Patents Examined by Norma S. Milestone
  • Intermediates for oxabicycloalkane herbicides
    Patent number: 4567283
    Abstract: Compounds of the formula ##STR1## wherein X is (--CR.sub.4 R.sub.4 --).sub.m in which m is 0 or 1;Y is (--CR.sub.5 R.sub.6 --).sub.n in which n is 0, 1 or 2;Z is (--CR.sub.7 R.sub.7 --).sub.p in which p is 1, 2 or 3;the sum of m+n+p is an integer of 2 to 5, inclusive;R.sub.2 and R.sub.3 each is H or alkyl, and the like;R.sub.1 is H or alkyl; andW is an unsaturated moiety, are useful as plant growth regulators and herbicides.
    Type: Grant
    Filed: June 25, 1984
    Date of Patent: January 28, 1986
    Assignee: Shell Oil Company
    Inventors: George B. Payne, Samuel B. Soloway, James E. Powell, Steven A. Roman, Willy D. Kollmeyer
  • Product separation from electrolyte salts maintained in molten state
    Patent number: 4564689
    Abstract: In processes for reacting acetic acid with butadiene in solvent to prepare acetoxyhexenoic acid and .gamma.-vinyl-.gamma.-butyrolactone, involving electrolytic regeneration of a metal ion oxidant such as trivalent manganese, the product separation is facilitated by using low melting electrolyte salts and separating product from salts maintained in a molten state.
    Type: Grant
    Filed: June 13, 1983
    Date of Patent: January 14, 1986
    Assignee: Monsanto Company
    Inventors: James P. Coleman, Dudley E. McMackins
  • Process for the preparation and isolation of polyglycidyl compounds
    Patent number: 4562274
    Abstract: Polyglycidyl compounds are prepared by reacting certain polyallyl compounds with a percarboxylic acid containing 3 or 4 C atoms, subsequently removing, by distillation, the carboxylic acid formed from the percarboxylic acid, then separating the remaining mixture by simultaneous extraction with a lipophilic and a hydrophilic phase, subsequently working up the laden lipophilic phase and the laden hydrophilic phase separately in a manner which is known per se, and obtaining the polyglycidyl compound as the residue from working up of the laden hydrophilic phase.
    Type: Grant
    Filed: December 12, 1983
    Date of Patent: December 31, 1985
    Assignee: Bayer Aktiengesellschaft
    Inventors: Gebhard Rauleder, Helmut Waldmann, Ludwig Bottenbruch, Hans-Joachim Traenckner, Wolfgang Gau
  • Process for preparing cyclic polyethers
    Patent number: 4562272
    Abstract: The invention relates to a process for preparing cyclic polyethers from cyclic alkylene carbonates in the presence of a solvent, wherein the process is carried out in the presence of a solvent selected from the group containing a carbonyl moiety, nitrile moiety or mixture thereof. In addition, ionic catalysts may be employed to increase the selectivity to cyclic polyether.
    Type: Grant
    Filed: March 27, 1981
    Date of Patent: December 31, 1985
    Assignee: Union Carbide Corporation
    Inventors: Arnold M. Harrison, Leonard Kaplan
  • Preparation and polymerization of oxether-1
    Patent number: 4560779
    Abstract: The present invention provides a method for synthesizing a novel oxether-1 monomer by a two step reaction scheme which involves effecting a reaction between 3-methyl-3-hydroxymethyl oxetane and 1,1,1-trinitroethane to form an intermediate reaction product which in turn is reacted with methyl iodide to produce the oxether-1 monomer. The monomer is easily polymerized using conventional polymerization techniques to produce a poly(oxether-1) polyol useful as a binder component in smokeless propellants and explosives.
    Type: Grant
    Filed: July 20, 1982
    Date of Patent: December 24, 1985
    Assignee: The United States of America as represented by the Secretary of the Air Force
    Inventors: John M. Guimont, Gerald E. Manser, Donald L. Ross
  • Production of lactone in molten salt electrolysis
    Patent number: 4560775
    Abstract: Butadiene and acetic acid are reacted with a metal salt oxidant in molten salt medium to form .gamma.-vinyl-.gamma.-butyrolactone. The process includes electrolytic regeneration of the oxidant and provides a simple reaction system which permits product recovery and reactant recycle without extensive solvent handling. A high surface area reactor can be employed.
    Type: Grant
    Filed: June 13, 1983
    Date of Patent: December 24, 1985
    Assignee: Monsanto Company
    Inventors: James P. Coleman, Richard C. Hallcher, Dudley E. McMackins, Charles R. Penquite, Steven R. Auvil
  • Process for the preparation of a lactam
    Patent number: 4560760
    Abstract: Disclosed is a process for preparing a lactam which consists essentially in the reductive amination in the gas phase of an oxoalkane carboxylic acid having the formula ##STR1## or an alkyl ester thereof, wherein R is an alkyl group having from 1 to 4 carbon atoms and n varies from 2 to 3, and wherein the reaction is carried out:A. in an atmosphere of hydrogen, andB. in the presence of a gas phase reactant selected from the group consisting of gaseous ammonia and a vaporized primary amine, andC. in the presence of a hydrogenation catalyst promoted with an alkali metal.The alkali metal particularly preferred as a promoter is sodium.
    Type: Grant
    Filed: August 31, 1984
    Date of Patent: December 24, 1985
    Assignee: Stamicarbon B.V.
    Inventors: Roland E. van der Stoel, Marcel A. R. Bosma, Petrus H. J. Janssen, Cornelis G. M. van de Moesdijk
  • Process for the preparation of aminolactone carboxylic acid
    Patent number: 4559406
    Abstract: The invention relates to a process for the preparation of the compound of the formula I, ##STR1## which comprises (a.sub.1) splitting off the ethylene ketal protecting group from the azetidinone derivative of the formula IVa, ##STR2## reducing the compound of the formula III thus obtained, ##STR3## treating the resulting compound of the formula II ##STR4## with concentrated aqueous hydrogen chloride solution; or (a.sub.2) reducing the compound of the formula III, treating the compound of the formula II thus obtained with concentrated aqueous hydrogen chloride solution; or (a.sub.3) treating the compound of the formula II with concentrated aqueous hydrogen chloride solution; and isolating the compound of the formula I thus obtained from the reaction mixture. The compound of the formula I is useful as an intermediate in the production of thienamycin, a highly potent antibiotic.
    Type: Grant
    Filed: June 27, 1983
    Date of Patent: December 17, 1985
    Assignee: Richter Gedeon Vegyeszeti Gyav R.T.
    Inventors: Karoly Lempert, Gabor Doleschall, Jozsef Fetter, Gyula Hornyak, Jozsef Nyitrai, Gyula Simig, Karoly Zauer
  • Intermediate in the production of vitamin E
    Patent number: 4559407
    Abstract: There is described a novel process for the manufacture of hydroquinone derivatives of the formula ##STR1## wherein R represents an ether protecting group, and their conversion into d-.alpha.-tocopherol starting from compounds of the formula ##STR2## wherein R has the above significance.
    Type: Grant
    Filed: October 11, 1983
    Date of Patent: December 17, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Richard Barner, Josef Hubscher
  • 8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(sulfinyl- and sulfonyl-containing acyl)hydrazides
    Patent number: 4559336
    Abstract: This invention relates to 8-chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(sulfinyl- and sulfonyl-containing acyl)hydrazides that are useful as prostaglandin antagonists and analgesic agents.
    Type: Grant
    Filed: February 25, 1985
    Date of Patent: December 17, 1985
    Assignee: G.D. Searle & Co.
    Inventor: Richard A. Mueller
  • 8-Chlorodibenz[b,f][1,4]oxazepine-10(11H)-carboxylic acid, 2-(alkoxy-containing acyl)hydrazides
    Patent number: 4559337
    Abstract: This invention relates to 8-chlorodibenz[b,f][1,4]-oxazepine-10(11H)-carboxylic acid, 2-(alkoxy-containing acyl)hydrazides that are useful as prostaglandin antagonists and analgesic agents.
    Type: Grant
    Filed: February 25, 1985
    Date of Patent: December 17, 1985
    Assignee: G.D. Searle & Co.
    Inventor: Richard A. Mueller
  • Pyridine derivatives
    Patent number: 4556661
    Abstract: Novel pyridine and pyrazine derivatives of the formula ##STR1## wherein R.sup.4 is 3-pyridyl, 3-pyridyl-1-oxide, 2-pyrazinyl, 2-pyrazinyl-1-oxide, 2-pyrazinyl-4-oxide or 2-pyrazinyl-1,4-dioxide, and R, R.sup.1, R.sup.2 and R.sup.3 are as hereinafter set forth, processes for their preparation, fungicidal compositions containing said compounds, and methods for the use of such compounds or compositions for combatting fungi in agriculture and in horticulture are disclosed. Novel starting materials and fungicidal active substances of the formula ##STR2## wherein R.sup.4' is 3-pyridyl or 2-pyrazinyl, and R and R.sup.1" as hereinafter set forth, which are used for the preparation of the compounds of formula I, and their N-oxides, as well as fungicidal compositions containing these compounds as the active substance, are also described.
    Type: Grant
    Filed: August 27, 1982
    Date of Patent: December 3, 1985
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Franz Dorn, Francois Montavon, Milos Suchy
  • 4-Chloro-4-methyl-5-methylene-1,3-dioxolane-2-one
    Patent number: 4554358
    Abstract: 4-Chloro-4-methyl-5-methylene-1,3-dioxolane-2-one is useful as an intermediate for the synthesis of 4-chloromethyl-5-methyl-1,3-dioxolene-2-one which, in turn, finds use as a modifying agent for making various prodrugs.Said intermediate compound gives said objective compound in a good yield by a rearrangement reaction.
    Type: Grant
    Filed: November 16, 1984
    Date of Patent: November 19, 1985
    Assignee: Kanebo, Ltd.
    Inventors: Yasushi Takebe, Koji Iuchi, Goro Tsukamoto
  • Piperidine derivatives and pharmaceutical compositions containing them
    Patent number: 4551465
    Abstract: The invention relates to new piperidine derivatives of the formula (I) ##STR1## wherein R.sub.1 is halogen, trihalomethyl, alkyl having from one to 4 carbon atoms or alkoxy having from one to 4 carbon atoms; andR.sub.2 is hydrogen or alkyl having from one to 4 carbon atoms, and acid addition and quaternary ammonium salts thereof. According to another aspect of the invention there are provided processes for the preparation of these compounds. The compounds of the formula (I) are pharmacologically active. In particular, they inhibit the microsomal monooxigenase enzyme system of the liver. Pharmaceutical compositions containing them as active ingredient are also within the scope of the invention.
    Type: Grant
    Filed: December 27, 1983
    Date of Patent: November 5, 1985
    Assignee: Richter Gedeon Vegyeszeti Gyar Rt.
    Inventors: Edit Toth, Jozsef Torley, Eva Palosi, Szabolcs Szeberenyi, Laszlo Szporny, Sandor Gorog, Istvan Hajdu
  • Method for making siloxanenorbornane bisanhydride
    Patent number: 4542226
    Abstract: A method is provided for making siloxanenorbornane bisanhydride. Norbornane anhydride is initially hydrosilylated with dimethylchlorosilane in the presence of a platinum catalyst. The resulting dimethylchlorosilyl norbornane anhydride is thereafter hydrolyzed while in the molten state.
    Type: Grant
    Filed: July 16, 1984
    Date of Patent: September 17, 1985
    Assignee: General Electric Company
    Inventors: Victoria J. Eddy, John E. Hallgren
  • Antibiotic compound
    Patent number: 4542154
    Abstract: A novel antibiotic compound 3-(6-isocyano-3,7-dioxatricyclo[4.1.0.0.sup.2,4 ]hept-4-yl)propenoic acid is produced by a newly isolated microorganism belonging to the genus Penicillium.
    Type: Grant
    Filed: July 8, 1983
    Date of Patent: September 17, 1985
    Assignee: Kureha Kagaku Kogyo Kabushiki Kaisha
    Inventors: Katsuhisa Ohsugi, Junji Ichida, Eisaku Takahashi
  • Process for preparing inhibitors of 3-hydroxy-3-methylglutaryl coenzyme a reductase via a chiral synthon
    Patent number: 4540796
    Abstract: Totally synthetic analogs of the known inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase, compactin and mevinolin, are prepared from a chiral synthon derived from D-glucose which has the same chirality as the natural products.
    Type: Grant
    Filed: January 6, 1984
    Date of Patent: September 10, 1985
    Assignee: Merck & Co., Inc.
    Inventor: John D. Prugh
  • Epoxy resin and process for preparing the same
    Patent number: 4540802
    Abstract: An epoxy resin of the general formula: ##STR1## wherein X.sub.1 and X.sub.2 are --OH or ##STR2## and X.sub.3 is --OH, ##STR3## or a group of the general formula: ##STR4## in which X.sub.4, X.sub.5 and X.sub.6 are --OH or ##STR5## provided that at least one of X.sub.1 to X.sub.6 is ##STR6## The epoxy resin is prepared by reacting gallic acid or tannic acid with an epihalohydrin in the presence of a phase transfer catalyst and reacting the obtained reaction mixture with an aqueous alkali solution.
    Type: Grant
    Filed: May 3, 1983
    Date of Patent: September 10, 1985
    Assignee: Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
    Inventors: Haruo Tomita, Kazuya Yonezawa
  • .beta.-Lactone process
    Patent number: 4533740
    Abstract: This invention relates to a process for converting an olefin to a .beta.-lactone using a palladium catalyst.
    Type: Grant
    Filed: May 14, 1984
    Date of Patent: August 6, 1985
    Assignee: Shell Oil Company
    Inventors: P. K. Wong, Mark K. Dickson
  • Crown ether compounds, process for the preparation of the crown ether complex forming agents and ion-selective membrane electrodes containing the same
    Patent number: 4531007
    Abstract: New crown ether derivatives of formula (I) ##STR1## wherein R stands for hydrogen or C.sub.1-4 alkyln stands for 1,2,X stands for oxygen, sulphur or a NH-groupY represents hydrogen or nitroZ represents a chemical bond, --CH.sub.2 --, --(CH.sub.2).sub.2-4 --, --CH.sub.2 OCH.sub.2 --, --CH.sub.2 SCH.sub.2 --, ##STR2## or a group of the formula ##STR3## suitable for forming cation complexes, process for the preparation thereof and alkali or alkali earth metal ion-selective membrane electrodes containing said compounds are described.
    Type: Grant
    Filed: March 7, 1983
    Date of Patent: July 23, 1985
    Assignee: Magyar Tudomanyos Akademia
    Inventors: Laszlo Toke, Bela gai, Istvan Bitter, Erno Pungor, Klara Szepesvary nee Toth, Erno Lindner, Maria Horvath, Jeno Havas