Abstract: Described herein, are the extended and newly discovered novel formulations of FL118 for cancer treatment to preclude, eliminate or reverse cancer phenotypes and treatment resistance.
Abstract: The present technology provides compounds selective for the Grp94 isoform, as well as compositions including such compounds, that are useful for treatment of multiple myeloma, melanoma, lung cancer, hepatocellular carcinoma, breast cancer, prostate cancer, and/or glaucoma. Methods using the compound are also provided.
Type:
Grant
Filed:
June 7, 2021
Date of Patent:
April 8, 2025
Assignee:
University of Kansas
Inventors:
Brian S. J. Blagg, Vincent Matthew Crowley
Abstract: An asymmetric fused aromatic ring derivative containing sulfonyl group, which includes a structure represented by formula (I). Formula (I) is defined as in the specification. A use of the asymmetric fused aromatic ring derivative containing sulfonyl group, which is used as a photocatalyst. A hydrogen production device, which includes the asymmetric fused aromatic ring derivative containing sulfonyl group. An optoelectronic component, which includes the asymmetric fused aromatic ring derivative containing sulfonyl group.
Abstract: The invention presents use of ion channel modulator to manipulate expression of the Tmem176b gene, also known as TORID (TOlerance Related and InduceD), to treat tumors.
Type:
Grant
Filed:
October 28, 2021
Date of Patent:
April 1, 2025
Assignees:
Institut Pasteur de Montevideo, University of the Republic
Inventors:
Marcelo Hill Mongabure, Sofia Russo Rossi, Mercedes Segovia Duarte, María Inés Varela Vega, Pablo Oppezzo Llorens
Abstract: A method for producing a halogenated zinc phthalocyanine pigment includes a step of forming a halogenated zinc phthalocyanine crude pigment into a pigment. The halogenated zinc phthalocyanine crude pigment is obtained by depositing a halogenated zinc phthalocyanine, which is synthesized by using an acidic compound or a compound that generates an acid by reacting with water, and the step includes a pretreatment step of kneading the halogenated zinc phthalocyanine crude pigment along with water.
Abstract: The present disclosure relates generally to the field of antimicrobial compounds and to methods of making and using them. These compounds are useful for treating, preventing, reducing the risk of, and delaying the onset of microbial infections in humans and animals. In some embodiments, the present disclosure provides a compound of Formula (I): or a tautomer thereof or a pharmaceutically acceptable salt of the compound or tautomer.
Type:
Grant
Filed:
February 17, 2021
Date of Patent:
February 25, 2025
Assignee:
BIOVERSYS AG
Inventors:
Erin M. Duffy, Ashoke Bhattacharjee, Zoltan F. Kanyo, Joseph A. Ippolito, Andrea Marra
Abstract: The present invention relates to compounds of formula (I) or a pharmaceutically acceptable salt form thereof, wherein the substituents are as defined in the specification; to intermediates in the preparation of the compounds, to pharmaceutical compositions comprising the compounds and to the use of the compounds in the treatment of disease.
Type:
Grant
Filed:
April 27, 2021
Date of Patent:
February 18, 2025
Assignee:
Novartis AG
Inventors:
Robin Alec Fairhurst, Christine Fritsch, Marc Gerspacher, Jürgen Hans-Hermann Hinrichs, Jean-Baptiste Georges Armand Langlois, Catherine Leblanc, Tengfei Li, Edwige Liliane Jeanne Lorthiois, Christophe Mura, Cristina Montserrat Nieto-Oberhuber, Milen Todorov, Andrea Vaupel, Nicolas Warin, Rainer Wilcken
Abstract: The present application relates to a compound serving as a selective PI3K? kinase inhibitor, comprising the compound shown in formula (I) or a pharmaceutically acceptable salt, solvate, ester, acid, metabolite or prodrug thereof, wherein X, R1, R2, R3, R4, R5 and R6 are as defined in the description. The present application also relates to a method for using the kinase inhibitor to inhibit PI3K? kinase activity or to treat or prevent diseases or conditions associated with tyrosine kinase activity of PI3K?, as well as a use thereof.
Abstract: A method for preparing 2,3-dichloro-5-trifluoromethylpyridine, comprising at a temperature of 100˜150° C. and a pressure of 0.5˜5.0 MP, in presence of at least one catalyst selected from supported metal chloride, supported zeolite molecular sieve and supported heteropolyacid, 2-chloro-5-trifluoromethylpyridine reacts with chlorine gas to obtain 2,3-dichloro-5-trifluoromethylpyridine. The preparing method provided by the present invention has advantages such as high selectivity of desired product, high utilization rate of chlorine gas, moderate process condition, simple operation and less three wastes. The present invention also discloses a preparing method for preparing 2-chloro-5-trifluoromethylpyridine, which is capable of reducing unit consumption, reducing separation cost, and improving safety compared to the prior art.
Type:
Grant
Filed:
September 17, 2021
Date of Patent:
February 11, 2025
Assignees:
ZHEJIANG LANTIAN ENVIRONMENTAL PROTECTION HI-TECH CO., LTD., ZHEJIANG RESEARCH INSTITUTE OF CHEMICAL INDUSTRY CO., LTD., SINOCHEM LANTIAN CO., LTD.
Abstract: Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process.
Type:
Grant
Filed:
July 5, 2021
Date of Patent:
February 4, 2025
Assignee:
Biohaven Therapeutics Ltd.
Inventors:
Jay Edward Wrobel, Allen B. Reitz, Jeffery Claude Pelletier, Garry Robert Smith, Haiyan Bian
Abstract: The present application discloses compounds having the following formula: or pharmaceutically acceptable salts thereof, wherein R1, R2, R3, and R4 are defined in the specification, as well as methods of making and using the compounds disclosed herein for treating or ameliorating an IL-17 mediated syndrome, disorder and/or disease.
Type:
Grant
Filed:
September 26, 2022
Date of Patent:
February 4, 2025
Assignee:
Janssen Pharmaceutica NV
Inventors:
Steven D. Goldberg, Douglas C. Behenna, Deane Gordon, Luke E. Hanna, Steven A. Loskot, Stefan McCarver, Steven P. Meduna, Brock T. Shireman, Alexander E. Valdes, Jennifer D. Venable, Dongpei Wu
Abstract: Disclosed is a method of reducing plasma level of macrophage migratory inhibitory factor in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of ibudilast, or a pharmaceutical salt thereof.
Abstract: The invention provides methods and compositions for treatment of pain, such as joint pain, using capsaicin in a procedure that attenuates transient burning sensation experienced by patients due to capsaicin administration. The methods desirably provide relief from joint pain, such as osteoarthritic knee joint pain, for an extended duration, such as at least about 3 months, 6 months, 9 months, or 1 year. To attenuate the adverse side effect of a transient burning sensation caused by capsaicin-induced neuronal excitation, the methods utilize a cooling article, such as a material wrap cooled via a circulating fluid, to reduce the temperature of tissue to be exposed to capsaicin to within a certain range for certain durations of time, optionally in combination with administering a local anesthetic agent, resulting in the substantial reduction or even elimination of transient burning sensation caused by capsaicin.
Type:
Grant
Filed:
June 4, 2021
Date of Patent:
January 21, 2025
Assignee:
Centrexion Therapeutics Corporation
Inventors:
James N. Campbell, Peter D. Hanson, Randall Stevens
Abstract: The invention relates to the technical field of gene treatment and nano targeted delivery, in particular to a siRNA delivery system compound as well as a preparation method and application thereof.
Abstract: Compound that is an inhibitor of at least one of the A2A and A2B adenosine receptors, and compositions containing the compound and methods for synthesizing the compound, are described herein. The use of such compound and compositions for the treatment of a diverse array of diseases, disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by the adenosine A2A receptor and/or the adenosine A2B receptor.
Abstract: A combination drug contains hypoxanthine and human immunoglobulin (HIg). HIg has a therapeutic effect on radiation injuries, and the combination of hypoxanthine and HIg can further enhance this therapeutic effect. The combination drug can be administered to patients undergoing radiotherapy and to those who accidentally have excessive irradiation.
Type:
Grant
Filed:
July 11, 2022
Date of Patent:
January 7, 2025
Assignees:
Institute of Blood Transfusion, Chinese Academy of Medical Sciences, Institute of Radiation Medicine, Chinese Academy of Medical Sciences, Shanghai RAAS Blood Products Co., Ltd.
Inventors:
Zongkui Wang, Ming Cui, Changqing Li, Jun Xu, Lu Cheng
Abstract: The present disclosure pertains to the field of biomedicine, and specifically relates to a method for treating, suppressing, reducing the severity of, lowering the risk of, or inhibiting the metastasis of cancer in an individual, the method comprising administering to the individual a therapeutically effective amount of an IAP inhibitor, a therapeutically effective amount of a modulator of an immune checkpoint molecule, and optionally a therapeutically effective amount of a tubulin inhibitor. The present disclosure further relates to a pharmaceutical composition or kit comprising an IAP inhibitor, a modulator of an immune checkpoint molecule, and optionally a tubulin inhibitor.
Type:
Grant
Filed:
July 30, 2019
Date of Patent:
January 7, 2025
Assignee:
Ascentage Pharma (Suzhou) Co., LTD.
Inventors:
Dajun Yang, Yifan Zhai, Douglas Dong Fang, Guangfeng Wang, Qiuqiong Tang, Wentao Pan, Jiao Ji
Abstract: Provided herein are compounds of the general Formula I: and stereoisomers and pharmaceutically acceptable salts or solvates thereof, in which Ring A, Ring B, Ring C, R1, R2, L, Y, and W have the meanings given in the specification, which are inhibitors of FGFR1, FGFR2, FGFR3 and/or FGFR4 and are useful in the treatment and prevention of diseases which can be treated with an FGFR inhibitor, including diseases or disorders mediated by FGFR1, FGFR2, FGFR3 and/or FGFR4.
Type:
Grant
Filed:
December 13, 2019
Date of Patent:
December 31, 2024
Assignee:
Array Biopharma Inc.
Inventors:
James F. Blake, David A. Moreno, Li Ren, Tony P. Tang, Shane M. Walls
Abstract: Methods and compositions for treating acute myeloid leukemia and diffuse large B cell lymphoma using combinations of venetoclax and indolinone derivatives are provided.
Type:
Grant
Filed:
March 28, 2022
Date of Patent:
December 10, 2024
Assignee:
Oncternal Therapeutics, Inc.
Inventors:
Brian Lannutti, Katayoun Jessen, James Bradley Breitmeyer
Abstract: Provided herein are oligonucleotides, cell penetrating peptides, and peptide-oligonucleotide-conjugates. Also provided herein are methods of treating a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject oligonucleotides, peptides, and peptide-oligonucleotide-conjugates described herein.
Type:
Grant
Filed:
October 17, 2018
Date of Patent:
November 12, 2024
Assignees:
Sarepta Therapeutics, Inc., Massachusetts Institute of Technology
Inventors:
Justin M. Wolfe, Colin M. Fadzen, Zi-Ning Choo, Rebecca L. Holden, Monica Yao, Gunnar J. Hanson, Bradley L. Pentelute