Patents Examined by Noble E Jarrell
  • Rigid chiral redox-active isosceles triangular materials
    Patent number: 11155554
    Abstract: Provided herein are rigid macrocycles comprising a first redox-active subunit and a second redox-active subunit, wherein the first redox-active unit and the second redox-active unit are different subunits. Also provided herein are methods of preparation of the rigid macrocycles and use thereof, for example, in the first of energy generation and storage.
    Type: Grant
    Filed: March 16, 2017
    Date of Patent: October 26, 2021
    Assignees: Northwestern University, KING ABDULAZIZ CITY FOR SCIENCE AND TECHNOLOGY (KACST)
    Inventors: James Fraser Stoddart, Siva Krishna Mohan Nalluri, Zhichang Liu
  • Nebivolol synthesis method and intermediate compound thereof
    Patent number: 11142512
    Abstract: The present invention relates to nebivolol synthesis method and intermediate compound thereof. Specifically, the present invention relates to a method for synthesizing nebivolol, intermediate compound thereof, and a method for preparing the intermediate compound.
    Type: Grant
    Filed: December 3, 2019
    Date of Patent: October 12, 2021
    Assignee: ZHEJIANG AUSUN PHARMACEUTICAL CO., LTD.
    Inventor: Zhiguo Zheng
  • Oxygen linked pyrimidine derivatives
    Patent number: 11135227
    Abstract: The present invention relates to pyrimidine compounds that are useful as anti-proliferative agents. More particularly, the present invention relates to oxygen linked and substituted pyrimidine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumours and cancers as well as other disorders or conditions related to or associated with kinases.
    Type: Grant
    Filed: November 7, 2019
    Date of Patent: October 5, 2021
    Assignee: CTI BIOPHARMA CORP.
    Inventors: Stephanie Blanchard, Cheng Hsia Angelina Lee, Harish Kumar Mysore Nagaraj, Anders Poulsen, Eric T. Sun, Yee Ling Evelyn Tan, Anthony Deodaunia William
  • Maytansinoid derivatives with self-immolative peptide linkers and conjugates thereof
    Patent number: 11135308
    Abstract: The invention relates to novel cell-binding agent-maytansinoid conjugate having a self-immolative peptide linker and more specifically to conjugates of formula (I). The invention also provides novel maytansinoid compounds of formula (II), (III), (IV) or (V). The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
    Type: Grant
    Filed: November 22, 2019
    Date of Patent: October 5, 2021
    Assignee: IMMUNOGEN, INC.
    Inventor: Wayne C. Widdison
  • Macrocycles as factor XIA inhibitors
    Patent number: 11136327
    Abstract: The present invention provides compounds of Formula (I): or a stereoisomer, a tautomer, or a pharmaceutically acceptable salt thereof, wherein all the variables are as defined herein. These compounds are selective Factor XIa inhibitors or dual inhibitors of fXIa and plasma kallikrein. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: October 5, 2021
    Assignee: Bristol-Myers Squibb Company
    Inventors: James R. Corte, Tianan Fang, Carl P. Decicco, Donald J. P. Pinto, Karen A. Rossi, Zilun Hu, Yoon Jeon, Mimi L. Quan, Joanne M. Smallheer, Yufeng Wang, Wu Yang
  • Process for the manufacture of vortioxetine HBr alpha-form
    Patent number: 11124491
    Abstract: A process for the manufacture of vortioxetine HBr ?-form is provided.
    Type: Grant
    Filed: April 20, 2018
    Date of Patent: September 21, 2021
    Assignee: H. Lundbeck A/S
    Inventor: Hans Petersen
  • Methylene carbamate linkers for use with targeted-drug conjugates
    Patent number: 11116847
    Abstract: The present invention provides Ligand-Drug Conjugates and Drug-Linker Compounds comprising a methylene carbamate unit. The invention provides inter alia, Ligand-Drug Conjugates, wherein the Ligand-Drug Conjugate is comprised of a Self-immolative Assembly Unit having a methylene carbamate unit for conjugation of a drug to a targeting ligand, methods of preparing and using them, and intermediates thereof. The Ligand-Drug Conjugates of the present invention are stable in circulation, yet capable of inflicting cell death once free drug is released from a Conjugate in the vicinity or within tumor cells.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: September 14, 2021
    Assignee: Seagen Inc.
    Inventors: Robert Kolakowski, Scott Jeffrey, Patrick Burke
  • Pyrrolo-pyridine derivative compound, method for preparing same, and pharmaceutical composition containing same as active ingredient for prevention or treatment of protein kinase-related diseases
    Patent number: 11117892
    Abstract: The present invention relates to a pyrrolo-pyridine derivative compound, a method for preparing the same, and a pharmaceutical composition containing the same as an active ingredient for the prevention or treatment of protein kinase-related diseases. A compound represented by chemical formula 1, an optical isomer thereof, or a pharmaceutically acceptable salt thereof, according to the present invention, has excellent inhibitory activity against various protein kinases including DYRK1A, and therefore, the pharmaceutical composition containing the same as an active ingredient can be favorably used in the treatment or prevention of protein kinase-related diseases. Particularly, the pharmaceutical composition can be effectively used in the prevention, treatment, or alleviation of Alzheimer's disease, dementia, or Alzheimer's dementia.
    Type: Grant
    Filed: March 23, 2018
    Date of Patent: September 14, 2021
    Inventors: Hwan Geun Choi, Eunhwa Ko, Joong-heui Cho, Jung Beom Son, Yi Kyung Ko, Jin-Hee Park, So Young Kim, Seock Yong Kang, Seungyeon Lee, Hee Yoon Ryu, Nam Doo Kim, Sang Bum Kim, Sun-Hwa Lee, Dayea Kim, Sun Joo Lee, Sungchan Cho, Kyu-Sun Lee, Kweon Yu, Miri Choi, Ja Wook Koo, Hyang-Sook Hoe
  • Spiroacridine derivatives
    Patent number: 11114617
    Abstract: Provided is a composition comprising a compound having structure (I) wherein each of A1, A2, A3, A4, A5, A6, A7, and A8 is independently CR12 or N; wherein one to four of A1, A2, A3, A4, A5, A6, A7, and A8 are N; wherein J1 is C or Si; wherein J2 is C(R13)n, O, (C(R13)n)2, S, NR13, or Se; wherein n is 1 or 2; wherein each of R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12, and R13 is independently H, deuterium, or an organic group. Also provided is a method of making the composition, a method of making an organic light-emitting diode using the composition, and an organic light-emitting diode made by that method.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: September 7, 2021
    Assignees: Rohm and Haas Electronic Materials LLC, Dow Global Technologies LLC
    Inventors: Laura Havens, Sukrit Mukhopadhyay, David S. Laitar, David D. Devore, Aaron A. Rachford, Erich J. Molitor
  • (+)-3-(2,3-difluorophenyl)-3-methoxypyrrolidine or pharmaceutically acceptable salts thereof, a process for preparation thereof and uses thereof
    Patent number: 11078158
    Abstract: The disclosure provides a process for manufacturing thereof a salt of Formula IIb:
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: August 3, 2021
    Assignee: INTEGRATIVE RESEARCH LABORATORIES SWEDEN AB
    Inventors: Clas Sonesson, Maija Buksa, Inese Reine
  • Compound and thin film transistor and electronic device
    Patent number: 11066418
    Abstract: Disclosed are a compound represented by Chemical Formula 1A or 1B, an organic thin film, a thin film transistor, and an electronic device. In Chemical Formulae 1A and 1B, X1, Ar1, R1 to R4, and n1 are the same as described in the detailed description.
    Type: Grant
    Filed: November 25, 2019
    Date of Patent: July 20, 2021
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Don-Wook Lee, Jeong Il Park, Eun Kyung Lee
  • Substituted methanopyrido [2, 1-a] isoindolones as mAChR modulators for treating various associated pathophysiological conditions and process for preparation thereof
    Patent number: 11065235
    Abstract: The present invention relates to substituted methanopyrido [2,1-a]isoindolones of formula I, wherein, R1 is selected from phenylsulfonyl or p-toluenesulfonyl; and n=1, 2, 3; their derivatives, stereoisomers, pharmaceutically acceptable salts and pharmaceutically acceptable compositions having potential muscarinic acetylcholine receptor modulator activity.
    Type: Grant
    Filed: May 18, 2018
    Date of Patent: July 20, 2021
    Assignees: Council of Scientific & Industrial Research, Centre for Biomedical Research
    Inventors: Ganesh Pandey, Rajesh Varkhedkar, Divya Tiwari, Prem Narayan Yadav, Shalini Dogra, Yusuf Hussain
  • Solid form of azetidine derivative and preparation method therefor and use thereof
    Patent number: 11066403
    Abstract: The present invention relates to a solid form of a compound of Formula (I), a method for preparing the solid form, a pharmaceutical composition comprising the solid form, and use of the solid form in the treatment of Janus kinase (JAK) related diseases comprising, for example, inflammatory diseases, autoimmune diseases, and cancers.
    Type: Grant
    Filed: May 28, 2018
    Date of Patent: July 20, 2021
    Assignee: SICHUAN KELUN-BIOTECH BIOPHARMACEUTICAL CO., LTD.
    Inventors: Jianhua Ge, Zengying Han, Fengchun Chen, Shihu Jiao, Hong Zhang, Ping Zhang, Lichun Wang, Jingyi Wang
  • Condensed heterocyclic compound or salt thereof, agricultural and horticultural insecticide comprising the compound or the salt, and method for using the insecticide
    Patent number: 11064699
    Abstract: In crop production in the fields of agriculture, horticulture and the like, the damage caused by insect pests etc. is still immense, and insect pests resistant to existing insecticides have emerged. The present invention has been made in view of such circumstances, and an object of the present invention is to develop and provide a novel agricultural and horticultural insecticide. The present invention provides a condensed heterocyclic compound represented by the general formula (1): {wherein Q represents a ring group represented by any of Q-1, Q-2, and Q-3, R5 and R8 each represent a hydrogen atom, R6 and R7 each represent a hydrogen atom, a halogen atom or a (C1-C6) haloalkyl group, and m represents 2}, or a salt thereof.
    Type: Grant
    Filed: April 26, 2018
    Date of Patent: July 20, 2021
    Assignee: Nihon Nohyaku Co., Ltd.
    Inventors: Akihiro Miyasaka, Ikki Yonemura, Akiyuki Suwa, Shunpei Fujie, Ryosuke Tanaka
  • PAK1 inhibitors and uses thereof
    Patent number: 11065251
    Abstract: Methods are disclosed for treating acute myeloid leukemia (AML) and myelodysplastic syndromes (MDS) using compounds that inhibit p21 protein (Cdc42/Rac)-activated kinase (PAK1).
    Type: Grant
    Filed: April 3, 2017
    Date of Patent: July 20, 2021
    Assignee: ALBERT EINSTEIN COLLEGE OF MEDICINE
    Inventors: Ulrich Steidl, Ashley M. Eckel, Robert F. Stanley, Boris Rogovoy, Ilya Okun
  • Organic thin film and organic thin film transistor and electronic device
    Patent number: 11069863
    Abstract: Disclosed are an organic thin film includes a first compound represented by one of Chemical Formula 1A and 1B and a second compound different from the first compound and represented by one of Chemical Formulae 2A and 2B, an organic thin film transistor, and an electronic device.
    Type: Grant
    Filed: October 23, 2019
    Date of Patent: July 20, 2021
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Yasutaka Kuzumoto, Jeong Il Park, Hyun Bum Kang, Eun Kyung Lee, Don-Wook Lee
  • Riluzole prodrugs and their use
    Patent number: 11052070
    Abstract: Pharmaceutical compositions of the invention include substituted riluzole prodrugs useful for the treatment of cancers including melanoma, breast cancer, brain cancer, and prostate cancer through the release of riluzole. Prodrugs of riluzole have enhanced stability to hepatic metabolism and are delivered into systemic circulation by oral administration, and then cleaved to release riluzole in the plasma via either an enzymatic or general biophysical release process.
    Type: Grant
    Filed: November 20, 2019
    Date of Patent: July 6, 2021
    Assignee: Biohaven Therapeutics Ltd.
    Inventors: Jay Edward Wrobel, Allen B. Reitz, Jeffery Claude Pelletier, Garry Robert Smith, Haiyan Bian
  • Methods for the site-selective coupling of a first agent to a second agent
    Patent number: 11053279
    Abstract: The present invention relates to a method for site-selective coupling of a first agent to a second agent, comprising the steps of: contacting a first agent comprising at least one furan moiety with an activation signal and with a second agent comprising at least one hydrazine moiety or at least one hydroxylamine moiety, thereby activating said furan moiety to an activated furan moiety; and reacting said activated furan moiety with the hydrazine moiety or the hydroxylamine moiety, thereby site-selectively coupling said first agent to said second agent.
    Type: Grant
    Filed: June 16, 2016
    Date of Patent: July 6, 2021
    Assignee: UNIVERSITEIT GENT
    Inventors: Annemieke Madder, Eirini Antonatou, Kurt Hoogewijs
  • Piperazine derivatives for influenza virus inhibitions
    Patent number: 11040963
    Abstract: The present invention provides piperazine derivatives exhibiting high affinity to the stem region (viral membrane proximal part) of influenza hemagglutinin as determined through competition binding and high virus neutralization activity while having low cytotoxity. Furthermore, the present invention relates to pharmaceutical compositions comprising said piperazine derivatives, methods of preparing said piperazine derivatives, as well as said piperazine derivatives for use in medical prevention or treatment, especially for preventing or treating influenza.
    Type: Grant
    Filed: February 1, 2018
    Date of Patent: June 22, 2021
    Assignee: JANSSEN VACCINES & PREVENTION B.V.
    Inventors: Maria Van Dongen, Jaroslaw Juraszek, Griet Wim Bert Schepens, Charles Edward Lawson, Brian Shook, Maria Tim Hugo Jonckers, Abdellah Tahri, Bernard Pierre Jean-Marie Raboisson, Nestor CHristophe Francis Robert Buyck
  • Compound and organic thin film and thin film transistor and electronic device
    Patent number: 11038116
    Abstract: Disclosed are a compound represented by Chemical Formula 1A or 1B, an organic thin film including the same, a thin film transistor, and an electronic device. In Chemical Formula 1A or 1B, X1, X2, Ar1, R1 to R4, and n1 are the same as described in the detailed description.
    Type: Grant
    Filed: August 5, 2019
    Date of Patent: June 15, 2021
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Eunkyung Lee, Don-Wook Lee, Jeong Il Park