myers Squibb Company
    Inventors: Upender Velaparthi, Peiying Liu
  • Chromane compounds
    Patent number: 9242973
    Abstract: The present invention provides a hydrate of N-[(4S)-2-amino-2?,2?-dimethyldispiro[1,3-oxazole-4,4?-chromene-3?,3?-oxetan]-6?-yl]-5-chloropyridine-2-carboxamide which is useful as an active ingredient of a pharmaceutical composition, in particular, a pharmaceutical composition for preventing or treating diseases or conditions associated with and/or mediated by ?-secretase activity, hydrolysis of a ?-secretase site of a ?-amyloid precursor protein, and/or ?-amyloid protein accumulation, including a pharmaceutical composition for preventing or treating diseases including, but not limited to, Glaucoma, MCI (Mild cognitive impairment) or Alzheimer's disease, especially, Alzheimer's disease.
    Type: Grant
    Filed: January 22, 2015
    Date of Patent: January 26, 2016
    Assignee: COMENTIS, INC.
    Inventors: Ryosuke Munakata, Makoto Inoue, Hiroaki Tominaga, Shingo Yamasaki, Yasuhiro Shiina, Kiyohiro Samizu, Hisao Hamaguchi, Lin Hong
  • Pharmaceutically active disubstituted pyridine derivatives
    Patent number: 9242937
    Abstract: The present invention relates to disubstituted pyridine derivatives and/or pharmaceutically acceptable salts thereof, the use of these derivatives as pharmaceutically active agents, especially for the prophylaxis and/or treatment of infectious diseases, including opportunistic diseases, immunological diseases, autoimmune diseases, cardiovascular diseases, cell proliferative diseases, inflammation, erectile dysfunction and stroke, and pharmaceutical compositions containing at least one of said disubstituted pyridine derivatives and/or pharmaceutically acceptable salts thereof. Furthermore, the present invention relates to the use of said disubstituted pyridine derivatives as inhibitors for a protein kinase.
    Type: Grant
    Filed: March 1, 2012
    Date of Patent: January 26, 2016
    Assignees: Bayer Intellectual Property GmbH, LEAD DISCOVERY CENTER GMBH
    Inventors: Gerd Rühter, Peter Nussbaumer, Axel Choidas, Carsten Schulz-Fademrecht, Bert Klebl, Jan Eickhoff
  • Covalent inhibition of bacterial quorum sensing
    Patent number: 9242951
    Abstract: Inhibitors of bacterial communication, such as quorum sensing, and method of use and manufacture thereof.
    Type: Grant
    Filed: June 26, 2013
    Date of Patent: January 26, 2016
    Assignee: THE NATIONAL INSTITUTE FOR BIOTECHNOLOGY IN THE NEGEV LTD.
    Inventors: Michael M. Meijler, Josep Rayo, Neri Amara
  • Treatment of pancreatic and related cancers with 5-acyl-6,7-dihydrothieno[3,2-c]pyridines
    Patent number: 9242994
    Abstract: Methods for inhibiting the growth of pancreatic cancer cells or other cancer cells driven by Sonic hedgehog are disclosed.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: January 26, 2016
    Assignees: Memorial Sloan-Kettering Cancer Center, The Rockefeller University
    Inventors: Marilyn D. Resh, Joseph Fraser Glickman, Elissaveta Petrova, Ouathek Ouerfelli
  • Methods for preparing D-threo methylphenidate using diazomethane, and compositions thereof
    Patent number: 9233924
    Abstract: Novel methods and systems for producing a substantially pure d-threo stereoisomer of methylphenidate or a salt thereof are provided. In particular, methods and systems for producing d-threo-methylphenidate hydrochloride in pure stereoisomeric form from d-threo-ritalinic acid hydrochloride using diazomethane are described. The described methods can be performed on a large scale, and thus provide d-threo methylphenidate or a salt thereof, and particularly the hydrochloride salt of d-threo-methylphenidate, in stereoisomerically pure form and in large quantities from a single batch reaction. Also described are novel compositions of d-threo methylphenidate hydrochloride.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: January 12, 2016
    Assignee: AMPAC Fine Chemicals LLC
    Inventors: Aslam Malik, Francis Hempenstall, Nicholas Duda, Ali Suleman
  • Preparation of 14-hydroxycodeinone sulfate
    Patent number: 9233972
    Abstract: Synthetic methods are provided for preparation of oxycodone and salts thereof with an improved impurity profile. Thebaine is converted to 14-hydroxycodeinone sulfate intermediate to minimize a 7,8-dihydro-8,14-dihydroxycodeinone impurity. Efficient methods for conversion of oxycodone base to oxycodone hydrochloride are provided to minimize 14-hydroxycodeinone impurity in the final product.
    Type: Grant
    Filed: August 14, 2014
    Date of Patent: January 12, 2016
    Assignee: Cody Laboratories, Inc.
    Inventors: Zinovy Itov, Vladimir F. Kuznetsov, Iouri Voitsekhovski
  • Luminescent compounds, method of preparation of luminescent compounds and applications thereof
    Patent number: 9217104
    Abstract: This invention relates to compounds of general formula (R?)xZny(L)z(A)n(XR)m, where L is a bi- or multifunctional organic neutral ligand or its deprotonated form, containing at least two heteroatoms selected from N, O, S, wherein at least one of the functional groups of the ligand is selected from —OH, —SH, —NH2, —NHR, —COOH, —CONH2, —CONRH or their deprotonated equivalents; A is an inorganic anion, X is oxygen or sulfur, R? is C1-C10 alkyl, straight or branched, benzyl, phenyl cyclohexyl or halogen, R is hydrogen, alkyl or aryl, x is a number from 0 to 6, y is a number from 1 to 12, z is a number from 1 to 12, n is a number from 0 to 6, m is a number from 0 to 6, wherein x?0, n?0 and m?0 at the same time and if n and m=0, then x?z. The invention also relates to the method of preparation of these compounds and applications thereof.
    Type: Grant
    Filed: July 6, 2011
    Date of Patent: December 22, 2015
    Assignee: Instytut Chemii Fizycznej Polskiejakademii Nauk
    Inventors: Janusz Zbigniew Lewinski, Kamil Sokolowski
  • Process for the preparation of 4-amino-5-fluoro-3-chloro-6-(substituted)picolinates
    Patent number: 9212141
    Abstract: 4-Amino-5-fluoro-3-chloro-6-(substituted)picolinates are prepared from trifluoroacetic acid, p-methoxyaniline, a 3,3-dialkoxyprop-1-yne and a substituted methylene amine by a series of steps.
    Type: Grant
    Filed: December 12, 2013
    Date of Patent: December 15, 2015
    Assignee: Dow AgroSciences, LLC.
    Inventors: James M. Renga, Gregory T. Whiteker, Peter L. Johnson, Christopher Galliford