Patents Examined by Olga V Tcherkasskaya
  • Antimicrobial compositions comprising minocycline and oxidized cellulose
    Patent number: 11000635
    Abstract: Disclosed are compositions comprised of Oxidized Cellulose (OC), such as oxidized regenerated cellulose (ORC), and an antibiotic comprised of minocycline, methods of preparation thereof and uses thereof.
    Type: Grant
    Filed: November 20, 2018
    Date of Patent: May 11, 2021
    Assignees: Omrix Biopharmaceuticals Ltd., Ethicon, Inc.
    Inventors: Eve Montia, Dwayne Looney, Theresa Scheuble, Ronen Eavri, Roi Mashiach
  • Direct application system and method for the delivery of bioactive compositions and formulations
    Patent number: 10980865
    Abstract: The embodiments relate to improved skin quality, health and appearance using a new delivery method and certain bioactive compositions and formulations. The system incorporates microneedle delivery technology with unique compositions and formulations. Such development allows for the pursuit of personalized medicine, or treatment delivery that can expand to remote controlled environment, immediate compounding and ultimate personalization with a state of the art longitudinal data predictive analytics. Certain formulations described herein are unique, combinatory and synergistic. Secured by high-tech proprietary system, there are unlimited potentials using AQT technology including but not limited to 3-D printing of a biodegradable micro chips that can be delivered via injection, AQT or any other possible route.
    Type: Grant
    Filed: August 4, 2014
    Date of Patent: April 20, 2021
    Assignee: AQUAVIT PHARMACEUTICALS, INC.
    Inventors: Sobin Chang, David J. Goldberg, David Shafer
  • Composition for solid preparation, solid preparation, and method for producing the same
    Patent number: 10980747
    Abstract: A composition which is used for the production of a solid preparation exhibiting a small variation of dissolution even at a low content of hydroxypropyl methyl cellulose (HPMC), and others. More specifically, provided are a composition for a solid preparation, the composition including HPMC having a polydispersity of 4.0 or more, as determined by absolute molecular weight measurement, and having a viscosity at 20° C. of 1,500 to 15,0000 mPa·s, as determined in a 2% by mass aqueous solution thereof, and an active ingredient; the solid preparation including the composition; and a method for producing a tablet including a step of dry-mixing said HPMC with an active ingredient to obtain a mixture, or granulating a mixture including said HPMC and an active ingredient to obtain a granulated product, and a step of tableting the mixture or the granulated product to obtain a tablet.
    Type: Grant
    Filed: November 16, 2018
    Date of Patent: April 20, 2021
    Assignee: SHIN-ETSU CHEMICAL CO., LTD.
    Inventor: Takuya Yokosawa
  • Composition and method of using medicament for treatment of cancers and tumors
    Patent number: 10925895
    Abstract: The composition includes a chemical depilatory that may be used in a method of destroying cancer and/or tumor cells and removing the resulting debris from the body. The composition includes thioglycolate and is directly applied to the cancer and/or tumor target cells to interrupt and disable their functioning. This method is unique because it enables the composition to affect the cancer and/or tumor cells without being transported by a carrier through the body to them. This anti-cancer and anti-tumor treatment not only targets the abnormal cells, but also eradicates the microorganisms in the tissue at the target site, which prevents the abnormal growth from recurring due to the presence of residual microorganisms that may trigger formation of dysplastic cells.
    Type: Grant
    Filed: October 24, 2019
    Date of Patent: February 23, 2021
    Inventor: Amy Dukoff
  • Injectable composition for delivery of a biologically active agent
    Patent number: 10905649
    Abstract: The invention relates to an injectable composition for rapid and sustained delivery of a biologically active agent and to uses of the injectable composition in the treatment or prevention of a condition in a subject. The injectable composition comprises a water-in-oil emulsion having an aqueous phase dispersed in an oil phase. The aqueous phase comprises a plurality of hydrogel particles and an aqueous liquid and a biologically active agent is contained in the hydrogel particles and in the aqueous liquid.
    Type: Grant
    Filed: April 11, 2017
    Date of Patent: February 2, 2021
    Assignee: CAPSULAR TECHNOLOGIES PTY LTD
    Inventors: Mohammad Al Kobaisi, David E. Mainwaring
  • Targeted nanoparticle conjugates
    Patent number: 10905762
    Abstract: A composition for treating a disorder in a subject includes a polyethylene glycolylated (PEGylated) nanoparticle, at least one hydrophobic therapeutic agent coupled to the surface of the nanoparticle; and at least one targeting moiety coupled to polyethylene glycol of the nanoparticle for targeting the composition to a cell associated with disorder.
    Type: Grant
    Filed: July 30, 2019
    Date of Patent: February 2, 2021
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: James Basilion, Clemens Burda
  • Nutraceuticals having sustained release for improved bioavailability and method of production
    Patent number: 10898477
    Abstract: The present disclosure describes economical processes to improve the bioavailability of nutraceuticals by formulations that induce micronization and sustained release. The inventive process can be used to increase the solubility and bioavailability of lipophilic and moderately water-soluble nutraceuticals by combining excipients that increase the solubility and induce sustained release of the active compounds. The inventive process also can be used to increase the residence time of highly water-soluble nutraceuticals that are metabolized and eliminated quickly from the body, consequently increasing the therapeutic potential. The disclosed formulations advantageously are freely flowing powders that can be used to formulate with other ingredients into tablets, capsules, or the like; or used as bulk powders.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: January 26, 2021
    Assignee: BIOACTIVES LLC
    Inventors: Doddabele L. Madhavi, Daniel I. Kagan
  • Methods of assessing suitability of use of pharmaceutical compositions of albumin and paclitaxel
    Patent number: 10900951
    Abstract: The present invention provides methods of assessing suitability of a pharmaceutical composition for medical use. The pharmaceutical composition comprises nanoparticles comprising paclitaxel coated with albumin and a non-nanoparticle portion comprising albumin and paclitaxel.
    Type: Grant
    Filed: July 22, 2019
    Date of Patent: January 26, 2021
    Assignee: Abraxis BioScience, LLC
    Inventors: Viktor Peykov, Willard Foss, Daniel W. Pierce, Neil P. Desai
  • Microbial-relief composition
    Patent number: 10894032
    Abstract: The present invention includes an antimicrobial composition comprising a safe and effective amount of a surfactant, e.g., sodium dodecylbenzene sulfonate, a safe and effective amount of ascorbic acid; and optionally a safe and effective amount of an excipient, e.g., magnesium stearate. The composition may further comprise a safe and effective amount of an antibiotic, a safe and effective amount of stearic acid, a dermatologically acceptable cream compound, a chlorine compound, and/or an abrasion material.
    Type: Grant
    Filed: March 27, 2015
    Date of Patent: January 19, 2021
    Assignee: CURAZENE, LLC
    Inventors: Ronald J. Lockard, Dominic G. Brown, James Pate
  • Methods and compositions for controlling fungus-growing ants
    Patent number: 10888089
    Abstract: The invention relates to a method for fighting fungus-growing ants, and to a formicide composition capable of destroying specifically the colonies of fungus-growing ants. The invention also relates a kit for use with said method.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: January 12, 2021
    Assignee: UNIVERSITE PARIS EST CRETEIL VAL DE MARNE
    Inventors: Philippe Mora, Léonide Celini
  • Fungicidal compositions
    Patent number: 10869474
    Abstract: The present invention relates to the use of a composition as a fungicide, wherein said composition comprises at least one compound of formula (I) or formula (II) wherein wherein R2, R3, R4, R5, R6 and R7 are independently of each other H, OH or OCH3.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: December 22, 2020
    Assignees: UNIVERSITÄT BASEL, FORSCHUNGSINSTITUT FÜR BIOLOGISCHEN LANDBAU (FIBL)
    Inventors: Matthias Hamburger, Olivier Potterat, Justine Ramseyer, Hans-Jakob Schärer, Barbara Thürig, Lucius Tamm, Thomas Oberhänsli
  • Solid nanoparticle with inorganic coating
    Patent number: 10864171
    Abstract: A nanoparticle having a solid core comprising a biologically active substance, said core being enclosed by an inorganic coating, a method for preparing the nanoparticle, and the use of the nanoparticle in therapy. A kit comprising the nanoparticle and a pharmaceutical composition comprising the nanoparticle.
    Type: Grant
    Filed: October 16, 2019
    Date of Patent: December 15, 2020
    Assignee: NANEXA AB
    Inventors: Jan-Otto Carlsson, Anders Johansson, Marten Rooth
  • Stable formulations for immune-modulatory macrolides
    Patent number: 10864200
    Abstract: The present description relates to a liquid composition having at least one immune-modulatory macrolide compound and an essentially cell-free blood hemolysate. The present description further relates to a method for manufacturing a stabilized immune-modulatory macrolide calibration solution, by a) preparing a solution comprising an essentially cell-free blood hemolysate, b) admixing a predetermined amount of at least one immune-modulatory macrolide into said solution comprising an essentially cell-free blood hemolysate, and, thereby c) manufacturing a stabilized immune-modulatory macrolide calibration solution. Furthermore, the present description relates to kits, uses, devices, methods and to an immune-modulatory macrolide compound calibration solution related thereto.
    Type: Grant
    Filed: September 6, 2019
    Date of Patent: December 15, 2020
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Ewelina Hegel, Hans-Peter Josel, Eloisa Lopez-Calle, Josef Roedl, Noah Weiss, Benjamin Tiemann
  • Secnidazole for use in the treatment of bacterial vaginosis
    Patent number: 10857133
    Abstract: Embodiments are directed to a secnidazole formulations and the use of a secnidazole formulation for the treatment of bacterial vaginosis (BV).
    Type: Grant
    Filed: September 27, 2019
    Date of Patent: December 8, 2020
    Assignee: LUPIN INC.
    Inventors: Helen S. Pentikis, David Palling, Carol J. Braun
  • Secnidazole for use in the treatment of bacterial vaginosis
    Patent number: 10849884
    Abstract: Embodiments are directed to a secnidazole formulations and the use of a secnidazole formulation for the treatment of bacterial vaginosis (BV).
    Type: Grant
    Filed: May 3, 2019
    Date of Patent: December 1, 2020
    Assignee: LUPIN INC.
    Inventors: Helen S. Pentikis, David Palling, Carol J. Braun
  • Foaming agent-containing cosmetic compositions having pigment-containing starch particulates and anionic polymer
    Patent number: 10835473
    Abstract: The present disclosure relates to cosmetic compositions for the cleaning of keratinic fibers. An exemplary cosmetic composition includes, based on the total weight of the cosmetic composition, a) a particulate comprising, based on the total weight of the particulate, a1) from about 65 to about 98% by weight of a starch, and a2) from about 1.0 to about 3.0% by weight of a pigment, b) an anionic polymer comprising structural units of the formula (I), the formula (II), and the formula (III): wherein R1, R2 and R4, each independently of one another, stand for a hydrogen atom or a C1-C4 alkyl group, R3 stands for a branched or unbranched, saturated or unsaturated C1-C12 alkyl group, R5 stands for a branched or unbranched, saturated or unsaturated C6-C14 alkyl group, A stands for oxygen, sulfur or an NH group, and c) a foaming agent.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: November 17, 2020
    Assignee: Henkel AG & Co. KGaA
    Inventors: Thorsten Knappe, Tim Bethge
  • Multi-layer hydrogel capsules for encapsulation of cells and cell aggregates
    Patent number: 10835486
    Abstract: Biocompatible hydrogel capsules encapsulating mammalian cells having a diameter of greater than 1 mm, and optionally a cell free core, are disclosed which have reduced fibrotic overgrowth after implantation in a subject. Methods of treating a disease in a subject are also disclosed that involve administering a therapeutically effective amount of the disclosed encapsulated cells to the subject.
    Type: Grant
    Filed: December 15, 2016
    Date of Patent: November 17, 2020
    Assignees: Massachusetts Institute of Technology, The Children's Medical Center Corporation
    Inventors: Minglin Ma, Daniel G. Anderson, Robert S. Langer, Omid Veiseh, Arturo Jose Vegas, Joshua Charles Doloff, Delai Chen, Christian J. Kastrup
  • Propellant-containing cosmetic preparations with starch particles and anionic polymer
    Patent number: 10835472
    Abstract: The present disclosure relates to cosmetic compositions for cleaning keratin fibres. An exemplary cosmetic composition includes, in relation to the total weight of the cosmetic composition, a) a particle comprising, in relation to the total weight of the particle, from about 65 to about 99% by weight of a native and/or physically modified starch, b) an anionic polymer comprising a structural unit of formula (I), a structural unit of formula (II), and a structural unit of formula (III): in which R1, R2 and R4, independently of one another, stand for a hydrogen atom or a C1-C4 alkyl group, R3 stands for a branched or unbranched, saturated or unsaturated C1-C12 alkyl group, R5 stands for a branched or unbranched, saturated or unsaturated C6-C14 alkyl group, and A stands for oxygen, sulfur or an NH group, and c) at least one propellant.
    Type: Grant
    Filed: August 30, 2018
    Date of Patent: November 17, 2020
    Assignee: Henkel AG & Co. KGaA
    Inventors: Thorsten Knappe, Tim Bethge
  • Layered bodies and compositions containing them
    Patent number: 10828263
    Abstract: A layered body comprising: a core region; at least one intermediate layer disposed around the core region; and an outer layer disposed around the at least one intermediate layer, wherein at least one of the at least one intermediate layers comprises a gas, the layered body having at least one dimension, measured across the body and through the core region, of 100 ?m or less.
    Type: Grant
    Filed: December 6, 2017
    Date of Patent: November 10, 2020
    Assignee: UCL Business Ltd
    Inventors: Mohan Edirisinghe, Ming Wei Chang, Eleanor Stride
  • Lactoferrin-conjugated nanoparticle complex and use thereof
    Patent number: 10828083
    Abstract: The present invention relates to a lactoferrin-conjugated nanoparticle complex and a novel use thereof. In the nanoparticle complex according to the present invention, lactoferrin or polyethylene glycol-lactoferrin is bound to metal nanoparticles, and according to this construction, it can be confirmed that the metal nanoparticles are not only efficiently targeted to the brain tumor tissues, but also the stability of the metal nanoparticles can be maintained even in the in vivo conditions, and thus it is expected in the treatment of brain tumors to be treatable to targets by approaching more fundamentally.
    Type: Grant
    Filed: March 28, 2017
    Date of Patent: November 10, 2020
    Assignee: INDUSTRY-UNIVERSITY COOPERATION FOUNDATION HANYANG UNIVERSITY
    Inventors: Dong Yun Lee, Seung Jae Lee, Hyung Shik Kim