Patents Examined by Norman A. Drezin
  • Patent number: 4083952
    Abstract: Substituted aurones useful as inhibitors of certain antigen-antibody reactions, particularly in alleviating allergic manifestations such as asthma, are prepared by reaction of a 3-coumaranone with an appropriately substituted benzaldehyde followed by treatment with aqueous mineral acid and an alkanol.
    Type: Grant
    Filed: May 17, 1976
    Date of Patent: April 11, 1978
    Assignee: SmithKline Corporation
    Inventors: Kenneth M. Snader, Chester R. Willis
  • Patent number: 4069224
    Abstract: A method of improving the endogenous production of prostaglandins by a mammal is disclosed, which comprises administering to the mammal an effective amount of an N-(pyridylalkyl)benzamides. Disclosed also are novel N-(pyridylalkyl)benzamides and therapeutic compositions thereof which are useful in carrying out the method of the invention.Disclosed also are methods of treating mammals for clinical conditions responsive to prostaglandins, such as for example, male infertility, epidermal injuries, atonic uterine bleeding, thromboembolic disease and like clinical conditions.
    Type: Grant
    Filed: June 25, 1975
    Date of Patent: January 17, 1978
    Assignee: The Upjohn Company
    Inventors: William A. Callahan, Eldridge Myles Glenn, Douglas L. Rector
  • Patent number: 4069345
    Abstract: Alkyl-substituted methanols are disclosed having the property of stimulating the cold receptors of the nervous system of the human body to produce a cold sensation and are used for this purpose in a variety of edible and topical preparations.
    Type: Grant
    Filed: August 16, 1974
    Date of Patent: January 17, 1978
    Assignee: Wilkinson Sword Limited
    Inventors: John M. Gascoyne, Roger Hems, David J. Spring
  • Patent number: 4057621
    Abstract: A composition and method of treatment for desensitizing hypersensitive dentin and cementum capable of effective results specially in one-treatment application. The essential ingredient or compound of the desensitizing composition is an alkali metal or ammonium oxalate where this salt may be mono- or di-substituted. The hydrogen or mono-substituted salts are preferred due to their lower pH which renders them more efficient in the protocol of this invention. These oxalates may be used effectively in the range 0.5% by weight to aqueous solution saturation. However, a range of 2.0% to solution saturation is much preferred due to the practice of the invention as a single-treatment agent. Furthermore, saturated solutions of the oxalates are most preferred also due to greater efficiency. The compositions may be used in aqueous solutions and as non-toxic paste with conventional fillers and excipients. In the paste form, the oxalate is preferred in a weight percent basis of 2-18%.
    Type: Grant
    Filed: May 24, 1976
    Date of Patent: November 8, 1977
    Inventors: David H. Pashley, William C. Outhwaite
  • Patent number: 4055659
    Abstract: Esters and amides of all-trans-retinoic acid are disclosed which are useful for the treatment of acne.
    Type: Grant
    Filed: November 3, 1975
    Date of Patent: October 25, 1977
    Assignee: Johnson & Johnson
    Inventors: Robert J. Gander, John A. Gurney
  • Patent number: 4055654
    Abstract: There are described certain mono-chromone-2-carboxylic acids of formula, ##STR1## having one substituent in the 5 or 6 position or having 2 or more substituents in the 5,6,7 or 8 positions. There are also described processes for making the compounds and pharmaceutical compositions, for the treatment of asthma, containing the compounds.
    Type: Grant
    Filed: January 2, 1976
    Date of Patent: October 25, 1977
    Assignee: Fisons Limited
    Inventors: Hugh Cairns, Albert Chambers, Thomas Brian Lee
  • Patent number: 4055649
    Abstract: Compounds of the formula ##STR1## wherein R is secondary alkyl of 3 to 7 carbon atoms or tertiary alkyl of 4 to 7 carbon atoms,R' is secondary alkyl of 3 to 7 carbon atoms or tertiary alkyl of 4 to 7 carbon atoms,R.sub.1 is primary or secondary alkyl of 1 to 5 carbon atoms, andR.sub.2 is hydrogen, chloro or bromo,And the pharmaceutically acceptable acid addition salts thereof, are useful as anti-obesity and anti-diabetic agents. The compounds wherein R and R' are tertiary alkyl of 4 to 7 carbon atoms and R.sub.2 is hydrogen are synthesized from ketenimines and amidines, all of the compounds wherein R.sub.2 is hydrogen are synthesized by reduction of the corresponding 3-cyanopyridines, and the compounds wherein R.sub.2 is chloro or bromo are synthesized from the corresponding compounds wherein R.sub.2 is hydrogen and an N-halosuccinimide.
    Type: Grant
    Filed: February 5, 1976
    Date of Patent: October 25, 1977
    Assignee: Sandoz, Inc.
    Inventors: William R. Simpson, Robert J. Strohschein
  • Patent number: 4054657
    Abstract: Anti-allergic agents of aromatic and heterocyclic oxamic acid derivation present the following formula: ##STR1## in which A is a member selected from the group consisting of 2-thiazolyl, 2-pyridyl, 2-pyridyl-N-oxide, 6-(lower)alkyl-2-pyridyl, 3-cyano-2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidinyl, 2-pyrazinyl, .alpha.-naphthyl, .beta.
    Type: Grant
    Filed: March 23, 1976
    Date of Patent: October 18, 1977
    Assignee: American Home Products Corporation
    Inventors: John H. Sellstedt, Charles J. Guinosso, Albert J. Begany
  • Patent number: 4054661
    Abstract: Anti-allergic agents of aromatic and heterocyclic oxamic acid derivation present the following formula: ##STR1## in which A is a member selected from the group consisting of 2-thiazolyl, 2-pyridyl, 2-pyridyl-N-oxide, 6-(lower)alkyl-2-pyridyl, 3-cyano-2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidinyl, 2-pyrazinyl, .alpha.-naphthyl, .beta.
    Type: Grant
    Filed: March 23, 1976
    Date of Patent: October 18, 1977
    Assignee: American Home Products Corporation
    Inventors: John H. Sellstedt, Charles J. Guinosso, Albert J. Begany
  • Patent number: 4054666
    Abstract: Anti-allergic agents of aromatic and heterocyclic oxamic acid derivation present the following formula: ##STR1## in which A is a member selected from the group consisting of 2-thiazolyl, 2-pyridyl, 2-pyridyl-N-oxide, 6-(lower)alkyl-2-pyridyl, 3-cyano-2-pyridyl, 3-pyridyl, 4-pyridyl, 2-pyrimidinyl, 2-pyrazinyl, .alpha.-naphthyl, .beta.
    Type: Grant
    Filed: March 23, 1976
    Date of Patent: October 18, 1977
    Assignee: American Home Products Corporation
    Inventors: John H. Sellstedt, Charles J. Guinosso, Albert J. Begany
  • Patent number: 4054656
    Abstract: 2-Aminothiophene-3-carboxamides are converted to oxamates or fumaramides by acylation of the amino group. Cyclization yields thieno[2,3-d]pyrimidines which may also be prepared from the corresponding oxazines. Compounds illustrative of those having inhibitory action on the immediate hypersensitivity reaction in mammmals are N-[3(aminocarbonyl)-4,5,6,7-tetrahydrobenzo[b]thien-2-yl]oxamic acid, ethyl 5,6,7,8-tetrahydro-4oxo-4H-benzothieno[2,3-d][1,3]oxazine-2-carboxyl ate, and ethyl 3,4-dihydro-6-ethyl-4-oxothieno[2,3-d]pyrimidine-2-carboxylate.
    Type: Grant
    Filed: September 10, 1975
    Date of Patent: October 18, 1977
    Assignee: Mead Johnson & Company
    Inventor: Davis L. Temple, Jr.
  • Patent number: 4053630
    Abstract: A treatment to prevent the symptoms of skin conditions characterized by an offensive odor of the body, and a treatment to alleviate the symptoms of diseases characterized by defects of keratinization consisting of the topical application of a solution, lotion, cream, ointment, powder, stick or spray containing cysteic acid, cysteinesulfinic acid, homocysteic acid or their metal chelates are disclosed. The metal chelates include molecular complexes of cysteic acid or its analogue and metal ions such as ferric, cupric, zinc and aluminum ions. The efficacious compositions may include the active ingredients present in a total amount of from 1 to 30 percent, and preferably from 2 to 10 percent by weight. In a prophylactic treatment topical application to skin areas of axilla, crotch (inguinalperineum) and feet has been found to prevent the formation of malodor.
    Type: Grant
    Filed: July 7, 1976
    Date of Patent: October 11, 1977
    Inventors: Ruey J. Yu, Eugene J. Van Scott
  • Patent number: 4052390
    Abstract: 8-Azapurin-6-ones substituted in the 2-position by a phenyl group carrying in a meta-position a sulphamoyl substituent, and also a hydroxy, alkoxy or alkylthio substituent para with respect to the said sulphamoyl grouping, and pharmaceutically acceptable salts thereof, possess pharmacological properties useful in the treatment of allergic respiratory disorders, for example allergic bronchial asthma.
    Type: Grant
    Filed: May 6, 1975
    Date of Patent: October 4, 1977
    Assignee: May & Baker Limited
    Inventors: Barbara Joyce Broughton, Bryan John Large, Stuart Malcolm Marshall, David Lord Pain, Kenneth Robert Harry Wooldridge
  • Patent number: 4052509
    Abstract: Novel pharmaceutical compositions containing as the active ingredient the compound 5-methyl-1-phenyl-2-(1H)-pyridone are described. Such compositions have been found to have a metabolic property which causes significant lowering of serum uric acid levels in humans and other mammals. The compositions containing 5-methyl-1-phenyl-2-(1H)-pyridone caused no irritation on oral administration or when applied to specific target tissues showed no significant irritation or other sequelae.
    Type: Grant
    Filed: May 14, 1976
    Date of Patent: October 4, 1977
    Assignee: Affiliated Medical Research, Inc.
    Inventor: Shreekrishna M. Gadekar
  • Patent number: 4049812
    Abstract: There is disclosed a novel heterocyclic compound of the general formula: ##STR1## wherein each of R.sup.1 and R.sup.2 represents hydrogen atom, or an alkyl group which may be substituted by alkyl-substituted amino, hydroxy or alkoxy group, or R.sup.1 and R.sup.2 may form a heterocyclic ring together with the nitrogen atom adjacent thereto; R.sup.3 represents hydrogen atom or a lower alkyl group; P.sub.y represents a pyridyl group; B represents a lower alkylene group which may have lower alkyl group as a substituent; Y represents oxygen atom, sulfur atom or --NH-- group; and ring A is either unsubstituted or substituted by halogen atom, nitro, lower alkyl, lower alkoxy or polyhalo-lower alkyl group. This class of compounds is found to be useful as medicine in human and animal therapy, which act on the central nervous system, for example, muscle relaxants, anticonvulsants, sedatives, minor tranquilizers. There is also disclosed intermediates for the production of said compound.
    Type: Grant
    Filed: April 30, 1975
    Date of Patent: September 20, 1977
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Yutaka Kuwada, Hideaki Natsugari, Kanji Meguro
  • Patent number: 4049666
    Abstract: Tricyclic benzodiazepine derivatives (A) bearing a hydroxylower alkyl substituent in the 1-position and a heterocyclic ring joined between positions 4 and 5 of the benzodiazepine moiety are described. The heterocyclic ring will contain the nitrogen atom appearing at position 4 of the benzodiazepine ring as well as the hetero atom, which may be either oxygen or nitrogen, attached to the carbon atom at the 5-position of the benzodiazepine ring. A bearing an oxygen atom in the new heterocyclic ring may be formed from the corresponding 4,5-unsaturated benzodiazepines by treatment with an epoxide compound in the presence of an acid catalyst. A bearing either a nitrogen or an oxygen atom in the new heterocyclic ring may be prepared by cyclization of the corresponding open compound. A are useful as sedative, muscle relaxant and anti-convulsant agents.
    Type: Grant
    Filed: April 12, 1976
    Date of Patent: September 20, 1977
    Assignee: Hoffman-La Roche Inc.
    Inventors: Michael Edward Derieg, James Valentine Earley, Rodney Ian Fryer, Leo Henryk Sternbach
  • Patent number: 4049798
    Abstract: A method for the treatment of Herpes Simplex comprising administration of a mixture comprising (a) Vitamin C and (b) Vitamin P.
    Type: Grant
    Filed: February 9, 1976
    Date of Patent: September 20, 1977
    Assignees: William K. Bottomley, O. J. Brightwell, Thomas J. Newell, III
    Inventor: William K. Bottomley
  • Patent number: 4049667
    Abstract: Tricyclic benzodiazepine derivatives ("A") bearing a hydroxylower alkyl substituent in the 1-position and a heterocyclic ring joined between positions 4 and 5 of the benzodiazepine moiety are described. The heterocyclic ring will contain the nitrogen atom appearing at position 4 of the benzodiazepine ring as well as the hetero atom, which may be either oxygen or nitrogen, attached to the carbon atom at the 5-position of the benzodiazepine ring. "A" bearing an oxygen atom in the new heterocyclic ring may be formed from the corresponding 4,5-unsaturated benzodiazepines by treatment with an epoxide compound in the presence of an acid catalyst. "A" bearing either a nitrogen or an oxygen atom in the new heterocyclic ring may be prepared by cyclization of the corresponding open compound. "A" are useful as sedative, muscle relaxant and anti-convulsant agents.
    Type: Grant
    Filed: April 12, 1976
    Date of Patent: September 20, 1977
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Michael Edward Derieg, James Valentine Earley, Rodney Ian Fryer, Leo Henryk Sternbach
  • Patent number: 4049668
    Abstract: Cationic fluorochemical surfactants useful as antistatic agents and lubricants for polymeric shapes are prepared from 2,2,3,4,4,4-hexafluorobutanol or perfluorobutyric acid. Hexafluorobutanol is reacted with bromoundecanoic acid to obtain a bromoester which is then reacted with pyridine to obtain a cationic surfactant. Perfluorobutyric acid is esterified with methanol to obtain methyl perfluorobutyrate which is then reacted with dimethylaminopropylamine to obtain an amino-amide which is then reacted with hydrogen peroxide to obtain the N-oxide derivative which is neutralized with glycolic acid to obtain a cationic surfactant, a salt of the N-oxide derivative.
    Type: Grant
    Filed: March 21, 1975
    Date of Patent: September 20, 1977
    Assignee: Diamond Shamrock Corporation
    Inventor: Alex J. Szur
  • Patent number: 4048300
    Abstract: Dental preparations containing materials having calcium and phosphate components are described. Such materials are typically fluorapatite, fluorohydroxyapatite, hydroxyapatite prepared by alternately changing the pH from about 7 to about 4 to about 7 several times, including such materials which have incorporated therein ions such as monofluorophosphate and carbonate or divalent ions such as zinc or fluoranions of a metal such as zinc, e.g. ZnF.sub.4.sup.-2.
    Type: Grant
    Filed: January 19, 1976
    Date of Patent: September 13, 1977
    Assignee: Colgate-Palmolive Company
    Inventors: Kenneth Tomlinson, Edward John Duff