Abstract: The inactivation of BK virus in patients diagnosed with BK virus, those receiving a kidney that is infected or suspected of being infected by BK virus, or in the transplanted kidney before, during, and/or after transplant surgery is described.
Type:
Grant
Filed:
July 8, 2022
Date of Patent:
July 23, 2024
Assignee:
Renibus Therapeutics, Inc.
Inventors:
Donald Jeffrey Keyser, Alvaro F. Guillem, Bhupinder Singh, Stacey Ruiz
Abstract: There are provided compounds containing benzo[d][1,3]oxathiole, benzo[d][1,3]oxathiole 3-oxide, and benzo[d][1,3]oxathiole 3,3-dioxide, as well as uses/methods related thereto, including treatment of diseases and condition associated with GPR119 dysregulation, Type 2 diabetes mellitus, and related metabolic disorders.
Abstract: Compounds of general formula (I) wherein R1, R2, R3, R4 and X are as defined herein are inhibitors of the epithelial sodium channel (ENaC) and are useful for the treatment or prevention respiratory diseases and conditions, skin conditions and ocular conditions.
Type:
Grant
Filed:
May 17, 2019
Date of Patent:
July 16, 2024
Assignee:
Enterprise Therapeutics Limited
Inventors:
Clive McCarthy, Duncan Alexander Hay, Thomas Beauregard Schofield
Abstract: A composition for an organic optoelectronic device, an organic optoelectronic device, and a display device, the composition including a first compound; a second compound; and a third compound, the first compound, the second compound, and the third compound are different from each other, the first compound is represented by Chemical Formula I, the second compound is represented by Chemical Formula II or Chemical Formula III, and the third compound is represented by Chemical Formula II or Chemical Formula III,
Type:
Grant
Filed:
February 14, 2020
Date of Patent:
July 2, 2024
Assignee:
SAMSUNG SDI CO., LTD.
Inventors:
Yongtak Yang, Dong Min Kang, Hyung Sun Kim, Jinhyun Lui, Seungin Park, Jaejin Oh, Sung-Hyun Jung, Ho Kuk Jung, Youngkyoung Jo, Pyeongseok Cho, Dalho Huh
Abstract: Disclosed in the present invention are an edaravone pharmaceutical composition and an application thereof as a sublingual preparation, the pharmaceutical composition containing edaravone or a salt thereof and mannitol. A sublingual administration preparation can avoid the first-pass effect of the liver, and samples feature good stability, convenience of transport and of use, among other advantages.
Type:
Grant
Filed:
December 27, 2018
Date of Patent:
June 25, 2024
Assignees:
BEIJING TIANTAN HOSPITAL, CAPITAL MEDICAL UNIVERSITY, NANJING BAIXINYU PHARMACEUTICAL CO. LTD.
Abstract: Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process.
Type:
Grant
Filed:
February 1, 2021
Date of Patent:
June 11, 2024
Assignee:
Biohaven Therapeutics Ltd.
Inventors:
Jay Edward Wrobel, Allen B. Reitz, Jeffrey Claude Pelletier, Garry Robert Smith, Haiyan Bian
Abstract: Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process.
Type:
Grant
Filed:
July 29, 2023
Date of Patent:
June 11, 2024
Assignee:
Biohaven Therapeutics Ltd.
Inventors:
Jay Edward Wrobel, Allen B. Reitz, Jeffery Claude Pelletier, Garry Robert Smith, Haiyan Bian
Abstract: The present invention relates to compounds of formula (I) for use in preventing and/or treating cancer.
Type:
Grant
Filed:
July 1, 2019
Date of Patent:
June 11, 2024
Assignees:
FUNDACIÓ HOSPITAL UNIVERSITARI VALL D'HEBRONINSTITUT DE RECERCA, INSTITUT UNIV. DE CIÈNCIA I TECNOLOGIA, S. A.
Inventors:
Josep Roma Castanyer, Marta Pascual Gilabert, José Sánchez De Toledo Codina, Soledad Gallego Melcón, Patricia Zarzosa Martínez, Javier Alonso Fernández, Sergio Pérez Ozcáriz, Cristina López Gómez, Josep Castells Boliart
Abstract: The Present invention provides a novel pyrazole derivative compound represented by Chemical formula 1, a stereoisomer thereof, a solvate thereof, an isotopic variant thereof, a tautomer thereof, or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition comprising the same. (In the above, A, B and R, and the like are the same as defined in the description of the invention.
Type:
Grant
Filed:
January 6, 2023
Date of Patent:
June 4, 2024
Assignee:
APTABIO THERAPEUTICS INC.
Inventors:
Soo Jin Lee, Sung Hwan Moon, Sooho Ban, Eunsil Lee, Eun Jung Shin, Yoo-Kyung Goh
Abstract: Disclosed are conjugates including a recognition element covalently bonded to or linked through a linker to a payload. The payload is a pharmaceutical agent (e.g., an antineoplastic agent, anti-infective agent, or anti-inflammatory agent) or a diagnostic agent. Also disclosed are methods of using the conjugates.
Type:
Grant
Filed:
February 11, 2021
Date of Patent:
June 4, 2024
Assignee:
Flagship Pioneering Innovations V, Inc.
Inventors:
Spencer Cory Peck, Steven John Taylor, Elijah Lane Bogart, Devin Forest Reed Doud, Joo Hyun Im, Dervla Tamara Isaac, Jenny Liu, Ferdinand Edward Massari, Robert Walter Myers, John Robert Proudfoot, Cheri Ross, John Patrick Casey, Jr., David Arthur Berry
Abstract: A 4,5-bis(4-chlorophenyl)-2-phenyl-1H-imidazole compound, its synthesis, and its use as an anticancer, anti-inflammatory, and/or antimicrobial agent.
Type:
Grant
Filed:
October 23, 2023
Date of Patent:
June 4, 2024
Assignee:
KING FAISAL UNIVERSITY
Inventors:
Hany Mohamed Abd El-Lateef Ahmed, Mai Mostafa Khalaf Ali, Amer A. Amer, Antar Ahmed Abdelhamid Ahmed
Abstract: A medicament with excellent JAK kinase (Janus Kinase) inhibitory activity can be used to prevent, treat and/or improve an autoimmune disease (e.g., psoriasis, rheumatoid arthritis, inflammatory bowel disease, Sjogren's syndrome, Behcet's disease, multiple sclerosis, systemic lupus erythematosus and the like). The present invention also provides a pharmaceutically acceptable composition containing the compound and a method for preparing these compounds.
Type:
Grant
Filed:
September 5, 2019
Date of Patent:
May 28, 2024
Assignees:
INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES & PEKING UNION MEDICAL COLLEGE, CHINA PARMACEUTICAL UNIVERSITY
Inventors:
Tiantai Zhang, Dayong Zhang, Chengjuan Chen, Yuan Yin, Runan Yu, Lei Shu
Abstract: Chemical compounds that inhibit cancer cell growth are provided. The compounds are heteroarotinoids and derivatives thereof with oxygen, nitrogen or sulfur in chroman systems, tetrahydroquinoline systems, and tetrahydrothiochroman systems.
Type:
Grant
Filed:
February 4, 2021
Date of Patent:
May 28, 2024
Assignee:
THE BOARD OF REGENTS FOR OKLAHOMA STATE UNIVERSITY
Inventors:
Kenneth Darrell Berlin, Richard A. Bunce, Krishna Kumar Gnanasekaran, Field M. Watts, Jr., Donghua Howard Zhou
Abstract: The disclosure provides methods for treating estrogen receptor positive (ER+) cancer in women with an effective amount of lasofoxifene, a pharmaceutically acceptable salt thereof, or a prodrug thereof. The disclosure also includes the detection of the Estrogen Receptor 1 (ESR1) gene mutations that lead to endocrine resistance and treatment of endocrine resistant ER+ cancers.
Type:
Grant
Filed:
March 30, 2023
Date of Patent:
May 14, 2024
Assignee:
Duke University
Inventors:
Kaitlyn Andreano, Ching-yi Chang, Donald P. McDonnell, Stephanie L. Gaillard
Abstract: A 9-(2-hydroxyquinolin-3-yl)-10-(2-hydroxyethyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydroacridine1,8(2H,5H)-dione compound, its synthesis, and its use as an antimicrobial agent.
Type:
Grant
Filed:
November 16, 2023
Date of Patent:
April 30, 2024
Assignee:
KING FAISAL UNIVERSITY
Inventors:
Hany Mohamed Abd El-Lateef Ahmed, Mai Mostafa Khalaf Ali, Antar Ahmed Abdelhamid Ahmed, Amer A. Amer
Abstract: The present disclosure provides 6-heteroaryloxy benzimidazole and azabenzimidazole compounds and compositions thereof useful for inhibiting JAK2.
Type:
Grant
Filed:
November 8, 2022
Date of Patent:
April 30, 2024
Assignee:
Ajax Therapeutics, Inc.
Inventors:
Craig E. Masse, Jeremy R. Greenwood, Jiayi Xu, Sayan Mondal, Phani Ghanakota
Abstract: The present invention provides 11-arylcinnolino[2,3-f]phenanthridinium salt compounds and method for producing the same by highly regioselective synthesis of 11-phenylimino[2,3-f]phenanthridin-9-ium salts from 2-azobiaryls and alkenes under catalysis of palladium, through double oxidative C—H coupling of alkenes, to give the polycyclic cinnolinophenanthridinium salts in moderate yields. The reaction mechanism involves ortho C—H olefination of 2-azobiaryls by alkenes, intramolecular aza-Michael addition, ?-hydride elimination, electrophilic palladation followed by intramolecular C—H activation and reductive elimination. The prepared quaternary ammonium salts are candidate materials for solution-processable OLED and bioimaging materials.
Abstract: The present invention relates to novel oxazolidinones (Formula I): or a pharmaceutically acceptable salt having ring A characterized by N-containing monocyclic, bicyclic or spirocyclic substituents, to their preparation, and to their use as drugs for treating Mycobacterium tuberculosis and other microbial infections, either alone or in combination with other anti-infective treatments.
Type:
Grant
Filed:
January 13, 2020
Date of Patent:
April 23, 2024
Assignee:
The Global Alliance for TB Drug Development, Inc.
Inventors:
Christopher B. Cooper, Haihong Huang, Dongfeng Zhang, Nader Fotouhi, Takushi Kaneko
Abstract: The present invention relates to compounds and methods for the treatment of cancer. In particular, the invention provides potent inhibitors of Aurora A kinase, pharmaceutical compositions comprising the compounds, and methods of using the compounds for the treatment of cancer.
Type:
Grant
Filed:
November 16, 2020
Date of Patent:
April 16, 2024
Assignee:
Millennium Pharmaceuticals, Inc.
Inventors:
Christopher F. Claiborne, Todd B. Sells, Stephen G. Stroud
Abstract: Preparation of optionally substituted dihydroisoquinolines. The present invention relates to a process for the preparation of optionally substituted dihydroi-soquinolines of the formula I.
Type:
Grant
Filed:
January 14, 2019
Date of Patent:
April 16, 2024
Assignee:
BASF SE
Inventors:
Bernd Mueller, Michael Rack, Michael Seet, Ana Escribano Cuesta, Jan Klaas Lohmann, Georg Christoph Rudolf, Markus Nett, Rainer Hoffmann