Patents Examined by P. Achutamurthy
  • Nucleic acids and polypeptides
    Patent number: 6919193
    Abstract: The present invention provides novel nucleic acids, novel polypeptide sequences encoded by these nucleic acids and uses thereof.
    Type: Grant
    Filed: April 10, 2002
    Date of Patent: July 19, 2005
    Assignee: Nuvelo, Inc.
    Inventors: Y. Tom Tang, Ryle Goodrich, Chenghua Liu, Feiyan Ren, Dunrui Wang, Radoje T. Drmanac
  • ?, ?-carotene 15, 15?-monooxygenases, nucleic acid sequences coding therefor and their use
    Patent number: 6897051
    Abstract: Nucleic acid sequences coding for a protein having ?,?-carotene 15,15?-monooxygenase activity and their uses in diagnostics, the synthesis of vitamin A and methods for the introduction of the ?,?-carotene 15,15?-monooxygenase cDNA into host cells are disclosed.
    Type: Grant
    Filed: January 15, 2002
    Date of Patent: May 24, 2005
    Assignee: DSM IP Assets B.V.
    Inventors: Heinrich Bachmann, Roland Brugger, Arno Martin Friedlein, Gabriele Margarethe Wirtz, Wolf-Dietrich Woggon, Adrian Wyss, Markus Wyss
  • DNA encoding a polypeptide required for biosynthesis of TA antibiotic
    Patent number: 6887694
    Abstract: There is provided DNA sequences isolated from Myxococcus xanthus partially encoding a functional portion of a polypeptide component required for the synthesis of antibiotic TA. Also provided are purified, isolated and cloned DNA sequences encoding a polypeptide component required for postmodification of antibiotic TA and encoding a gene product involved in the regulation of the biosynthesis of antibiotic TA. A purified, isolated and cloned DNA sequence having a DNA sequence (seq. ID No:2 and 20) encoding a polypeptide component required for encoding the TA gene cluster and any mutations thereof is provided. Also provided are methods of using the TA genes for combinatorial genetics and of using the TA genes encoding for synthesis and modification or regulation of antibiotic TA.
    Type: Grant
    Filed: November 10, 2000
    Date of Patent: May 3, 2005
    Assignee: Ramot At Tel Aviv University Ltd.
    Inventors: Eugene Rosenberg, Eliora Ron, Elisha Orr, Yossi Paitan
  • Polyhydroxyalkanoate synthase and gene encoding the same enzyme
    Patent number: 6875596
    Abstract: A novel polyhydroxyalkanoate (PHA) synthase derived from a microorganism capable of producing a PHA having a novel side-chain structure and a DNA encoding the amino acid sequence for the synthase are provided. Two PHA synthase proteins (SEQ ID Nos. 1 and 3) derived from Pseudomonas jessenii P161 (FERM BP-7376) and PHA synthase genes encoding these PHA synthases are provided, respectively (SEQ ID Nos. 2 and 4). A recombinant microorganism is endowed with a PHA producing ability.
    Type: Grant
    Filed: September 24, 2002
    Date of Patent: April 5, 2005
    Assignee: Canon Kabushiki Kaisha
    Inventors: Tetsuya Yano, Takeshi Imamura, Sakae Suda, Tsutomu Honma
  • Human GDP-mannose 4,6-dehydratase
    Patent number: 6861055
    Abstract: The invention provides a novel GDP-mannose 4,6-dehydratase.
    Type: Grant
    Filed: June 11, 2001
    Date of Patent: March 1, 2005
    Assignee: Genetics Institute, LLC
    Inventors: Francis Sullivan, Ronald Kriz, Ravindra Kumar
  • Cytosolic phospholipase A2-beta enzymes
    Patent number: 6858421
    Abstract: The invention provides a novel calcium-independent cytosolic phospholipase A2-Beta enzyme, polynucleotides encoding such enzyme and methods for screening unknown compounds for anti-inflammatory activity mediated by the arachidonic acid cascade.
    Type: Grant
    Filed: October 7, 2002
    Date of Patent: February 22, 2005
    Assignee: Genetics Institute, L.L.C.
    Inventors: Ronald Kriz, Chuanzheng Song
  • Hydrogen production
    Patent number: 6858718
    Abstract: The enzyme, iron hydrogenase (HydA), has industrial applications for the production of hydrogen, specifically, for catalyzing the reversible reduction of protons to molecular hydrogen. The present invention relates to the isolation of a nucleic acid sequence from the algae Scenedesmus obliquus, Chlamydomonas reinhardtii, and Chlorella fusca that encodes iron hydrogenase. The invention further discloses the genomic nucleic acid, c-DNA and the protein sequences for HydA. The genes and gene products may be used in a photosynthetic process for hydrogen production which includes growing a microorganism containing the gene coding for HydA in a culture medium under illuminated conditions sufficient to accumulate an endogenous substrate; depleting a nutrient selected from the group consisting of sulfur, iron, and manganese from the medium; then allowing the culture to become anaerobic by consumption of an endogenous or exogenous substrate in the light.
    Type: Grant
    Filed: February 15, 2002
    Date of Patent: February 22, 2005
    Assignee: Melis Energy
    Inventor: Thomas Happe
  • Proteases from gram-positive organisms
    Patent number: 6849440
    Abstract: The present invention relates to the identification of novel serine proteases in Gram-positive microorganisms. The present invention provides the nucleic acid and amino acid sequences for the Bacillus subtilis serine proteases SP1, SP2, SP3, SP4 and SP5. The present invention also provides host cells having a mutation or deletion of part or all of the gene encoding SP1, SP2, SP3, SP4 and SP5. The present invention also provides host cells further comprising nucleic acid encoding desired heterologous proteins such as enzymes. The present invention also provides a cleaning composition comprising a serine protease of the present invention.
    Type: Grant
    Filed: March 26, 2003
    Date of Patent: February 1, 2005
    Assignee: Genencor International, Inc.
    Inventor: David A. Estell
  • Proteases from gram-positive organisms
    Patent number: 6833261
    Abstract: The present invention relates to the identification of novel serine proteases in Gram-positive microorganisms. The present invention provides the nucleic acid and amino acid sequences for the Bacillus subtilis serine proteases SP1, SP2, SP3, SP4 and SP5. The present invention also provides host cells having a mutation or deletion of part or all of the gene encoding SP1, SP2, SP3, SP4 and SP5. The present invention also provides host cells further comprising nucleic acid encoding desired heterologous proteins such as enzymes. The present invention also provides a cleaning composition comprising a serine protease of the present invention.
    Type: Grant
    Filed: March 26, 2003
    Date of Patent: December 21, 2004
    Assignee: Genencor International, Inc.
    Inventor: David A. Estell
  • Sphingosine kinase, cloning, expression and methods of use
    Patent number: 6830916
    Abstract: The invention provides molecules that encode sphingosine kinase, the enzyme that catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (SPP). Vectors and host cells which express sphingosine kinase are also provided, as are methods for evaluating the stimulatory or inhibitory effects of agents on sphingosine kinase production and activity.
    Type: Grant
    Filed: March 2, 2001
    Date of Patent: December 14, 2004
    Inventor: Sarah Spiegel
  • Mutants of Mycobacterium vaccae-derived formate dehydrogenase and uses thereof
    Patent number: 6830907
    Abstract: An objective of the present invention is to provide polypeptides capable of retaining a strong enzyme activity of formate dehydrogenase in the presence of an organic solvent and to provide the uses thereof. Formate dehydrogenase mutant polypeptides, which are resistant to organic solvents, were constructed by substituting cysteines at position 146 and/or at position 256 in the amino acid sequence of Mycobacterium vaccae-derived formate dehydrogenase by site-directed mutagenesis. The polypeptides have strong activities of formate dehydrogenase in the presence of an organic solvent. The mutants are useful for the production of alcohols using ketones as raw material, etc.
    Type: Grant
    Filed: November 28, 2001
    Date of Patent: December 14, 2004
    Assignee: Daicel Chemical Industries, Ltd.
    Inventors: Kazuya Mitsuhashi, Hiroaki Yamamoto, Norihiro Kimoto
  • Polyhydroxyalkanoate synthase and gene encoding the same
    Patent number: 6812013
    Abstract: The present invention provides a PHA (polyhydroxyalkanoate) synthase useful in a process for preparing a PHA, a gene encoding the enzyme, a recombinant vector comprising the gene, a transformant transformed by the vector, a process for producing a PHA synthase utilizing the transformant and a process for preparing a PHA utilizing the transformant. A transformant obtained by introducing a PHA synthase gene from Pseudomonas putida P91 strain into a host microorganism is cultured to produce a PHA synthase or PHA.
    Type: Grant
    Filed: September 18, 2002
    Date of Patent: November 2, 2004
    Assignee: Canon Kabushiki Kaisha
    Inventors: Tetsuya Yano, Takeshi Imamura, Sakae Suda, Tsutomu Honma
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6808911
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: October 21, 2002
    Date of Patent: October 26, 2004
    Assignee: Applera Corporation
    Inventors: Marion Webster, Ming-Hui Wei, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Polyhydroxyalkanoate synthase and gene encoding the same enzyme
    Patent number: 6808910
    Abstract: A novel polyhydroxyalkanoate (PHA) synthase derived from a microorganism capable of producing a PHA having a novel side-chain structure and a DNA encoding the amino acid sequence for the synthase are provided. Two PHA synthase proteins (SEQ ID Nos. 1 and 3) derived from Pseudomonas jessenii P161 (FERM BP-7376) and PHA synthase genes encoding these PHA synthases are provided, respectively (SEQ ID Nos. 2 and 4). A recombinant microorganism is endowed with a PHA producing ability.
    Type: Grant
    Filed: October 9, 2002
    Date of Patent: October 26, 2004
    Assignee: Canon Kabushiki Kaisha
    Inventors: Tetsuya Yano, Takeshi Imamura, Sakae Suda, Tsutomu Honma
  • Isolated human kinase proteins, nucleic acid molecules encoding human kinase proteins, and uses thereof
    Patent number: 6806072
    Abstract: The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the kinase peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the kinase peptides, and methods of identifying modulators of the kinase peptides.
    Type: Grant
    Filed: January 16, 2003
    Date of Patent: October 19, 2004
    Assignee: Applera Corporation
    Inventors: Jane Ye, Chunhua Yan, Valentina Di Francesco, Ellen M. Beasley
  • Polyhydroxyalkanoate synthase and gene encoding the same enzyme
    Patent number: 6803220
    Abstract: A novel polyhydroxyalkanoate (PHA) synthase derived from a microorganism capable of producing a PHA having a novel side-chain structure and a DNA encoding the amino acid sequence for the synthase are provided. Two PHA synthase proteins (SEQ ID NOs. 1 and 3) derived from Pseudomonas cichorii H45 (FERM BP-7374) and PHA synthase genes encoding these PHA synthases are provided, respectively (SEQ ID NOs. 2 and 4). A recombinant microorganism is endowed with a PHA producing ability.
    Type: Grant
    Filed: September 30, 2002
    Date of Patent: October 12, 2004
    Assignee: Canon Kabushiki Kaisha
    Inventors: Tetsuya Yano, Takeshi Imamura, Sakae Suda, Tsutomu Honma
  • 1,3-dicarbonyl-dioxygenase—a new c-c-bond cleaving enzyme
    Patent number: 6790644
    Abstract: An enzyme that cleaves 1,3-dicarbonyl compounds by incorporating molecular oxygen into the substrate in amounts equimolar to the amount of substrate cleaved. The enzyme from Acinetobacter johnsonii is a multimer of about 67 kilodaltons made up of subunits of about 16.6 kilodaltons. Nucleotide and amino acid sequence analysis of a cloned A. johnsonii subunit indicates little homology with other proteins. Native or recombinant enzyme can be used to decontaminate or detoxify acetylacetone or related diketones.
    Type: Grant
    Filed: May 7, 2002
    Date of Patent: September 14, 2004
    Assignee: Biocatalytics, Inc.
    Inventors: Grit Straganz, Anton Glieder, Lothar Brecker
  • Cytochrome P450 oxygenases and their uses
    Patent number: 6787343
    Abstract: Oxygenase enzymes and the use of such enzymes to produce paclitaxel (Taxol™), related taxoids, as well as intermediates in the Taxol biosynthetic pathway are disclosed. Also disclosed are nucleic acid sequences encoding the oxygenase enzymes.
    Type: Grant
    Filed: May 8, 2002
    Date of Patent: September 7, 2004
    Assignee: Washington State University Research Foundation
    Inventors: Rodney B. Croteau, Anne Schoendorf, Stefan Jennewein
  • Human proteases and polynucleotides encoding the same
    Patent number: 6743621
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: August 7, 2002
    Date of Patent: June 1, 2004
    Assignee: Lexicon Genetics Incorporated
    Inventors: Gregory Donoho, John Scoville, C. Alexander Turner, Jr., Glenn Friedrich, Alejandro Abuin, Brian Zambrowicz, Arthur T. Sands
  • Human calcium dependent proteases, polynucleotides encoding the same, and uses thereof
    Patent number: 6716614
    Abstract: Novel human polynucleotide and polypeptide sequences are disclosed that can be used in therapeutic, diagnostic, and pharmacogenomic applications.
    Type: Grant
    Filed: July 23, 2002
    Date of Patent: April 6, 2004
    Assignee: Lexicon Genetics Incorporated
    Inventors: Gregory Donoho, C. Alexander Turner, Jr., Michael C. Nehls, Glenn Friedrich, Brian Zambrowicz, Arthur T. Sands