Abstract: A device for and a method of measuring a blood flow of a living body having blood vessels that emit bio-photons and through which blood flows, the device including a detector positioned adjacent to a predetermined portion of the living body for measuring a bio-photon emission from the living body and a processor for analyzing and displaying the blood flow of the living body based on a value of the bio-photon emission.

Abstract: Systems and methods for processing sensor analyte data, including initiating calibration, updating calibration, evaluating clinical acceptability of reference and sensor analyte data, and evaluating the quality of sensor calibration. During initial calibration, the analyte sensor data is evaluated over a period of time to determine stability of the sensor. The sensor may be calibrated using a calibration set of one or more matched sensor and reference analyte data pairs. The calibration may be updated after evaluating the calibration set for best calibration based on inclusion criteria with newly received reference analyte data. Fail-safe mechanisms are provided based on clinical acceptability of reference and analyte data and quality of sensor calibration. Algorithms provide for optimized prospective and retrospective analysis of estimated blood analyte data from an analyte sensor.

Abstract: Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism, when such parameters are potentially affected by other concurrent events. In one exemplary embodiment, apparatus and methods for compensating for occlusive events (e.g., pressure cuff inflation) occurring ipsilateral to the location of parameter measurement are disclosed. Upon passive detection of signal degradation resulting from the event, the apparatus selectively enters a “wait state” wherein further processing of the hemodynamic data is suspended until the degrading event subsides. This behavior mitigates any adverse effects the event might have on the accuracy of the representation of the measured hemodynamic parameter generated by the system. In another exemplary embodiment, the measured data is analyzed in order to classify the type of event (e.g.

Abstract: Embodiments of the present invention improve the accuracy of measurements and/or in vivo calibrations of a biosensor by (1) using more than one sensor signal value and/or more than one directly sampled and measured value, such as a capillary blood glucose value, and/or by (2) delaying the acquisition of a sensor output value that is compared with a directly sampled and measured value, such as a capillary blood glucose value, during a calibration. In an embodiment of the present invention, the median of a series of measured values, or a median or mean of the medians, may be utilized to provide more consistent and accurate measurement data and/or to compensate for error or artifact.

Abstract: A hypovolemia monitor comprises a plethysmograph input responsive to light intensity after absorption by fleshy tissue. A measurement of respiration-induced variation in the input is made. The measurement is normalized and converted into a hypovolemia parameter. An audible or visual indication of hypovolemia is provided, based upon the hypovolemia parameter.

Abstract: A pressure sensor is deployed in the right atrium and is in contact with the tissue of the fossa ovalis. The fossa ovalis acts as a membrane and the pressure sensor determines the relative and/or absolute pressure within the left atrium while remaining within the right atrium. A variety of embodiment are provided to deploy and anchor the sensor into the proper position.

Abstract: A method of diabetes management, comprising (a) providing a glucose meter in communication with a portable microprocessor-based unit; (b) transmitting blood glucose level data into the hand-held microprocessor-based unit from the blood glucose meter; (c) running a program of instructions on the portable microprocessor-based unit or the glucose meter or both; (d) inputting data based upon the blood glucose level data as input data for the program of instructions; and (e) providing a signal to inject insulin when the blood glucose level data indicates.

Abstract: Handling of the condensate collecting vessel in conventional breath analysis apparatuses having a cold condensation mechanism is complicated, and time consuming.

Abstract: Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices, that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices comprise a unique microarchitectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.

Abstract: The present application is directed to a detector to detect or generate measuring signals that are indicative of the respiration of a person, wherein said detector can be used advantageously in view of hygiene and stands out due to a simple and robust configuration. According to a first aspect, the detector detects a signal that is indicative of the activity of the respiratory muscles of a person to be examined, the detector comprising a band which, in the application position, is passed around a torso region which widens and narrows when the person to be examined breathes, as well as a structure that is included in the band and loaded in accordance with the narrowing or widening of the torso region. The structure is configured such that it causes a change in the volume of a measuring space device depending on a tensile force.

Abstract: Devices and methods for detecting inadequate tissue perfusion by measuring a parameter other than heart rate such as vascular blood pressure, intracardiac blood pressure, vascular blood flow or tissue perfusion, in addition to or as a substitute for heart rate. Such devices and methods improve the accuracy of determining when and to what degree therapy should be administered to treat inadequate tissue perfusion, such as pre-syncope, syncope, or orthostatic hypotension, particularly in the absence of abnormal cardiac function.

Abstract: Devices and methods for determining analyte levels are described. The devices and methods allow for the implantation of analyte-monitoring devices, such as glucose monitoring devices, that result in the delivery of a dependable flow of blood to deliver sample to the implanted device. The devices comprise a unique microarchitectural arrangement in the sensor region that allows accurate data to be obtained over long periods of time.

Abstract: A blood-pressure meter having storing means for storing a blood pressure measurement result, and time measurement means for measuring a time is disclosed. The blood-pressure meter includes: input means for entering behavior history; means for storing the blood pressure measurement result into the storing means while associating the blood pressure measurement result with a time when blood pressure measurement is performed; and means for storing the entered behavior history into the storing means while associating the behavior history with a time corresponding to the behavior history.

Abstract: The invention is directed to a method and a device for determining the blood pressure, in which a pressure sensor is applied to an individual's limb to detect the blood pressure prevailing in said limb. According to the present invention, the orientation of the limb is detected by means of an orientation sensing unit, and the detected blood pressure is corrected in an evaluating unit in response to the limb's detected orientation.

Abstract: A system and apparatus implementing a graphical user interface module for displaying information conveying a level of risk of delivery with shoulder dystocia associated to an obstetrics patient. The graphical user interface module displays a set of user modifiable information fields for allowing a user to enter a set of patient information data elements associated to the obstetrics patient. The graphical user interface module also displays a control allowing a user to cause the set of information data elements to be transmitted to a processing unit adapted to derive patient risk data at least in part on the basis of the set of information data elements, the patient risk data conveying a level of risk of delivery with shoulder dystocia. The graphical user interface module then displays the patient risk data with reference to risk assessment information.

Abstract: A method and an apparatus for estimating a level of risk of shoulder dystocia with neonatal injury associated to an obstetrics patient are provided. A set of information data elements associated to an obstetrics patient is received including information derived from a maternal weight component, a maternal height component and a fetal weight component. The set of information data elements is processing to derive a ranking data element associated to the obstetrics patient. The ranking data element conveys a level of risk of shoulder dystocia associated to the obstetrics patient. The ranking data element is then released.

Abstract: A method and system for utilizing neurophysiologic information obtained by techniques such as quantitative electroencephalography (QEEG), electrode recordings, MRI in appropriately matching patients with therapeutic entities is disclosed. The present invention enables utilization of neurophysiologic information, notwithstanding its weak correlation with extant diagnostic schemes for mental disorders, for safer and expeditious treatment for mental disorders, discovering new applications for therapeutic entities, improved testing of candidate therapeutic entities, inferring the presence or absence of a desirable response to a treatment, and deducing the mode of action of one or more therapeutic entities. In particular, methods for effectively comparing neurophysiologic information relative to a reference set are disclosed along with database-based tools for deducing therapeutic entity actions on particular patients such that these tools are readily accessible to remote users.

Abstract: Improved methods and apparatus for non-invasively assessing one or more parameters associated with fluidic systems such as the circulatory system of a living organism. In a first aspect, an improved method of continuously measuring pressure from a compressible vessel is disclosed, wherein a substantially optimal level of compression for the vessel is achieved and maintained using perturbations (e.g., modulation) of the compression level of the vessel. In one exemplary embodiment, the modulation is conducted according to a pseudo-random binary sequence (PBRS). In a second aspect, an improved apparatus for determining the blood pressure of a living subject is disclosed, the apparatus generally comprising a pressure sensor and associated processor with a computer program defining a plurality of operating states related to the sensed pressure data. Methods for pressure waveform correction and reacquisition, as well as treatment using the present invention, are also disclosed.

Abstract: A method of measuring pressure within the human body including implanting a pressure sensing assembly having a flexible structure and first and second sensor elements having self-contained power supplies coupled to the flexible structure. Periodic data collection events are performed to collect data from the sensor elements. A data collection event includes a request for data from a remote communication device, a transfer of sensor data to the remote communication device and a processing of the sensor data. The invention also includes a sensor assembly for implantation into a human body. The sensor assembly includes a first sensor having a self-contained power supply, a sensing element and an integral communication device capable of communicating with a remote communication device. The sensor assembly also includes a second sensor and a flexible structure to which the first and second sensor are attached.

Abstract: Devices and methods for maintaining a medical device on-body are provided. Embodiments include medical device securement systems having first and second on-body securement elements. Also provided are systems and kits for use maintaining a medical device on-body.